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Age as a predictor of clinical outcomes and determinant of therapeutic measures for emergency medical services treated cardiogenic shock

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Journal of Geriatric Cardiology 2023年第1期20卷 1-10页

作者： Xiaoman Xiao jason e bloom emily Andrew Luke P Dawson Ziad Nehme Michael Stephenson David Anderson Himawan Fernando Samer Noaman Shelley Cox William Chan David M Kaye Karen Smith Dion Stub Department of Cardiology Alfred Health55 Commercial RoadMelbourneAustralia Baker Heart and Diabetes Institute 75 Commercial RoadMelbourneAustralia Department of Cardiology Western HealthFurlong RoadSt AlbansAustralia Ambulance Victoria 31 Joseph StreetBlackburnAustralia School of Public Health and Preventive Medicine Monash University553 St Kilda RoadMelbourneAustralia Department of Paramedicine Monash UniversityMcMahons RoadFrankstonAustralia

BACKGROUND The impact of age on outcomes in cardiogenic shock(CS)is poorly described in the pre-hospital *** assessed the impact of age on outcomes of patients treated by emergency medical services(eMS).MeTHODS This population-based cohort study included consecutive adult patients with CS transported to hospital by *** linked patients were stratified into tertiles by age(18-63,64-77,and>77 years).Predictors of 30-day mortality were assessed through regression *** primary outcome was 30-day all-cause *** A total of 3523 patients with CS were successfully linked to state health *** average age was 68±16 years and 1398(40%)were *** patients were more likely to have comorbidities including pre-existing coronary artery disease,hypertension,dyslipidemia,diabetes mellitus,and cerebrovascular *** incidence of CS was significantly greater with increasing age(incidence rate per 100,000 person years 6.47[95%CI:6.1-6.8]in age 18-63 years,34.34[32.4-36.4]in age 64-77 years,74.87[70.6-79.3]in age>77 years,Pere was a step-wise increase in the rate of 30-day mortality with increasing age *** adjustment,compared to the lowest age tertile,patients aged>77 years had increased risk of 30-day mortality(adjusted hazard ratio=2.26[95%CI:1.96-2.60]).Older patients were less likely to receive inpatient coronary *** Older patients with eMS-treated CS have significantly higher rates of short-term *** reduced rates of invasive interventions in older patients underscore the need for further development of systems of care to improve outcomes for this patient group.

关键词： assessed services shock

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Handwriting Analysis Based on Belief of Targeted Individual Supporting Insider Threat Detection

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Journal of Information Security 2024年第3期15卷 308-319页

作者： jason Slaughter Carole e. Chaski Kellep Charles Center for Cybersecurity Research and Analysis (CCRA) Capitol Technology University Laurel United States

The Unintentional Insider Threat (UIT) concept highlights that insider threats might not always stem from malicious intent and can occur across various domains. This research examines how individuals with medical or psychological issues might unintentionally become insider threats due to their perception of being targeted. Insights from the survey A Survey of Unintentional Medical Insider Threat Category indicate that such perceptions can be linked to underlying health conditions. The study emotion Analysis Based on Belief of Targeted Individual Supporting Insider Threat Detection reveals that anger is a common emotion among these individuals. The findings suggest that UITs are often linked to medical or psychological issues, with anger being prevalent. To mitigate these risks, it is recommended that Insider Threat programs integrate expertise from medicine, psychology, and cybersecurity. Additionally, handwriting analysis is proposed as a potential tool for detecting insider threats, reflecting the evolving nature of threat assessment methodologies.

关键词： Insider Threat Detection Targeted Medical

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Dynamics of self-hybridized exciton–polaritons in 2D halide perovskites

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Light(Science & Applications) 2024年第1期13卷 13-22页

作者： Surendra B.Anantharaman jason Lynch Christopher e.Stevens Christopher Munley Chentao Li Jin Hou Hao Zhang Andrew Torma Thomas Darlington Francis Coen Kevin Li Arka Majumdar PJames Schuck Aditya Mohite Hayk Harutyunyan Joshua R.Hendrickson Deep Jariwala Department of electrical and Systems engineering University of PennsylvaniaPhiladelphiaPA19104USA KBR Inc. BeavercreekOH45431USA Air Force Research Laboratory Sensors DirectorateWright-Patterson Air Force BaseOH45433USA Department of Physics University of WashingtonSeattleWA98195USA Department of Physics Emory UniversityAtlantaGA30322USA Department of Chemical and Biomolecular engineering Rice UniversityHoustonTX77005USA Department of Materials Science and Nanoengineering Rice UniversityHoustonTX77005USA Applied Physics Program Smalley‐Curl InstituteRice UniversityHoustonTX77005USA Department of Mechanical engineering Columbia UniversityNew YorkNY10027USA Department of electrical and Computer engineering University of WashingtonSeattleWA98195USA

