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Anterior and posterior capsule densitometry levels after femtosecond laser-assisted cataract surgery

International Journal of Ophthalmology(English edition) 2018年第4期11卷 623-628页

作者： Txomin Alberdi javier Mendicute Lucia Bascaran Olatz Barandika javier ruiz-ederra Department of Ophthalmology Donostla University HospitalDonostia-San Sebastian 20014Spain Biodonostia Health Research Institute Donostia-San Sebastian 20014Spain

AIM： To analyze and compare five different variables over one year follow-up（1 wk, 1, 3, 6 and 12 mo）： anterior capsule（AC）, and posterior capsule（PC） area densitometry values, AC and PC linear densitometry values, and AC opening area reduction ratio after femtosecond laserassisted cataract surgery. METHODS： This was a prospective comparative study. Seventy-one patients underwent femtosecond laser-assisted cataract surgery on single eye between June 2014 and December 2015. A 5.0 mm diameter laser assisted anterior capsulotomy was performed on all eyes. In every postsurgery evaluation, AC opacificaction（ACO） and PC opacification（PCO） density levels were provided by Oculus Pentacam·HR using area and linear densitometry methods. Digital images were captured with a slit-lamp Topcon photographic camera and IMAGEnet· 5 software. The AC opening area on the digital images was measured using the Sketchandcalc area calculator and converted to reduction ratio ***： Using Pearson correlation coefficient（PCC）, we found no correlation（r=-0.091, P=0.46） in the twelfth month assessment between the evolution of ACO area densitometry values and PCO area densitometry values considered as independent variables. We found no correlation, using PCC（r=-0.096, P=0.43） between the evolution of ACO linear densitometry values and PCO linear densitometry values, in the twelfth month visit, working both as independent variables. AC linear densitometry levels and AC area densitometry levels continued to grow strongly from sixth to twelfth months. Analysis of the values of AC opening area reduction ratio（1 wk, 1, 3, 6, 12 mo） revealed statistically significant differences between the values of successive examinations but the magnitude of the change decreased. In the final period of monitoring between six and twelve months the magnitude of change was ***： Our results show strong increases of Scheimpflug ACO densitometry values from the sixth to the twelfth month while capsulorh

关键词： anterior capsule opacification area densitometry femtosecond laser-assisted cataract surgery linear densitometry Pentacam?HR Scheimpflug posterior capsule pacification

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船厂1862

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城市环境设计 2024年第1期147卷 16-23页

作者： javier Villar ruiz 寺崎豊涌田纯树胡实秋天 Rita Topa 埃里塔·阿塔利加纳永一

我们维护并修复了一个建于1972年的砖砌造船厂，该船厂位于上海黄浦江边，翻修后成为一个新的综合设施，包含剧院和零售空间。一个高20米、长150米的“洞穴”穿透建筑的中心，让你感受到一艘巨轮的体量感，在空间中产生强烈的印象。支...

我们维护并修复了一个建于1972年的砖砌造船厂，该船厂位于上海黄浦江边，翻修后成为一个新的综合设施，包含剧院和零售空间。一个高20米、长150米的“洞穴”穿透建筑的中心，让你感受到一艘巨轮的体量感，在空间中产生强烈的印象。支撑原建筑的混凝土柱子进一步强化了这种效果。西侧的外墙是一道半透明的“屏风”，由多孔砖制成，用直径8毫米的不锈钢丝固定。砖排列的密度会发生变化，就像渐变色一样。

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All-fiber ellipsometer for nanoscale dielectric coatings

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Opto-Electronic Advances 2023年第10期6卷 31-43页

作者： Jose javier Imas Ignacio R.Matías Ignacio Del Villar Aritz Ozcáriz Carlos ruiz Zamarreño Jacques Albert Department of Electrical Electronic and Communications EngineeringPublic University of NavarrePamplona 31006Spain Institute of Smart Cities Public University of NavarrePamplona 31006Spain Department of Electronics Carleton UniversityOttawa(Ontario)K1S 5B6Canada.

