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In vitro antioxidant and anti-cancer activities and phytochemical analysis of Commelina benghalensis L. root extracts

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Asian Pacific Journal of Tropical Biomedicine 2020年第9期10卷 417-425页

作者： Riffat Batool Ejaz Aziz javed iqbal Hina Salahuddin Benny Kwong-Huat Tan Saira Tabassum Tariq Mahmood University Institute of Biochemistry and Biotechnology PMAS-UAAR RawalpindiPakistan Department of Botany GDC KhanpurHaripur Pakistan Department of Plant Sciences Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabad-45320Pakistan Department of Zoology University of OkaraOkaraPakistan Department of Pharmacology Yong Loo Lin School of MedicineNational University of SingaporeSingapore Department of Biotechnology Faculty of Biological SciencesQuaid-i-Azam UniversityIslamabad-45320Pakistan

Objective:To explore antioxidant potential,anti-cancer activity,and phytochemicals of Commelina benghalensis ***:The roots of Commelina benghalensis were extracted in different solvents(methanol,ethanol,benzene,chloroform,n-hexane)with a range of *** activity was evaluated by reducing power assay,DPPH radical scavenging activity and phosphomolybdenum method,cytotoxicity by MTT assay,apoptotic and cell cycle analysis by flow cytometry,migratory and invasive potential by wound scratch assay and invasion assay,respectively,functional groups analysis by FT-IR spectroscopy and phytochemicals by aluminum chloride colorimetric and FolinCiocalteu ***:The extracts showed worthy antioxidant *** chloroform extract demonstrated the most significant cytotoxic effect on MDA-MB-231(breast cancer)cell line,induced apoptosis and reduced migratory and invasive potential of MDA-MB-231 *** and ethanol extracts presented good yield of total phenolic and total flavonoid *** FTIR spectroscopic studies revealed different characteristic peak values with various functional compounds such as alkenes,alkanes,aliphatic amines,aromatics,alkyl halides,carboxylic acid,alcohols,ester,aldehydes and ***:The results demonstrate the potential use of Commelina benghalensis as a good antioxidant with significant anticancer effect.

关键词： Commelina benghalensis Anti-cancer Antioxidant FT-IR

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A User-friendly Model for Ransomware Analysis Using Sandboxing

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Computers, Materials & Continua 2021年第6期67卷 3833-3846页

作者： Akhtar Kamal Morched Derbali Sadeeq Jan javed iqbal Bangash Fazal Qudus Khan Houssem Jerbi Rabeh Abbassi Gulzar Ahmad Department of Computer Science&Information Technology National Center for Cyber SecurityUniversity of Engineering&TechnologyPeshawar25120Pakistan Department of Information Technology Faculty of Computing and Information TechnologyKing Abdulaziz UniversityJeddah21589Saudi Arabia Institute of Computer Sciences and Information Technology(ICS/IT) University of AgriculturePeshawar25130Pakistan Department of Industrial/Electrical Engineering College of EngineeringUniversity of Ha’ilHail1234Saudi Arabia Department of Electrical Engineering University of Engineering&TechnologyPeshawar25120Pakistan

Ransomware is a type of malicious software that blocks access to a computer by encrypting user’s files until a ransom is paid to the *** have been several reported high-profile ransomware attacks including WannaCry,Petya,and Bad Rabbit resulting in losses of over a billion dollars to various individuals and businesses in the *** analysis of ransomware is often carried out via sandbox environments;however,the initial setup and configuration of such environments is a challenging ***,it is difficult for an ordinary computer user to correctly interpret the complex results presented in the reports generated by such environments and analysis *** this research work,we aim to develop a user-friendly model to understand the taxonomy and analysis of ransomware ***,we aim to present the results of analysis in the form of summarized reports that can easily be understood by an ordinary computer *** model is built on top of the well-known Cuckoo sandbox environment for identification of the ransomware as well as generation of the summarized *** addition,for evaluating the usability and accessibility of our proposed model,we conduct a comprehensive user survey consisting of participants from various fields,e.g.,professional developers from software houses,people from academia(professors,students).Our evaluation results demonstrate a positive feedback of approximately 92%on the usability of our proposed model.

