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Aberrant DNA methylation reprogramming during induced pluripotent stem cell generation is dependent on the choice of reprogramming factors

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Cell Regeneration 2014年第1期3卷 30-43页

作者： Aline C Planello Junfeng Ji Vivek Sharma Rajat Singhania Faridah Mbabaali Fabian Müller javier a alfaro Christoph Bock Daniel D De Carvalho Nizar N Batada Campbell Family Cancer Research Institute Ontario Cancer InstitutePrincess Margaret Cancer CentreUniversity Health NetworkTorontoON M5G 2 M9Canada Department of Morphology Piracicaba Dental SchoolUniversity of CampinasPiracicabaSPBrazil Ontario Institute for Cancer Research TorontoOntario M4G 0A3Canada Center of Stem Cell and Developmental Biology Zhejiang UniversityHangzhouZhejiang Province 310058China National Cancer Institute NIHBethesdaMD 20892USA Department of Medical Biophysics University of TorontoTorontoON M5G 2 M9Canada Max Planck Institute for Informatics Campus E1.466123 SaarbrückenGermany CeMM Research Center for Molecular Medicine of the Austrian Academy of Sciences Lazarettgasse 141090 ViennaAustria Department of Laboratory Medicine Medical University of ViennaWähringer Gürtel 18-201090 ViennaAustria

The conversion of somatic cells into pluripotent stem cells via overexpression of reprogramming factors involvesepigenetic remodeling. DNA methylation at a significant proportion of CpG sites in induced pluripotent stem cells(iPSCs) differs from that of embryonic stem cells (ESCs). Whether different sets of reprogramming factors influencethe type and extent of aberrant DNA methylation in iPSCs differently remains unknown. In order to help resolvethis critical question, we generated human iPSCs from a common fibroblast cell source using either the Yamanakafactors (OCT4, SOX2, KLF4 and cMYC) or the Thomson factors (OCT4, SOX2, NANOG and LIN28), and determinedtheir genome-wide DNA methylation profiles. In addition to shared DNA methylation aberrations present in all ouriPSCs, we identified Yamanaka-iPSC (Y-iPSC)-specific and Thomson-iPSC (T-iPSC)-specific recurrent ***, not only were the genomic locations of the aberrations different but also their types: reprogrammingwith Yamanaka factors mainly resulted in failure to demethylate CpGs, whereas reprogramming with Thomsonfactors mainly resulted in failure to methylate CpGs. Differences in the level of transcripts encoding DNMT3b andTET3 between Y-iPSCs and T-iPSCs may contribute partially to the distinct types of aberrations. Finally, de novoaberrantly methylated genes in Y-iPSCs were enriched for NANOG targets that are also aberrantly methylated insome cancers. Our study thus reveals that the choice of reprogramming factors influences the amount, location,and class of DNA methylation aberrations in iPSCs. These findings may provide clues into how to produce humaniPSCs with fewer DNA methylation abnormalities.

关键词： SOX2 programming Thomson

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Regeneration patterns in Mexican pine-oak forests

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Forest Ecosystems 2019年第4期6卷 384-395页

作者： Teresa alfaro Reyna Jordi Martínez-Vilalta javier Retana CREAF E-08193 Cerdanyola del VallèsBarcelonaSpain Universitat Autònoma de Barcelona E-08193 Cerdanyola del VallèsBarcelonaSpain

Background: Global change is causing an increase in the incidence of natural and anthropogenic disturbances on forests, which frequently interact synergistically and promote changes in forest structure, composition and functioning. In this study we evaluate the regeneration of Pinaceae and Fagaceae species in pure and mixed stands in Mexico to determine if current regeneration patterns are indicative of changes in the relative dominance of these two tree families, as observed in other temperate regions. We also identify the environmental factors that determine the regeneration patterns of Pinaceae and Fagaceae species in these ***: We use data from two consecutive surveys of the National Inventory of Forests and Soils of Mexico(INFyS),obtained in 2004–2009 and 2009–2014. Our results show that the spatial patterns of regeneration are affected by forest structure, by climate, by the type and intensity of disturbances and by land tenure. Importantly, the presence and abundance of Fagaceae regeneration is generally higher than that of Pinaceae, and tends to be favoured(relative to Pinaceae) under warmer climates and by the presence of ***: The higher regeneration of Fagaceae relative to Pinaceae under warmer and fire-prone conditions could have important impacts on the composition and functioning of Mexican temperate forests under ongoing climate change, as well as affect their resilience to future disturbances.

