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在乌克兰探测地雷

科技纵览 2024年第5期 44-51,4页

作者： jasper Baur 不详

无人机和人工智能可以发挥作用。2023年6月的一个清晨,我和同事们驱车行驶在乌克兰基辅北部一条坑洼不平的土路上。乌克兰武装部队正在附近演习,迫击炮弹划过天空。我们来到一片开阔的场地,开展由联合国组织的技术演示。在这片25公项(... 详细信息

无人机和人工智能可以发挥作用。2023年6月的一个清晨,我和同事们驱车行驶在乌克兰基辅北部一条坑洼不平的土路上。乌克兰武装部队正在附近演习,迫击炮弹划过天空。我们来到一片开阔的场地,开展由联合国组织的技术演示。在这片25公项(大约相当于62个美式橄榄球场的面积)的土地上,联合国工作人员已经埋下了50到100枚惰性地雷和其他弹药。我们的任务是驾驶无人机在这片区域上空飞行,并使用机器学习软件尽可能多地探测这些地雷,而且必须在72小时内提交结果。

关键词：迫击炮弹技术演示地雷机器学习人工智能乌克兰基辅无人机美式橄榄球

Single-cell transcriptome atlases of soybean root and mature nodule reveal new regulatory programs that control the nodulation process

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Plant Communications 2024年第8期5卷 69-91页

作者： Sergio Alan Cervantes-Perez Prince Zogli Sahand Amini Sandra Thibivilliers Sutton Tennant Md Sabbir Hossain Hengping Xu Ian Meyer Akash Nooka Pengchong Ma Qiuming Yao Michael J.Naldrett Andrew Farmer Olivier Martin Samik Bhattacharya jasper Klaver Marc Libault Department of Agronomy and Horticulture University of Nebraska-LincolnLincolnNE 68503USA Division of Plant Science and Technology College of AgricultureFoodand Natural ResourcesUniversity of Missouri-ColumbiaColumbiaMO 65211USA Interdisciplinary Plant Group of Missouri-Columbia ColumbiaMO 65211USA School of Computing University of Nebraska-LincolnLincolnNE 68503USA Proteomics and Metabolomics Facility Center for BiotechnologyUniversity of Nebraska-LincolnLincolnNE 68588USA National Center for Genome Resources Santa FeNM 87505USA INRAE UniversiteParis-SaclayInstitut des Sciences des Plantes de Paris SaclayIPS2Batiment 630 Plateau du MoulonRue Noetzlin91192 Gif sur Yvette CedexFrance Resolve Biosciences Monheim am RheinGermany Present address:The School of Plant Sciences University of ArizonaTucsonAZ 85721USA Present address:GALY Co. 100 Hood Park Dr.BostonMA 02126USA

The soybean root system is *** addition to being composed of various cell types,the soybean root system includes the primary root,the lateral roots,and the nodule,an organ in which mutualistic symbiosis with N-fixing rhizobia occurs.A mature soybean root nodule is characterized by a central infection zone where atmospheric nitrogen is fixed and assimilated by the symbiont,resulting from the close cooperation between the plant cell and the *** date,the transcriptome of individual cells isolated from developing soybean nodules has been established,but the transcriptomic signatures of cells from the mature soybean nodule have not yet been *** single-nucleus RNA-seq and Molecular Cartography technologies,we precisely characterized the transcriptomic signature of soybean root and mature nodule cell types and revealed the co-existence of different sub-populations of ***-infected cells in the mature soybean nodule,including those actively involved in nitrogen fixation and those engaged in *** of the single-cell-resolution nodule transcriptome atlas and the associated gene co-expression network confirmed the role of known nodulation-related genes and identified new genes that control the nodulation *** instance,we functionally characterized the role of GmFWL3,a plasma membrane microdomain-associated protein that controls rhizobial *** study reveals the unique cellular complexity of the mature soybean nodule and helps redefine the concept of cell types when considering the infection zone of the soybean nodule.

关键词： soybean root nodule single-cell RNA-seq nanodomains

Identification of novel small-molecule inhibitors of SARS-CoV-2 by chemical genetics

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Acta Pharmaceutica Sinica B 2024年第9期14卷 4028-4044页

