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Myxoid and Lipomatous Solitary Fibrous Tumor of Soft Tissue: A Case Description

Open Journal of Pathology 2017年第1期7卷 20-24页

作者： javier ortiz rodríguez-parets Cristina González Velasco Elisa Muñ oz Torres María Dolores Ludeñ a de la Cruz Departamento de Anatomía Patológica Hospital Universitario de Salamanca Salamanca Spain

We present a case of a myxoid and lipomatous solitary fibrous tumor that was observed in a 67-year-old man. The tumor, which had a maximum diameter of 10 cm, was located in the soft tissues of the dorsal region and appeared macroscopically well delimited and encapsulated. Upon cutting, a markedly gelatinous internal surface was observed. A microscopic study revealed an intense and diffusely myxoid neoplasia, with small areas of adipose aspect, in which histological (staghorn vessels, perivascular hyalinization, fusiform cells of benign aspect) and immunohistochemical (intensive positivity for CD34, Bcl-2 and Cd99 and negativity for muscle markers) data were consistent with a solitary fibrous tumor were observed. To conclude, the main characteristics of this lesion are discussed, and a differential diagnosis is established with other entities.

关键词： Solitary Fibrous Tumor Myxoid and Lipomatous Differentiation Histopathology Immunohistochemistry

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Dysplastic Gangliocytoma: A Rare Example of Cerebellar Tumor with An Evident Genetic Profile (Cowden Syndrome)

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Open Journal of Pathology 2021年第2期11卷 33-37页

作者： javier ortiz rodríguez-parets Luis Miguel Chinchilla Tábora Enrique Montero Mateos Elisa Muñoz Torres María Dolores Ludeña de la Cruz Department of Pathology University Hospital of Salamanca (Spain) Salamanca Spain Department of Cell Biology and Pathology The Medical School University of Salamanca Salamanca Spain

Objective: To describe the histological and immunohistochemical findings observed when studying a dysplastic cerebellar gangliocytoma observed in a 33-year-old man with a history of Thyroid Cancer. Material and Methods: Radiological images (MRI) and histological and immunohistochemical preparations obtained from the cerebellar tissue were received in our laboratory. Results: A neoplasm constituted by aberrant-looking mature neurons was observed that showed negativity for the immunohistochemical markers of the PTEN protein, expression of the activity of the PTEN gene. Conclusions: Verify the diagnosis of a rare entity, clearly related in scientific publications with Cowden’s Syndrome.

关键词： Dysplastic Gangliocytoma Immunohistochemistry Cowden Syndrome

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