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Intense pulsed light‑based treatment for the improvement of symptoms in glaucoma patients treated with hypotensive eye drops

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Eye and Vision 2024年第2期10卷 12-21页

作者： Jose Maria Martinez‑de‑la‑Casa Carlos Oribio‑Quinto Almudena Milans‑del‑Bosch Pilar Perez‑garcia Laura Morales‑Fernandez javier garcia‑Bella Jose Manuel Benitez‑del‑Castillo Julian garcia‑Feijoo David P.Pinero Ophthalmology Unit Department of Ophthalmology and ORLFaculty of MedicineHospital Clinico San-CarlosUniversidad Complutense de MadridInstituto de Investigacion Sanitaria del Hospital Clinico San-Carlos(IdISSC)28040 MadridSpain department of Immunology Ophthalmology and ORLSchool of MedicineInstituto de Investigaciones Oftalmologicas Ramon CastroviejoUniversidad Complutense de MadridMadridSpain department of Optics Pharmacology and AnatomyUniversity of AlicanteAlicanteSpain

Background:Ocular surface disease in glaucoma patients is a significant ocular co-morbidity that can affect 40%to 59%of these patients *** current study was aimed at evaluating the potential clinical benefit of an intense pulsed light(IPL)-based treatment in glaucomatous patients with ocular surface disease due to prolonged hypotensive eyedrop *** our knowledge,this is the first series analyzing the therapeutic effect of this treatment option in this type of ***:This non-comparative prospective case series study enrolled a total of 30 glaucoma patients ranging in age from 57 to 94 years old and treated with hypotensive eyedrops for years with dry eye *** patients received four sessions of IPL treatment using the Optima IPL system(Lumenis,Yokneam,Israel)adjusted to the official optimized Lumenis *** in symptomatology,corneal staining,conjunctival hyperemia,non-invasive break-up time(NIBUT),tear osmolarity,tear meniscus height(TMH),meiboscore and meibomian gland expressibility was analyzed after ***:Statistically significant reductions were observed after IPL treatment in the symptomatology scores measured with different questionnaires[ocular surface disease index(OSDI),standard patient evaluation of eye dryness(SPEED)and symptom assessment questionnaire in dry eye(SANde)]as well as with the visual analogue scale(Pde 3 eyes from 44.4%before IPL to 17.2%after ***:IPL therapy combined with meibomian gland expression(MGX)seems to be an effective option to improve symptomatology in glaucomatous patients with ocular surface diseas

关键词： Glaucoma Intense pulsed light Dry eye Meibomian glands

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西班牙阿尔卡萨尔德圣胡安旅游办公室

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现代装饰 2015年第11期 62-67页

作者： David Pérez Rocio Pina Carmelo Rodriguez Enrique Espinosa javier de paz garcia 姜敏华 PKMN Architectures

传统的旅游办公厅往往张贴着一些具有当地特色的景点海报,或是摆放极具特色的纪念品,而本案则是一间外表看似如同店铺的旅游办公室。项目位于西班牙阿尔卡萨尔德圣胡安,由PKMN建筑事务所设计。乍一看,这似乎是一个除了几把＂座椅＂,连... 详细信息

传统的旅游办公厅往往张贴着一些具有当地特色的景点海报,或是摆放极具特色的纪念品,而本案则是一间外表看似如同店铺的旅游办公室。项目位于西班牙阿尔卡萨尔德圣胡安,由PKMN建筑事务所设计。乍一看,这似乎是一个除了几把＂座椅＂,连个像样的家具都没有的空间,身处其中,却能深切地感受到轻松惬意的氛围。

关键词：圣胡安卡萨阿尔建筑事务所雕刻艺术品动态效果几何造型陶壶工作区堂吉诃德

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A Sustained Force for Economic Growth

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China Today 2024年第5期73卷 42-44页

作者： javier garcia Spanish news agency Agencia EFE's Beijing office

A green industry chain has been formed in China,in which the latest technologies can be applied and further *** 2018,due to a job change,I came to China and became the head of the Spanish news agency Agencia EFE’s Beijing *** the end of 2021,I made a brave move from media to college,and started my new career as a teacher at the School of Journalism and Communication at Renmin University of China,which enabled me to get closer to China and the young Chinese.

