检索结果-南通市图书馆

Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions

Journal of Pharmaceutical Analysis 2018年第6期8卷 407-412页

作者： Jayesh A.Dhanani Suzanne L.Parker Jeffrey Lipman Steven C.Wallis Jeremy Cohen John Fraser Adrian Barnett Michelle Chew jason A.Roberts Burns Trauma and Critical Care Research Centre The University of Queensland UQ Centre for Clinical Research Department of Intensive Care Medicine Royal Brisbane & Women's Hospital Faculty of Health Queensland University of Technology Critical Care Research group The University of Queensland Institute of Health and Biomedical Innovation & School of Public Health and Social Work Queensland University of Technology Department of Anaesthesiology and Intensive Care and Department of Medical and Health Sciences Link?ping University School of Pharmacy The University of Queensland Department of Pharmacy Royal Brisbane & Women's Hospital

Microdialysis is a technique used to measure the unbound antibiotic concentration in the interstitial spaces, the target site of action. In vitro recovery studies are essential to calibrating the microdialysis system for in vivo studies. The effect of a combination of antibiotics on recovery into microdialysate requires investigation. In vitro microdialysis recovery studies were conducted on a combination of vancomycin and tobramycin, in a simulated in vivo model. Comparison was made between recoveries for three different concentrations and three different perfusate flow rates. The overall relative recovery for vancomycin was lower than that of tobramycin. For tobramycin, a concentration of 20μg/mL and flow rate of 1.0μL/min had the best recovery. A concentration of 5.0μg/mL and flow rate of 1.0μL/min yielded maximal recovery for vancomycin. Large molecular size and higher protein binding resulted in lower relative recoveries for vancomycin. Perfusate flow rates and drug concentrations affected the relative recovery when a combination of vancomycin and tobramycin was tested. Low perfusate flow rates were associated with higher recovery rates. For combination antibiotic measurement which includes agents that are highly protein bound, in vitro studies performed prior to in vivo studies may ensure the reliable measurement of unbound concentrations.

关键词： Microdialysis Combination antibiotic therapy Relative recovery rate Pharmacokinetics Anti-infectives Protein binding

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

文化如何影响人类的基因

引用

求知导刊 2014年第4期 76-79页

作者： jason g.goldman 秦鹏

我们的祖先进食、烹饪、探险,以及互动的方式对我们的基因传承造成了重大的影响.那么现代文化又将如何影响我们留给后代的基因遗产呢？

关键词：现代文化基因人类祖先

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

变泥质岩递进部分熔融作用的构造物理学效应

引用

地质通报 2008年第12期27卷 1992-2000页

作者：曾令森高利娥 jason B．Saleeby 中国地质科学院地质研究所大陆动力学实验室北京100037 美国加州理工学院地质与行星科学系加州帕萨迪纳91125

在南内华达岩基中,晚中生代花岗岩的侵位导致表壳岩广泛的变质及部分熔融,形成混合岩杂岩体。对伊萨贝拉湖南羊圈混合岩杂岩体构造的野外观测和应变测量表明:①变泥质混合岩和鹅卵石砾岩记录了类似强度的应变;②变泥质岩发生了递进部分... 详细信息

在南内华达岩基中,晚中生代花岗岩的侵位导致表壳岩广泛的变质及部分熔融,形成混合岩杂岩体。对伊萨贝拉湖南羊圈混合岩杂岩体构造的野外观测和应变测量表明:①变泥质混合岩和鹅卵石砾岩记录了类似强度的应变;②变泥质岩发生了递进部分熔融,表现为离羊圈花岗闪长岩岩体的距离越远,部分熔融程度越低;③随部分熔融程度的变化,变泥质岩的应变承载构造也逐渐从混合岩带的弱相承载构造(IWL)往强相承载构造(LBF)过渡;④在同岩浆构造作用中,浅色体的流变学性质与鹅卵石砾岩中泥质组分相当,为应变的主要承载体。该结果表明:在高级变质岩区中,部分熔融程度是否足够高及熔体能否形成互相链接的网络,是高级变质岩的流变学强度发生突降、深部岩石发生侧向流动的前提。

关键词：部分熔融应变分解混合岩内华达岩基

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Allograft loss from acute Page kidney secondary to trauma after kidney transplantation

引用

World Journal of Transplantation 2017年第1期7卷 88-93页

作者： Kazuhiro Takahashi Rohini Prashar Krishna g Putchakayala William J Kane jason E Denny Dean Y Kim Lauren E Malinzak Transplant and Hepatobiliary Surgery Henry Ford Hospital Nephrology and Internal Medicine Henry Ford Hospital

