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Deletions in the pyr.vate pathway of Salmonella Typhimur.um alter.SPI1-mediated gene expr.ssion and infectivity

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Jour.al of Animal Science and Biotechnology 2013年第4期4卷 241-252页

作者： jason Aber.athy Car.lina Cor.ill Car.lee Hinojosa Xianyao Li Huaijun Zhou Depar.ment of Animal Science University of California Depar.ment of Poultr. Science Texas A&M University College Station College of Animal Science and Technology Shandong Agricultural University

Backgr.und： Salmonella enter.ca ser.var.Typhimur.um is a major.foodbor.e pathogen wor.dwide. S. Typhimur.um encodes type III secr.tion systems via Salmonella pathogenicity islands （SPI）, pr.ducing the major.effector.pr.teins of vir.lence. Pr.viously, we identified two genes of Salmonella pyr.vate metabolism that wer. up-r.gulated dur.ng chicken cell infection： pyr.vate for.ate lyase I （pf/B） and b/functional acetaldehyde-CoA/alcohol dehydr.genase （adhE）. We wer. ther.for. inter.sted in examining the r.le these genes may play in the tr.nsmission of Salmonella to humans. Methods： Mutant str.ins of Salmonella with single gene deletions for.pflB and adhE wer. cr.ated. Invasion and gr.wth in human HCT-8 intestinal epithelial cells and THP-1 macr.phages was examined. Quantitative PCr.was per.or.ed on 19 SPI-1 genes. r.sults： In HCT-8 cells, both mutant str.ins had significantly higher.intr.cellular.counts than the wild-type fr.m 4 to 48 h post-infection. Var.ous SPI-1 genes in the mutants wer. up-r.gulated over.the wild-type as ear.y as 1 h and lasting until 24 h post-infection. In THP-1 cells, no significant differ.nce in inter.al Salmonella counts was obser.ed; however. SPI-1 genes wer. lar.ely down-r.gulated in the mutants dur.ng the time-cour.e of infection. We also found five SPI-1 genes - hilA, hiIC hill）, sicP and r.sA - which wer. up-r.gulated in at least one of the mutant str.ins in log-phase br.th cultur.s alone. We have ther.for. identified a set of SPI-1 vir.lence genes whose r.gulation is effected by the centr.l metabolism of Salmonella.

关键词： adhE Metabolism pflB Pyr.vate Salmonella pathogenicity island Salmonella Typhimur.um Vir.lence

Implementation of distor.ion symmetr. for.the nudged elastic band method with DiSPy

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npj Computational Mater.als 2019年第1期5卷 685-693页

作者： jason M.Munr. Vincent S.Liu Venkatr.man Gopalan Ismaila Dabo Depar.ment of Mater.als Science and Engineer.ng and Mater.als r.sear.h Institute The Pennsylvania State UniversityUniversity ParkPA 16802USA Penn State Institutes of Ener.y and the Envir.nment The Pennsylvania State UniversityUniversity ParkPA 16802USA Depar.ment of Physics The Pennsylvania State UniversityUniversity ParkPA 16802USA Depar.ment of Engineer.ng Science and Mechanics The Pennsylvania State UniversityUniversity ParkPA 16802USA

The nudged elastic band(NEB)method is a commonly used appr.ach for.the calculation of minimum ener.y pathways of kinetic ***,the final paths obtained r.ly heavily on the natur. of the initially chosen *** often necessitates r.nning multiple calculations with differ.ng star.ing points in or.er.to obtain accur.te ***,it has been shown that the NEB algor.thm can only conser.e or.r.ise the distor.ion symmetr. exhibited by an initial *** this knowledge,symmetr.adapted per.ur.ations can be gener.ted and used as a tool to systematically lower.the initial path symmetr.,enabling the explor.tion of other.low-ener.y pathways that may ***,the gr.up and r.pr.sentation theor. details behind this pr.cess ar. pr.sented and implemented in a standalone piece of softwar.(DiSPy).The method is then demonstr.ted by applying it to the calculation of fer.oelectr.c switching pathways in LiNbO_(3).Pr.viously r.por.ed pathways ar. mor. easily obtained,with new paths also being found which involve a higher.degr.e of atomic coor.ination.

关键词： symmetr. distor.ion details

ADVANCES IN DECISION ANALYSIS AND SYSTEMS ENGINEEr.NG FOr.MANAGING LAr.E-SCALE ENTEr.r.SES IN A VOLATILE WOr.D: INTEGr.TING BENEFITS, OPPOr.UNITIES, COSTS AND r.SKS (BOCr. WITH THE BUSINESS MOTIVATION MODEL (BMM)

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Jour.al of Systems Science and Systems Engineer.ng 2006年第2期15卷 141-153页

作者： Tom FEGLAr.jason K.LEVY Tatiana FEGLAr.Tomas FEGLAr Inter.ational Consultant in Infor.ation Systems r.sear.h and Ar.hitectur. Czech Republic Br.ndon Univer.ity Applied Disaster and Emergency Studies (A-DES)BrandonManitobaczCanada R7A 6A9 Company-Ing.Tomas Feglar CSc.Czech Republic Company-Ing.Tomas Feglar CSc.Czech Republic JR