关键词： closer Spanish college

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Lesser kestrels of the same colony do not overwinter together

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Current Zoology 2024年第4期70卷 505-512页

作者： Jorge garcia-Macia Munir Chaouni Sara Morollon javier Bustamante Lina Lopez-Ricaurte Juan Martinez-Dalmau Beatriz Rodriguez-Moreno and Vicente Urios Grupo de Investigacion Zoologia de Vertebrados Universidad de AlicanteApdo.99E-03080 AlicanteSpain department of Wetland Ecology Estacion Biologica de Donana(CSIC)C/Americo Vespucio 2641092SevillaSpain GREFA C/MontedelPilarS/NE-28220MajadahondaMadridSpain

Migratory connectivity describes the linkage between breeding and nonbreeding sites,having major ecological implications in birds:1 season influence the success of an individual or a population in the following *** studies on migratory connectivity have used large-scale approaches,often considering regional populations,but fine-scale studies are also necessary to understand colony *** lesser kestrel Falco naumanni,an insectivorous migratory raptor which form colonies during the breeding period,was considered to have strong connectivity based on regional ***,no small-scale studies on migratory connectivity have been ***,we GPS(Global Positioning System)-tracked 40 adult lesser kestrels from 15 different Spanish breeding colonies,estimating the overlap index between home ranges and the distance between their *** was found that lesser kestrels from the same breeding colony placed their nonbreeding areas at 347±281 km(mean±standard deviation)away from each other(range=23-990),and their home ranges over-lapped by 38.4±23.6%.No differences between intra-colony and inter-colony metrics were found,which suggests that lesser kestrels from the same breeding cluster do not overwinter together,but they spread out and mixed independently of the colony belonging throughout the nonbreeding range of the ***,this study highlights the importance of performing connectivity studies using fine-scale approaches.

关键词： Falco naumanni GPS telemetry migratory connectivity nonbreeding raptor spatial ecology wintering.

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Mental health in the virtual world:Challenges and opportunities in the metaverse era

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World Journal of Clinical Cases 2024年第17期12卷 2939-2945页

作者： Yolanda López del Hoyo Matilde Elices javier garcia-Campayo department of Psychology and Sociology University of ZaragozaZaragoza 50009Spain Mental Health Research Group Hospital del Mar Medical Research InstituteBarcelona 08003Spain department of Psychiatry Miguel Servet HospitalAragon Institute for Health ResearchUniversity of ZaragozaZaragoza 50009Spain

Current rates of mental illness are *** illness mainly affects females and younger age *** use of the internet to deliver mental health care has been growing since 2020 and includes the implementation of novel mental health treatments using virtual reality,augmented reality,and artificial intelligence.A new three dimensional digital environment,known as the metaverse,has emerged as the next version of the *** intelligence,augmented reality,and virtual reality will create fully immersive,experiential,and interactive online environments in the *** will use a unique avatar to do anything they do in their“real”lives,including seeking and receiving mental health *** this opinion review,we reflect on how the metaverse could reshape how we deliver mental health treatment,its opportunities,and its challenges.

