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Incidence of T3151 mutation in BCR/ABL-positive CML and ALL patients

Frontiers in Biology 2016年第5期11卷 404-411页

作者： Fatemeh Norozi javad mohammadi-asl Tina Vosoughi Mohammad Ali Jalali Far Areal Saki Malehi Najmaldin Saki Health Research Institute Thalassemia and Hemoglobinopathy Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Medical Genetics Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

OBJECTIVES： Targeted therapy of Philadelphia-positive ALL and CML patients using imatinib （IM） has caused significant changes in treatment course and has increased the survival of patients. A small group of patients show resistance to IM. Acquired mutations in tyrosine kinase domain of BCR-ABL protein are a mechanism for development of resistance. T315I is one of the most common acquired mutations in this domain, which occurs in ATP binding site and inhibits the formation of hydrogen bond with IM. The aim of this study was to evaluate the prevalence of this mutation in BCR/ABL-positive CML and ALL patients. METHODS： To conduct this study, 60 BCR-ABL-positive patients （including 50 CML and 10 ALL patients） who were subject to treatment with IM were selected. After taking the samples, presence of T315I mutation was assessed using ARMS- PCR on cDNA and its polymorphism was evaluated by sequencing. RESULTS： The results showed that among 60 patients, only three patients had T315I mutation, which was detected using ARMS technique. The three patients bearing mutation were afflicted with CML and no significant association was found between blood parameters with duration of treatment in presence of mutation. CONCLUSIONS： The mutation was found in three CML patients, which indicated lower likelihood and diagnostic value of this mutation in ALL patients. Given the negative direct sequencing results in T3151 patients, it can be concluded that ARMS- PCR is a more sensitive technique when the number of cancer cells is low in patients during treatment.

关键词： BCR-ABL T315I mutation imatinib CML ALL

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Evaluation of miR-21 and miR-150 expression in immune thrombocytopenic purpura pathogenesis： a case-control study

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Frontiers in Biology 2017年第5期12卷 361-369页

作者： Elahe Khodadi Ali Amin Asnafi javad mohammadi-asl Seyed Ahmad Hosseini Amal Saki Malehi Najmaldin Saki Thalassemia & Hemoglobinopathy Research center research institute of health Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Department of Medical Genetics Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran Nutrition and Metabolic Diseases Research Center Ahvaz Jundishapur University of Medical Sciences Ahvaz Iran

BACKGROUND： Immune thrombocytopenic purpnra （ITP） is a common autoimmune disorder diagnosed with thrombocytopenia and bleeding symptoms due to production of autoantibodies （Abs） against platelets. Nowadays, microRNAs are known as novel biomarkers for diagnosis of diseases. The aim of this study was to investigate the expression levels of miR-21 and miR-150 in ITP patients and determine the role of these miRNAs in ITP pathogenesis. MATERIALS and METHODS： Thirty newly diagnosed patients with acute ITP and 30 healthy subjects（ age and sex matched） as controls were enrolled in this study. The expression level ofmiR-21 and miR- 150 was investigated using Real-time-PCR. Comparison of demographic characteristics of the cases was done using independent t-test and chi-square test. Comparison of the expression level of miR-21 and miR-150 with the related parameters was done using independent t-test or Mann-Whitney and Kruskal-Wallis test, Spearman rho correlation coefficient was used to investigate the relationship between the expression of miR-21 and miR-150 with demographic characteristics. RESULTS： The expression of miR-21, 150 in the patients was not different compared with the control group in general. A significant relationship between the expression of miR-21 with hemoglobin, hematocrit and red blood cell hemoglobin concentration was observed. DISCUSSION： Expression of miR-21 and miR-150 is not associated with pathogenesis of acute ITP and can involve the synergistic role of other miRNAs. Investigation of miR-21 and miR-150 expression along with other miRNAs and cytokines can be helpful in diagnosis and pathogenesis of ITP.