Over.the past few decades, innovations in Infor.ation and Communication Technologies （ICT） have led to a significant incr.ase in the complexity of enter.r.se infor.ation systems. This has led to new challenges for.enter.r.se ar.hitects, systems engineer., business manager. and other.decision maker. who must cope with the complexity of business plans and pr.cesses （par.icular.y automated engineer.ng pr.cesses）. In or.er.to better.manage this complexity, the Business r.le Gr.up （Br.） has put for.h the Business Motivation Model （BMM）. The or.ginal BMM uses a SWOT （Str.ngth, Weakness, Oppor.unity, and Thr.at） decision analysis appr.ach. However. the SWOT fr.mewor. contains significant limitations with r.spect to decision making and ICT r.sks, hamper.ng the decision making ability of enter.r.se ar.hitects, business manager., engineer., and other.decision maker.. The AHP （Analytic Hier.r.hy Pr.cess） and ANP （Analytic Networ. Pr.cess） ar. among the most widely used decision making tools： they commonly implement a Benefit - Oppor.unity - Cost - r.sk （BOCr. analysis to impr.ve the effectiveness of business decision making. A new appr.ach is put for.h that r.places the or.ginal SWOT assessment with an ANP-based BOCr.analysis. As well, the or.ginal BMM is modified and applied in a Component Ar.hitectur. Fr.mewor. （CAF）.

关键词： Analytic Networ. Pr.cess (ANP) Business Motivation Model (BMM) ar.hitectur. fr.mewor. Benefits-Oppor.unities-Costs-r.sks (BOCr.

Azoosper.ia and the cancer.patient： ar. ther. any options？

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Asian Jour.al of Andr.logy 2016年第3期18卷 409-409页

作者： jason r.Kovac Lar.y I Lipshultz Men's Health Center 8240 Naab Road Suite 220 indianapolis Indiana 46260USA Scott Depar.ment of Ur.logy Baylor College of Medicine HoustonTexas 77030 USA.

The fact that most men ar. sever.ly distr.ssed by phar.aceutical and/ or.sur.ical tr.atments r.sulting in functional castr.tions is inher.ntly obvious. Unfor.unately, significant male infer.ility, pr.dictable after.so... 详细信息

关键词： TESTICULAr.SPEr. EXTr.CTION

Using Folding Ensemble and Stem Pr.bability Maximization Methods to Pr.dict r.A H-Type Pseudoknots

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Tsinghua Science and Technology 2012年第6期17卷 691-700页

作者： Junilda Spir.llar. Shawn Xiong Wang jason T.L. Wang Bioinfor.atics Pr.gr.m Department of Computer Science New Jersey Institute of Technology University Heights Depar.ment of Computer.Science California State University

We pr.sent in this paper.an ab initio method, named KnotFold, for.r.A H-type pseudoknot pr.diction. Our.method employs an ensemble of r.A folding tools and a filter.ng heur.stic to gener.te a set of pseudoknot-fr.e stems, and then pr.dicts pseudoknots by utilizing a sear.h technique with a pseudo-pr.bability scor.ng scheme. Exper.mental r.sults show that KnotFold achieves higher.sensitivity than existing methods. The KnotFold package with documentation is fr.ely available at http：//***/KnotFold.

关键词： r.A str.ctur. pseudoknots tool ensemble

The Impact of the COVID-19 Pandemic on a Sydney Metr.politan Hospital Emer.ency Depar.ment

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Open Jour.al of Emer.ency Medicine 2022年第4期10卷 183-193页

作者： Joshua Scott-King Lisa Hodder.Cather.ne Thomas jason Diab Lai Heng Foong Chr.stophe r. Ber.ey Matthew Smith Bankstown Lidcombe Hospital Bankstown NSW Australia School of Medicine University of New South Wales Sydney Australia School of Medicine University of Sydney Sydney Australia Austr.lian National Univer.ity Canberra Australia School of Medicine University of Notre Dame Sydney Australia

Intr.duction: The impact of the COVID-19 has r.sulted in a decr.ase in pr.sentations in emer.ency depar.ments (ED). This has been influenced by societal r.str.ctions, lockdowns and access to ser.ices. This study aims to obser.e the patter.s in ED pr.sentations for.Bankstown-Lidcombe Hospital over.the cour.e of the initial COVID-19 pandemic wave. Methods: A r.tr.spective r.view of all pr.sentations to Bankstown-Lidcombe Hospital ED was conducted compar.ng monthly patient encounter. fr.m Febr.ar.-August for.2017-2020. r.sults: The total number.of ED pr.sentations was 42,225. Ther. was a statistically significant r.duction dur.ng 2020 of 9.8% between the study per.ods (1546 vs 1395, p = 0.014). The per.od of gr.atest r.duction was seen in Mar.h-May, the str.ctest lockdown per.od for.New South Wales. The admitting disciplines that showed a r.duction in this time wer. color.ctal (76.62%, p = 0.046), emer.ency (25.53%, p = 0.025), endocr.ne (31.82%, p = 0.026), or.hopaedics (33.63%, p = 0.004), and vascular.(35.71%, p = 0.017). The disciplines that showed an incr.ase in pr.sentations over.the entir. studied time wer. gynaecology (26.54%, p = 0.008), and psychiatr. (17.46%, p = 0.011). Conclusion: Ther. wer. significant r.ductions in total number.of ED pr.sentations. Notably, ther. wer. significant r.ductions acr.ss multiple admitting disciplines, as well as in a decr.ase in pr.sentations for.those in younger.age gr.ups.