关键词： Metaverse Virtual world Artificial intelligence Mental health Virtual reality Augmented reality Technology

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Distribution and Relation of Primes with Tesla Numbers 3, 6, and 9

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Journal of Applied Mathematics and Physics 2024年第4期12卷 1021-1027页

作者： javier Mendoza-Navarrete Huetzin Perez Ismael Ojeda Victor Verdugo Gabriel Luna Sandoval Ricardo Jimenez garcia Jaime Alvarez departametno de Matemá ticas CBTis 256 DGETI Cabo San Lucas M&#233xico DCI departamento de Fisica Mé dica Universidad de Guanajuato Leon M&#233xico Divisió n de Ingenieria en Sistemas Computacionales Tecnol&#243gico Nacional de M&#233xico ITES Los Cabos Cabo San Lucas M&#233xico departamento de Ingenieria Industrial en Manufactura Universidad Estatal de Sonora Navojoa M&#233xico departamento de Elé ctrica-Electr&#243nica Tecnol&#243gico Nacional de M&#233xico Campus Mexicali Mexicali M&#233xico Guanajuato M&#233xico

This work presents a different approach to twin primes, an approach from the perspective of the Tesla numbers and gives a refresh and new observation of twin primes that could lead us to an answer to the Twin Prime Conjecture problem. We expose a peculiar relation between twin primes and the generation of prime numbers with Tesla numbers. Tesla numbers seem to be present in so many domains like time, vibration and frequency [1], and the space between twin primes is not the exception. Let us say that twin primes are more than just prime numbers plus 2 or minus 2, and Tesla numbers are more involved with twin primes than we think, and hopefully, this approach give us a better understanding of the distribution of the twin pairs.

关键词： Tesla Numbers Prime Number Twin Prime Numbers Twin Pair

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The Nikola Tesla Constant and Its Relation to the Circumference Inscribed in a Square

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Journal of Applied Mathematics and Physics 2024年第1期12卷 277-283页

作者： javier Mendoza Navarrete José Ismael Ojeda Campaña Huetzin Perez Gabriel Luna-Sandoval Victor Verdugo Ricardo Jiménez garcia departamento de Matemáticas CBTis 256 DGETI Cabo San Lucas México División de Ingeniería en Sistemas Computacionales Tecnológico Nacional de México/ITES de Los Cabos Cabo San Lucas México DCI departamento de Física Médica Universidad de Guanajuato León México departamento de Ingeniería Industrial en Manufactura Universidad Estatal de Sonora Navojoa México departamento de Eléctrica-Electrónica Tecnológico Nacional de México Campus Mexicali Mexicali México

This research work relates the surface of a square and the area circumscribed by a circle, resulting in a value called Nikola Tesla constant. This constant starts with the calculation of the areas of the square and the inscribed circle, giving a ratio of 9/40 and from which a residual area of the area proportions of the geometric figures described is obtained. Plotting smooth curves, particularly those in round shapes, can be represented efficiently with the use of Nikola Tesla constant, reducing complex mathematical calculus.

关键词： Tesla Numbers Prime Number Circle Binary Area

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Performance analysis of visual markers for indoor navigation systems

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Frontiers of Information Technology & Electronic Engineering 2016年第8期17卷 730-740页

作者： Gaetano C.LA deLFA Salvatore MONTELEONE Vincenzo CATANIA Juan F.de paz javier BAJO department of Electrical Electronics and Computer Engineering (DIEEI) University of Catania Catania 95125 Italy BISITE Research Group Faculty of Science University of Salamanca Salamanca 37007 Spain department of Artificial Intelligence Polytechnic University of Madrid Madrid 28660 Spain

The massive diffusion of smartphones, the growing interest in wearable devices and the Internet of Things, and the exponential rise of location based services（LBSs） have made the problem of localization and navigation inside buildings one of the most important technological challenges of recent years. Indoor positioning systems have a huge market in the retail sector and contextual advertising; in addition, they can be fundamental to increasing the quality of life for citizens if deployed inside public buildings such as hospitals, airports, and ***, in emergency situations, they can make the difference between life and death. Various approaches have been proposed in the literature. Recently, thanks to the high performance of smartphones＇ cameras, marker-less and marker-based computer vision approaches have been investigated. In a previous paper, we proposed a technique for indoor localization and navigation using both Bluetooth low energy（BLE） and a 2D visual marker system deployed into the floor. In this paper, we presented a qualitative performance evaluation of three 2D visual markers, Vuforia,Ar Uco marker, and AprilT ag, which are suitable for real-time applications. Our analysis focused on specific case study of visual markers placed onto the tiles, to improve the efficiency of our indoor localization and navigation approach by choosing the best visual marker system.

