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It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis

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Stroke & Vascular Neurology 2019年第5期4卷 28-35页

作者： jason P Appleton Lisa j.Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins j.hn Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongj.n Wang j.anna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators Stroke Division of Clinical NeurosciencesUniversity of NottinghamNottinghamUK Stroke Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurology Semmelweis UniversityBudapestHungary Department of Internal Medicine and Cardiology Oslo University HospitalOsloNorway Stroke Unit Santa Maria della Misericordia HospitalUniversity of PerugiaPerugiaItaly Department of Neurology Singapore General HospitalSingaporeSingapore Neurology Bispebjerg and Frederiksberg HospitalCopenhagenDenmark Tallaght Hospital Trinity College DublinDublinIreland Department of Medicine Hawke's Bay District Health BoardHastingsNew Zealand Department of Clinical Science Danderyd HospitalKarolinska InstituteStockholmSweden Department of Medicine University of ThessalyLarissaGreece Neurology Selcuk University Faculty of MedicineKonyaTurkey Neurology Nottingham University Hospitals NHS TrustNottinghamUK Department of Neurology Clinical County Emergency HospitalTargu MuresRomania Neurology Beijing Tiantan HospitalBeijingChina Centre for Clinical Brain Sciences EdinburghUK

Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid *** assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)*** ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of *** on prestroke antihypertensives were also randomised to stop or continue their medication for 7 *** primary outcome was the modified Rankin Scale(mRS)at day *** carotid stenosis was split:j.sted for baseline prognostic *** 2023(60.5%)ischaemic stroke participants had carotid *** compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 *** outcomes did not differ across bilateral stenosis *** Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 *** appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis.

关键词： stenosis carotid hypertensive

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Notch signaling:Its essential roles in bone and craniofacial development

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Genes & Diseases 2021年第1期8卷 8-24页

作者： Mikhail Pakvasa Pranav Haravu Michael Boachie-Mensah Alonzo j.nes Elam Coalson j.nyi Liao Zongyue Zeng Di Wu Kevin Qin Xiaoxing Wu Huaxiu Luo j.ng Zhang Meng Zhang Fang He Yukun Mao Yongtao Zhang Changchun Niu Meng Wu Xia Zhao Hao Wang Linj.an Huang Deyao Shi Qing Liu Na Ni Kai Fu Michael j.lee j.nnifer Moriatis Wolf Aravind Athiviraham Sherwin S.Ho Tong-Chuan He Kelly Hynes jason Strelzow Mostafa El Dafrawy Russell R.Reid Molecular Oncology Laboratory Department of Orthopaedic Surgery and Rehabilitation MedicineThe University of Chicago Medical CenterChicagoIL 60637USA Pritzker School of Medicine University of ChicagoChicagoIL 60637USA Section of Plastic and Reconstructive Surgery Department of SurgeryThe University of Chicago Medical CenterChicagoIL 60637USA Departments of Orthopaedic Surgery Gastrointestinal SurgeryObstetrics and Gynecologyand NephrologyThe First Affiliated Hospital of Chongqing Medical UniversityChongqing400016PR China Ministry of Education Key Laboratory of Diagnostic Medicine and School of Laboratory and Diagnostic MedicineChongqing Medical UniversityChongqing400016PR China Department of Burn and Plastic Surgery West China Hospital of Sichuan UniversityChengduSichuan610041PR China Department of Orthopaedic Surgery The First Affiliated HospitalGuangzhou University of Chinese MedicineGuangzhouGuangdong510405PR China Departments of Orthopaedic Surgery and Neurosurgery The Affiliated Zhongnan Hospital of Wuhan UniversityWuhanHubei430072PR China Department of Orthopaedic Surgery The Affiliated Hospital of Qingdao UniversityQingdaoShandong266061PR China Department of Laboratory Diagnostic Medicine Chongqing General HospitalChongqing400021PR China Institute of Bone and j.int Research and the Department of Orthopaedic SurgeryThe Second Hospitals of Lanzhou UniversityGansuLanzhou730030PR China Department of Orthopaedics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei430072PR China Department of Spine Surgery Second Xiangya HospitalCentral South UniversityChangshaHunan410011PR China

Notch is a cellecell signaling pathway that is involved in a host of activities including development,oncogenesis,skeletal homeostasis,and much *** specifically,recent research has demonstrated the importance of Notch signaling in osteogenic differentiation,bone healing,and in the development of the *** craniofacial skeleton is complex and understanding its development has remained an important focus in *** this review we briefly summarize what recent research has revealed about Notch signaling and the current understanding of how the skeleton,skull,and face *** then discuss the crucial role that Notch plays in both craniofacial development and the skeletal system,and what importance it may play in the future.