作者： Chris Chun-Yiu Chan Qian Guo jasper Fuk-Woo Chan Kaiming Tang Jian-Piao Cai Kenn Ka-Heng Chik Yixin Huang Mei Dai Bo Qin Chon Phin Ong Allen Wing-Ho Chu Wan-Mui Chan Jonathan Daniel Ip Lei Wen Jessica Oi-Ling Tsang Tong-Yun Wang Yubin Xie Zhenzhi Qin Jianli Cao Zi-Wei Ye Hin Chu Kelvin Kai-Wang To Xing-Yi Ge Tao Ni Dong-Yan Jin Sheng Cui Kwok-Yung Yuen Shuofeng Yuan State Key Laboratory of Emerging Infectious Diseases Carol Yu Centre for InfectionDepartment of MicrobiologySchool of Clinical MedicineLi Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China Department of Infectious Diseases and Microbiology the University of Hong Kong-Shenzhen HospitalShenzhen 518000China Centre for Virology Vaccinology and TherapeuticsHong Kong Science and Technology ParkHong Kong SAR 999077China Academician Workstation of Hainan Province Hainan Medical University-the University of Hong Kong Joint Laboratory of Tropical Infectious DiseasesHaikou 571100China School of Biomedical Sciences Li Ka Shing Faculty of Medicinethe University of Hong KongPokfulamHong Kong SAR 999077China NHC Key Laboratory of Systems Biology of Pathogens Institute of Pathogen Biology Chinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100730China College of Biology Hunan Provincial Key Laboratory of Medical VirologyHunan UniversityChangsha 410082China

There are only eight approved small molecule antiviral drugs for treating *** them,four are nucleotide analogues(remdesivir,JT001,molnupiravir,and azvudine),while the other four are protease inhibitors(nirmatrelvir,ensitrelvir,leritrelvir,and simnotrelvir-ritonavir).Antiviral resistance,unfavourable drug‒drug interaction,and toxicity have been reported in previous *** there is a dearth of new treatment options for *** this work,a three-tier cell-based screening was employed to identify novel compounds with anti-SARS-CoV-2 *** compound,designated 172,demonstrated broad-spectrum antiviral activity against multiple human pathogenic coronaviruses and different SARS-CoV-2 variants of *** studies validated by reverse genetics showed that compound 172 inhibits the 3-chymotrypsin-like protease(3CLpro)by binding to an allosteric site and reduces 3CLpro dimerization.A drug synergistic checkerboard assay demonstrated that compound 172 can achieve drug synergy with nirmatrelvir in *** vivo studies confirmed the antiviral activity of compound 172 in both Golden Syrian Hamsters and K18 humanized ACE2 ***,this study identified an alternative druggable site on the SARS-CoV-23CLpro,proposed a potential combination therapy with nirmatrelvir to reduce the risk of antiviral resistance and shed light on the development of allosteric protease inhibitors for treating a range of coronavirus diseases.

关键词： SARS-CoV-2 High throughput screening Broad-spectrum antiviral treatment 3CLpro inhibitor Allosteric-site inhibitor Animal models Chemical genetics Reverse genetics

Structural study of Yb^(3+), Eu^(3+) and Pr^(3+) doped Ca_9Lu(PO_4)_7

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Journal of Rare Earths 2015年第9期33卷 977-982页

作者： Fabio Piccinelli Mattia Trevisani jasper R.Plaisier Marco Bettinelli Luminescent Materials Laboratory DB University of Verona and INSTM UdR VeronaStrada Le Grazie 15 37134 Verona Italy Synchrotron Light Laboratory (ELETTRA) Trieste S.C.p.A. Strada Statale 14 - km 1635 in AREA Science Park

The whitlockite-like crystal structure of Ca9Lu（PO4）7 when doped with several ions （Yb3＋, EU3＋ and Pr3＋） at different concentrations （1 tool.%, 5 mol.% and 10 tool.%） was studied, by means of synchrotron X-ray diffraction. In particular for Eu3＋ and Pr3＋, the presence of the dopant ion significantly changed the occupation factors （OFs） of the Ca2＋ and Lu3＋ cations and gave rise to a distortion of the metal-oxygen polyhedra. The observed structural features clearly showed significant impact of the dopant ion on the crystal structure of the host.

关键词： Rietveld refinement crystal structure X-ray diffraction synchrotron radiation rare earths

2000年后中国Q热的临床表现及诊疗研究进展

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中国感染与化疗杂志 2024年第2期24卷 231-239页

作者：邓超文孙林琳叶海燕陈福和邢凡凡香港大学深圳医院感染性疾病医学部感染科广东深圳518000

Q热(Q fever)是贝纳柯克斯体(Coxiella burnetii)感染引起的一种世界性分布的人畜共患病,可累及颅脑、肺脏、肝脏、心脏瓣膜、血管、骨关节等部位。Q热侵入人体网状内皮系统可引起多系统发热性急性或持续性局灶感染,急性感染表现为发热... 详细信息

Q热(Q fever)是贝纳柯克斯体(Coxiella burnetii)感染引起的一种世界性分布的人畜共患病,可累及颅脑、肺脏、肝脏、心脏瓣膜、血管、骨关节等部位。Q热侵入人体网状内皮系统可引起多系统发热性急性或持续性局灶感染,急性感染表现为发热、头痛、肺炎、肝炎等,持续性局灶感染表现为心内膜炎、血管感染、骨髓炎等。由于Q热的临床表现多样、流行病学史资料无特异性、未纳入我国法定传染性疾病、医务工作者对其诊断和治疗方面存在认识不足以及实验室检查方法未被广泛应用等原因,导致误诊和延误诊断时有发生。另一方面,国内关于Q热的研究更多聚焦在畜牧业领域或病例报告,较少有临床或研究工作者对该病进行分析总结。