关键词： Fagaceae Forest dynamics Forest inventory Mexico Pinaceae Regeneration Temperate forests

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Approximate Metric for a Rotating Deformed Mass

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International Journal of Astronomy and Astrophysics 2015年第1期5卷 1-10页

作者： Francisco Frutos-alfaro Paulo Montero-Camacho Miguel Araya javier Bonatti-González Space Research Center and School of Physics University of Costa Rica San José Costa Rica Nuclear Research Center and School of Physics University of Costa Rica San José Costa Rica

A new Kerr-like metric with quadrupole moment is obtained by means of perturbing the Kerr spacetime. The form of this new metric is simple as the Kerr metric. By comparison with the exterior Hartle-Thorne metric, it is shown that it could be matched to an interior solution. This approximate metric may represent the spacetime of a real astrophysical object with any Kerr rotation parameter a and slightly deformed.

关键词： Approximate Solutions of Einstein Equations Kerr Metric Erez-Rosen Metric Quadrupole

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Metric of a Slow Rotating Body with Quadrupole Moment from the Erez-Rosen Metric

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International Journal of Astronomy and Astrophysics 2013年第4期3卷 431-437页

作者： Francisco Frutos-alfaro Edwin Retana-Montenegro Iván Cordero-García javier Bonatti-González School of Physics University of Costa Rica San Pedro Costa Rica

A metric representing a slowly rotating object with quadrupole moment is obtained using a perturbation method to include rotation into the weak limit of the Erez-Rosen metric. This metric is intended to tackle relativ... 详细信息

关键词： General Relativity Einstein Field Equations Quadrupole Moment Erez-Rosen Metric

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A Computer Program for the Newman-Janis Algorithm

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Journal of Modern Physics 2015年第15期6卷 2226-2230页

作者： Carlos Gutiérrez-Chávez Francisco Frutos-alfaro Iván Cordero-García javier Bonatti-González Technological Institute of Costa Rica Cartago Costa Rica Space Research Center and School of Physics University of Costa Rica San José Costa Rica School of Physics University of Costa Rica San José Costa Rica Nuclear Research Center and School of Physics University of Costa Rica San José Costa Rica

A REDUCE code for the Newman-Janis algorithm is described. This algorithm is intended to include rotation into nonrotating solutions of the Einstein field equations with spherically symmetry or perturbed spherically symmetry and has been successfully applied to many spacetimes. The applicability of the code is restricted to metrics containing potentials of the form 1/r.

关键词： General Relativity Newman-Janis Formalism Null Tetrads Complex Transformations

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Boron nitride nanoresonators for phonon-enhanced molecular vibrational spectroscopy at the strong coupling limit

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Light(Science & Applications) 2017年第1期6卷 55-62页

作者： Marta Autore Peining Li Irene Dolado Francisco J alfaro-Mozaz Ruben Esteban Ainhoa Atxabal Fèlix Casanova Luis E Hueso Pablo Alonso-González javier Aizpurua Alexey Y Nikitin Saül Vélez Rainer Hillenbrand CIC nanoGUNE Donostia-San Sebastián 20018Spain Donostia International Physics Center(DIPC) Donostia-San Sebastián 20018Spain IKERBASQUE Basque Foundation for ScienceBilbao 48013Spain Departamento de Física Universidad de OviedoOviedo 33007Spain Centro de Física de Materiales(MPC CSIC-UPV/EHU)Donostia-San Sebastián 20018Spain Current address:Department of Materials ETH ZürichZürich 8093Switzerland CIC nanoGUNE and UPV/EHU Donostia-San Sebastián 20018Spain

Enhanced light-matter interactions are the basis of surface-enhanced infrared absorption(SEIRA)spectroscopy,and conventionally rely on plasmonic materials and their capability to focus light to nanoscale spot *** polariton nanoresonators made of polar crystals could represent an interesting alternative,since they exhibit large quality factors,which go far beyond those of their plasmonic *** recent emergence of van der Waals crystals enables the fabrication of highquality nanophotonic resonators based on phonon polaritons,as reported for the prototypical infrared-phononic material hexagonal boron nitride(h-BN).In this work we use,for the first time,phonon-polariton-resonant h-BN ribbons for SEIRA spectroscopy of small amounts of organic molecules in Fourier transform infrared ***,the interaction between phonon polaritons and molecular vibrations reaches experimentally the onset of the strong coupling regime,while numerical simulations predict that vibrational strong coupling can be fully *** polariton nanoresonators thus could become a viable platform for sensing,local control of chemical reactivity and infrared quantum cavity optics experiments.

