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Stereotactic radiosurgery for haemorrhagic cerebral cavernous malformation:a multi-institutional,retrospective study

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Stroke & Vascular Neurology 2024年第3期9卷 221-229,I0130,I0131页

作者： Chloe Dumot Georgios Mantziaris Sam Dayawansa Zhiyuan Xu Stylianos Pikis Selcuk Peker Yavuz Samanci Gokce D Ardor Ahmed M Nabeel Wael A Reda Sameh R Tawadros Khaled Abdelkarim Amr M N el-Shehaby Reem M emad eldin Ahmed H elazzazi Nuria Martínez Moreno Roberto MartínezÁlvarez Roman Liscak Jaromir May David Mathieu Jean-Nicolas Tourigny Manjul Tripathi Akshay Rajput Narendra Kumar Rupinder Kaur Piero Picozzi Andrea Franzini Herwin Speckter Wenceslao Hernandez Anderson Brito Ronald e Warnick Juan Alzate Douglas Kondziolka Greg N Bowden Samir Patel jason Sheehan Department of Neurological Surgery Hospices Civils de LyonLyonFrance Department of Neurological Surgery University of VirginiaCharlottesvilleVirginiaUSA Department of Neurosurgery Koc University School of MedicineIstanbulTurkey Gamma-knife Center Nasser institute HospitalCairoEgypt Neurosurgery Department Benha UniversityBenhaEgypt Departments of Neurosurgery Ain Shams UniversityCairoEgypt Department of Clinical Oncology Ain Shams UniversityCairoEgypt Department of Radiation Oncology National Cancer InstituteCairo UniversityGizaEgypt Faculty of Medicine Extended Modular ProgramAin Shams UniversityCairoEgypt Department of Radiosurgery Rúber Internacional HospitalMadridSpain Department of Stereotactic and Radiation Neurosurgery Na Homolce HospitalPragueCzech Republic Neurosurgery Centre de recherche du CHUSUniversitéde SherbrookeSherbrookeQuebecCanada Neurosurgery PGIMERChandigarhChandigarhIndia Radiation Therapy PGIMERChandigarhChandigarhIndia Neurosurgery IRCCS Istituto Clinico HumanitasRozzanoMilanItaly Dominican Gamma Knife Center and Radiology Department CEDIMATSanto DomingoDominican Republic Gamma Knife Center Mayfield ClinicThe Jewish Hospital-Mercy HealthCincinnatiOhioUSA Neurosurgery NYU Langone HealthNew YorkNew YorkUSA Neurosurgery University of AlbertaEdmontonAlbertaCanada Division of Radiation Oncology Department of OncologyUniversity of AlbertaEdmontonAlbertaCanada

Background Cerebral cavernous malformations(CCMs)frequently manifest with *** radiosurgery(SRS)has been employed for CCM not suitable for *** effect on reducing haemorrhage risk is still *** aim of this study was to expand on the safety and efficacy of SRS for haemorrhagic *** This retrospective multicentric study included CCM with at least one haemorrhage treated with single-session *** annual haemorrhagic rate(AHR)was calculated before and after *** event analysis and Cox regression were used to evaluate factors associated with *** radiation effects(ARes)and occurrence of new neurological deficits were *** The study included 381 patients (median age:37.5 years(Q1–Q3:25.8–51.9))with 414 *** AHR from diagnosis to SRS excluding the first haemorrhage was 11.08 per 100 CCM-years and was reduced to 2.7 per 100 CCM-years after *** recurrent event analysis,SRS,HR 0.27(95%CI 0.17 to 0.44),ped with a decreased risk of haemorrhage,and the presence of developmental venous anomaly(DVA)with an increased risk,HR 1.60(95%CI 1.07 to 2.40),p=*** cumulative risk of first haemorrhage after SRS was 9.4%(95%CI 6%to 12.6%)at 5 years and 15.6%(95%CI%9 to 21.8%)at 10 *** doses>13 Gy,HR 2.27(95%CI 1.20 to 4.32),p=0.012 and the presence of DVA,HR 2.08(95%CI 1.00 to 4.31),p=0.049 were factors associated with higher probability of post-SRS ***-SRS haemorrhage was symptomatic in 22 out of 381(5.8%)patients,presenting with transient(15/381)or permanent(7/381)neurological *** occurred in 11.1%(46/414)CCM and was responsible for transient neurological deficit in 3.9%(15/381)of the patients and permanent deficit in 1.1%(4/381)of the *** doses>13 Gy and CCM volume>0.7 cc were associated with increased risk of ARe.