excitons,bound electron–hole pairs,in two-dimensional hybrid organic inorganic perovskites(2D HOIPs)are capable of forming hybrid light-matter states known as exciton-polaritons(e–Ps)when the excitonic medium is confined in an optical *** the case of 2D HOIPs,they can self-hybridize into e–Ps at specific thicknesses of the HOIP crystals that form a resonant optical cavity with the ***,the fundamental properties of these self-hybridized e–Ps in 2D HOIPs,including their role in ultrafast energy and/or charge transfer at interfaces,remain ***,we demonstrate that>0.5µm thick 2D HOIP crystals on Au substrates are capable of supporting multiple-orders of self-hybridized e–P *** e–Ps have high Q factors(>100)and modulate the optical dispersion for the crystal to enhance sub-gap absorption and *** varying excitation energy and ultrafast measurements,we also confirm energy transfer from higher energy e–Ps to lower energy e–***,we also demonstrate that e–Ps are capable of charge transport and transfer at *** findings provide new insights into charge and energy transfer in e–Ps opening new opportunities towards their manipulation for polaritonic devices.

关键词： charge polar excitation

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Systematic Radio Telescope Alignment Using Portable Fringe Projection Profilometry

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Nanomanufacturing and Metrology 2024年第1期7卷 75-85页

作者： Joel Berkson Justin Hyatt Nathan Julicher Byeongjoon Jeong Isaac Pimienta Rachel Ball Wyatt ellis jason Voris Diego Torres‑Barajas Daewook Kim James C.Wyant College of Optical Sciences University of Arizona1630 E.University Blvd.TucsonAZ 85721USA Department of Astronomy at Steward Observatory University of Arizona933 N Cherry Ave.TucsonAZ 85721USA

In 2019,the event Horizon Telescope(eHT)released the first-ever image of a black hole event *** are now aiming for higher angular resolutions of distant targets,like black holes,to understand more about the fundamental laws of gravity that govern our *** achieve this higher resolution and increased sensitivity,larger radio telescopes are needed to operate at higher frequencies and in larger *** like the next-generation Very Large Array(ngVLA)and the Square-Kilometer Array(SKA)require building hundreds of telescopes with diameters greater than 10 ms over the next *** has a twofold *** telescope surfaces need to be more accurate to operate at higher frequencies,and the logistics involved in maintaining a radio telescope need to be simplified to support them properly in large *** of these problems can be solved with improved methods for surface metrology that are faster and more accurate with a higher *** leads to faster and more accurate panel alignment and,therefore,a more productive *** this paper,we present the use of binocular fringe projection profilometry as a solution to this problem and demonstrate it by aligning two panels on a 3-m radio telescope *** measurement takes only 10 min and directly delivers feedback on the tip,tilt,and piston of each panel to create the ideal reflector shape.

关键词： Metrology Fringe projection profilometry Off-axis alignment Radio astronomy Radio antenna

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Degradation and resynthesis of chlorophyll during increased oxidative stress and prolonged darkness differ between annual and perennial flax(Linum L.)

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Oil Crop Science 2024年第2期9卷 121-130页

作者： Kenyon J. Nisbett Abida Alokozai Su Hyun elizabeth Ko G. Adam Mott jason C.L. Browna Department of Biological Sciences University of Toronto ScarboroughTorontoONCanada Department of Cell&Systems Biology University of TorontoTorontoONCanada Centre for the Analysis of Genome evolution&Function University of TorontoTorontoONCanada

Among plants,there is considerable variation in lifespan:annuals live less than one year,whereas perennials live for several years,with the longest-living perennial having survived 43,600 *** proposed by the Disposable Soma Theory,this lifespan variation among plants likely reflects differential investment of limited energy and nutrient resources,with perennials investing more energy and nutrients into biomolecular maintenance compared to annuals in order to ensure persistence over multiple *** differential investment may be particularly important during periods of exogenous stress,which are known to accelerate biomolecular *** present study evaluated this hypothesis using annual and perennial flax(Linum L.)subjected to two exogenous stressors—increased oxidative stress(i.e.,foliar H2O2spraying)and complete prolonged *** chlorophyll has been shown to exhibit degradation in response to changes in environmental conditions,we utilized changes in chlorophyll levels during and after periods of exogenous stress to evaluate our *** predicted that i)perennials would exhibit a slower rate of chlorophyll degradation during exposure to exogenous stressors compared to annuals,and ii)perennials would exhibit a faster rate of chlorophyll resynthesis following such exposure compared to *** levels before,during,and after exposure to both exogenous stressors were measured in two separate trails,once using image colour analysis and once using *** chlorophyll degradation rates in response to oxidative stress did not differ between annuals and perennials,contrary to our predictions,chlorophyll resynthesis rates following such exposure were significantly higher in perennials,as *** plants were subjected to complete prolonged darkness,chlorophyll degradation rates were significantly lower in perennials than annuals,as predicted;however,when plants were subsequently reintroduced to natural photoperiod,ch

