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Whole-exome sequencing and microRNA profiling reveal PI3K/AKT pathway＇s involvement in juvenile myelomonocytic leukemia

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Frontiers of Electrical and Electronic Engineering in China 2018年第1期6卷 85-97页

作者： Saad M Khan jason E Denney Michael X Wang dong Xu Informatics Institute and C. S. Bond Life Sciences Center Universitv of Missouri. Columbia. MO 65211 USA Department of Pathology and Anatomical Sciences University of Missouri Columbia MO 65211 USA Department of computer Science University of Missouri Columbia MO 65211 USA

Background： Clinical studies and genetic analyses have revealed that juvenile myelomonocytic leukemia （JMML） is caused by somatic and/or germline mutations of genes involved in the RAS/MAPK signalling pathway. Given the vastly different clinical prognosis among individual patients that have had this disease, mutations in genes of other pathways may be involved. Methods： In this study, we conducted whole-exome and cancer-panel sequencing analyses on a bone marrow sample from a 2-year old juvenile myelomonocytic leukemia patient. We also measured the microRNA profile of the same patient＇s bone marrow sample and the results were compared with the normal mature monocytic cells from the pooled peripheral blood. Results： We identified additional novel mutations in the Pi3K/AKT pathway and verified with a cancer panel targeted sequencing. We have confirmed the previously tested PTPNII gene mutation （exon 3 181G〉T） in the same sample and identified new nonsynonymous mutations in NTRKI, HMGA2, MLH3, MYH9 and AKT1 genes. Many of the microRNAs found to be differentially expressed are known to act as oncogenic MicroRNAs （onco^MicroRNAs or oncomiRs）, whose target genes are enriched in the PI3K/AKT signalling pathway. Conclusions： Our study suggests an alternative mechanism for JMML pathogenesis in addition to RAS/MAPK pathway. This discovery may provide new genetic markers for diagnosis and new therapeutic targets for JMML patients in the future.

关键词： single-cell RNA-Seq differential expression

Noise and detectivity limits in organic shortwave infrared photodiodes with low disorder

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npj Flexible Electronics 2020年第1期4卷 58-65页

作者： Zhenghui Wu Ning Li Naresh Eedugurala jason DAzoulay dong-Seok Leem Tse Nga Ng Department of Electrical and Computer Engineering University of California San Diego9500 Gilman DriveLa JollaCA 92093-0407USA Department of Electrical and Electronic Engineering Southern University of Science and Technology1088 Xueyuan AvenueShenzhenGuangdong 518023China Center for Optoelectronic Materials and Devices School of Polymer Science and EngineeringUniversity of Southern Mississippi118 College Drive#5050HattiesburgMS 39406USA Samsung Advanced Institute of Technology(SAIT) Samsung ElectronicsCo.Ltd.130 Samsung-roYeongtong-guSuwon-siGyeonggi-do 443-803South Korea

To achieve high detectivity in infrared detectors,it is critical to reduce the device ***,for non-crystalline semiconductors,an essential framework is missing to understand and predict the effects of disorder on the dark *** report presents experimental and modeling studies on the noise current in exemplar organic bulk heterojunction photodiodes,with 10 donor-acceptor combinations spanning wavelength between 800 and 1600 nm.A significant reduction of the noise and higher detectivity were found in devices using non-fullerene acceptors(NFAs)in comparison to those using fullerene *** low noise in NFA blends was attributed to a sharp drop off in the distribution of bandtail states,as revealed by variable-temperature density-of-states *** disorder into account,we developed a general physical model to explain the dependence of thermal noise on the effective bandgap and bandtail *** model provides theoretical targets for the maximum detectivity that can be obtained at different detection wavelengths in inherently disordered infrared photodiodes.

关键词： heterojunction noise donor

High performance columnar-like Fe2O3@carbon composite anode via yolk@shell structural design

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Journal of Energy Chemistry 2020年第2期29卷 126-134页

作者： Zhiming Zheng Pei Li jason Huang Haodong Liu Yi Zao Zhongli Hu Li Zhang Huixin Chen Ming-Sheng Wang dong-Liang Peng Qiaobao Zhang Department of Materials Science and Engineering College of MaterialsXiamen UniversityXiamen 361005FujianChina Department of Nanoengineering University of California San DiegoLa Jolla 92093CAUSA Joint Laboratory for Extreme Conditions Matter Properties Southwest University of Science and TechnologyMianyang 621010SichuanChina Soochow Institute for Energy and Materials Innovations(SIEMIS) Key Laboratory of Advanced Carbon Materials and Wearable Energy Technologies of Jiangsu ProvinceSoochow UniversitySuzhou 215006Jiangsu.China Xiamen Institute of Rare Earth Materials Haixi institutesChinese Academy of SciencesXiamen 361024Fujian.China