关键词： Ransomware sandbox user-friendly model survey

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Impact of non-alcoholic fatty liver disease on coronavirus disease 2019: A systematic review

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World Journal of Hepatology 2024年第8期16卷 1185-1198页

作者： Abdul Moeed Muhammad Omar Larik Muhammad Ahmed Ali Fahim Hafsah Alim Ur Rahman Lubna Najmi Mah I Kan Changez Muhammad Moiz javed Md Al Hasibuzzaman Department of Internal Medicine Dow University of Health SciencesKarachi 74200SindhPakistan Department of Internal Medicine Dow International Medical CollegeKarachi 74200SindhPakistan Department of Internal Medicine Ziauddin UniversityKarachi 75000SindhPakistan Department of Research Yale UniversityNew Haven 06520CTUnited States Department of Internal Medicine King Edward Medical UniversityLahore 54000PunjabPakistan Institute of Nutrition and Food Science University of DhakaDhaka 1000Bangladesh Department of Medicine The Affiliated Hospital of Medical School of Ningbo UniversityNingbo 315211Zhejiang ProvinceChina

BACKGROUND Many studies have revealed a link between non-alcoholic fatty liver disease(NA-FLD)and coronavirus disease 2019(COVID-19),making understanding the relationship between these two conditions an absolute *** To provide a qualitative synthesis on the currently present data evaluating COVID-19 and *** This systematic review was conducted in accordance with the guidelines pro-vided by preferred reporting items for systematic reviews and meta-analyses and the questionnaire utilized the population,intervention,comparison,and outcome *** search strategy was run on three separate databases,PubMed/MEDLINE,Scopus,and Cochrane Central,which were systematically searched from inception until March 2024 to select all relevant *** addition,***,***,and Google Scholar were searched to identify grey *** After retrieval of 11 studies,a total of 39282 patients data were *** was found in 11.5%and 9.4%of people in NAFLD and non-NAFLD *** all,23.2%of NAFLD patients and 22%of non-NAFLD admissions diagnosed with COVID-19 were admitted to the intensive care unit,with days of stay *** support ranged from 5%to 40.5%in the NAFLD cohort and from 3.1%to 20%in the non-NAFLD *** incidence of acute liver injury showed *** improvement on days 7 and 14 between the two classifications was *** stay ranged from 9.6 days to 18.8 days and 7.3 days to 16.4 days in the aforementioned cohorts respectively,with 73.3%and 76.3%of patients being *** rates *** Clinical outcomes except mortality consistently showed a worsening trend in patients with NAFLD and concomitant *** research in conducting prospective longitudinal studies is essential for a more powerful conclusion.

关键词： Non-alcoholic fatty liver disease Coronavirus disease 2019 Mechanical ventilation Intensive care unit Acute liver injury

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The Influence of Depression on Different Age and Gender Groups in Bahawalpur

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Journal of Clinical and Nursing Research 2024年第7期8卷 196-207页

作者： Mehran Khan Muhammad Shahbaz Tooba Waris Shoaib Yaseen Iqra Afzal Emaan Khadim Sawera Usman Muhammad Ismail Shah Sulaiman Aslam Zafar iqbal Bahawalpur College of Pharmacy BMDC Complex63100PunjabPakistan

In Bahawalpur,a cross-sectional study assessed depression prevalence across age and gender groups,involving 442 participants from diverse socioeconomic backgrounds and *** the PHQ9 questionnaire,84%were found to meet depression *** findings revealed a higher incidence in females(88%)than males(79%),with the greatest disparity among young adults,particularly young women,due to factors like academic pressure and financial *** children had the lowest depression rates(68%),possibly due to better *** individuals exhibited more severe depression,likely related to aging and domestic *** study’s findings highlight a significant variation in depression severity across different demographic groups,with an overall higher incidence in *** research underscores the necessity for targeted mental health resources and interventions tailored to the specific needs of each demographic *** also points to the importance of addressing academic and socioeconomic stressors to mitigate depression,particularly among young *** the study provides valuable insights,it relies on self-reported data,which may introduce ***,future research should include clinical assessments to validate these findings and ensure a more accurate representation of depression within the community.