关键词： Ageing Life history Maximum lifespan Oxidative stress Somatic maintenance

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Machine Learning Analysis of Impact of Western US Fires on Central US Hailstorms

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Advances in Atmospheric Sciences 2024年第7期41卷 1450-1462页

作者： Xinming LIN Jiwen FAN Yuwei ZHANG Zjason HOU Pacific Northwest National Laboratory RichlandWA 99354USA Argonne National Laboratory LemontIL 60439USA

Fires,including wildfires,harm air quality and essential public services like transportation,communication,and *** fires can also influence atmospheric conditions,including temperature and aerosols,potentially affecting severe convective ***,we investigate the remote impacts of fires in the western United States(WUS)on the occurrence of large hail(size:≥2.54 cm)in the central US(CUS)over the 20-year period of 2001–20 using the machine learning(ML),Random Forest(RF),and extreme Gradient Boosting(XGB)*** developed RF and XGB models demonstrate high accuracy(>90%)and F1 scores of up to 0.78 in predicting large hail occurrences when WUS fires and CUS hailstorms coincide,particularly in four states(Wyoming,South Dakota,Nebraska,and Kansas).The key contributing variables identified from both ML models include the meteorological variables in the fire region(temperature and moisture),the westerly wind over the plume transport path,and the fire features(i.e.,the maximum fire power and burned area).The results confirm a linkage between WUS fires and severe weather in the CUS,corroborating the findings of our previous modeling study conducted on case simulations with a detailed physics model.

关键词： wildfire severe convective storm hailstorm machine learning

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Innovations in otorhinolaryngology in the age of COVID-19: A systematic literature review

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2022年第3期8卷 224-238页

作者： e.Berryhill McCarty Liuba Soldatova jason A.Brant jason G.Newman Perelman School of Medicine at the Universityof Pennsylvania PhiladelphiaPAUSA Department of Otorhinolaryngology-Head and Neck Surgery Universityof Pennsylvania Health SystemPhiladelphiaPennsylvaniaPAUSA

Objective: Otolaryngologists are at increased occupational risk of Coronavirus Disease 2019 (COVID-19) infection due to exposure from respiratory droplets and aerosols generated during otologic, nasal, and oropharyngeal examinations and procedures. There have been a variety of guidelines and precautions developed to help mitigate this risk. While many reviews have focused on the personal protective equipment (PPe) and preparation guidelines for surgery in the COVID-19 era, none have focused on the more creative and unusual solutions designed to limit viral transmission. This review aims to fill that *** Sources: PubMed, Ovid/Medline, and ScopusMethods: A comprehensive review of literature was performed on September 28, 2020 using PubMed, Ovid/Medline, and Scopus databases. All english-language studies were included if they proposed or assessed novel interventions developed for Otolaryngology practice during the COVID-19 pandemic. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines were ***: A total of 41 papers met inclusion criteria and were organized into 5 categories ("General Recommendations for Otolaryngologic Surgery’, "equipment Shortage Solutions’, "Airway Procedures’, "Nasal endoscopy and Skull Base Procedures’, and "Otologic Procedures’). Articles were summarized, highlighting the innovations created and evaluated during the COVID-19 pandemic. Creative solutions such as application of topical viricidal agents, make-shift mask filters, three-dimensional (3-D) printable adapters for headlights, aerosol containing separation boxes, and a variety of new draping techniques have been developed to limit the risk of COVID-19 ***: Persistent risk of COVID-19 exposure remains high. Thus, there is an increased need for solutions that mitigate the risk of viral transmission during office procedures and surgeries, especially given that most COVID-19 positive patients present asymptomatically

关键词： COVID-19 Innovations Inventions Literature Review Otolaryngology

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Altered leukocyte gene expression after traumatic spinal cord injury:clinical implications

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Neural Regeneration Research 2018年第9期13卷 1524-1529页

作者： Paige e.Herman Ona bloom The Feinstein Institute for Medical Research Northwell Health Departments of Physical Medicine and Rehabilitation Molecular MedicineDonald and Barbara Zucker School of Medicine at Hofstra Northwell

In addition to changes in motor and sensory function, individuals with spinal cord injury （SCI） experience immunological changes. These changes are clinically significant, as infections are the leading cause of death for this population. Along with increased infections, inflammation is commonly observed in persons with SCI, where it may promote many common medical consequences. These include elevated risk of cardio- vascular disease, impaired wound healing, diabetes and neuropathic pain. It has also been proposed that chronic inflammation dampens neurological recovery. In order to identify therapeutic strategies to im- prove immune function, we need a greater understanding of the molecular changes that occur in immune cells after SCI. The purpose of this mini-review is to discuss two recent studies that used functional genom- ics to investigate gene expression in circulating leukocytes isolated from persons with SCI. In the future, the molecular pathways that are altered after SCI may be targeted to improve immunological function, as well as overall health and functional recovery, after SCI.