Multiple mode resonance shifts in tilted fiber Bragg gratings(TFBGs)are used to simultaneously measure the thickness and the refractive index of TiO_(2) thin films formed by Atomic Layer Deposition(ALD)on optical *** is achieved by comparing the experimental wavelength shifts of 8 TFBG resonances during the deposition process with simulated shifts from a range of thicknesses(T)and values of the real part of the refractive index(n).The minimization of an error function computed for each(n,T)pair then provides a solution for the thickness and refractive index of the deposited film and,a posteriori,to verify the deposition rate throughout the process from the time evolution of the wavelength shift *** of the results were carried out with a conventional ellipsometer on flat witness samples deposited simultaneously with the fiber and with scanning electron measurements on cut pieces of the fiber *** final values obtained by the TFBG(n=2.25,final thickness of 185 nm)were both within 4%of the validation *** approach provides a method to measure the formation of nanoscale dielectric coatings on fibers in situ for applications that require precise thicknesses and refractive indices,such as the optical fiber sensor ***,the TFBG can also be used as a process monitor for deposition on other substrates for deposition methods that produce uniform coatings on dissimilar shaped substrates,such as ALD.

关键词： tilted fiber Bragg grating(TFBG) mode transition ellipsometer

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Deep convolutional neural network for damaged vegetation segmentation from RGB images based on virtual NIR-channel estimation

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Artificial Intelligence in Agriculture 2022年第1期6卷 199-210页

作者： Artzai Picon Arantza Bereciartua-Perez Itziar Eguskiza javier Romero-Rodriguez Carlos javier Jimenez-ruiz Till Eggers Christian Klukas Ramon Navarra-Mestre TECNALIA Basque Research and Technology Alliance(BRTA)Parque Tecnológico de BizkaiaC/Geldo.Edificio 700E-48160 Derio-BizkaiaSpain University of the Basque Country Plaza Torres Quevedo48013 BilbaoSpain BASF Espanola S.L.Carretera A376 41710 Utrera SevillaSpain BASF SE Speyererstrasse 267117 LimburgerhofGermany

Performing accurate and automated semantic segmentation of vegetation is a first algorithmic step towards more complex models that can extract accurate biological information on crop health,weed presence and phenological state,among ***,models based on normalized difference vegetation index(NDVI),near infrared channel(NIR)or RGB have been a good indicator of vegetation ***,these methods are not suitable for accurately segmenting vegetation showing damage,which precludes their use for downstream phenotyping *** this paper,we propose a comprehensive method for robust vegetation segmentation in RGB images that can cope with damaged *** method consists of a first regression convolutional neural network to estimate a virtual NIR channel from an RGB ***,we compute two newly proposed vegetation indices from this estimated virtual NIR:the infrared-dark channel subtraction(IDCS)and infrared-dark channel ratio(IDCR)***,both the RGB image and the estimated indices are fed into a semantic segmentation deep convolutional neural network to train a model to segment vegetation regardless of damage or *** model was tested on 84 plots containing thirteen vegetation species showing different degrees of damage and acquired over 28 *** results show that the best segmentation is obtained when the input image is augmented with the proposed virtual NIR channel(F1=0:94)and with the proposed IDCR and IDCS vegetation indices(F1=0:95)derived from the estimated NIR channel,while the use of only the image or RGB indices lead to inferior performance(RGB(F1=0:90)NIR(F1=0:82)or NDVI(F1=0:89)channel).The proposed method provides an end-to-end land cover map segmentation method directly from simple RGB images and has been successfully validated in real field conditions.

