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Current and novel approaches in the pharmacological treatment of hepatocellular carcinoma

World Journal of Gastroenterology 2023年第17期29卷 2571-2599页

作者： Fernanda Villarruel-Melquiades María Eugenia Mendoza-Garrido Claudia M garc.a-Cuellar Yesennia Sánchez-Pérez Julio Isael Pérez-Carreón javier Camacho Departamento de Farmacología Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAV-IPN)Mexico City 07360Mexico Departamento de Fisiología Biofísica y NeurocienciasCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional(CINVESTAVIPN)Mexico City 07360Mexico Subdirección de Investigación Básica Instituto Nacional de Cancerología(INCan)Mexico City 14080Mexico Instituto Nacional de Medicina Genómica Instituto Nacional de Medicina Genómica(INMEGEN)Mexico City 14610Mexico

Hepatocellular carcinoma(HCC)is one of the most lethal malignant tumours *** mortality-to-incidence ratio is up to 91.6%in many countries,representing the third leading cause of cancer-related *** drugs,including the multikinase inhibitors sorafenib and lenvatinib,are first-line drugs used in HCC ***,these therapies are ineffective in most cases due to late diagnosis and the development of tumour ***,novel pharmacological alternatives are urgently *** instance,immune checkpoint inhibitors have provided new approaches targeting cells of the immune ***,monoclonal antibodies against programmed cell death-1 have shown benefits in HCC *** addition,drug combinations,including first-line treatment and immunotherapy,as well as drug repurposing,are promising novel therapeutic ***,we review the current and novel pharmacological approaches to fight *** studies,as well as approved and ongoing clinical trials for liver cancer treatment,are *** pharmacological opportunities analysed here should lead to significant improvement in HCC therapy.

关键词： Liver cancer Systemic therapy Immunotherapy Drug repurposing Drug combinations Hepatocellular carcinoma

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Comparison of the impact of nesofilcon A hydrogel contact lens on the ocular surface and the comfort of presbyopic and non-presbyopic wearers

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International Journal of Ophthalmology(English edition) 2019年第4期12卷 640-646页

作者： Amalia Lorente-Velázquez María garc.a-Montero Francisco javier Gómez-Sanz Laura Rico del Viejo José Luis Hernández-Verdejo David Madrid-Costa Department of Optometry and Vision Faculty of Optics and Optometry Complutense University of Madrid

AIM: To assess and compare the impact of a daily disposable contact lens(CL) with high water content on the ocular surface and comfort of the presbyopic and nonpresbyopic population after one day of use. METHODS: Totally 20 presbyopes and 30 non-presbyopes non-contact wearers were fitted with nesofilcon A CLs. CL thickness was measured to assess material stability during daily wear, and ocular surface parameters were also assessed. Optical quality was analyzed for all cases. In addition, CL comfort was ***: No significant differences were found in CL thickness, tear film osmolarity, average tear break-up time, bulbar redness, central corneal thickness, corneal volume, root-mean-square of higher-order aberrations(RMS of HOAs) and vertical and horizontal coma, either as a function of the group or time of use. A significant decrease in tear meniscus height and first break-up of the tear film was found in the presbyopic group(P=0.038; P=0.007 respectively). A decrease in spherical aberration coefficient was found after CL insertion(P=0.031 monofocal CL; P=0.023 low addition multifocal CL; P=0.016 high addition multifocal CL). Multifocal CL were thicker than monofocal CL(P=0.045). Comparison between groups showed more discomfort in presbyopes than non-presbyopes(P=0.003).CONCLUSION: This study evidence that the behavior of the daily disposable CL with high water content seems to be stable during the day of use. Ocular parameters measured during wear show that CL behavior is the same for presbyopes and non-presbyopes, being more uncomfortable for presbyopes.