关键词： Q热贝纳柯克斯体诊断治疗

NIR Hyperspectral Imaging Measurement of Sugar Content in Peach Using PLS Regression

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Journal of Shanghai Jiaotong university(Science) 2007年第5期12卷 597-601页

作者：郭峰曹其新 Nagata Masteru jasper Tallada Research Institute of Robotics Shanghai Jiaotong Univ. Faculty of Agriculture Miyazaki Univ.

Near infrared （NIR） hyperspectral imaging measurement of sugar content in peach was introauced. NIR spectral images （650～1 000 nm, resolution： 2 nm） of peach samples were captured with developed hyperspectral imaging setup. Partial least square （PLS） regression prediction model was developed to estimate the sugar content in peach; step-wise backward method was utilized to determine optimal wavelength subsets. Experimental results show that the calibration model with optimal wavelength subsets has a correlation coefficient of prediction of 0.97 and a standard error of prediction of 0.19, the prediction accuracy is higher than the calibration model applied over the whole wavelength, which proves that variable selection plays an important role in improving the prediction accuracy of PLS regression model.

关键词： near infrared hyperspectral imaging system sugar content partial least square regression

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地拉那金字塔

世界建筑导报 2024年第4期39卷 121-125页

作者： Ronald Hoogeveen Stavros Gargaretas Guido Boeters Angel Sanchez Navarro Boris Tikvarski jasper van der Ven Mirco Facchinelli Manuel Magnaguagno Leo Stuckardt MVRDV

地拉那金字塔是一个新型的文化中心,位于阿尔巴尼亚首都的中心地带。地拉那金字塔最初是作为纪念共产主义者恩维尔·霍查(EnverHoxha)而建的博物馆,MVRDV对其进行了巨大的改造,现在的地拉那金字塔重新使用了混凝土结构,已经成为了一个... 详细信息

地拉那金字塔是一个新型的文化中心,位于阿尔巴尼亚首都的中心地带。地拉那金字塔最初是作为纪念共产主义者恩维尔·霍查(EnverHoxha)而建的博物馆,MVRDV对其进行了巨大的改造,现在的地拉那金字塔重新使用了混凝土结构,已经成为了一个新公园中的开放式雕塑。公园和雕塑中散布着一个个五颜六色的盒子,这些盒子散落在原来的建筑中及其周围,里面有咖啡馆、工作室、工作坊、创业办公室、孵化器、节庆活动,还有供阿尔巴尼亚青年免费学习各种技术和知识的教室。建筑倾斜的外墙还增加了台阶,让阿尔巴尼亚人民可以在这位前共产主义者的杰作上漫步。

关键词：工作坊金字塔节庆活动孵化器阿尔巴尼亚咖啡馆工作室混凝土结构

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The differential benefit of laparoscopic over open minor liver resection for lesions situated in the anterolateral or posterosuperior segments

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Hepatobiliary Surgery and Nutrition 2024年第4期13卷 604-615,I0015-I0021页

作者： jasper P.Sijberden Guido Fiorentini Jacopo Lanari Davit Aghayan Daniel Osei-Bordom Nadia Russolillo Arjun Takhar Andrea Benedetti Cacciaguerra Santi Lopez-Ben Mathieu D’Hondt Felice Giuliante David Fuks Fernando Rotellar Andrea Ruzzenente Adnan Alseidi Mikhail Efanov Burak Görgec Giuseppe Zimmitti Enrico Gringeri Federica Cipriani Åsmund Avdem Fretland Ravi Marudanayagam Marco Vivarelli John N.Primrose Alessandro Ferrero Robert P.Sutcliffe Bjørn Edwin Umberto Cillo Marc G.Besselink Mohammad Abu Hilal Luca A.Aldrighetti Department of Surgery Fondazione Poliambulanza Istituto OspedalieroBresciaItaly Amsterdam UMC location University of Amsterdam Department of SurgeryAmsterdamthe Netherlands Cancer Center Amsterdam Amsterdamthe Netherlands Hepatobiliary Surgery Division IRCCS San Raffaele HospitalMilanItaly Department of Surgical Oncological and Gastroenterological SciencesGeneral Surgery 2Hepatobiliary Surgery and Liver TransplantationPadua University HospitalPaduaItaly The Intervention Centre and Department of HPB Surgery Oslo University Hospital and Institute of Clinical MedicineUniversity of OsloOsloNorway Department of Surgery Ringerike HospitalVestre Viken Hospital TrustDrammenNorway Liver Unit Queen Elizabeth HospitalBirminghamUK Department of General and Oncological Surgery Umberto I Mauriziano HospitalLargo TuratiTurinItaly Department of Surgery University Hospital Southampton NHS Foundation TrustSouthamptonUK Hepatobiliary and Abdominal Transplantation Surgery Department of Experimental and Clinical MedicineRiuniti HospitalPolytechnic University of MarcheAnconaItaly Servei de Cirurgia General i Digestiva Hospital Doctor Josep Trueta de GironaGironaCataloniaSpain Department of Digestive and Hepatobiliary/Pancreatic Surgery Groeninge HospitalKortrijkBelgium Chirurgia Epatobiliare UniversitàCattolica del Sacro Cuore-IRCCSRomeItaly Department of Digestive Oncologic and Metabolic SurgeryInstitut Mutualiste MontsourisUniversitéParis DescartesParisFrance HPB and Liver Transplantation Unit Department of SurgeryUniversity ClinicUniversidad de NavarraNavarraSpain Institute of Health Research of Navarra(IdisNA) PamplonaSpain Department of Surgery University of VeronaVeronaItaly Department of Surgery Virginia Mason Medical CenterSeattleWAUSA Department of Surgery University of California San FranciscoSan FranciscoCAUSA Department of Hepato-Pancreato-Biliary Surgery Moscow Clinical Research CentreMoscowRussia