关键词： Vegetation indices estimation Vegetation coverage map Near infrared estimation Convolutional neural network Deep learning

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Serum levels of the novel adipokine isthmin-1 are associated with obesity in pubertal boys

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World Journal of Pediatrics 2023年第9期19卷 864-872页

作者： Francisco javier ruiz‑Ojeda Augusto Anguita‑ruiz Maria C.Rico Rosaura Leis Gloria Bueno Luis A.Moreno Mercedes Gil‑Campos Ángel Gil Concepción M.Aguilera Department of Biochemistry and Molecular Biology Ⅱ School of PharmacyUniversity of GranadaGranadaSpain Instituto de Investigación Biosanitaria Ibs.GRANADA 18012 GranadaSpain Institute of Nutrition and Food Technology“JoséMataix” Center of Biomedical ResearchUniversity of GranadaAvda.del Conocimiento S/N.18016 ArmillaGranadaSpain RG Adipocytes and Metabolism Institute for Diabetes and ObesityHelmholtz Center Munich85764 MunichGermany Barcelona Institute for Global Health ISGlobal08003 BarcelonaSpain CIBEROBN (Physiopathology of Obesity and Nutrition CB12/03/30038)Institute of Health Carlos Ⅲ(ISCⅢ)28029 MadridSpain Unit of Investigation in Human Nutrition Growth and Development of Galicia(GALINUT)University of Santiago de Compostela(USC)Santiago de CompostelaSpain Pediatric Nutrition Research Group Institute of Sanitary Research of Santiago de Compostela(IDIS)CHUS-USC15706 Santiago de CompostelaSpain Unit of Pediatric Gastroenterology Hepatology and NutritioPediatric ServiceUniversity Clinical Hospital of Santiago(CHUS)15706 Santiago de CompostelaSpain GENUD Research group Institute of Sanitary Research of Aragón(IIS Aragón)University of ZaragozaZaragozaSpain Instituto Agroalimentario de Aragón(IA2) Universidad de Zaragoza-CITAZaragozaSpain Unit of Pediatric Endocrinology University Clinical Hospital Lozano Blesa50009 ZaragozaSpain Metabolism and Investigation Unit Reina Sofa University HospitalMaimónides Institute of Biomedicine Research of Córdoba(IMIBIC)University of Córdoba14071 CórdobaSpain

Objectives To evaluate whether there is an association between the serum levels of the novel insulin-like adipokine isthmin-1(ISM1)and obesity-related phenotypes in a population of Spanish children and to investigate the plausible molecular alterations behind the alteration of the serum levels of this protein in children with *** The study population is a sub-cohort of the PUBMEP research project,consisting of a cross-sectional population of 119 pubertal children with overweight(17 boys,19 girls),obesity(20 boys,25 girls),and normal weight(17 boys,21 girls).All subjects were classified into experimental groups according to their sex,obesity,and insulin resistance(IR)*** were counted anthropometry,glucose and lipid metabolism,inflammation and cardiovascular biomarkers as well as isthmin-1(ISM1)serum *** population was intended as a discovery population to elucidate the relationship between obesity and ISM1 levels in ***,the study population had blood whole-genome DNA methylation examined,allowing deepening into the obesity–ISM1 molecular *** Higher serum ISM1 levels were observed in boys with obesity than in normal weight(P=0.004)and overweight(P=0.007)***1 serum levels were positively associated with body mass index(BMI)Z-score(P=0.005)and fat mass(P=0.058)and negatively associated with myeloperoxidase(MPO)(P=0.043)in *** we did not find associations between ISM1 serum levels and metabolic outcomes in girls,which may indicate a putative sexual dimorphism,fat mass was positively associated in all children,including boys and girls(P=0.011).DNA methylation levels in two-enhancer-related CpG sites of ISM1(cg03304641 and cg14269097)were associated with serum levels of ISM1 in *** ISM1 is associated with obesity in boys at the pubertal stage,elucidating how this protein might be of special relevance as a new biomarker of obesity in *** studies including a longitudina

关键词： Children Epigenetics Isthmin-1 Obesity Puberty

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2-Cys Peroxiredoxins Participate in the Oxidation of Chloroplast Enzymes in the Dark

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Molecular Plant 2018年第11期11卷 1377-1388页

作者： Valle Ojeda Juan Manuel Perez-ruiz Francisco javier Cejudo Instituto de Bioquimica Vegetaly Fotosintesis Universidad de Sevilla and Consejo Superior de lnvestigaciones CientificasAvenida Americo Vespucio 4941092SevillaSpain