关键词： nesofilcon A hydrogel material ocular surface parameters presbyopia multifocal daily contact lenses

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Quantification of corneal neovascularization after ex vivo limbal epithelial stem cell therapy

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International Journal of Ophthalmology(English edition) 2014年第6期7卷 988-995页

作者： Adriano Guarnieri javier Moreno-Monta?és Belén Alfonso-Bartolozzi Alfonso L.Sabater María garc.a-Guzmán Enrique J.Andreu Felipe Prosper Department of Ophthalmology Clínica Universidad de Navarra Department of Cell Therapy Clínica Universidad de Navarra

AIM: To assess cultured limbal epithelial stem cell transplantation in patients with limbal stem cell deficiency by analyzing and quantifying corneal ***: This retrospective, interventional case series included eight eyes with total limbal stem cell deficiency. Ex vivo limbal epithelial stem cells were cultured on human amniotic membrane using an animalfree culture method. The clinical parameters of limbal stem cell deficiency, impression cytology, and quantification of corneal neovascularization were evaluated before and after cultured limbal stem cell transplantation. The area of corneal neovascularization,vessel caliber(VC), and invasive area(IA) were analyzed before and after stem cell transplantation by image analysis software. Best-corrected visual acuity(BCVA),epithelial transparency, and impression cytology were also ***: One year after surgery, successful cases showed a reduction(improvement) of all three parameters of corneal neovascularization [neovascular area(NA), VC, IA], while failed cases did not. NA decreased a mean of 32.31%(P =0.035), invasion area29.37%(P =0.018) and VC 14.29%(P =0.072). BCVA improved in all eyes(mean follow-up, 76 ±21mo).Epithelial transparency improved significantly from 2.00 ±0.93 to 0.88±1.25(P =0.014). Impression cytology showed that three cases failed after limbal epithelial stem cell therapy before 1y of ***: This method of analyzing andmonitoring surface vessels is useful for evaluating the epithelial status during follow-up, as successful cases showed a bigger reduction in corneal neovascularization parameters than failed cases. Using this method,successful cases could be differentiated from failed cases.

关键词： limbal stem cell corneal neovascularization stem cell therapy impression cytology limbal stem cell deficiency

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Phytoclimatic Dynamics of Mediterranean Forests under Climate Change. A Case Study in a Southern European <i>Pinus sylvestris</i>L. Stand

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American Journal of Plant Sciences 2013年第3期4卷 655-662页

作者： javier M. garc.a-López Carmen Allué Regional Government of Castilla y León Environmental Service Burgos Spain Regional Government of Castilla y León Environmental Service Burgos Spain.

Some effects of climate change on the composition and competitive capacity of southern European Pinus sylvestris L. forests in the Mediterranean basin were evaluated. The variation over the period 1910-2008 through 30-year mobile averages of a Phytoclimatic Suitability Index (PSI) of the main tree species of the forest cover are used to indicate the competitive hierarchy of Pinus sylvestris and Fagus sylvatica L. The methodology was applied at a specific location on the Spanish south-facing slopes of the Pyrenees mountain range in the Iberian Peninsula, where the increase in the average temperature was 1.4?C in the period of observation. The results indicated that the apparent equilibrium between the two species studied changed from the 1934-1963 average. Due to the loss of competitive capacity of Scots pine with respect to European beech, particularly from the years 1970-1999, the model predicted an inversion of the situation as it was up until now, so that beech had a higher PSI than pine. The phytoclimatic approach proposed here offers new methodological horizons for the study of the effects of climate change on the future of the forests.

关键词： Biodiversity Complexity Suitability Competition Phytoclimatology Scots Pine European Beech

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Lie Symmetries of Quasihomogeneous Polynomial Planar Vector Fields and Certain Perturbations

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Acta Mathematica Sinica,English Series 2005年第1期21卷 185-192页

作者： javier CHAVARRIGA Isaac A.garc.a Departament de Matemdtica Universitat de LleidaAvda.Jaume II6925001LleidaSpain

In this work we study Lie symmetries of planar quasihomogeneous polynomialvector fields from different points of view, showing its integrability. Additionally, we show thatcertain perturbations of such vector fields w... 详细信息

关键词： Lie symmetries Quasi-homogeneous systems Planar vector fields

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Cyber-applications as gateway to data-rich Digital Earth systems

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International Journal of Digital Earth 2014年第7期7卷 576-593页

作者： javier Morales Rolf A.de By Department of Geo-Information Processing Faculty of Geo-Information Science and Earth ObservationUniversity of TwenteEnschedethe Netherlands

The underlying vision of the Digital Earth(DE)calls for applications that can embed vast quantities of geo-referenced data and allow users to study and analyse of our *** the declaration of this vision in the late 90s,a significant number of DE data-sets have been created by the industry,governments,non-governmental organisations and *** overwhelming majority of the successful applications that use DE data-sets has its end-user applications running on the *** these applications are great tools,they remain inaccessible to the community as a *** this paper,we present a framework for the development of *** define an abstract architecture for cyber-applications based on the model-view-controller paradigm,which allows the dynamic inclusion of functional and data components into its execution engine at *** define the operational characteristics of *** also specify the interface of pluggable components to the ***,we demonstrate the appropriateness of the abstract architecture by means of a case study.