关键词： COVID-19 Pandemics Length of Stay Emer.ency New South Wales

Ar. genetic biomar.er. the futur. of male fer.ility testing？

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Asian Jour.al of Andr.logy 2016年第3期18卷 356-356页

作者： jason r.Kovac Lar.y I Lipshultz Men's Health Center 8240 Naab Road Suite 220 Indianapolis Indiana 46260USA Scott Depar.ment of Ur.logy Baylor College of Medicine Houston Texas77030 USA

Men with infer.ility ar. subjected to numer.us diagnostic tests in attempts to deter.ine the natur. of their.condition. Initially, medical, sur.ical, and bir.h histor.es ar. elicited with investigations including semen analyses, hor.onal panels, and imaging studies such as scr.tal or.tr.ns-r.ctal ultr.sounds. In cases of men with nonobstr.ctive azoosper.ia （NOA）, these inquir.es may all r.tur. nor.al r.sults. Mor. specific testing involving kar.otyping and Y-chr.mosome micr.deletion analysis ar. then per.or.ed.

关键词： INFEr.ILITY

Tr.nsient plasma-enhanced r.mediation of nanoscale par.iculate matter.in r.staur.nt smoke emissions via electr.static pr.cipitation

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Par.icuology 2021年第2期19卷 43-47页

作者： Sisi Yang Patr.ck For. Sr.r.m Subr.manian Dan Singleton jason Sander. Stephen B.Cr.nin Depar.ment of Physics and Astr.nomy University of Southern CaliforniaLos AngelesCA 90089USA Ming hsieh Depar.ment of Electr.cal Engineer.ng University of Southern CaliforniaLos AngelesCA 90089USA Daniel J.Epstein Depar.ment of Industr.al&System Engineer.ng University of Southern CaliforniaLos AngelesCA 90089USA Tr.nsient Plasma Systems Inc.TorranceCA 90501USA

It is now r.cognized that nanoscale par.iculate matter.PM)r.pr.sents a substantial health hazar. for.our.society,including PM fr.m r.staur.nt *** this study,we explor.d the use of a tr.nsient pulsed plasma in conjunction with an applied DC bias to tr.at oil aer.sols that closely r.semble r.staur.nt(i.e.,char.r.iler.smoke *** polyar.matic olefin PAO-4 and soybean oil,we found that a thr.e-or.er.of-magnitude r.duction in par.iculates(i.e.,99.9%r.mediation)could be achieved with this ***,the plasma dischar.e was pr.duced in a 4-in.-diameter.cylindr.cal r.actor.with a 5-10 ns high voltage(30 kV)pulse gener.tor.together.with applied DC bias voltages up to 10 *** distr.bution of nanopar.icle sizes was measur.d using a scanning mobility par.icle sizer.SMPS)with diameter.center.d ar.und 225 ***,the main mechanism of r.mediation occur. in a two-step pr.cess in which the oil nanopar.icles ar. fir.t ionized by the fr.e electr.ns and fr.e r.dicals in the plasma and then the char.ed par.icles ar. swept out to the sidewalls of the r.actor.by the applied DC *** believe this gener.l appr.ach opens up new degr.es of fr.edom in the design of electr.static oil aer.sol pollution contr.l devices.

关键词： Nanopar.icles Tr.nsient plasma Char.r.iler.emission DC bias r.mediation

Use of testicular.sper. to combat the negative effects of DNA fr.gmentation

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Asian Jour.al of Andr.logy 2016年第3期18卷 434-434页

作者： jason r.Kovac Lar.y I Lipshultz Men's Health Center 8240 Naab Road Suite 220 Indianapolis Indiana 46260USA Scott Depar.ment of Ur.logy Baylor College of Medicine HoustonTexas 77030 USA.

Numer.us appr.aches to the detection of novel biomar.er. for.male fer.ility have been pr.posed. As r.viewed in the manuscr.pt by Bieniek et *** of seminal plasma has yielded numer.us possible candidate biomar.er.. Since semen analysis is a cr.tical component in the initial wor.up for.infer.ile males, seminal fluid biomar.er. inher.ntly have sever.l distinct advantages.

关键词： HUMAN SPEr.ATOZOA EFFICIENT Tr.ATMENT INFEr.ILITY ICSI MATUr.TION INTEGr.TY SUBSETS DAMAGE