关键词： immune thrombocytopenic purpura miR-21 miR- 15 0

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Context-dependency in medicine:how neuronal excitability influences the impact of dopamine on cognition

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Neural Regeneration Research 2025年第11期20卷 3225-3226页

作者： Mahboubeh Ahmadi Nahid Rouhi javad Mirnajafi-Zadeh Bechara J.Saab Department of Physiology Faculty of Medical SciencesTarbiat Modares UniversityTehranIran Mobio Interactive Pte.Ltd. SingaporeRepublic of Singapore

Dopamine,often termed the"feel-good"neurotransmitter,plays a crucial role in myriad physiological and psychological brain *** dopamine is primarily associated with pleasure,reward,and motivation,its effects can be quite complex;and this complexity is further compounded when examining how dopamine functions in typical versus disease-affected neural *** pa rticula r,epilepsy,characte rized by heightened brain excitability,is linked to cognitive dysfunction,and dopamine is implicated in elements of both its pathology and *** has been successful in describing the synaptic abnormalities believed to contribute to memory issues in epilepsy,aiding in the search for effective therapies for what persists as a major medical issue.

关键词： dopamine epilepsy primarily

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Fast Convergence Resource Allocation in IEEE 802.16 OFDMA Systems with Minimum Rate Guarantee

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China Communications 2016年第12期13卷 120-131页

作者： Mohammad Mostafavi javad Musevi Niya Hosein mohammadi Behzad Mozaffari Tazehkand Faculty of Electrical and Computer Engineering University of Tabriz Faculty of Electrical and Computer Engineering University of Zanjan

Resource allocation in the context of OFDMA-based systems is challenging, given a combinatorial nature of the problem. In the context of IEEE 802.16 systems this problem is further exacerbated by additional constraints that are faced with its two dimensional frame nature. The main challenges associated with resource allocation in these systems are: mapping the allocated bandwidth resources to users in this two dimensional frame, power and frequency allocation, and Qo S guarantee. This optimization problem can usually be solved by an iterative algorithm. The solutions proposed have a constant step size in iterations which causes a long convergence time. For this reason, the solutions proposed are not applicable in IEEE 802.16 systems. In this paper we propose a novel resource allocation algorithm in IEEE 802.16 systems which has an adaptive step size in iterations while taking into account the minimum rate guarantee for users.

关键词： burst pack channel aware la grangian function OFDMA power allocation sub-channel allocation

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Solvent extraction of rubidium from gold waste using conventional SX and new CFE methods

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Rare Metals 2015年第11期34卷 818-828页

作者： Mohammad Reza Tavakoli mohammadi Seyed Mohammad javad Koleini Sepideh Javanshir Hossein Abolghasemi Mahmoud Abdollahy Mineral Processing Department Tarbiat Modares University Mining Engineering Department University of Birjand Oil and Gas Center of Excellence School of Chemical Engineering College of Engineering University of Tehran

Solvent extraction（SX） of rubidium（Rb） from leaching filtrate of gold waste（GW） in Mouteh Processing Plant by 18-crown-6（18C6） was studied. High potential of new column flotoextraction（CFE） method in extraction of Rb from dilute solutions was also demonstrated. First, the factors affecting SX of Rb from a synthetic rubidium sulfate solution(containing 100 mg·L-1Rb) were identified.0.05 mol·L-118C6 in kerosene, 0.02 mol·L-1picric acid in aqueous phase, aqueous to organic（A/O） ratio of 1, p H7 and mixing time of 15 min are the optimum values for affective factors. The three-stage precipitation with sodium carbonate, p H adjustment with sulfuric acid and two-stage evaporation and crystallization were conducted to purify the leaching from impurities such as Fe, Al, Mn, Ca and especially competing cations of K and Na. Almost complete extraction of Rb and K from final filtrate containing 0.08 mol·L-1picric acid was performed using 0.2 mol·L-118C6 in kerosene. The Rb and K strippings of 99.12 % and 9.93 %, respectively, are obtained with 2 mol·L-1nitric acid with A/O ratio of 2. Finally, the performance comparison of the CFE and SX methods in similar conditionsshows increased extraction of K and Rb by 16 % and 5 %,respectively, using CFE method.