关键词： Influence Depression Different age Gender groups Bahawalpur

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3D Kronecker Convolutional Feature Pyramid for Brain Tumor Semantic Segmentation in MR Imaging

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Computers, Materials & Continua 2023年第9期76卷 2861-2877页

作者： Kainat Nazir Tahir Mustafa Madni Uzair iqbal Janjua Umer javed Muhammad Attique Khan Usman Tariq Jae-Hyuk Cha Medical Imaging and Diagnostics Lab NCAIDepartment of Computer ScienceCOMSATS University IslamabadIslamabad44000Pakistan Department of Electrical and Computer Engineering COMSATS University IslamabadWah CampusWahPakistan Department of Computer Science HITEC UniversityTaxilaPakistan Department of Management Information Systems College of Business AdministrationPrince Sattam Bin Abdulaziz UniversityAl-Kharj16273Saudi Arabia Department of Computer Science Hanyang UniversitySeoul04763Korea

Brain tumor significantly impacts the quality of life and changes everything for a patient and their loved *** a brain tumor usually begins with magnetic resonance imaging(MRI).The manual brain tumor diagnosis from the MRO images always requires an expert ***,this process is time-consuming and ***,a computerized technique is required for brain tumor detection in MRI *** the MRI,a novel mechanism of the three-dimensional(3D)Kronecker convolution feature pyramid(KCFP)is used to segment brain tumors,resolving the pixel loss and weak processing of multi-scale lesions.A single dilation rate was replaced with the 3D Kronecker convolution,while local feature learning was performed using the 3D Feature Selection(3DFSC).A 3D KCFP was added at the end of 3DFSC to resolve weak processing of multi-scale lesions,yielding efficient segmentation of brain tumors of different sizes.A 3D connected component analysis with a global threshold was used as a post-processing *** standard Multimodal Brain Tumor Segmentation 2020 dataset was used for model *** 3D KCFP model performed exceptionally well compared to other benchmark schemes with a dice similarity coefficient of 0.90,0.80,and 0.84 for the whole tumor,enhancing tumor,and tumor core,***,the proposed model was efficient in brain tumor segmentation,which may facilitate medical practitioners for an appropriate diagnosis for future treatment planning.

关键词： Brain tumor segmentation connect component analysis deep learning kronecker convolution magnetic resonance imaging

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Substrates and Electrolytes Dependent Electrocatalytic Performance of Metal Selenides for Hydrogen Evolution Reaction:A Review

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Renewables 2024年第2期2卷 111-137页

作者： Muhammad Faisal iqbal Mengjiao Li Tao Xu Jiajie Yu Dingrui Xiong Zhiyu Mao Enlai Hu Jing Zhang Pan Xu Zhongwei Chen Key Laboratory of the Ministry of Education for Advanced Catalysis Materials College of Chemistry and Materials ScienceZhejiang Normal UniversityJinhua 321004 State Key Laboratory of Catalysis Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023 Power Battery and Systems Research Center Dalian Institute of Chemical PhysicsChinese Academy of SciencesDalian 116023 Zhejiang Fenergy Technology Co. Ltd.Pinghu 314200