关键词： Indoor localization Visual markers Computer vision

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Use of a lyophilized bovine pericardium graft to repair tunical defect in patients with Peyronie＇s disease： experience in a clinical setting

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Asian Journal of Andrology 2017年第3期19卷 316-320页

作者： javier Romero Otero Borja garcia Gomez Jose Medina Polo Carlos Pascual Mateoe Silvia garcia Barreras Eduard garcia Cruz javier de la Riva de la Vifia Alfredo Rodriguez Antolin 12 de Octubre University Hospital Department of Urology Madrid Spain Monteprincipe University Hospital Department of Urology Madrid Spain Clinic Hospital Department of Urology Barcelona Spain

Many different materials are available for grafting during surgery for Peyronie＇s disease （PD）. To study the outcomes associated with the use of a lyophilized bovine pericardium graft （Peri-Guard） to repair tunical defects in patients with PD, descriptive study of 43 patients with disabling penile curvature was performed. Curvature was measured before and after the intervention using a standardized procedure. Surgical technique was plaque excision and grafting of the tunical defect carried out by a single surgeon. A lyophilized bovine pericardium patch was used for grafting. We measured the change in penile curvature and length, the ability to perform successful sexual intercourse without further pharmacological or surgical treatment, and the satisfaction with treatment. Follow-up data were available for a total of 41 patients. Median age was 50 years （IQR 48-52）; mean follow-up time was 14 ± 6 months. Complete penile straightening was achieved in 33 patients （80.5%） and five patients （12.2%） had curvature under 20. Three months after surgery and stretching therapy, mean （s.d.） flaccid penile length increased from 11.2 ± 2.8 cm to 12.1 ± 2.9 cm （P = 0.062）. Seventy-five percentage of patients reported being able to achieve successful intercourse without further treatment. Eighty-five percentage of patients reported to be satisfied with the treatment. There was no evidence of tissue rejection or infection, and only four patients suffered an adverse event. Plaque excision and grafting of the tunical defect with lyophilized bovine pericardium seems to be a safe and effective treatment for patients with PD.

关键词： penile curvature pericardium patch Peyronie's disease surgical treatment

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Quantum nonlocal effects in individual and interacting graphene nanoribbons

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Light(Science & Applications) 2015年第1期4卷 513-517页

作者： Ivan Silveiro Juan Manuel Plaza Ortega F javier garcia de Abajo ICFO-Institut de Ciencies Fotoniques Mediterranean Technology Park08860 Castelldefels(Barcelona)Spain ICREA-Institucio Catalana de Recerca i Estudis Avanc¸ats Passeig Lluis Companys 2308010 BarcelonaSpain

We show that highly doped graphene ribbons can support surface plasmons at near-infrared frequencies when their width is in the nanometer range,leading to important nonlocal and finite quantum-size corrections,such as sizable *** magnitude of these effects is assessed by comparing classical and quantum-mechanical models to describe graphene *** precisely,we examine individual and interacting 6–8 nm wide zigzag and armchair ribbons doped to 0.4–1.5 eV Fermi *** find a strong influence of nonlocal effects on the orientation of graphene edges,with plasmons in zigzag ribbons undergoing strong quenching when their energy is below the Fermi *** is also affecting the hybridization between ribbon plasmons in dimers and arrays for separations below a few ***,the removal of a single row of atomic bonds in a ribbon produces a strong plasmon frequency shift,whereas the removal of bonds along an array of rows separated by several nanometers in an extended sheet causes a dramatic increase in the *** the fundamental interest of these results,our work supports the use of narrow ribbons to achieve electro-optical modulation in the near infrared.

关键词： graphene graphene plasmons graphene ribbons metamaterials plasmonics

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