Conversion-type reaction anode materials with high specific capacity are attractive candidates to improve lithium ion batteries(LIBs), yet the rapid capacity fading and poor rate capability caused by drastic volume change and low electronic conductivity greatly hinder their practical applications. To circumvent these issues, the successful design of yolk@shell Fe2 O3@C hybrid composed of a columnar-like Fe2O3 core within a hollow cavity completely surrounded by a thin, self-supported carbon(C) shell is presented as an anode for high-performance LIBs. This yolk@shell structure allows each Fe2O3 core to swell upon lithiation without deforming the carbon shell. This preserves the structural and electrical integrity against pulverization, as revealed by in situ transmission electron microscopy(TEM) measurement. Benefiting from these structural advantages, the resulting electrode exhibits a high reversible capacity(1013 m Ah g-1 after80 cycles at 0.2 A g-1), outstanding rate capability(710 m Ah g-1 at 8 A g-1) and superior cycling stability(800 m Ah g-1 after 300 cycles at 4 A g-1). A Li-ion full cell using prelithiated yolk@shell Fe2 O3@C hybrid as the anode and commercial Li CoO2(LCO) as the cathode demonstrates impressive cycling stability with a capacity retention of 84.5% after 100 cycles at 1 C rate, holding great promise for future practical applications.

关键词： Fe2O3 Mesoporous carbon Yolk@shell Lithium ion battery

活性瓷釉涂层钢筋及钢纤维增强混凝土板动、静力学特性研究（英文）

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2016年第5期17卷 366-377页

作者： dong-ming YAN Shi-kun CHEN Gen-da CHEN jason BAIRD School of Civil and Architectural Engineering Zhejiang University Department of Civil Architectural and Environmental Engineering Missouri University of Science and Technology

目的:活性瓷釉涂层能够显著增强钢筋的防腐蚀能力,同时明显提升钢筋与混凝土的粘结力。通过对活性瓷釉涂层钢筋以及钢纤维增强混凝土板在动、静力荷载作用下的承载力、变形特性以及破坏特征的研究,为活性瓷釉涂层技术在钢筋混凝土结构... 详细信息

目的:活性瓷釉涂层能够显著增强钢筋的防腐蚀能力,同时明显提升钢筋与混凝土的粘结力。通过对活性瓷釉涂层钢筋以及钢纤维增强混凝土板在动、静力荷载作用下的承载力、变形特性以及破坏特征的研究,为活性瓷釉涂层技术在钢筋混凝土结构中的应用奠定理论基础。创新点:1.对活性瓷釉涂层钢筋混凝土板的动、静力学性能进行系统研究;2.探究活性瓷釉钢纤维在混凝土结构中的作用机理。方法:1.通过对活性瓷釉涂层钢筋混凝土板进行爆炸实验(图3),揭示活性瓷釉涂层钢筋混凝土结构的动力破坏特征(图5和6);2.通过对活性瓷釉涂层钢筋混凝土板进行静力实验(图4),研究在"点"荷载和"线"荷载作用下混凝土板的力学性能;3.通过分析钢纤维在钢筋混凝土结构中的传力机理,提出活性瓷釉涂层钢纤维在钢筋混凝土结构中的设计方法(图13)。结论:1.活性瓷釉涂层能够显著改善钢筋在混凝土结构中的传力性能;在动力荷载作用下,涂层钢筋混凝土结构的破坏程度明显减轻。2.活性瓷釉涂层能够显著改善钢筋混凝土结构的变形特性,大大增强其耗能能力。3.采用活性瓷釉涂层的钢纤维,其纤维长度可适当减小。

关键词：活性瓷釉涂层爆炸荷载破坏特征钢纤维

Therapeutics of Integrative Medicine Ameliorate Immunological Disorders of the Nervous System: A Meta-Analysis

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World Journal of Traditional Chinese Medicine 2022年第1期8卷 153-167页

作者： Jin-Yun Ma Jennifer Cruz jason Jin Xiao-Yan Peng Ai-Ming Zhang Xiao-dong Cheng Institute of Clinical Immunology Yue-yang Hospital of Integrative MedicineShanghai University of Traditional Chinese MedicineShanghai 200437China Doctoral Program of Acupuncture and Oriental Medicine The Atlantic Institute of Oriental MedicineFlorida 33301USA Department of Neurology Min-Hang Hospital of Integrative MedicineShanghai 200241China

