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The Iberian Roma Population Variant Server(IRPVS)

Journal of Genetics and Genomics 2024年第7期51卷 769-773页

作者： Fabiola Mavillard javier Perez-Florido Francisco M.Ortuño Amador Valladares Miren L.Álvarez-Villegas Gema Roldán Rosario Carmona Manuel Soriano Santiago Susarte Pilar Fuentes Daniel López-López Ana María Nuñez-Negrillo Alejandra Carvajal Yolanda Morgado Daniel Arteaga Rosa Ufano Pablo Mir Juan F.Gamella Joaquín Dopazo Carmen Paradas Macarena Cabrera-Serrano Instituto de Biomedicina de Sevilla(IBiS) Hospital Universitario Virgen del Rocío/CSIC/Universidad de SevillaSevillaSpain Centro Investigación Biomédica en Red Enfermedades Neurodegenerativas(CIBERNED) Instituto de Salud CarlosⅢSevillaSpain Plataforma Andaluza de Medicina Computacional Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevillaSpain Grupo de medicina computacional de sistemas Instituto de Biomedicina de Sevilla(IBiS)Hospital Virgen del RocíoSevillaSpain Nodo de Genómica Funcional (INB-ELIXIR-es)Fundación Progreso y Salud(FPS)Hospital Virgen del RocíoSevilla 41013Spain Bioinformática en Enfermedades raras(BiER) Centro de Investigación Biomédica en Red de Enfermedades Raras(CIBERER)Instituto de salud CarlosⅢSevillaSpain Departamento de Ingeniería de Computadores Automática y RobóticaUniversidad de GranadaGranadaSpain Servicio de Urgencias de Atención Primaria Distrito SevillaSevillaSpain Centro de Servicios Sociales Negociado de Servicios EspecializadosAyuntamiento de SevillaSevillaSpain Departamento de Enfermería Facultad de Ciencias de la SaludUniversidad de GranadaGranadaSpain Departamento de Neurología Hospital Virgen de las NievesGranadaSpain Departamento de Neurología Hospital Virgen de ValmeSevillaSpain Centro de Salud Utrera Sur SevillaSpain Centro de Salud Polígono Sur SevillaSpain Unidad de Trastornos del Movimiento Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain Departamento de Medicina Facultad de MedicinaUniversidad de SevillaSevilleSpain Departamento de Antropología Social Universidad de GranadaSpain Unidad Enfermedades Neuromusculares Servicio de Neurología y Neurofisiología ClínicaHospital Universitario Virgen del RocíoSevillaSpain

In recent years,the number of known disease genes has exponentially grown due to the widespread adoption of cost-effective massive parallel *** identify new disease variants,especially in monogenic disorders,a frequen... 详细信息

关键词： Server filtering massive

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“Rescue” regimens after Helicobacter pylori treatment failure

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World Journal of Gastroenterology 2008年第35期14卷 5385-5402页

作者： javier P Gisbert Gastroenterology Unit Hospital Universitario de la Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y DigestivasMadridSpain

Helicobacter pylori (H pylori) infection is the main cause of gastritis, gastroduodenal ulcer disease, and gastric cancer. After more than 20 years of experience in H pylori treatment, in my opinion, the ideal regimen to treat this infection is still to be found. Currently, apart from having to know first-line eradication regimens well, we must also be prepared to face treatment failures. Therefore, in designing a treatment strategy we should not focus on the results of primary therapy alone, but also on the final (overall) eradication rate. The choice of a "rescue" treatment depends on which treatment is used initially. If a clarithromycin- based regimen was used initially, a subsequent metronidazole-based treatment (quadruple therapy) may be used afterwards, and then a levofloxacin- based combination would be a third "rescue" option. Alternatively, it has recently been suggested that levofloxacin-based rescue therapy constitutes an encouraging second-line strategy, representing an alternative to quadruple therapy in patients with previous PPI-clarithromycin-amoxicillin failure, with the advantage of efficacy, simplicity and safety. In this case, a quadruple regimen may be reserved as a third-line rescue option. Finally, rifabutin-based rescue therapy constitutes an encouraging empirical fourth- line strategy after multiple previous eradication failures with key antibiotics such as amoxicillin, clarithromycin, metronidazole, tetracycline, and levofloxacin. Even after two consecutive failures, several studies have demonstrated that H pylori eradication can finally be achieved in almost all patients if several rescue therapies are consecutively given. Therefore, the attitude in H pylori eradication therapy failure, evenafter two or more unsuccessful attempts, should be to fight and not to surrender.