The electrochemical skeleton for the production of hydrogen production from water splitting consists of electrocatalysts,electrolytes,substrates,and standard *** selenides have been considered efficient electrocatalysts due to their outstanding ***,electrolytes and employed substrates can significantly influence the electrocatalytic performance of the metal selenides for hydrogen evolution reaction(HER).Several studies of metal selenides for HERs have been carried out and summarized,but there are some severe limitations regarding the synchronization of the employed substrates,electrolytes,and *** experiments suggest that metal selenides deposited on carbon-based substrates inject and transport the charge carriers effectively in an acidic medium and boost the electrocatalytic ***,the metal selenides deposited on materials other than carbon-based substrates inject and make the facile transportation of the charge carriers in an alkaline medium and promote the electrocatalytic ***,the fundamental characteristics,critical factors,and electrocatalytic performance of metal selenides deposited on carbon-based substrates in acidic electrolytes have been effectively *** electrocatalytic performance of the metal selenides in an alkaline electrolyte and substrates like nickel foam have also been summarized to provide direction,challenges,and feedback about the electrocatalytic performance of metal selenides.

关键词： metal selenides electrolytes substrates characteristics of metal selenides hydrogen evolution reaction

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Deep Learning Method to Detect the Road Cracks and Potholes for Smart Cities

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Computers, Materials & Continua 2023年第4期75卷 1863-1881页

作者： Hong-Hu Chu Muhammad Rizwan Saeed javed Rashid Muhammad Tahir Mehmood Israr Ahmad Rao Sohail iqbal Ghulam Ali College of Civil Engineering Hunan UniversityChangsha410082China Department of CS University of OkaraOkara56310Pakistan Department of CS&SE Islamic International UniversityIslamabad44000Pakistan Department of IT Services University of OkaraOkara56310Pakistan Department of CS Government College UniversityFaisalabad38000Pakistan Department of Automation Science Beihang UniversityBeijing100191China

The increasing global population at a rapid pace makes road trafficdense;managing such massive traffic is challenging. In developing countrieslike Pakistan, road traffic accidents (RTA) have the highest mortality percentageamong other Asian countries. The main reasons for RTAs are roadcracks and potholes. Understanding the need for an automated system forthe detection of cracks and potholes, this study proposes a decision supportsystem (DSS) for an autonomous road information system for smart citydevelopment with the use of deep learning. The proposed DSS works in layerswhere initially the image of roads is captured and coordinates attached to theimage with the help of global positioning system (GPS), communicated tothe decision layer to find about the cracks and potholes in the roads, andeventually, that information is passed to the road management informationsystem, which gives information to drivers and the maintenance *** the decision layer, we projected a CNN-based model for pothole crackdetection (PCD). Aimed at training, a K-fold cross-validation strategy wasused where the value of K was set to 10. The training of PCD was completedwith a self-collected dataset consisting of 6000 images from Pakistani *** proposed PCD achieved 98% of precision, 97% recall, and accuracy whiletesting on unseen images. The results produced by our model are higher thanthe existing model in terms of performance and computational cost, whichproves its significance.

关键词： Road cracks and potholes CNN smart cities pothole crack detection decision support system

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Estimation of Seismic Landslide Hazard in the Eastern Himalayan Syntaxis Region of Tibetan Plateau

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Acta Geologica Sinica(English Edition) 2017年第2期91卷 658-668页

作者： DU Guoliang ZHANG Yongshuang YANG Zhihua javed iqbal TONG Bin GUO Changbao YAO Xin WU Ruian Institute of Geomechanics Chinese Academy of Geological SciencesKey Laboratory of Neotectonic Movement and GeohazardBeijing 100081China China Institute of Geo-Environment Monitoring Beijing 100081China Department of Earth Sciences Abbottabad University of Science and TechnologyAbbottabad 22010Pakistan

The eastern Himalayan syntaxis is one of the most tectonically active and earthquake-prone regions on Earth where earthquake-induced geological disasters occur frequently and caused great damages. With the planning and construction of Sichuan-Tibet highway, Sichuan-Tibet railway and hydropower development on the Yarlung Zangbo River etc. in recent years, it is very important to evaluate the seismic landslide hazard of this region. In this paper, a seismic landslide hazard map is produced based on seismic geological background analysis and field investigation using Newmark method with 10% PGA exceedance probabilities in future 50 years by considering the influence of river erosion, active faults and seismic amplification for the first time. The results show that the areas prone to seismic landslides are distributed on steep slopes along the drainages and the glacier horns as well as ridges on the mountains. The seismic landslide hazard map produced in this study not only predicts the most prone seismic landslide areas in the future 50 years but also provides a reference for mitigation strategies to reduce the exposure of the new building and planning projects to seismic landslides.