Objective: The objective of the study is to evaluate the therapeutic efficacy of integrative medicine in the treatment of immunological disorders of the nervous system. Methods: The Preferred Reporting Items for Systematic Reviews and Meta-Analysis guidelines were adopted to conduct this study, which included randomized controlled trials with a confirmed diagnosis of multiple sclerosis(MS), myasthenia gravis(MG), and Guillain–Barre syndrome(GBS), all of which were treated with integrative medicine. The effective rate, recurrent frequency, and disease score were used as the markers of outcome variables for the meta-analysis. Results: A total of 48 randomized control trials were included. The effective rates of treatment with integrative medicine were noticeably higher than those with Western medicine alone for the three diseases. The recurrence frequency for MS and the recurrence rate for MG treated with integrative medicine were reduced more than those with Western medicine alone. The Extended Disability Status Scale, acetylcholine receptor antibody, and Hughes scores for MS, MG, and GBS, respectively, treated with integrative medicine were significantly lower than those with Western medicine alone. The risks of bias in the literature evaluation showed that the quality of the included studies was not high. Conclusions: Compared to treatment with Western medicine alone, integrative medicine might ameliorate immunological disorders of the nervous system.

关键词： Guillain–Barre syndrome integrative medicine meta-analysis multiple sclerosis myasthenia gravis

Wide-field ophthalmic space-division multiplexing optical coherence tomography

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Photonics Research 2020年第4期8卷 539-547页

作者： jason JERWICK YONGYANG HUANG ZHAO dong ADRIENNE SLAUDADES ALEXANDER J.BRUCKER CHAO ZHOU Department of Electrical and Computer Engineering Lehigh UniversityBethlehemPennsylvania 18015USA Department of Biomedical Engineering Washington University in St.LouisSt.LouisMissouri 63130USA Scheie Eye Institute Penn Presbyterian Medical CenterUniversity of PennsylvaniaPhiladelphiaPennsylvania 19104USA Department of Bioengineering Lehigh UniversityBethlehemPennsylvania 18015USA

High-speed ophthalmic optical coherence tomography(OCT)systems are of interest because they allow rapid,motion-free,and wide-field retinal ***-division multiplexing optical coherence tomography(SDMOCT)is a high-speed imaging technology that takes advantage of the long coherence length of micro electro mechanical vertical cavity surface emitting laser sources to multiplex multiple images along a single imaging *** demonstrate wide-field retinal OCT imaging,acquired at an effective A-scan rate of 800,000 A-scans/s with volumetric images covering up to 12.5 mm×7.4 mm on the retina and captured in less than 1 s.A clinical feasibility study was conducted to compare the ophthalmic SDM-OCT with commercial OCT systems,illustrating the high-speed capability of SDM-OCT in a clinical setting.

关键词： Wide-field ophthalmic space-division multiplexing optical coherence tomography

Forest succession in post-agricultural Larix olgensis plantations in northeast China

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Journal of Forestry Research 2020年第6期31卷 2495-2505页

作者： Wei Ma Shen Lei Yujun Sun jason Grabosky Academy of Forest Inventory and Planning State Forestry AdministrationBeijing 100714China The Key Laboratory of Silviculture and Conservation of the Ministry of Education College of ForestryBeijing Forestry UniversityBeijing 100083China New Jersey Agricultural Experiment Station Rutgers UniversityNew BrunswickNJUSA

In order to understand the management of regional vegetation,numerical classification and ordination are widely used to investigate community distribution and vegetation *** particular,two-way indicator-species analysis programs(TWINSPAN)classifies plots and species into different ***-trended correspondence analysis(DCA)and canonical correspondence analysis(CCA)reflects the relationship between community and site *** with Larix olgensis *** is a suitable restoration strategy on post-agricultural fields in the Lesser Khingan *** results of this study show how these plantations develop over time to establish a reliable pathway model by measuring and clarifying the succession ***-eight *** plantations along a 48-year chronosequence of afforestation were investigated with a quadrat sampling *** composition,community structure attributes of diversity,and site conditions were *** were classified by TWINSPAN into five successional stages:immature,juvenile,mid-aged,nearmature and *** were validated by DCA and CCA *** conditions such as soil and litter thickness,soil organic matter,soil density,and pH were *** stages varied in community composition and species population,accompanied by time from afforestation and a gradient of site *** gradient showed changes in vegetation occurrence and diversity coinciding with changes in soil *** study showed that *** plantations had marked predominance in growth and were associated with improved soil fertility and the formation of a stable plant community.