关键词： boron nitride phonon polaritons strong coupling surface-enhanced infrared absorption spectroscopy SEIRA

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Magazzino意大利艺廊

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现代装饰 2018年第7期 50-55页

作者： Miguel Quismondo Jesús Aparicio alfaro Rocio Calzado López Miguel Bello Escribano javier Callejas 范嘉苑美国MQ ARCHITECTURE Waterhouse Cifuentes Design MQ ARCHITECTURE

Magazzino意大利艺廊位于纽约,是由展品主人Nancy Olnick和Giorgio Spanu构思出的一个私人项目,旨在收藏他们的战后意大利艺术品。设计团队受业主委托,要对已有的11000平方英尺的建筑进行全面翻修,并增建一个14000平方英尺的新建筑。现... 详细信息

Magazzino意大利艺廊位于纽约,是由展品主人Nancy Olnick和Giorgio Spanu构思出的一个私人项目,旨在收藏他们的战后意大利艺术品。设计团队受业主委托,要对已有的11000平方英尺的建筑进行全面翻修,并增建一个14000平方英尺的新建筑。现有的L形建筑结构于1946年建成,当时是奶制品的分销中心,并被装货码头和檐蓬包围。新的建筑需要一个更高的空间,用于收藏一些大件的艺术品,并易于引入自然光线。

关键词：简易屋顶建筑体 Magazzino 意大利

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智利儿童参与校外项目——主观幸福感、空闲时间利用满意度与校外项目满意度调查

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中国校外教育 2022年第3期 101-128页

作者：洛雷托·迪策尔费伦·卡萨斯哈维尔·托雷斯-瓦莱霍斯费尔南多·雷耶斯杰米·阿尔法罗周宇雯张乐云费知行韩戈玲庄甘林(译) Faculty of Psychology Universidad del DesarrolloChile Doctoral Program in sychology Health and Quality of Life University of GironaSpain Research Institute on Quality of Life University of GironaSpain Doctoral Program on Education and Society Faculty of Education and Social SciencesUniversidad Andres BelloChile Faculty of Education of Social Sciences Universidad Andres BelloChile 华东理工大学外国语学院伯明翰大学上海理工大学上海外国语大学贤达经济人文学院

对1033名9~14岁智利儿童(其中49.1%为女孩)的主观幸福感和其空闲时间利用的满意度进行调查,其中568人参加了公共校外项目,465人没有参加。所有参与调查的儿童就读于市立学校,且生活在高度脆弱的社会环境中。研究采用此前智利研究人员验... 详细信息

对1033名9~14岁智利儿童(其中49.1%为女孩)的主观幸福感和其空闲时间利用的满意度进行调查,其中568人参加了公共校外项目,465人没有参加。所有参与调查的儿童就读于市立学校,且生活在高度脆弱的社会环境中。研究采用此前智利研究人员验证有效的幸福感量表和国际通用的空闲时间利用项目量表,采用验证性因素分析和多群组结构方程模型分析评估量表的拟合度和组间评分的等效性。总体结果显示,两组儿童的主观幸福感都很高。尽管大多数参加校外项目的儿童得分较高,但该结果所体现的差异并不具备统计学意义。进一步分析结果表明,参加校外项目的儿童在主观幸福感的某些方面得分明显更高,且与未参加校外项目的儿童相比,他们更快乐,对空闲时间的利用也更满意。调查结果还表明,学生对校外项目的高满意度与参与度和校外活动的多样性显著相关。此外,采用多元回归分析了年龄和性别等社会人口学变量的影响。目前,关于公共校外项目对儿童幸福感影响的研究不足,鉴于此,对这一问题展开另外两点论述。具体来说,研究不仅可以丰富人们对儿童主观幸福感的认知,还讨论了对支持儿童的公共政策进行评价时使用主观幸福感指标的问题。

关键词：主观幸福感童年校外项目空闲时间利用公共政策

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Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

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Cellular & Molecular Immunology 2021年第9期18卷 2128-2139页