关键词： Rubidium Gold waste Solvent extraction Column flot

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Inhibition of E. coli and bio-preservation of ground beef by Lactobacillus,black pepper extract and EDTA

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Food Bioscience 2022年第3期47卷 1098-1103页

作者： Shadieh mohammadi javad Aliakbarlu Hossein Tajik Leila Manafi Negar Mortazavi Department of Food Hygiene and Quality Control Faculty of Veterinary MedicineUrmia UniversityUrmiaIran Environmental Health Research Center Research Institute for Health DevelopmentKurdistan University of Medical SciencesSanandajIran

The objectives of present study were to evaluate the potential of Lactobacillus reuteri or Lactobacillus casei combined with black pepper extract(BPE)and ethylenediamine tetraacetic acid(EDTA)for controlling the growth of *** O157:H7 and improving the chemical,microbiological and sensory quality of ground beef stored at 10℃ for 12 *** in vitro results indicated that the combination of *** with BPE and EDTA had the most potent antibacterial effect against *** and resulted in 2.7 log CFU/ml *** ground beef,the combination of *** or *** with BPE and EDTA decreased *** and aerobic mesophilic bacteria counts up to 1 and 1.6 log CFU/g,***,this combination significantly reduced the lipid oxidation rate(up to 60%)and improved odor and overall acceptability scores of ground *** was concluded that the combination of *** with BPE and EDTA could be used in ground beef to control microbial proliferation,retard lipid oxidation,and improve sensory quality.

关键词： Lactobacillus Ground beef Black pepper EDTA E.coli

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Magnetic force microscopy of an operational spin nano-oscillator

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Microsystems & Nanoengineering 2022年第3期8卷 247-252页

作者： Seyed Amir Hossein Banuazizi Afshin Houshang Ahmad A Awad javad mohammadi Johan Akerman Liubov M.Belova Faculty of New Sciences and Technologies University of TehranTehranIran Materials and Nanophysics Department of Applied PhysicsSchool ofEngineering SciencesKTH Royal Institute of Technology11419 StockholmSweden Department of Physics University of Gothenburg41296 GothenburgSweden Department of Materials Science and Engineering KTHRoyal Institute of Technology10044 StockholmSweden

Magnetic force microscopy(MFM)is a powerful technique for studying magnetic microstructures and nanostructures that relies on force detection by a cantilever with a magnetic *** detected magnetic tip interactions are used to reconstruct the magnetic structure of the sample ***,we demonstrate a new method using MFM for probing the spatial profle of an operational nanoscale spintronic device,the spin Hall nano-osillator(SHNO),which generates high-intensity spin wave auto-osillations enabling novel microwave applications in magnonics and neuromorphic *** developed an MFM system by adding a microwave probe station to allow electrical and microwave characterization up to 40 GHz during the MFM ***-based on NiFe/Pt bilayers with a specific design compatible with the developed system-were fabricated and scanned using a Co magnetic force microscopy tip with 10 nm spatial MFM resolution,while a DC current sufficient to induce auto-oscillation *** results show that this developed method provides a promising path for the characterization and nanoscale magnetic field imaging of operational nano-osilators.

关键词： microwave characterization system

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Astragalus adscendens extract shows antidiabetic effects through controlling oxidative stress,inflammation and apoptosis in streptozotocin-induced diabetic rats

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Asian Pacific Journal of Tropical Biomedicine 2023年第6期13卷 242-249页

作者： Yosra Raziani Kimia Karami Hamid Reza mohammadi Hossein Mahmoudvand Mohammad Nabi Moradi javad Ghasemian Yadegari Nursing Department Al-Mustaqbal University College51001 HillahBabylonIraq Razi Herbal Medicines Research Center Lorestan University of Medical SciencesKhorramabadIran Molecular and Cellular Laboratory School of Allied MedicineLorestan University of Medical SciencesKhorramabadIran