Background:It is well known that laparoscopic liver surgery can offer advantages over open liver surgery in selected ***,what type of procedures can benefit most from a laparoscopic approach has been investigated poorly thus *** aim of this study is thus to define the extent of advantages of laparoscopic over open liver surgery for lesions in the anterolateral(AL)and posterosuperior(PS)***:In this international multicentre retrospective cohort study,laparoscopic and open minor liver resections for lesions in the AL and PS segments were compared after propensity score *** differential benefit of laparoscopy over open liver surgery,calculated using bootstrap sampling,was compared between AL and PS resections and expressed as a Delta of the ***:After matching,3,040 AL and 2,336 PS resections were compared,encompassing open and laparoscopic procedures in a 1:1 *** and PS laparoscopic liver resections were more advantageous in comparison to open in terms of blood loss,transfusion rate,complications,and length of ***,AL resections benefitted more from laparoscopy than PS in terms of overall and severe complications(D-difference were 4.8%,P=0.046 and 3%,P=0.046)and blood loss(D-difference was 195 mL,P<0.001).Similar results were observed in the subset for high-volume centres,while in recent years no significant differences were found in the differential benefit between AL and PS ***:The advantage of laparoscopic over open liver surgery is greater in the AL segments than in the PS segments.

关键词： Liver neoplasms hepatectomy laparoscopic liver resection open liver resection

Repeated occurrence of palaeo-wildfires during deposition of the Bahariya Formation(early Cenomanian) of Egypt

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Journal of Palaeogeography 2019年第4期8卷 332-345页

作者： Haytham El Atfy Tarek Anan Andre jasper Dieter Uhl Department of Geology Faculty of ScienceMansoura UniversityMansoura 35516Egypt Programa de Pos-Graduacao em Ambiente e Desenvolvimento PPGADUniversidade do Vale do Taquari UnivatesLajeadoRio Grande do SulBrazil Senckenberg Research Institute and Natural History Museum 60325 Frankfurt am MainGermany Senckenberg Centre for Human Evolution and Palaeoenvironment Tubingen University72076 TubingenGermany

The Upper Cretaceous(early Cenomanian)Bahariya Formation of Egypt has an outstanding reputation for its wealth of vertebrate remains,including a variety of iconic dinosaurs,like the carnivorous Spinosaurus and Carcharodontosaurus,as well as the herbivorous Aegyptosaurus and *** these dinosaur fossils,the Bahariya Formation yielded also a wealth of invertebrate and plant remains,but even today many aspects concerning the continental palaeoenvironments reflected in these deposits(including the occurrence of palaeo-wildfires)have not been studied in *** far six distinct macro-charcoal bearing levels could be identified within the type section of the Bahariya Formation at Gabal El Dist profile,one of the most prolific outcrops of this formation in terms of fossil occurrence located in the north of the Bahariya Oasis,Western Desert,*** of the charcoal investigated by means of SEM originates from ferns,pointing to a considerable proportion of this plant group within the palaeo-ecosystems that experienced *** and(putative)angiosperms have less frequently been *** collected data present evidence that the landscapes at the northern shores of Gondwana repeatedly experienced palaeo-wildfires,adding extra proof to previous statements that the Late Cretaceous was a fiery world on a global scale.

关键词： Bahariya Oasis Gabal El Dist Charcoal Wildfire Dinosaurs Upper Cretaceous Early Cenomanian Egypt