关键词： digital earth architecture cyber-application geobrowser design framework hardware independence

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Altitudinal variation in the reproductive performance of the Mediterranean shrub Rhamnus lycioides L.

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Journal of Plant Ecology 2012年第3期5卷 330-336页

作者： javier Gulías Anna Traveset Research group on Plant Biology under Mediterranean Conditions Department of BiologyUniversitat de les Illes BalearsCarretera de Valldemossa km 7.507122-Palma de MallorcaBalearic IslandsSpain Institut Mediterrani d’Estudis Avancxats(CSIC-UIB) C/Miquel Marques 2107190 EsporlesMallorcaBalearic IslandsSpain

Aims Rhamnus lycioides ***(Rhamnaceae)is a perennial shrub native to the Mediterranean Basin distributed along an altitudinal gradient,from sea level up to 1000 m *** specific goals of our study were(i)to compare plant morphology between two contrasting populations,(ii)to determine the reproductive system of ***,quantifying the relative importance of insects and wind as pollen vectors,(iii)to test if pollen limitation differs between populations,(iv)to study the main factors influencing fruit set and(v)to compare plant reproductive performance(mass allocation to flowers,fruits and seeds)between the two *** In the present study,we examined plant morphology and the reproductive performance of *** *** contrasting environments in two populations located at the extremes of its altitudinal range in the island of Mallorca(Balearic Islands,Western Mediterranean Basin)along a 3-year *** morphology,the relative importance of insects and wind as pollen vectors,the pollen limitation to seed production and the plant reproductive performance(mass allocation to flowers,fruits and seeds)were *** Findings Rhamnus lycioides individuals showed a higher plant surface/plant height ratio at the mountain than at the *** species appeared to be ambophilous despite its inconspicuous flowers,although the relative importance of wind as a pollination vector was higher at the mountain than at the coastal *** set was much higher at the mountain,where pollen appeared to be a limiting *** contrast,fruit set was not limited by pollen availability at the coastal population,where resource(water and nutrients)limitation seemed to be more *** size was greater at the coast,in contrast to fresh fruit weight that was higher at the *** the relatively few differences between sites in precipitation patterns along the study period,water availability appeared to be the key factor explaining

关键词： ambophily fruit set Mediterranean vegetation pollen limitation reproductive performance

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Runoff and losses of nutrients and herbicides under long-term conservation practices (no-till and crop rotation) in the U.S. Midwest:A variable intensity simulated rainfall approach

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International Soil and Water Conservation Research 2018年第4期6卷 265-274页

作者： javier M.Gonzalez United States Department of Agriculture Agricultural Research ServiceNational Soil Erosion Research LaboratoryWest LafayetteIN 47907USA

The U.S. Farm Bill includes conservation practices that benefit both the environment and the farmer. The USDA Conservation Effects Assessment Project (CEAP) is a multi-agency effort to assess the efficiency of conservation practices to minimize non-point source pollution. This is follow-up study of a 28-year experiment design to assess the influence of the conservation practices of no-till and crop rotation systems (corn [Zea mays]-soybean [Glycine max]), compared to chisel tillage and monocropping systems (continuous corn) on soil health and water quality. In this study, changes on soil C and N, soil water content, runoff, and losses of ammonium-N, nitrate-N, soluble reactive P (SRP), atrazine, metolachlor, and glyphosate were compared to determine the influence of no-till and corn-soybean rotation systems, relative to chisel tillage and continuous corn, on plots planted with corn using variable intensity rainfall simulations. The long-term no-till systems had a positive impact on soil C and N, soil water, runoff, and losses of ammonium-N and nitrate-N;however, no effect was observed on losses of SRP, atrazine, metolachlor, and glyphosate. The corn-soybean rotation negatively influenced, compared to the continuous corn, soil C and N, soil water content, and increased runoff and the losses of all nutrients and herbicides measured in this study. These results suggest that additional conservation practices, in conjunction with no-till and corn-soybean rotations are needed to reduce surface losses of nutrients and pesticides while improving soil health.

