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World Journal of Gastroenterology 2014年第23期20卷 7252-7259页

作者： Juan Acevedo javier Fernández Department of Gastroenterology and Hepatology Hospital of Calella08370 BarcelonaCatalunyaSpain Liver Unit Hospital ClínicUniversity of Barcelona08150 BarcelonaCatalunyaSpain Institut d’Investigacions Biomèdiques August-Pi-Sunyer (IDIBAPS) 08036 BarcelonaSpain Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas (CIBEREHED) 08150 BarcelonaSpain

Despite major advances in the knowledge and management of liver diseases achieved in recent decades,decompensation of cirrhosis still carries a high burden of morbidity and *** infections are one of the main causes of *** is very important for clinical management to be aware of the population with the highest risk of poor *** review deals with the new determinants of prognosis in patients with cirrhosis and bacterial infections reported *** of multiresistant bacteria has led to an increasing failure rate of the standard empirical antibiotic therapy recommended by international ***,it has been recently reported that endothelial dysfunction is associated with the degree of liver dysfunction and,in infected patients,with the degree of *** has also been reported that relative adrenal insufficiency is frequent in the non-critically ill cirrhotic population and it is associated with a higher risk of developing infection,severe sepsis,hepatorenal syndrome and *** advise a change in the standard empirical antibiotic therapy in patients with high risk for multiresistant infections and also to take into account endothelial and adrenal dysfunction in prognostic models in hospitalized patients with decompensated cirrhosis.

关键词： Bacterial infections Liver cirrhosis Drug resistance Bacterial Endothelial dysfunction Relative adrenal insufficiency

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飞秒激光烧蚀氟化钙晶体表面特性

光学学报 2019年第1期39卷 271-277页

作者：郭太勇张立木任莹莹蔡阳健 Carolina romero javier R.Vázquez de Aldana 山东师范大学物理与电子科学学院光场调控及应用中心山东省光学与光子器件技术重点实验室山东济南250014 萨拉曼卡大学应用物理系激光微加工组西班牙萨拉曼卡37008

采用飞秒激光对氟化钙晶体表面进行加工。通过调控激光参数,采用静止聚焦和动态扫描两种方式在晶体表面加工出一系列微结构(烧蚀孔和烧蚀线)。分别对两种加工方式烧蚀后的氟化钙晶体表面微结构进行系统研究,包括参数依赖关系、材料表面... 详细信息

采用飞秒激光对氟化钙晶体表面进行加工。通过调控激光参数,采用静止聚焦和动态扫描两种方式在晶体表面加工出一系列微结构(烧蚀孔和烧蚀线)。分别对两种加工方式烧蚀后的氟化钙晶体表面微结构进行系统研究,包括参数依赖关系、材料表面烧蚀阈值等。计算结果表明:在静止聚焦情况下,累积因子为0.0033;在动态扫描情况下,当扫描方向与激光偏振方向垂直或平行时,累积因子分别为0.0043和0.0052。飞秒激光加工过程中的脉冲累积效应能够对晶体的烧蚀产生重要影响。

关键词：物理光学飞秒激光烧蚀微结构累积效应氟化钙晶体

Gold Nanozymes:From Concept to Biomedical Applications

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Nano-Micro Letters 2021年第1期13卷 138-173页

作者： javier Lou‑Franco Bhaskar Das Christopher Elliott Cuong Cao Institute for Global Food Security School of Biological SciencesQueen’s University of Belfast19 Chlorine GardensBelfast BT95DLUK Present Address:Department of Biotechnology and Medical Engineering National Institute of Technology RourkelaRourkelaIndia

In recent years,gold nanoparticles have demonstrated excellent enzyme-mimicking activities which resemble those of peroxidase,oxidase,catalase,superoxide dismutase or ***,merged with their ease of synthesis,tunability,biocompatibility and low cost,makes them excellent candidates when compared with biological enzymes for applications in biomedicine or biochemical ***,over 200 research papers have been systematically reviewed to present the recent progress on the fundamentals of gold nanozymes and their potential *** review reveals that the morphology and surface chemistry of the nanoparticles play an important role in their catalytic properties,as well as external parameters such as pH or ***,real applications often require specific biorecognition elements to be immobilized onto the nanozymes,leading to unexpected positive or negative effects on their ***,rational design of efficient nanozymes remains a challenge of paramount *** implementation paths have already been explored,including the application of peroxidase-like nanozymes for the development of clinical diagnostics or the regulation of oxidative stress within cells via their catalase and superoxide dismutase *** review also indicates that it is essential to understand how external parameters may boost or inhibit each of these activities,as more than one of them could ***,further toxicity studies are required to ensure the applicability of gold nanozymes in *** challenges and future prospects of gold nanozymes are discussed in this review,whose significance can be anticipated in a diverse range of fields beyond biomedicine,such as food safety,environmental analyses or the chemical industry.