Most redox-regulated chloroplast enzymes are reduced during the day and oxidized during the *** the reduction mechanism of light-dependent enzymes is well known,the mechanism mediating their oxidation in the dark remains *** thiol-dependent peroxidases,2-Cys peroxiredoxins (Prxs),play a key role in light-dependent reduction of chloroplast *** transfer reducing equivalents of thiols to hydrogen peroxide,suggesting the participation of these peroxidases in enzyme oxidation in the ***,we have addressed this issue by analyzing the redox state of well-known redox-regulated chloroplast enzymes in response to darkness in Arabidopsis thaliana mutants deficient in chloroplastlocalized Prxs (2-Cys Prxs A and B,Prx ⅡE,and Prx Q).Mutant plants lacking 2-Cys Prxs A and B,and plants overexpressing NADPH-dependent thioredoxin (Trx) reductase C showed delayed oxidation of chloroplast enzymes in the *** contrast,the deficiencies of Prx ⅡE or Prx Q exerted no *** vitro assays allowed the reconstitution of the pathway of reducing equivalents from reduced fructose 1,6-bisphosphatase to hydrogen peroxide mediated by Trxs and 2-Cys *** together,these results suggest that 2-Cys Prxs participate in the short-term oxidation of chloroplast enzymes in the dark.

关键词： chloroplast enzyme oxidation peroxiredoxin thioredoxin hydrogen peroxide darkness

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Macular atrophy after combined intravitreal triamcinolone and photodynamic therapy to treat choroidal neovascularization

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International Journal of Ophthalmology(English edition) 2010年第2期3卷 161-163页

作者： Jose M ruiz-Moreno javier A Montero Pedro Amat Francisco Lugo Department of Ophthalmology Albacete Medical SchoolUniversity of Castilla La ManchaSpain Alicante Institute of Ophthalmology Vitreo-Retinal Unit.Spain Pio del Rio Hortega University Hospital Ophthalmology UnitValladolidSpain

AIMTo report the appearance of choriocapillaris atrophy after combined high dose intravitreal triamcinolone acetonide (TA) and photodynamic therapy (PDT) to treat choroidal neovascularization (CNV) associated with age... 详细信息

关键词： age related macular degeneration choriocapillaris atrophy intravitreous triamcinolone photodynamic therapy retinal pigment epithelium atrophy

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Roles of Ubiquitination in the Control of Phosphate Starvation Responses in Plants

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Journal of Integrative Plant Biology 2013年第1期55卷 40-53页

作者： Mónica Rojas-Triana Regla Bustos Ana Espinosa-ruiz Salom Prat javier Paz-Ares Vicente Rubio The Samuel Roberts Noble Foundation Department of Plant Biology 2510 Sam Noble Parkway Ardmore CBGP (INIA-UPM) Departamento de Biotecnología Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria Campus de Montegancedo Centro Nacional de Biotecnología (CNB-CSIC) Darwin

Throughout evolution, plants have evolved sophisticated adaptive responses that allow them to grow with a limited supply of phos-phate, the preferential form in which the essential macronutrient phosphorus is absorbed by plants. Most of these responses are aimed to increase phosphate availability and acquisition through the roots, to optimize its usage in metabolic processes, and to protect plants from the deleterious effects of phosphate deficiency stress. Regulation of these adaptive responses requires fine percep- tion of the external and internal phosphate levels, and a complex signal transduction pathway that integrates information on the phosphate status at the whole-plant scale. The molecular mecha-nisms that participate in phosphate homeostasis include transcriptional control of gene expression, RNA silencing mediated by microRNAs, regulatory non-coding RNAs of miRNA activity, phosphate transporter trafficking, and post-translational modification of proteins, such as phosphorylation, sumoylation and ubiquitination. Such a varied regulatory repertoire reflects the complexity intrinsic to phosphate surveying and signaling pathways. Here, we describe these regulatory mechanisms, emphasizing the increasing importance of ubiquitination in the control of phosphate starvation responses.