关键词： Chronosequence Community structure Lesser Khingan Mountains Site conditions Species composition

核数据对球床式高温气冷堆燃料元件中子学特性的影响

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原子能科学技术 2017年第9期51卷 1591-1598页

作者：王黎东郭炯李富 jason Hou Kostadin Ivanov 清华大学核能与新能源技术研究院先进核能技术协同创新中心先进反应堆工程与安全教育部重点实验室北京100084 北卡罗来纳州立大学美国罗利NC27695

球床式高温气冷堆采用了球形燃料元件,燃料区域由石墨基体和弥散在其中的包覆燃料颗粒构成,其外有与石墨基体相同材料的包壳;燃料球堆叠成填充率约为0.61的球床式堆芯活性区。在堆芯物理计算中,必须考虑其特殊的双重非均匀性结构对共振... 详细信息

球床式高温气冷堆采用了球形燃料元件,燃料区域由石墨基体和弥散在其中的包覆燃料颗粒构成,其外有与石墨基体相同材料的包壳;燃料球堆叠成填充率约为0.61的球床式堆芯活性区。在堆芯物理计算中,必须考虑其特殊的双重非均匀性结构对共振计算的影响。此外,由于石墨起到了中子慢化和结构材料的重要作用,其截面参数的准确性对共振计算和临界计算均有很大影响。本文采用蒙特卡罗中子输运计算程序SCALE/KENO-Ⅵ和Serpent-2,对比分析了ENDF/B Ⅶ.0和ENDF/B Ⅶ.1版本核数据库对不同燃料模型的有效增殖因数(keff)及反应率的影响,并进一步比较了不同双重非均匀性处理方法对计算结果的影响。结果表明,由于石墨吸收率增大,使用ENDF/B Ⅶ.1版本核数据库所得keff小于使用ENDF/B Ⅶ.0版本核数据库的结果,且计算模型中石墨材料越多,计算结果相差越大:对于包覆颗粒模型差别约为200pcm,对于燃料元件约为700pcm,对于堆芯单元约为1 600pcm。SCALE/KENO-Ⅵ程序使用DOUBLEHET模型进行多群蒙特卡罗计算所得结果与连续能量模型计算结果吻合良好,且计算效率高,对燃料球模型而言可节省约85%的计算时间。

关键词： ENDF/B Ⅶ.1 SCALE Serpent-2 高温气冷堆双重非均匀性

Blast response of full-size concrete walls with chemically reactive enamel （CRE）-coated steel reinforcement

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2016年第9期17卷 689-701页

作者： dong-ming YAN Hua-wei YIN Cheng-lin WU Yan-long LI jason BAIRD Gen-da CHEN School of Civil and Architectural Engineering Zhejiang University Hangzhou 310058 China College of Civil Engineering Hunan University Changsha 410082 China Department of Civil Architectural and Environmental Engineering Missouri University of Science and Technology Rolla 654009 USA State Key Laboratory Base of Eco-Hydraulic Engineering in Arid Area Xi'an University of Technology Xi'an 710048 China Rock Mechanics and Explosives Missouri University of Science and Technology Rolla 654009 USA Center for Infrastructure Engineering Studies Missouri University of Science and Technology Rolla 654009 USA

In this study, two full-size concrete wails were tested and analyzed to demonstrate the effectiveness of a chemically reactive enamel （CRE） coating in improving their mechanical behavior under blast loading： one with CRE-coated rebar and the other with uncoated rebar. Each wall was subjected in sequence to four explosive loads with equivalent 2, 4, 6-trinitrotoluene （TNT） charge weights of 1.82, 4.54, 13.6, and 20.4 kg. A finite element model of each wall under a close-in blast load was developed and validated with pressure and strain measurements, and used to predict rebar stresses and concrete surface sWain distributions of the wall. The test results and visual inspections consistently indicated that, compared with the barrier wall with uncoated reinforcement, the wall with CRE-coated rebar has fewer concrete cracks on the front and back faces, more effective stress transfers from concrete to steel rebar, and stronger connections with its concrete base. The concrete surface strain distributions predicted by the model under various loading conditions are in good agreement with the crack patterns observed during the tests.

关键词： Chemically reactive enamel (CRE) coating Blast loading Crack pattern Bond strength Finite element model