关键词： Gold nanoparticles Catalysis Nanozymes Diagnosis Nanomedicine

Gone with the wind： Seasonal trends in foraging movement directions for a central-place forager

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Current Zoology 2014年第5期60卷 604-615页

作者： Jesus HERNANDEZ-PLIEGO Carlos RODRIGUEZ javier BUSTAMANTE Department of Wetland Ecology Estacion Biologica de Dofiana CSIC c/Amorico Vespucio s/n 41092 Seville Spain Department of Conservation Biology Estacion Biologica de Dofiana C SIC c/Amorico Vespucio s/n 41092 Seville Spain

Lesser kestrels Falco naumanni are migratory central-place foragers that breed in dynamic arable landscapes. After arriving from migration, kestrels have no knowledge of the distribution of crops, and consequently prey, around their colony. The energy demand of pairs increases as breeding season progresses, but at the same time prey abundance, and their knowledge on prey distribution, also increases. Wind can have a strong influence on flight cost and kestrels should try to reduce energy expendi- ture when possible. When prey abundance is low, kestrels have little knowledge of prey distribution, and pairs have no chicks, they could reduce foraging flight cost by leaving the colony with tailwinds. When prey is abundant, knowledge on prey distribu- tion has increased, and chick demand is high, kestrels should fly to the most favorable foraging patches. We analyzed foraging trips directions in a lesser kestrel colony along the breeding season and in relation to wind speed and direction. We recorded 664 foraging trips from 19 individuals using GPS-dataloggers. We found that outward flights direction changed from uniform to a concentrated distribution along the season, as prey abundance and individual experience increased. We also found a temporal trend in the angular difference between outward flights and wind directions, with low values early in the season and then increa- sing as expected, but again low values at the end, contrary to expectation. Results suggest changes in kestrels foraging strategy along the season in relation to wind. Kestrels depart more with tailwinds in exploratory flights early in the season, while there is a spurious coincidence in direction to preferred foraging patches and dominant wind direction at the end [Current Zoology 60 （5）： 604-615, 2014].

关键词： Falco naumanni Movement ecology Foraging behavior Wind effect GPS-dataloggers

Anemia and digestive diseases: An update for the clinician

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World Journal of Gastroenterology 2009年第37期15卷 4615-4616页

作者： Fernando Gomollón javier P Gisbert Digestive Diseases Service Clinical University Hospital CIBEREHD IACS Avenida San Juan Bosco 15 Zaragoza 50009 Spain Digestive Diseases Service University Hospital "La Princesa" CIBEREHD C/ Diego León 62 Madrid 28006 Spain

Anemia and iron deficiency are so common in digestive diseases that often are underestimated and undertreated. Our goal is to review from classif ication to treatment of the diverse types of anemias in different digestive diseases to update our knowledge on diagnosis and treatment. With the goal of improving the prognosis and quality of life of digestive diseases patients, we will review current transfusion, intravenous iron, and erythropoietin roles in the treatment of anemia.

关键词： Anemia Iron deficiency Inflammatory bowel disease Crohn's disease Ulcerative colitis

Manipulation of parasite load induces significant changes in the structural-based throat color of male iberian green lizards

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Current Zoology 2018年第3期64卷 293-302页

作者： Rodrigo MEGiA-PALMA javier MARTiNEZ Santiago MERINO Dept Ecologia Evolutiva Museo Nacional de Ciencias Naturales-CSIC J. Gutierrez Abascal 2 E-28006 Madrid Spain Area Parasitologia Dept Biomedicina y Biotecnologia Area de Parasitologia. Facultad de Farmacia Universidad de Alcala de Henares Alcala de Henares E-28871 Madrid Spain

The honesty of structural-based ornaments is controversial. Sexual selection theory predicts that the honesty of a sexual signal relies on its cost of production or maintenance. Therefore, environmental factors with negative impact on individuals could generate high costs and affect the expres- sion of these sexual signals. In this sense, parasites are a main cost for their hosts. To probe the effect of parasites on the structural-based coloration of a lacertid species Lacerta schreiberi, we have experimentally removed ticks from a group of male Iberian green lizards using an acaricide treatment （i.e., the broad-use insecticide fipronil）. All individuals were radio-tracked and recaptured after 15 days to study changes in coloration in both the ultraviolet （UV）-blue （structural-based） and UV-yellow （structural and pigment-based） ornamentations after manipulation, as well as changes in endoand ectoparasitic load and body condition. Additionally, after the experiment, we measured the skin inflammatory response to a mitogen. The fipronil treatment was effective in reducing ticks and it was associated with a significant reduction of hemoparasite load. Throughout the season, individuals treated with fipronil tended to maintain the brightness of the UV-blue throat coloration while control lizards tended to increase it. However, individuals treated with fipronil that were not infected with hemoparasites significantly reduced the brightness of the UV-blue throat color ation. Individuals with a higher initial tick load exhibited a lower UV saturation increment （UV-blue） and a higher brightness increment （UV-yellow） during the experiment. Overall these results experimentally support the idea that parasites adversely influence the expression of the structural-based coloration of male Iberian green lizards. This adds evidence to the hypothesis that sexual ornaments in lizards function as honest signals.