关键词： Helicobacter pylori Rescue Salvage Rifabutin Levofloxacin

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Validation of GIS layers in the EU:getting adapted to available reference data

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International Journal of Digital Earth 2011年第S1期4卷 42-57页

作者： Francisco javier Gallego IPSC Joint Research Centre of the ECIspraItaly

An optimal validation of a thematic map would ideally require in-situ observations of a large sample of units specifically conceived for the map under *** is often not possible due to budget *** alternative can be using photo-interpretation of high or very high resolution images instead of in-situ observations or using available data sets that do not fully comply with the ideal characteristics:unit size,reference date or sampling *** paper illustrates some examples of use of available data in the European *** land cover maps,the best existing data set is probably Land Use/Cover Areaframe Survey(LUCAS)that has been conducted by Eurostat on four occasions since *** LUCAS is based on systematic sampling,advantages and limitations of systematic sampling are discussed.A fine-scale population density map is presented as an example of a situation in which reference data on a statistical sample cannot be collected.

关键词： accuracy assessment area frame sampling systematic sampling LUCAS land cover maps population density

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Optimizing clarithromycin-containing therapy for Helicobacter pylori in the era of antibiotic resistance

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World Journal of Gastroenterology 2014年第30期20卷 10338-10347页

作者： javier Molina-Infante javier P Gisbert Department of Gastroenterology Hospital San Pedro de Alcantara10003 CaceresSpain Department of Gastroenterology Hospital Universitario de la PrincesaInstituto de Investigación Sanitaria Princesa and Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas28006 MadridSpain

The efficacy of triple therapy for Helicobacter pylori infection has dramatically declined over the last decade,largely related to increasing clarithromycin resistance *** a microbiological standpoint,bismuth quadruple therapy is the ideal replacement since it combines drugs for which resistance does not impair its ***,several obstacles such as availability,complexity or tolerance prevent a general implementation of bismuth quadruple therapy,so nonbismuth quadruple regimens remain the best firstline treatment in clinical practice in many geographical *** review the rationale and efficacy of several optimization tools(increasing the length of duration,high-dose acid suppression,probiotics),which have been largely evaluated over the last 5 years to increase the effectiveness of standard triple ***,we update available evidence on the effectiveness of several non-bismuth quadruple therapies(sequential,concomitant,hybrid,miscellaneous therapy),which have gained interest *** also revise evidence on the efficacy of the aforementioned optimization tools for non-bismuth quadruples schemes and,finally we provide a novel regionalized therapeutic algorithm,based on novel formulas recently developed for predicting the outcome of non-bismuth quadruple regimens,upon local antibiotic resistance rates.

关键词： Helicobacter pylori Eradication Clarithromycin Sequential Concomitant Hybrid Antibiotic resistance Bismuth

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Do supplemental perches influence electrocution risk for diurnal raptors?

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Avian Research 2020年第2期11卷 139-149页

作者： Roberto Sánchez javier Sánchez javier Oria Francisco Guil Fundación CBD-Hábitat C/Gustavo Fernández Balbuena28002 MadridSpain Tragsa Group C/Conde de Peñalver8428006 MadridSpain Boscaje S.L. Plaza Conde de Cheste540001 SegoviaSpain Ministry for the Ecological Transition and the Demographic Challenge Plaza San Juan de la CruzS/N28071 MadridSpain