We report a rare case of allograft loss from acute Page kidney secondary to trauma that occurred 12 years after kidney transplantation. A 67-year-old Caucasian male with a past surgical history of kidney transplant presented to the emergency department at a local hospital with left lower abdominal tenderness. He recalled that his cat, which weighs 15 lbs, jumped on his abdomen 7 d prior. On physical examination, a small tender mass was noticed at the incisional site of the kidney transplant. He was producing a normal amount of urine without hematuria. His serum creatinine level was slightly elevated from his baseline. Computer tomography revealed a large subscapular hematoma around the transplant kidney. The patient was observed to have renal trauma grade Ⅱ at the hospital over a period of three days, and he was finally transferred to a transplant center after his urine output significantly decreased. Doppler ultrasound demonstrated an extensive peri-allograft hypoechoic area and abnormal waveforms with absent arterial diastolic flow and a patent renal vein. Despite surgical decompression, the allograft failed to respond appropriately due to the delay in surgical intervention. This is the third reported case of allograft loss from acute Page kidney following kidney transplantation. This case reinforces that kidney care differs if the kidney is solitary or a transplant. Early recognition and aggressive treatments are mandatory, especially in a case with Doppler signs that are suggestive of compression.

关键词： Page kidney Kidney transplantation Trauma Subcapsular hematoma Doppler ultrasound

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

轻微精神病综合征:明确识别的好处（英文）

引用

上海精神医学 2015年第1期27卷 48-51页

作者： jason SCHIFFMAN William T.CARPENTER Department of Psychology University of MarylandBaltimore County Department of Psychiatry University of Maryland School of MedicineMaryland Psychiatric Research Centerand VA Capitol Health Care Network(VISN 5) MIRECC

符合轻微精神病综合征(attenuated psychosis syndrome,APS)标准的个体具有独有的特征,越来越多的文献认为对符合APS标准的个体提供服务在临床上能获益,因而APS的诊断在精神病学中有着重要作用,但过去却被忽视了。推行这一诊断将有助于... 详细信息

符合轻微精神病综合征(attenuated psychosis syndrome,APS)标准的个体具有独有的特征,越来越多的文献认为对符合APS标准的个体提供服务在临床上能获益,因而APS的诊断在精神病学中有着重要作用,但过去却被忽视了。推行这一诊断将有助于减少对具有前驱期精神病性状态个体的过度诊断和治疗。因为青少年是被诊断为APS的主要群体,所以也应鼓励那些主要为青少年服务的医生接受关于轻微精神病综合征的全面培训。虽然只有一部分APS个体最终会发展为精神病,但是临床上所有的APS个体都需要得到帮助——无论他们的转归如何。DSM-5正式列出APS,这将有利于开展如何识别这类个体的临床需求以及如何满足这些需求的研究。

关键词：精神病综合征减毒利益临床医生 APS 诊断服务

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Virtual Reality Enhanced Bilateral Teleoperation with Communication Constraints

Virtual Reality Enhanced Bilateral Teleoperation with Commun...

引用

Joint 48th IEEE Conference on Decision and Control and 28th Chinese Control Conference

作者： Ilia g.Polushin jason P.Rhinelander Peter X.Liu Chung-Horng Lung the Department of Electrical and Computer Engineering University of Western Ontario the Department of Systems and Computer Engineering Carleton University

In force reflecting teleoperator systems,the existence of even small communication delays and jitters may lead to transparency deterioration and *** alternative approach to the delayed force feedback is to design a virtual environment（VE） on the master side that duplicates the essential features of the remote slave-environment *** this work,we present an approach to the design of VE-enhanced force reflecting teleoperation in presence of network induced communication *** approach is based on using an approximate discrete-time model of the remote slave/environment interconnection,which is implemented on the master side together with certain observation/identification/prediction mechanism that allows to approximately recover the current state/parameters of the remote environment based on delayed and possibly distorted measurement data.A control algorithm and a communication protocol are designed which guarantee the stability of the overall teleoperator system in the presence of network induced communication constraints if the loss of the information during communication is sufficiently small.