关键词： doses haemorrhagic diagnosis

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Crustacean parasites associated with hermit crabs from the western Mediterranean Sea,with first documentation of egg predation by the burrowing barnacle Trypetesa lampas(Cirripedia:Acrothoracica:Trypetesidae)

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Integrative Zoology 2011年第1期6卷 13-27页

作者： jason D.WILLIAMS Alejandra GALLARDO Angela e.MURPHY Department of Biology Hofstra UniversityHempsteadNYUSA

Parasitic isopods(family Bopyridae)and burrowing barnacles(family Trypetesidae)infesting hermit crabs were investigated from shallow subtidal collections made along the southeastern coast of Spain in 2009.A total of 713 specimens of Clibanarius erythropus(Latreille,1818)and 82 Calcinus tubularis(L.,1767)were *** shells and worm tubes inhabited by hermit crabs were collected by hand while snorkeling and were cracked to determine host species,size,sex and presence of *** species of bopyrid isopods were found on ***:the branchial parasite Bopyrissa fraiseii(Carayon,1943)and the abdominal parasite Parathelges cardonae Codreanu and Codreanu in Codreanu,*** all *** examined,Bopyrissa fraiseii was found on 0.6%of hermit crabs and *** was found on 0.3%.A redescription of *** is provided and the species is documented with light and scanning electron microscopy for the first *** Calcinus tubularis harbored parasitic isopods,but one specimen was parasitized by an unidentified rhizocephalan barnacle of the genus Septosaccus(1.2%).The burrowing barnacle Trypetesa lampas(Hancock,1849)was found associated with both hermit crab species and evidence of predation on host eggs by this barnacle is shown for the first *** lampas was found in 4.2%of the shells *** present study expands our knowledge of the parasite fauna of hermit crabs from the Mediterranean Sea and indicates that additional research is needed to determine the impact of trypetesid egg predators on hermit crab populations.

关键词： Bopyridae egg predator Isopoda parasitism Rhizocephala

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Utility of positron emission tomography-computed tomography scan in detecting residual hepatocellular carcinoma post treatment:Series of case reports

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World Journal of Gastrointestinal Oncology 2020年第3期12卷 358-364页

作者： jason T Cheng Nelly e Tan Michael L Volk Transplantation Institute Loma Linda University Medical CenterSan BernardinoCA 92408United States Department of Radiology Loma Linda University Medical CenterLoma LindaCA 92354United States

BACKGROUND Multi-phase computed tomography(CT)or magnetic resonance imaging(MRI)has been the standard of care for hepatocellular carcinoma(HCC)diagnosis for *** SUMMARY We report a case series of four patients in whom positron emission tomographycomputed tomography(PeT-CT)scan complemented the conventional CT/MRI scans in evaluating treatment *** these four cases the conventional multi-phase CT and MRI failed to identify residual HCC disease post-treatment,while PeT-CT complemented and aided in treatment response *** each case,the addition of PeT-CT identified and located residual HCC disease,allowed retreatment,and altered medical *** This case series suggests that PeT-CT should perhaps play a role in the HCC management algorithm,in addition to the conventional contrast-enhanced multiphase scans.

关键词： Hepatocellular carcinoma Positron emission tomography Contrast-enhanced multiphase scan Cirrhosis Residual cancer Treatment response evaluation Case series

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COVID-19 Vaccine Allocation: Modeling Health Outcomes and equity Implications of Alternative Strategies

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engineering 2021年第7期7卷 924-935页

作者： Maddalena Ferranna Daniel Cadarette David e.bloom Harvard T.H.Chan School of Public Health BostonMA 02115USA

Given the scarcity of safe and effective COVID-19 vaccines,a chief policy question is how to allocate them among different sociodemographic *** paper evaluates COVID-19 vaccine prioritization strategies proposed to date,focusing on their stated goals;the mechanisms through which the selected allocations affect the course and burden of the pandemic;and the main epidemiological,economic,logistical,and political issues that arise when setting the prioritization *** paper uses a simple,agestratified susceptible–exposed–infectious–recovered model applied to the United States to quantitatively assess the performance of alternative prioritization strategies with respect to avoided deaths,avoided infections,and life-years *** demonstrate that prioritizing essential workers is a viable strategy for reducing the number of cases and years of life lost,while the largest reduction in deaths is achieved by prioritizing older adults in most scenarios,even if the vaccine is effective at blocking viral *** regarding this property and potential delays in dose delivery reinforce the call for prioritizing older ***,we investigate the strength of the equity motive that would support an allocation strategy attaching absolute priority to essential workers for a vaccine that reduces infectionfatality risk.