Background:Power lines are amongst the main causes of mortality for birds *** drives the population dynamics of several threatened species of raptors,at local and global *** the many solutions that have been tested to minimize this threat are supplemental perches;however,their efficiency has rarely been ***:We designed 43 transects in 4 districts in mainland Portugal to gather data from birds perching on pylons with or without supplemental *** 2015 to 2018,transects were surveyed by car at least *** analyzed the factors driving the use of these supplemental perches,and we analyzed if there were differences in the perceived risk(calculated from measurements and not from field surveys)depending on whether the perching was on pylons with or without supplemental ***:We recorded 548 perches of 14 *** conditions seemed to play a role in birds’choice of pylons with supplemental perches versus pylons without supplemental *** also indicated a strong influence of observational *** use of models showed us an important specific effect in the selection of supplemental perches where available:there are some species with a greater tendency to perch on supplemental perches,even when they use both pylons with and without supplemental *** most of the analyzed species and species groups,perceived risk was higher in pylons without supplemental perches compared to pylons with supplemental perches,but there were differences between ***:Supplemental perches may be a useful and efficient tool for mitigating raptor ***,there are many influential factors affecting their success,and their effectiveness with different species groups is not *** studies show higher electrocution rates for certain species and devices and thus,their efficacy must be *** propose a two-step validation process,first in controlled conditions and then in the

关键词： Aquila adalberti Circaetus gallicus Diurnal raptors Electrocution Power lines Pylons

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Pathogenesis of glaucoma: how to prevent ganglion cell from axonal destruction?

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Neural Regeneration Research 2014年第23期9卷 2046-2047页

作者： Francisco javier Carreras Department of Surgery(Ophthalmology) Faculty of MedicineUniversity of Granada

Glaucoma is the main cause of irreversible blindness globally, but the pathogenesis of glaucoma is still pending consensus. In spite of great advances during the 20th and early 21st centuries in terms of detailed knowledge of pathological processes that take place in glaucoma, the exact pathogenesis is much less clear. Hypotheses abound, and the most researched areas are ischemia at the optic nerve head, blockade of ganglion cell axonal transport, peripapillary atrophy, and changes in the characteristics of the lamina cribrosa （Nucci et al., 2008）.

关键词： Pathogenesis of glaucoma RGCs cell

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Lessons from glaucoma: rethinking the fluid-brain barriers in common neurodegenerative disorders

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Neural Regeneration Research 2019年第6期14卷 962-966页

作者： Francisco javier Carreras Department of Surgery Faculty of MedicineUniversity of Granada

Glaucoma has been recently characterized as a member of the group of anoikis-related diseases. Anoikis, a form of apoptosis, can be triggered by the unfastening of adherent junctions present in astrocytes. In those areas of the central nervous system in which the soma of the neurons or their axons and dendrites are metabolically dependent on the activity of astrocytes, a derangement of the lactate shuttle caused by a separation between the plasma membranes of neurons and astrocytes would result in metabolic impairment of the neurons themselves. In glaucoma, the triggering event has been attributed to the posterior deviation of aqueous humor towards the astrocyte-rich prelaminar tissue of the optic nerve head. The mean calcium content in the aqueous is able to interfere with calcium-dependent adherent junctions and induce anoikis of the astrocytes. As the cerebrospinal fluid has a similar base calcium concentration, a shunt of cerebrospinal fluid through the cerebral parenchyma would be able to interfere in the astrocytic architecture with dire consequences to the metabolically dependent neurons. Here the similitude between glaucoma,amyotrophic lateral sclerosis and Alzheimer's disease are discussed and the concept of the break in the fluid-brain barrier, as an event separated from the blood-brain barrier, is stressed.

关键词： fluid-brain barriers blood-brain barrier cerebrospinal fluid aqueous humor calcium ion glaucoma amyotrophic lateral sclerosis Alzheimer’s disease

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Advanced Oxidation Wastewater Treatment of 3 LPS of an Avocado Sauce Company,at Morelia,Michoacan,Mexico

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Journal of Environmental Science and Engineering(A) 2024年第5期13卷 151-155页

作者： Alfonso Espitia-Cabrera Francisco javier Barrón-Santos JoséL.Méndez-Antonio Héctor M.Alemán-Vásquez Omar G.Color-Vázquez Saneamiento y Planeación Ambiental Azcapotzalco CDMX 02200México Energy Department Metropolitan Autonomous University Azcapotzalco CampusCDMX 02200Mexico Environmental System Engineering Department Environmental Engineering AcademyNational School of Biological SciencesNational Polytechnic InstituteCiudad de MéxicoCDMX 07738México Planta Congeladora y Empacadora Nacional Morelia 58190MichoacánMéxico