Objective:To assess the effect of oral treatment of methanolic extract of the aerial parts of Astragalus adscendens in streptozotocin-induced diabetic ***:In order to induce diabetes,rats intraperitoneally received streptozotocin at 65 mg/*** adult male Wistar rats were allocated into six groups(10 rats per each)including the healthy control group,the diabetic group as well as the diabetic group treated with Astragalus adscendens methanolic extract at 50,100,and 200 mg/kg per day or glibenclamide(0.6 mg/kg/day)for 28 *** effects of Astragalus adscendens methanolic extract on the levels of glucose,insulin,alanine aminotransferase,alkaline phosphatase,aspartate aminotransferase,bilirubin,creatinine,urea,uric acid,total protein,albumin,triglyceride,cholesterol,α-amylase,oxidant/antioxidant enzymes,and inflammatory cytokines were *** time-PCR was also used for measuring the gene expression of caspase-3,Bcl2,and ***:The levels of glucose,cholesterol,triglyceride,creatinine,urea,uric acid,alanine aminotransferase,aspartate aminotransferase,alkaline phosphatase,bilirubin,and malondialdehyde considerably declined(P<0.001)in diabetic rats after treatment with Astragalus adscendens methanolic extract especially at a dose of 200 mg/*** addition,treatment with Astragalus adscendens methanolic extract noticeably increased the level of insulin,total protein,and albumin as well as improved the activities of catalase,glutathione peroxidase,and superoxide dismutase,as well as the expression levels of TNF-α,IL-1β,caspase-3,Bcl2 and Bax(P<0.001)compared to the diabetic control *** extract also inhibitedα-amylase in a dose-dependent manner with an IC_(50)value of 19.6μg/***:Astragalus adscendens methanolic extract shows potent antidiabetic,anti-inflammatory,anti-apoptotic,and antioxidant effects in diabetic ***,more studies are needed to verify the underlying mechanism of the effect of this plant extract and test its effica

关键词： Herbal medicines Astragalus adscendens Diabetes Antioxidant Antidiabetes Streptozotocin Antiinflammation

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A Nonlinear Coordinated Approach to Enhance the Transient Stability of Wind Energy-Based Power Systems

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IEEE/CAA Journal of Automatica Sinica 2020年第4期7卷 1087-1097页

作者： Mohammad javad Morshed the Department of Electrical and Computer Engineering University of Louisiana at LafayetteLafayetteLA 70504 USA

This paper proposes a novel framework that enables the simultaneous coordination of the controllers of doubly fed induction generators(DFIGs) and synchronous generators(SGs).The proposed coordination approach is based on the zero dynamics method aims at enhancing the transient stability of multi-machine power systems under a wide range of operating conditions. The proposed approach was implemented to the IEEE39-bus power systems. Transient stability margin measured in terms of critical clearing time along with eigenvalue analysis and time domain simulations were considered in the performance assessment. The obtained results were also compared to those achieved using a conventional power system stabilizer/power oscillation(PSS/POD) technique and the interconnection and damping assignment passivity-based controller(IDA-PBC). The performance analysis confirmed the ability of the proposed approach to enhance damping and improve system’s transient stability margin under a wide range of operating conditions.

关键词： Doubly fed induction generator(DFIG) excitation controller multi-machine power system synchronous generator(SG) transient stability zero dynamics

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Scale adaptive simulation of vortex structures past a square cylinder

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Journal of Hydrodynamics 2018年第4期30卷 657-671页

作者： javad Aminian Faculty of Mechanical and Energy Engineering Shahid Beheshti University

The scale adaptive simulation（SAS） turbulence model is evaluated on a turbulent flow past a square cylinder using the open-source CFD package OpenF OAM 2.3.0. Two and three-dimensional simulations are performed to determine global quantities like drag and lift coefficients and Strouhal number in addition to mean and fluctuating velocity profiles in the recirculation and wake regions. SAS model is evaluated against the Shear Stress Transport k-ω（SST） model and also compared with previously reported results based on DES, LES and DNS turbulence approaches. Results show that global quantities along with mean velocity profiles are well-captured by 2-D SAS model. The 3-D SAS model also succeeded in providing comparable results with recently published DES study on Reynolds shear stress and velocity fluctuation components using about 12 times lower computational cost. It is shown that large values of the SAS model constant result in too dissipative behavior, so that proper calibration of the SAS model constant for different turbulent flows is vital.

关键词： Scale adaptive simulation (SAS) turbulence model bluff body mean and fluctuating properties anisotropic turbulence computational costs

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