关键词： Phosphate homeostasis phosphate signaling phosphate starvation post-translational control ubiquitin.

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The Quaternary Structure of NADPH Thioredoxin Reductase C Is Redox-Sensitive

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Molecular Plant 2009年第3期2卷 457-467页

作者： Juan Manuel Pérez-ruiz Maricruz Gonzalez Maria Cristina Spinola Luisa Maria Sandalio Francisco javier Cejudo Instituto de Bioqulmica Vegetal y Fotoslntesis Universidad de Sevilla y CSIC Avda Américo Vespucio 49 41092-Sevilla Spain Present address: Plant Biology Laboratory The Salk Institute 10010 N. Torrey Pines Rd La Jolla CA 92037 USA Estacion Experimental del Zaidin CSIC C/Prof Albareda 1 18008-Granada Spain

NADPH thioredoxin reductase C （NTRC） is a chloroplast enzyme able to conjugate NADPH thioredoxin reductase （NTR） and thioredoxin （TRX） activities for the efficient reduction of 2-Cys peroxiredoxin （2-Cys PRX）. Because NADPH can be produced in chloroplasts during darkness, NTRC plays a key role for plant peroxide detoxification during the night. Here, it is shown that the quaternary structure of NTRC is highly dependent on its redox status. In vitro, most of the enzyme adopted an oligomeric state that disaggregated in dimers upon addition of NADPH, NADH, or DTT. Gel filtration and Western blot analysis of protein extracts from Arabidopsis chloroplast stroma showed that native NTRC forms aggregates, which are sensitive to NADPH and DTT, suggesting that the aggregation state might be a significant aspect of NTRC activity in vivo. Moreover, the enzyme is localized in clusters in Arabidopsis chloroplasts. NTRC triple and double mutants, A164G- V182E-R183F and A164G-R183F, replacing key residues of NADPH binding site, showed reduced activity but were still able to dimerize though with an increase in intermediary forms. Based on these results, we propose that the catalytically active form of NTRC is the dimer, which formation is induced by NADPH.

关键词： Abiotic/environmental stress oxidative and photo-oxidative stress photosynthesis Arabidopsis rice.

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Machine learning-based zero-touch network and service management:a survey

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Digital Communications and Networks 2022年第2期8卷 105-123页

作者： Jorge Gallego-Madrid Ramon Sanchez-Iborra Pedro M.ruiz Antonio F.Skarmeta Department of Information and Communication Engineering University of Murcia30100MurciaSpain Department of Engineering and Applied Techniques University Center of Defense30729San Javier Air Force BaseSpain

The exponential growth of mobile applications and services during the last years has challenged the existing network ***,the arrival of multiple management solutions to cope with this explosion along the end-to-end network chain has increased the complexity in the coordinated orchestration of different segments composing the whole *** Zero-touch Network and Service Management(ZSM)concept has recently emerged to automatically orchestrate and manage network resources while assuring the Quality of Experience(QoE)demanded by *** Learning(ML)is one of the key enabling technologies that many ZSM frameworks are adopting to bring intelligent decision making to the network management *** paper presents a comprehensive survey of the state-of-the-art application of ML-based techniques to improve ZSM *** this end,the main related standardization activities and the aligned international projects and research efforts are deeply *** this dissection,the skyrocketing growth of the ZSM paradigm can be ***,different standardization bodies have already designed reference architectures to set the foundations of novel automatic network management functions and resource *** with these advances,diverse ML techniques are being currently exploited to build further ZSM developments in different aspects,including multi-tenancy management,traffic monitoring,and architecture coordination,among ***,different challenges,such as the complexity,scalability,and security of ML mechanisms,are also identified,and future research guidelines are provided to accomplish a firm development of the ZSM ecosystem.

关键词： Zero-touch network and service management(ZSM) Next generation networks(NGN) Artificial intelligence(AI) Machine learning(ML)

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