关键词： animal communication ectoparasites Hamilton & Zuk structural-coloration.

Human condition monitoring in hazardous locations using pervasive RFID sensor tags and energy-efficient wireless networks

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Journal of Zhejiang University-Science C(Computers and Electronics) 2012年第9期13卷 674-688页

作者： javier G.ESCRIBANO Andrés GARCIA Autolog Group Industrial Engineering SchoolUniversity of Castilla-La ManchaAvda.Camilo José Cela s/n13071 Ciudad RealSpain

Tracking persons in dangerous situations as well as monitoring their physical condition, is often crucial for their safety. The systems commonly used for this purpose do not include individual monitoring or are too expensive and intrusive to be deployed in common situations. In this project, a mobile system based on energy-efficient wireless sensor networks (WSNs) and active radio frequency identification (RFID) has been developed to achieve ubiquitous positioning and monitoring of people in hazardous situations. The system designed can identify each individual, locate him/her, send data regarding their physical situation, and ascertain whether they are located in a confined space. A new algorithm called time division double beacon scheduling (TDDBS) has been implemented to increase operation time and data transmission rate of the nodes in the system. The results show that the use of this system allows us to find the location and state of a person, as well as to provide an analysis of the potential risks at each moment, in real time and in an energy-efficient way. In an emergency, the system also allows for quicker intervention, as it not only provides the location and causes of the event, but also informs about the physical condition of the individual at that moment.

关键词： Active RFID Wireless sensor networks (WSNs) ZigBee Human monitoring Time division double beacon sched-uling (TDDBS)

Main factors affecting lacertid lizard thermal ecology

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Integrative Zoology 2019年第3期14卷 293-305页

作者： Zaida ORTEGA Francisco javier MARTÍN-VALLEJO Postgraduate Program in Ecology and Conservation Federal University of Mato Grosso do SulCampo GrandeMato Grosso do SulBrazil Department of Statistics University of SalamancaSpain

The thermal ecology of ectotherms has been studied for almost 2 centuries,but additional attention is currently being paid to it,to understand how organisms deal with the environment in a climate change context.A consensus is still far away due to the large number of factors involved and their complex *** this context,3 analyses in lacertid lizards were carried out:(i)a meta-analysis,to test for differences between body and air temperatures from 71 populations;(ii)a meta-analysis concerning correlations between body and air temperatures from 60 populations;and(iii)a multimodel inference of thermoregulation effectiveness indices from 45 *** importance of different factors,including body size,habitat,insularity,altitude,climate and season,was evaluated in all analyses to model the response variables.A strong seasonality effect was observed,with a consistent pattern of less effective thermoregulation in summer compared to other *** was the second most important factor,with a consistent higher thermoregulation effort in populations occurring at high elevations(>1000 m above sea level).Other factors,such as insularity or body size,can also be important,but did not exhibit a clear ***,thermoregulation was less affected by climate and habitat type.

关键词： lizards meta-analysis seasonality temperature thermoregulation

Effective parameter study for the facile and controlled growth of silver molybdate nano/micro rods

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Frontiers of Materials Science 2016年第4期10卷 375-384页

作者： javier Esteban Enriquez MONTENEGRO Dinesh Pratap SINGH Department of Physics University of Santiago Chile Avenida Ecuador 3493 Estacion Central Santiago 9170124 Chile

Controlled growth of nano/micro structures by controlling the effective parameters is the basic requirement for the application point of view in various areas. Here we report the facile growth of silver molybdate nanolmicro rods by mixing the solution of silver nitrate and ammonium molybdate at ambient condition followed by hydrothermal treatment at various temperatures for 12 h. To achieve the goal for the synthesis of long, high yield and homogeneous nanorods various effective parameters have been studied to set the most effective conditions for the growth. Among possible effective parameters first the temperature of the furnace was set by warring the temperature and then at the set temperature the concentration of reactants （NH4）6Mo7O24 and silver nitrate are varied respect to each other. The pH and temperature values were monitored during the mixing of the reactants. Structurallmicrostructural characterization revealed the optimum condition of 150℃ of the furnace and the concentration of （NH4）sMo7O24 and silver nitrate as described in various tables.

关键词： silver molybdate nanorod Ag6Mo10O33 controlled growth silver nitrate