关键词： probabilistic seismic hazard Newmark method seismic landslide the eastern Himalayan syntaxis Tibet Proto-Tethys

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Channel aware receiver for next generation wireless communication system

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Journal of Central South University 2021年第7期28卷 2131-2139页

作者： MUHAMMAD Asim ASFANDYAR Khan javed iqbal Bangash ABDULLAH Khan Department of Computer Science and Information Technology ICS/ITFMCSThe University of AgriculturePeshawarPakistan

We consider an iterative phase synchronization scheme based on maximum a posteriori probability *** classical approaches,the phase noise estimation model considers one sample per symbol at the channel and ***,information theoretic studies suggested use of more than one sample per symbol at the channel and receiver for achieving higher *** this article,a soft-information aided iterative receiver is derived,which uses off-the-shelf blocks for detection and demodulation by keeping the complexity of the receiver *** consider here two samples per symbols at the channel and receiver in a pragmatic *** is shown that phase noise estimation can be significantly improved at the expense of modest processing *** results are presented for low-density parity check coded quadrature amplitude *** results show a significant performance improvement for strong phase noise values compared to classical receiver approaches.

关键词： phase noise channel iterative receiver multi-sample LDPC coded modulations

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Is intra-operative cholangiography necessary during laparoscopic cholecystectomy? A multicentre rural experience from a developing world country

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World Journal of Gastroenterology 2007年第33期13卷 4493-4497页

作者： iqbal Saleem Mir Mir Mohsin Omar Kirmani Tafazul Majid Khurshid Wani Mehmood-ul Hassan javed Naqshbandi Mohammed Maqbool Minimal Access Surgery Unit Government Gousia Hospital Khanyar Kashmir 190010 India Department of Radiology Government Gousia Hospital Khanyar Kashmir 190010 India Anaesthesia Unit Government Gousia Hospital Khanyar Kashmir 190010 India

AIM: To evaluate the feasibility and safety of performing laparoscopic cholecystectomy (LC) in nonteaching rural hospitals of a developing country without intra-operative cholangiography (IOC). To evaluate the possibility of reduction of costs and hospital stay for patients undergoing ***: A prospective analysis of patients with symptomatic benign diseases of gall bladder undergoing LC in three non-teaching rural hospitals of Kashmir Valley from Jan 2001 to Jan 2007. The cohort represented a sample of patients requiring LC, aged 13 to 78 (mean 47.2) years. Main outcome parameters included mortality, complications, re-operation, conversion to open procedure without resorting to IOC, reduction in costs borne by the hospital, and the duration of hospital ***: Twelve hundred and sixty-seven patients (976 females/291 males) underwent laparoscopic cholecystectomy. Twenty-three cases were converted to open procedures; 12 patients developed port site infection, nobody died because of the procedure. One patient had common bile duct (CBD) injury, 4 patients had biliary leak, and 4 patients had subcutaneous emphysema. One cholecystohepatic duct was detected and managed intraoperatively, 1 patient had retained CBD stones, while 1 patient had retained cystic duct stones. Incidental gallbladder malignancy was detected in 2 cases. No long-term complications were detected up to ***: LC can be performed safely even in non-teaching rural hospitals of a developing country provided proper equipment is available and the surgeons and other team members are well trained in the procedure. It is stressed that IOC is not essential to prevent biliary tract injuries and missed CBD stones. The costs to the patient and the hospital can be minimized by using reusable instruments, intracorporeal sutures, and condoms instead of titanium clips and endobags.

关键词： Laparoscopic cholecystectomy Intraoperative cholangiography

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