关键词： Vaccine allocation COVID-19 equity SeIR model

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A Composite State Convergence Scheme for Bilateral Teleoperation Systems

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Ieee/CAA Journal of Automatica Sinica 2019年第5期6卷 1166-1178页

作者： Muhammad Usman Asad Umar Farooq jason Gu Ghulam Abbas Rong Liu Valentina e.Balas the Department of electrical &Computer engineering Dalhousie UniversityN.S.Canada the Department of electrical & Computer engineering Dalhousie UniversityN.S.Canada the Department of electrical engineering University of the Punjab LahorePakistan the Department of electrical engineering The University of LahorePakistan the Department of Biomedical engineering Dalian University of TechnologyChina the Department of Automatics &Applied Software “Aurel Vlaicu” University of AradRomania

State convergence is a novel control algorithm for bilateral teleoperation of robotic systems. First, it models the teleoperation system on state space and considers all the possible interactions between the master and slave systems. Second, it presents an elegant design procedure which requires a set of equations to be solved in order to compute the control gains of the bilateral loop. These design conditions are obtained by turning the master-slave error into an autonomous system and imposing the desired dynamic behavior of the teleoperation system. Resultantly, the convergence of master and slave states is achieved in a well-defined manner. The present study aims at achieving a similar convergence behavior offered by state convergence controller while reducing the number of variables sent across the communication channel. The proposal suggests transmitting composite master and slave variables instead of full master and slave states while keeping the operator's force channel intact. We show that,with these composite and force variables;it is indeed possible to achieve the convergence of states in a desired way by strictly following the method of state convergence. The proposal leads to a reduced complexity state convergence algorithm which is termed as composite state convergence controller. In order to validate the proposed scheme in the absence and presence of communication time delays, MATLAB simulations and semi-real time experiments are performed on a single degree-of-freedom teleoperation system.

关键词： Composite variables linear control systems state convergence teleoperation time delay

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Pancreaticoduodenectomy complicated by Budd-Chiari syndrome: A case report and review of literature

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World Journal of Gastrointestinal Surgery 2018年第9期10卷 107-110页

作者： Damien Dousse eric bloom Bertrand Suc Department of Visceral Surgery Toulouse-Purpan University Hospital Department of Visceral Surgery Toulouse-Rangueil University Hospital

BACKGROUND Pancreaticoduodenectomy(PD)-induced morbidity, consisting mainly of the pancreatic fistula and its hemorrhagic and infectious consequences, is well described in the literature, in terms of its definition, risk factors, preventive measures, and standardized management of complications. However, some lifethreatening complications remain atypical and undescribed. CASe SUMMARY We report here the case of a 69-year-old patient with Budd-Chiari syndrome that occurred after arterial embolization of postpancreatectomy hemorrhage. Diagnosis was established with biological findings(i.e., acute liver failure) and radiological findings(i.e., compressive hematoma of the retrohepatic vena cava). emergency surgical revision was performed to evacuate the hematoma. The postoperative course was uneventful, with rapid recovery of liver function. To our knowledge, post-PD Budd-Chiari syndrome has never been described in the literature. CONCLUSION Acute liver failure in early post-PD should prompt investigation to rule out Budd-Chiari syndrome.

关键词： Pancreaticoduodenectomy Pancreatic fistula Acute liver failure Budd-Chiari syndrome Case report

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Brain, mind, and behavior / Floyd e. bloom, Charles A. Nelson, Arlyne Lazerson. 3rd ed.

Brain, mind, and behavior / Floyd E. Bloom, Charles A. Nelso...

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2001年

作者： Floyd e. bloom Charles A. Nelson Arlyne Lazerson.

Accompanied by electronic and print supplements for teachers and students.

ISBN: (纸本)0716723891

Accompanied by electronic and print supplements for teachers and students.

关键词： Neuropsychology

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Whole-exome sequencing and microRNA profiling reveal PI3K/AKT pathway＇s involvement in juvenile myelomonocytic leukemia

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Frontiers of electrical and electronic engineering in China 2018年第1期6卷 85-97页

作者： Saad M Khan jason e Denney Michael X Wang Dong Xu Informatics Institute and C. S. Bond Life Sciences Center Universitv of Missouri. Columbia. MO 65211 USA Department of Pathology and Anatomical Sciences University of Missouri Columbia MO 65211 USA Department of computer Science University of Missouri Columbia MO 65211 USA