关键词： Alagille syndrome Bone Craniofacial development Craniosynostosis Notch Oncogenesis Osteogenesis Spondylocostal dysosotosis

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Advancing the Understanding of Environmental Transformations, Bioavailability and Effects of Nanomaterials, an International US Environmental Protection Agency—UK Environmental Nanoscience Initiative j.int Program

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j.urnal of Environmental Protection 2018年第4期9卷 385-404页

作者： Mitch M.Lasat Kian Fan Chung j.mie Lead Steve McGrath Richard j.Owen Sophie Rocks jason Unrine j.nfeng Zhang Office of Research and Development United States Environmental Protection AgencyWashington DCUSA National Heart and Lung Institute Imperial CollegeLondonUK Centre for Environmental Nanoscience and Risk University of South CarolinaColumbiaUSA University of Birmingham EdgbastonUK Rothamsted Research HarpendenUK Business School University of ExeterExeterUK Institute for Resilient Futures Cranfield UniversityCranfieldUK Department of Plant and Soil Sciences University of KentuckyLexingtonUSA Nicholas School of the Environment Duke UniversityDurhamUSA

Nanotechnology has significant economic, health, and environmental benefits, including renewable energy and innovative environmental solutions. Manufactured nanoparticles have been incorporated into new materials and products because of their novel or enhanced properties. These very same properties also have prompted concerns about the potential environmental and human health hazard and risk posed by the manufactured nanomaterials. Appropriate risk management responses require the development of models capable of predicting the environmental and human health effects of the nanomaterials. Development of predictive models has been hampered by a lack of information concerning the environmental fate, behavior and effects of manufactured nanoparticles. The United Kingdom (UK) Environmental Nanoscience Initiative and the United States (US) Environmental Protection Agency have developed an international research program to enhance the knowledgebase and develop risk-predicting models for manufactured nanoparticles. Here we report selected highlights of the program as it sought to maximize the complementary strengths of the transatlantic scientific communities by funding three integrated US-UK consortia to investigate the transformation of these nanoparticles in terrestrial, aquatic, and atmospheric environment. Research results demonstrate there is a functional relationship between the physicochemical properties of environmentally transformed nanomaterials and their effects and that this relationship is amenable to modeling. In addition, the j.int transatlantic program has allowed the leveraging of additional funding, promoting transboundary scientific collaboration.

关键词： Aquatic Environment Consumer Products Manufactured Nanomaterials Predictive Models Terrestrial Ecosystem

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α核素用于放射治疗:从基础放射化学到临床研究(第一部分)

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中华核医学与分子影像杂志 2020年第11期40卷 698-704页

作者：杨晖(译) 关志伟(译) 徐白萱(审校) Sophie Poty Lynn C.Francesconi Michael R.McDevitt Michael j.Morris jason S.Lewis 解放军总医院第一医学中心核医学科北京100853 Department of Radiology and Program in Molecular Pharmacology Memorial Sloan Kettering Cancer CenterNew YorkNew York Department of Chemistry Hunter CollegeNew YorkNew York Graduate Center of City University of New York New YorkNew York Department of Radiology Weill Cornell Medical CollegeNew YorkNew York Department of Medicine Memorial Sloan Kettering Cancer CenterNew YorkNew York Departments of Radiology and Pharmacology Weill Cornell Medical CollegeNew YorkNew York

α粒子具有较短的射程和较高的传能线密度,表现出很强的细胞杀伤能力。尽管有大量核素为α衰变,释放出α粒子,却只有一小部分可用于治疗,原因在于放射性同位素的获得及其物理性质(如半衰期)会限制其广泛的应用。该篇综述的第一部分将研... 详细信息

α粒子具有较短的射程和较高的传能线密度,表现出很强的细胞杀伤能力。尽管有大量核素为α衰变,释放出α粒子,却只有一小部分可用于治疗,原因在于放射性同位素的获得及其物理性质(如半衰期)会限制其广泛的应用。该篇综述的第一部分将研究α核素的多样性、基本放射化学性质、局限性及使用的困难。