关键词： traumatic spinal cord injury inflammation immune cells functional genomics gene expression autoimmunity microarray chronic spinal cord injury

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COVID-19 Vaccine Allocation: Modeling Health Outcomes and equity Implications of Alternative Strategies

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engineering 2021年第7期7卷 924-935页

作者： Maddalena Ferranna Daniel Cadarette David e.bloom Harvard T.H.Chan School of Public Health BostonMA 02115USA

Given the scarcity of safe and effective COVID-19 vaccines,a chief policy question is how to allocate them among different sociodemographic *** paper evaluates COVID-19 vaccine prioritization strategies proposed to date,focusing on their stated goals;the mechanisms through which the selected allocations affect the course and burden of the pandemic;and the main epidemiological,economic,logistical,and political issues that arise when setting the prioritization *** paper uses a simple,agestratified susceptible–exposed–infectious–recovered model applied to the United States to quantitatively assess the performance of alternative prioritization strategies with respect to avoided deaths,avoided infections,and life-years *** demonstrate that prioritizing essential workers is a viable strategy for reducing the number of cases and years of life lost,while the largest reduction in deaths is achieved by prioritizing older adults in most scenarios,even if the vaccine is effective at blocking viral *** regarding this property and potential delays in dose delivery reinforce the call for prioritizing older ***,we investigate the strength of the equity motive that would support an allocation strategy attaching absolute priority to essential workers for a vaccine that reduces infectionfatality risk.

关键词： Vaccine allocation COVID-19 equity SeIR model

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Dose-dependent associations of joint aerobic and muscle-strengthening exercise with obesity:A cross-sectional study of 280,605 adults

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Journal of Sport and Health Science 2023年第2期12卷 186-193页

作者： jason A Bennie Ding Ding Katrien De Cocker Physically Active Lifestyles Research Group(USQ-PALs) Centre for Health ResearchUniversity of Southern QueenslandSpringfield CentralQLD 4300Australia Prevention Research Collaboration Sydney School of Public HealthUniversity of SydneySydneyNSW 2006Australia Charles Perkins Centre epidemiology Unit Charles Perkins CentreUniversity of SydneySydneyNSW 2006Australia

Background:emerging epidemiological evidence suggests that compared to engaging in 1 activity mode alone,a combination of moderate-tovigorous physical activity(MVPA:brisk walking/jogging,cycling)and muscle-strengthening exercise(MSe:push-ups/sit-ups,using weight machines)has more favorable associations with optimal weight ***,few studies have examined the dose-dependent and joint associations of MVPA and MSe with ***:Based on cross-sectional analyses of the european Health Interview Survey Wave 2(2013-2014),we examined prevalence ratios(PRs)of joint and stratified associations between MVPA(4 categories:(ⅰ)0 min/week,(ⅱ)1-149 min/week,(ⅲ)150-299 min/week,and(ⅳ)≥300 min/week)and MSe(3 categories:(ⅰ)0 day/week,(ⅱ)1 day/week,and(ⅲ)>2 days/week)with body mass index-defined obesity(body mass index of>30.0 kg/m2)using Poisson regression with robust error *** were examined unadjusted and adjusted for sociodemographic and lifestyle characteristics(e.g.,sex,age,education,income,and smoking status).Results:Data were available for 280,456 adults(≥18 years),of which 46,166(15.5%)were *** interaction MVPA x MSe guideline adherence was statistically significant for obesity(p≤0.05).The joint MVPA-MSe analysis showed that compared to the reference group(i.e.,no MVPA and no MSe),the PRs followed a dose-dependent pattern,with the lowest observed among those reporting≥150 MVPA min/week and≥1 MSe days/week(PR:0.43;95%confidence interval:0.41-0.46).When stratified across each MVPA strata,the PRs were mostly lower among those engaging in MSe 1 day/week,as compared to those doing MSe≥2 days/***:"There was evidence for a dose-dependent association between joint MVPA-MSe with a reduced prevalence of *** health strategies for the prevention and management of obesity should recommend both MVPA and MSe.

关键词： Body mass index epidemiology Public health Resistance exercise

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