Background： Clinical studies and genetic analyses have revealed that juvenile myelomonocytic leukemia （JMML） is caused by somatic and/or germline mutations of genes involved in the RAS/MAPK signalling pathway. Given the vastly different clinical prognosis among individual patients that have had this disease, mutations in genes of other pathways may be involved. Methods： In this study, we conducted whole-exome and cancer-panel sequencing analyses on a bone marrow sample from a 2-year old juvenile myelomonocytic leukemia patient. We also measured the microRNA profile of the same patient＇s bone marrow sample and the results were compared with the normal mature monocytic cells from the pooled peripheral blood. Results： We identified additional novel mutations in the Pi3K/AKT pathway and verified with a cancer panel targeted sequencing. We have confirmed the previously tested PTPNII gene mutation （exon 3 181G〉T） in the same sample and identified new nonsynonymous mutations in NTRKI, HMGA2, MLH3, MYH9 and AKT1 genes. Many of the microRNAs found to be differentially expressed are known to act as oncogenic MicroRNAs （onco^MicroRNAs or oncomiRs）, whose target genes are enriched in the PI3K/AKT signalling pathway. Conclusions： Our study suggests an alternative mechanism for JMML pathogenesis in addition to RAS/MAPK pathway. This discovery may provide new genetic markers for diagnosis and new therapeutic targets for JMML patients in the future.

关键词： single-cell RNA-Seq differential expression

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ADVANCeS IN SUSTAINABLe SeCURITY SYSTeMS eNGINeeRING WITH DRAMA THeORY (DT) Ⅱ

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Journal of Systems Science and Systems engineering 2009年第4期18卷 403-422页

作者： jason K. LeVY Nigel HOWARD Wilder School of Government and Public Affairs Virginia Commonwealth University Sheffield Hallam University

We put forth Drama Theory II （DT II） as a formal multiple participant decision making framework that can be used to systematically model complex security challenges, and advance the field of Sustainable Security Systems engineering. DT II is defined as a theory of ＂large world＂ pre-game communication and equilibrium selection. While game theoretic tools have been widely applied to resolve environmental conflicts and promote global security, traditional game theory assumes that decision makers, options, and preferences are fixed. A mathematical treatment of key drama theoretic concepts （i.e. positions, intentions, doubts and dilemmas） is provided. The dynamics of the drama theoretic process are discussed and the expected equilibrium set is derived. The fundamental theorem of drama theory is proven and all theoretical results are applied to promote sustainable security solutions. It is emphasized that DT II represents a flexible systems engineering technique to address time-sensitive, multi-faceted, and complex multiple participant negotiations.

关键词： Drama Theory II sustainable security systems engineering game theory

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Properties of alkylbenzimidazoles for CO_2 and SO_2 capture and comparisons to ionic liquids

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Science China Chemistry 2012年第8期55卷 1638-1647,1-2页

作者： SHANNON Matthew S. HINDMAN Michelle S. DANIeLSeN Scott. P. O. TeDSTONe jason M. GILMORe Ricky D. BARA jason e. Department of Chemical & Biological engineering University of Alabama Tuscaloosa USA NSF-ReU Site: engineering Solutions for Clean energy Generation Storage and Consumption Department of Chemical & Biological Engineering University of Alabama Tuscaloosa USA Department of Chemical & Biomolecular engineering University of Pennsylvania Philadelphia USA Department of Chemical & Biomolecular engineering Clemson University Clemson USA

To date, few reports have been concerned with the physical properties of the liquid phases of imidazoles and benzimidazoles- potential starting materials for a great number of ionic liquids. Prior research has indicated that alkylimidazole solvents exhibit different, and potentially advantageous physical properties, when compared to corresponding imidazolium-based ionic liquids. Given that even the most fundamental physical properties of alkylimidazole solvents have only recently been reported, there is still a lack of data for other relevant imidazole derivatives, including benzimidazoles. In this work, we have synthesized a se- ries of eight 1-n-alkylbenzimidazoles, with chain lengths ranging from ethyl to dodecyl, all of which exist as neat liquids at ambient temperature. Their densities and viscosities have been determined as functions of both temperature and molecular weight. Alkylbenzimidazoles have been found to exhibit viscosities that are more similar to imidazolium-based ILs than al- kylimidazoles, owed to a large contribution to viscosity from the presence of a fused ring system. Solubilities of CO2 and SO2, two species of concern in the emission of coal-fired power generation, were determined for selected alkylbenzimidazoles to understand what effects a fused ring system might have on gas solubility. For both gases, alkylbenzimidazoles were deter- mined to experience physical, non-chemically reactive, interactions. The solubility of CO2 in alkylbenzimidazoles is 10%-30% less than observed for corresponding ILs and alkylimidazoles. 1-butylbenzimidazole was found to readily absorb at least 0.333 gram SO2 per gram at low pressure and ambient temperature, which could be readily desorbed under an N： flush, a behavior more similar to imidazolium-based ILs than alkylimidazoles. Thus, we find that as solvents for gas separations, benzimidazoles share characteristics with both ILs and alkylimidazoles.

关键词： benzimidazole imidazole ionic liquids carbon dioxide (CO2) capture sulfur dioxide (S02)

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