This paper describes the wastewater treatment of 3 liters per second of capacity of discharges of capacity,from the avocado washed,as well as the production of avocado *** were pretreated with a grease and oil trap and contained small amounts of oil and grease,dissolved and total solids,organic matter and trace of organic and inorganic compounds from the vitamins and minerals of *** treatment train is located in an small surface and the train is integrated with coagulation in line with alumina in a static mixer,rapid filtration in two steps,double advanced oxidation with ozone and heterocyclic photocatalysis with a nanofilm of zinc oxide as,photocatalyzer and final adsorption of refractory compounds with activated *** treated wastewater meets the environmental regulation to urban sewerage discharges of the city,according to the results of a Mexican Certified Laboratory.

关键词： Wastewater primary treatment rapid filter performance static mixer

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Moult intensity constraints along the complete moult sequence of the House Sparrow(Passer domesticus)

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Avian Research 2023年第3期14卷 394-404页

作者： Santi Guallar javier Quesada Departament de Vertebrats Museu de Ciencies Naturals de BarcelonaBarcelona08003CataloniaSpain

Sequence and intensity are two essential components of bird *** the moult sequences of remex tracts are highly homogenous across passerines,other tracts apparently show a high ***,order of moult activation among tracts are insufficiently ***,dynamics of moult intensity as moult progresses remains poorly ***,we provide detailed quantitative description of moult sequence and intensity in the House Sparrow(Passer domesticus).To understand their role,we tested two hypotheses on the:1) protection function of moult sequence,and 2) aerodynamic and physiological constraints on moult *** scored percentage growth of 313 captured sparrows using the mass of the feathers of each tract(also length for remiges)to monitor moult intensity throughout the complete moult progress,which is defined as the fraction of new and growing feathers in a moulting bird relative to the total *** sequence was highly variable both within wing coverts and among feather tracts,with moult sequence differing among all birds to some *** only found support for the protection function between greater coverts and both tertials and ***-moult intensity conformed to theoretical predictions,therefore lending support to the aerodynamic-constraint ***,remex-moult speed plateaued during the central stages of moult ***,overall plumage-moult speed did not fit predictions of the physiological-constraint hypothesis,showing that the remex moult is only constrained by *** results indicate that aerodynamic loss is not simply the inevitable effect of moult,but that moult is finely regulated to reduce aerodynamic *** propose that the moult of the House Sparrow is controlled through sequence and intensity adjustments in order to:1) avoid body and wing growth peaks;2) fulfil the protection function between some key feather tracts;3) reduce detrimental effects on flight ability;4) keep remex seque

关键词： Functional constraints Local polynomial regression Passerine moult Physiological constraints Raggedness

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Holographic Duals of Quark Gluon Plasmas with Unquenched Flavors

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Communications in Theoretical Physics 2012年第3期57卷 364-386页

作者： Francesco Bigazzi Aldo Cotrone javier Mas Daniel Mayerson javier Tarrio Dipartimento di Fisica e Astronomia Universita' di Firenze Via G.Sansone 1 I-50019 Sesto Fiorentino (Firenze)Italyand INFNSezione di PisaLargo B.Pontecorvo356127 PisaItaly Dipartimento di Fisica Universita' di Torino and INFN Sezione di Torino Via P.Giuria 1 I-10125 TorinoItaly Departamento de F' sica de Part' culas Universidade de Santiago de Compostela and Instituto Galego de F' sica de Altas Enerx' as (IGFAE) E-15782 Santiago de CompostelaSpain Institute for Theoretical Physics University of AmsterdamScience Park 904Postbus 944851090 GL AmsterdamThe Netherlands Institute for Theoretical Physics Universiteit Utrecht3584 CEUtrechtThe Netherlands

We review the construction of gravitational solutions holographically dual to N=1 quiver gauge theories with dynamical flavor *** focus on the D3-D7 construction and consider the finite temperature,finite quark chemical potential case where there is a charged black hole in the dual *** physical outputs of the model include its thermodynamics (with susceptibilities) and general hydrodynamic properties.

关键词： AdS/CFT correspondence quark-gluon plasma flavor physics finite baryon density

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