关键词： No-till Crop residue Nutrients Herbicides Runoff

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不同固定床位置生物质热解挥发物蒸汽催化重整反应中焦炭的形成和演化

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Chinese Journal of Catalysis 2023年第5期48卷 101-116页

作者： Enara Fernandez Laura Santamaria Irati garc.a Maider Amutio Maite Artetxe Gartzen Lopez javier Bilbao Martin Olazar 巴斯克大学化工系西班牙巴斯克科学基金会西班牙

对生物质热解挥发物蒸汽重整反应过程中催化剂的失活过程和主要机理进行了研究.在圆锥形喷动床反应器中于500℃进行生物质热解,随后在固定床反应器中于600℃进行重整反应;同时在不同轴向位置分析了催化剂位置对重整反应器的影响.采用N_... 详细信息

对生物质热解挥发物蒸汽重整反应过程中催化剂的失活过程和主要机理进行了研究.在圆锥形喷动床反应器中于500℃进行生物质热解,随后在固定床反应器中于600℃进行重整反应;同时在不同轴向位置分析了催化剂位置对重整反应器的影响.采用N_(2)吸附-脱附、X射线衍射、扫描电镜、透射电镜、程序升温氧化、拉曼光谱和傅里叶变换红外光谱对失活样品进行表征.结果表明,焦炭沉积是初始催化剂活性衰减的主要原因,且没有观察到镍位点的烧结或氧化.随着反应的进行,沿着重整催化床观察到失活情况,焦炭沉积于催化剂内,其性质和组成取决于到达床中每个轴向位置的挥发物组成.在催化床的入口部分,焦炭沉积在Ni位点上,并且具有一定的含氧量.在更深的轴向床位置,催化剂与挥发性物质接触,该挥发性物质的组成已经明显改变,从而形成具有石墨化程度更高的焦炭,并且形成更多的缩合聚芳烃化合物.此外,沉积在所有失活样品上的焦炭没有呈现任何特定的形态,这也表明,无论所处的催化床位置和反应时间,焦炭均呈现无定形结构.

关键词：生物质热解蒸汽重整失活积碳氢气生物油

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Diffusion dynamics and characterization of attogram masses in optically trapped single nanoparticles using laser-induced plasma imaging

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Nano Research 2023年第5期16卷 7470-7480页

作者： Pablo Purohit Francisco J.Fortes javier Laserna UMALASERLAB Departamento de Química AnalíticaUniversidad de MálagaC/Jiménez Fraud 4Malaga 29010Spain Niels Bohr Institute University of CopenhagenBlegdamsvej 172100 CopenhagenDenmark

In the present work,a wavelength-selected plasma imaging analysis system is presented and used to track photons emitted from single-trapped nanoparticles in air at atmospheric *** isolated nanoentities were atomized and excited into plasma state using single nanosecond laser *** use of appropriate wavelength filters alongside time-optimized acquisition settings enabled the detection of molecular and atomic emissions in the *** photon detection efficiency of the imaging line resulted in a signal>400 times larger than the simultaneously-acquired dispersive spectroscopy *** increase in sensitivity outlined the evolution of diverse physicochemical processes at the single particle scale which included heat and momentum transfer from the plasma into the particle as wells as chemical *** imaging detection of excited fragments evidenced different diffusion kinetics and time frames for atoms and molecules and their influence upon both the spectroscopic emission readout and fabrication processes using the plasma as a ***,the origin of molecular species,whether naturally-occurring or derived from a chemical reaction in the plasma,could also be studied on the basis of compositional gradients found on the *** of detection for the inspected species ranged from tens to hundreds attograms,thus leading to an exceptional sensing principle for single nanoentities that may impact several areas of science and technology.

关键词： single nanoparticle inspection wavelength-selected laser-induced plasma imaging laser fabrication attogram characterization atomic/molecular diffusion

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