关键词：放射治疗 α核素放射化学临床试验

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A key‘foxy’aroma gene is regulated by homologyinduced promoter indels in the iconic j.ice grape‘Concord’

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Horticulture Research 2020年第1期7卷 2028-2039页

作者： Yingzhen Yang j.séCuenca Nian Wang Zhenchang Liang Honghe Sun Benj.min Gutierrez Xiaoj.n Xi j.e Arro YiWang Peige Fan jason Londo Peter Cousins Shaohua Li Zhangj.n Fei Gan-Yuan Zhong US Department of Agriculture-Agricultural Research Service Grape Genetics Research UnitGenevaNYUSA Beij.ng Key Laboratory of Grape Sciences and Enology Laboratory of Plant ResourcesInstitute of BotanyChinese Academy of SciencesBeijingChina Boyce Thompson Institute for Plant Research Cornell UniversityIthacaNYUSA US Department of Agriculture-Agricultural Research Service Plant Genetic Resources UnitGenevaNYUSA Forestry and Pomology Research Institute Shanghai Academy of Agricultural SciencesShanghaiChina University of Chinese Academy of Sciences BeijingChina E.&j.Gallo Winery ModestoCAUSA US Department of Agriculture–Agricultural Research Service Robert W.Holley Center for Agriculture and HealthIthacaNYUSA Present address:Centro de Citricultura y Producción Vegetal.Instituto Valenciano de Investigaciones Agrarias MoncadaValenciaSpain Present address:College of Horticulture and Forestry Huazhong Agricultural UniversityWuhanHubeiChina

‘Concord’,the most well-known j.ice grape with a parentage of the North American grape species Vitis labrusca L.,possesses a special‘foxy’aroma predominantly resulted from the accumulation of methyl anthranilate(MA)in *** aroma,however,is often perceived as an undesirable attribute by wine consumers and rarely noticeable in the common table and wine grape species *** we discovered homology-induced promoter indels as a maj.r genetic mechanism for species-specific regulation of a key‘foxy’aroma gene,anthraniloyl-CoA:methanol acyltransferase(AMAT),that is responsible for MA *** found the absence of a 426-bp and/or a 42-bp sequence in AMAT promoters highly associated with high levels of AMAT expression and MA accumulation in‘Concord’and other ***-derived *** promoter variants,all with direct and inverted repeats,were further confirmed in more than 1,300 Vitis ***,functional impact of these indels was validated in transgenic *** on the promoter regulation,large structural changes including exonic insertion of a retrotransposon were present at the AMAT locus in some *** *** of the AMAT genetic regulation advances our understanding of the‘foxy’aroma trait and makes it genetically trackable and amenable in grapevine breeding.

关键词： insertion aroma grape

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Predicting Mortality and Functional Outcomes after Ischemic Stroke: External Validation of a Prognostic Model

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j.urnal of Behavioral and Brain Science 2018年第10期8卷 587-597页

作者： Achala Vagal Heidi Sucharewv Christopher Lindsell Dawn Kleindorfer Kathleen Alwell Charles j. Moomaw Daniel Woo Matthew Flaherty Pooj. Khatri Opeolu Adeoye Simona Ferioli jason Mackey Sharyl Martini Felipe De Los Rios La Rosa F. Brett Kissela Departments of Radiology University of Cincinnati Medical Center Cincinnati OH USA Department of Biostatistics and Epidemiology Cincinnati Children’s Hospital Cincinnati OH USA Department of Emergency Medicine University of Cincinnati Medical Center Department of Neurology Cincinnati OH USA University of Cincinnati Medical Center Cincinnati OH USA Department of Neurology Indiana University School of Medicine Indianapolis Indiana USA Baylor College of Medicine Baptist Health Neuroscience Center Miami Florida USA