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

Endoscopic sinus surgery and aspirin desensitization improve otologic-specific SNOT-22 scores

引用

World Journal of Otorhinolaryngology-Head and Neck Surgery 2020年第4期6卷 248-254页

作者： James g.Naples Andrew Corr Siddhant Tripathi Morgan Berman jason A.Brant Michael J.Ruckenstein John Bosso Beth Israel Deaconess Medical Center Harvard Medical SchoolDivision of Otolaryngolosy-Hecid and Neck SurgeryOtology/Neurotology110 Francis StSuite 6EBostonMA 02215USA University of Pennsylvania Health System Departm ent of Otorhinolaryngology-Head and Neck SurgeryOtolosy/Neurotology3400 Spruce St5 SHversteinPhiladelphiaPA 19104USA University of Cincinnati School of Medicine 230 Eden AveCincinnatiOH 45267USA

Objective:There are few studies evaluating the impact of Aspirin-exacerbated respiratory disease(AERD)treatment on otologic *** aim of this study is to evaluate the effects of endoscopic sinus surgery(ESS)and aspirin desensitization(AD)on otologic symptoms in subjects with ***:Retrospective chart review of adult patients diagnosed with AERD at our tertiary Care Academic Medical Center-Otorhinolaryngology *** of adult patients diagnosed with AERD who underwent ESS and ASA desensitization at our institution’s AERD Center from 2016 to 2019 were ***-Nasal Outcomes Test 22-item survey(SNOT-22)scores were evaluated for patients at various time points including:pre-surgery,post-surgery/pre-aspirin desensitization,and various times post-desensitization up to>12 *** the SNOT-22,otologic-specific subdomain scores were evaluated at similar time *** on immunomodulatory medications other than corticosteroids were excluded from ***:SNOT-22 scores were analyzed for 121 *** was a significant improvement in overall SNOT scores from pre-surgery(44.62)to post surgery/pre-desensitization(23.34)(Pgic-specific scores also improved after surgery prior to desensitization(3.19-2.04)(P=0.005).Following AD,the improvement in the overall SNOT-22 continued to improve for up to 12 months(Pgic-specific SNOT-22 scores remained stable after surgery and ASA ***:ESS and AD reduce otologic-specific SNOT-22 scores and parallel trends in overall SNOT-22 *** effect of treatment is durable over the course of 12 *** work should aim to correlate otologic SNOT-22 scores with objective otologic data.

关键词： Aspirin exacerbated respiratory disease Otologic symptoms SNOT-22

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A flexible and scalable scheme for mixing computed formation energies from different levels of theory

引用

npj Computational Materials 2022年第1期8卷 1857-1867页

作者： Ryan S.Kingsbury Andrew S.Rosen Ayush S.gupta jason M.Munro Shyue Ping Ong Anubhav Jain Shyam Dwaraknath Matthew K.Horton Kristin A.Persson Department of Materials Science and Engineering University of California BerkeleyBerkeleyCA94720USA Energy Technologies Area Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Materials Science Division Lawrence Berkeley National LaboratoryBerkeleyCA94720USA Miller Institute for Basic Research in Science University of CaliforniaBerkeleyCA94720USA University of California San Diego La JollaCA92093USA Molecular Foundry Lawrence Berkeley National LaboratoryBerkeleyCA94720USA

Computational materials discovery efforts are enabled by large databases of properties derived from high-throughput density functional theory(DFT),which now contain millions of calculations at the generalized gradient approximation(ggA)level of *** is now feasible to carry out high-throughput calculations using more accurate methods,such as meta-ggA DFT;however recomputing an entire database with a higher-fidelity method would not effectively leverage the enormous investment of computational resources embodied in existing(ggA)***,we propose here a general procedure by which higher-fidelity,low-coverage calculations(e.g.,meta-ggA calculations for selected chemical systems)can be combined with lower-fidelity,high-coverage calculations(e.g.,an existing database of ggA calculations)in a robust and scalable *** then use legacy PBE(+U)ggA calculations and new r2SCAN meta-ggA calculations from the Materials Project database to demonstrate that our scheme improves solid and aqueous phase stability predictions,and discuss practical considerations for its implementation.

关键词： theory scheme theory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

自闭症儿童和青少年游戏治疗

引用

作者： (美)Robert jason grant

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

Naked2 Antagonizes Canonical Wnt Signaling by Targeting Dishevelled-1 for their Mutual Degradation

Naked2 Antagonizes Canonical Wnt Signaling by Targeting Dish...

引用

2008年全国生物化学与分子生物学学术大会

作者： Terence J.Van Raay jason g.Smith Lila Solnica-Krezel Robert J.Coffey Department of Medicine Vanderbilt University School of MedicineNashvilleTN 37232USA

Naked1 and Naked2 are two mammalian orthologs of Drosophila Naked *** reportedly interact with Dishevelled(Dvl)and antagonize Wnt but the precise mechanisms are *** have found that Naked2 is rapidly degraded(half-life...

关键词：

来源： cnki会议评论

在线全文

cnki会议

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：