作者： Alberto Pérez-Gómez Joana Vitallé Carmen Gasca-Capote Alicia Gutierrez-Valencia María Trujillo-Rodriguez Ana Serna-Gallego Esperanza Muñoz-Muela María de los Reyes Jiménez-Leon Mohamed Rafii-El-Idrissi Benhnia Inmaculada Rivas-Jeremias Cesar Sotomayor Cristina Roca-Oporto Nuria Espinosa Carmen Infante-Domínguez Juan Carlos Crespo-Rivas Alberto Fernández-Villar Alexandre Pérez-González Luis Fernando López-Cortés Eva Poveda Ezequiel Ruiz-Mateos JoséMiguel Cisneros Sonsoles Salto-Alejandre Judith Berastegui-Cabrera Pedro Camacho-Martínez Carmen Infante-Domínguez Marta Carretero-Ledesma Juan Carlos Crespo-Rivas Eduardo Márquez JoséManuel Lomas Claudio Bueno Rosario Amaya JoséAntonio Lepe Jerónimo Pachón Elisa Cordero javier Sánchez-Céspedes Manuela Aguilar-Guisado Almudena Aguilera Clara Aguilera Teresa Aldabo-Pallas Verónica alfaro-Lara Cristina Amodeo javier Ampuero María Dolores Avilés Maribel Asensio Bosco Barón-Franco Lydia Barrera-Pulido Rafael Bellido-Alba Máximo Bernabeu-Wittel Candela Caballero-Eraso Macarena Cabrera Enrique Calderón Jesús Carbajal-Guerrero Manuela Cid-Cumplido Yael Corcia-Palomo Juan Delgado Antonio Domínguez-Petit Alejandro Deniz Reginal Dusseck-Brutus Ana Escoresca-Ortega Fátima Espinosa Nuria Espinosa Michelle Espinoza Carmen Ferrándiz-Millón Marta Ferrer Teresa Ferrer Ignacio Gallego-Texeira Rosa Gámez-Mancera Emilio García Horacio García-Delgado Manuel García-Gutiérrez María Luisa Gascón-Castillo Aurora González-Estrada Demetrio González Carmen Gómez-González Rocío González-León Carmen Grande-Cabrerizo Sonia Gutiérrez Carlos Hernández-Quiles Inmaculada Concepción Herrera-Melero Marta Herrero-Romero Luis Jara Carlos Jiménez-Juan Silvia Jiménez-Jorge Mercedes Jiménez-Sánchez Julia Lanseros-Tenllado Carmina López Isabel López Álvaro López-Barrios Luis F.López-Cortés Rafael Luque-Márquez Daniel Macías-García Guillermo Martín-Gutiérrez Luis Martín-Villén JoséMolina Aurora Morillo María Dolores Navarro-Amuedo Dolores Nieto-Martín Francisco Ortega María Paniagua-García Amelia Peña-Rodríguez E Clinical Unit of Infectious Diseases Microbiology and Preventive MedicineInstitute of Biomedicine of Seville(IBiS)Virgen del Rocío University HospitalCSICUniversity of SevilleSevilleSpain Department of Medical Biochemistry Molecular Biologyand ImmunologySchool of MedicineUniversity of SevilleSevilleSpain Pneumology Service Galicia Sur Health Research Instituto(IIS Galicia Sur)SERGAS-UVigoVigoSpain Infectious Diseases Unit Department of Internal MedicineComplexo HospitalarioUniversitario de VigoIIS Galicia SurSERGAS-UVigoVigoSpain Group of Virology and Pathogenesis Galicia Sur Health Research Institute(IIS Galicia Sur)-Complexo Hospitalario Universitario de VigoSERGAS-UVigoVigoSpain Unit of Infectious Diseases Microbiologyand Preventive MedicineVirgen del Rocío University HospitalSevilleSpain Institute of Biomedicine of Seville(IBiS) Virgen del Rocío University Hospital/CSIC/University of SevilleSevilleSpain Medico-Surgical Unit of Respiratory Diseases Virgen del Rocío University HospitalSevilleSpain Unit of Emergencies Virgen del Rocío University HospitalSevilleSpain Intensive Care Unit Virgen del Rocío University HospitalSevilleSpain Department of Medicine University of SevilleSevilleSpain Cardiology and Cardiovascular Surgery Unit Virgen del Rocío University HospitalSevilleSpain Rheumatology Unit Virgen del Rocío University HospitalSevilleSpain Internal Medicine Unit Virgen del Rocío University HospitalSevilleSpain Digestive and Hepatobiliary Unit Virgen del Rocío University HospitalSevilleSpain Neurology and Clinical Neurophysiology Unit Virgen del Rocío University HospitalSevilleSpain Endocrinology and Nutrition Unit Virgen del Rocío University HospitalSevilleSpain Urology and Nephrology Unit Virgen del Rocío University HospitalSevilleSpain Unit of Clinical Investigation and Clinical Trials Virgen del Rocío University HospitalSevilleSpain

Severe Acute Respiratory Syndrome Coronavirus(SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity *** cells(DCs)play a key role in the defense against viral infections,for instance plasmacytoid DCs(pDCs),have the capacity to produce vast amounts of interferon-alpha(IFN-α).In COVID-19 there is a deficit in DC numbers and IFN-αproduction,which has been associated with disease *** this work,we described that in addition to the DC deficiency,several DC activation and homing markers were altered in acute COVID-19 patients,which were associated with multiple inflammatory ***,previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+myeloid DCs and pDCs seven months after SARS-CoV-2 ***,the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients,while no restoration of integrinβ7 and indoleamine 2,3-dyoxigenase(IDO)levels were *** findings contribute to a better understanding of the immunological sequelae of COVID-19.

关键词： SARS-CoV-2 COVID-19 Dendritic cell Long-COVID

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