Background: We previously developed predictive models for 3-month mortality and modified Rankin Score (mRS) after ischemic stroke. Aim: The aim was to test model validity for 3-month mortality and mRS after ischemic stroke in two independent data sets. Methods: Our derivation models used data from 451 subj.cts with ischemic stroke in 1999 enrolled in the Greater Cincinnati/Northern Kentucky Stroke Study (GCKNSS). We utilized two separate cohorts of ischemic strokes through GCKNSS (460 in 2005 and 504 in 2010) to assess external validity by utilizing measures of agreement between predicted and observed values, calibration, and discrimination using Transparent Reporting of a multivariable prediction model for Individual Prognosis or Diagnosis. Results: The 3-month mortality model performed well in the validation datasets with an average prediction error (Brier score) of 0.045 for 2005 and 0.053 for 2010 and excellent discrimination with an area under the curve of 0.86 (95% CI: 0.79, 0.93) for 2005 and 0.84 (0.76, 0.92) for 2010. Predicted 3-month mRS also performed well in the validation datasets with R2 of 0.57 for 2005 and 0.50 for 2010 and a root mean square error of 0.85 for 2005 and 1.05 for 2010. Predicted mRS tended to be higher than actual in both validation datasets. Re-estimation of the model parameters for age and severe white matter hyperintensity in both 2005 and 2010, and for diabetes in 2005, improved predictive accuracy. Conclusions: Our previously developed stroke models performed well in two study periods, suggesting validity of the model predictions.

关键词： Ischaemic Stroke Epidemiology Stroke Leukoaraiosis African American Stroke Prevalence

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Rapid, continuous proj.ction multi-photon 3D printing enabled by spatiotemporal focusing of femtosecond pulses

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Light(Science & Applications) 2021年第10期10卷 1987-1997页

作者： Paul Somers Zihao Liang jason E.j.hnson Bryan W.Boudouris Liang Pan Xianfan Xu School of Mechanical Engineering and Birck Nanotechnology Center Purdue UniversityWest LafayetteINUSA Charles D.Davidson School of Chemical Engineering Purdue UniversityWest LafayetteINUSA Department of Chemistry Purdue UniversityWest LafayetteINUSA

There is demand for scaling up 3D printing throughput,especially for the multi-photon 3D printing process that provides sub-micrometer structuring capabilities required in diverse *** this work,high-speed proj.ction multiphoton printing is combined with spatiotemporal focusing for fabrication of 3D structures in a rapid,layer-by-layer,and continuous *** focusing confines printing to thin layers,thereby achieving print thicknesses on the micron and sub-micron *** proj.ction of dynamically varying patterns with no pause between patterns,a continuous fabrication process is established.A numerical model for computing spatiotemporal focusing and imaging is also presented which is verified by optical imaging and printing *** 3D structures with smooth features are fabricated,with millimeter scale printing realized at a rate above 10−3 mm3 s−*** method is further scalable,indicating its potential to make fabrications of 3D structures with micro/nanoscale features in a practical time scale a reality.

关键词： proj.ction continuous thereby

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FPGA在电机控制系统设计中的应用

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世界电子元器件 2013年第8期 36-42页

作者： Kevin Smith Wil Florentino jason Chiang Stefano j.Zammattio Altera公司

在工业能牦中，三分之二：以上的能耗来自工业电机驱动没备，因此，在工厂费用开支中，高效的电气特性是非常重要的因素。在电机驱动系统中采用速率可变驱动器（VSD）来替代传统的驱动器能够显著提高效率。

关键词：电机驱动系统控制系统设计 FPGA 应用电气特性驱动器工业

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LTV公司6号高炉紧凑式无料钟炉顶的安装及开炉

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涟钢科技与管理 2003年第4期 58-63页

作者： j.nathan j.Maude Robert j.jason,William Ebner 李曙霞

LTV公司克利夫兰(Cleveland)厂6号高炉于1999年换衬大修,安装了Paul Wurth的紧凑式无料钟炉顶(CBLT)。无料钟炉顶装料系统使高炉布料更灵活、更方便。LTV公司在5高炉的炉喉活动钢板(MTA)——有钟炉顶交替布料技术生产经验的基础上,选择... 详细信息

LTV公司克利夫兰(Cleveland)厂6号高炉于1999年换衬大修,安装了Paul Wurth的紧凑式无料钟炉顶(CBLT)。无料钟炉顶装料系统使高炉布料更灵活、更方便。LTV公司在5高炉的炉喉活动钢板(MTA)——有钟炉顶交替布料技术生产经验的基础上,选择了CBLT。

关键词：高炉紧凑式无料钟炉顶安装开炉炼铁

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jason Got It Wrong

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小学生时代（大嘴英语） 2023年第1期 4-9页

作者： j.Victor Tsway 不详

Dear Big Mouth English readers,Happy New Year!Some words sound the *** may be confused when we hear ***,atleast jason *** is playing in the *** hears Mum calling him.

关键词： hear words Wrong

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