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Glasgow prognostic score after concurrent chemoradiotherapy is a prognostic factor in advanced head and neck cancer

Chinese Journal of Cancer Research 2017年第3期29卷 172-178页

作者： Pei-Hung Chang Cheng-Hsu Wang Eric Yen-Chao Chen Shih-Wei Yang Wen-Chi Chou jason chia-hsun hsieh Feng-Che Kuan Kun-Yun Yeh Division of Hemato-oncology Department of Internal MedicineChang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445 TaiwanChina Cancer Center Chang Gung Memorial HospitalKeelung 20445TaiwanChina Department of Radiation Oncology Chang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445TaiwanChina Otolaryngology Head and Neck SurgeryChang Gung Memorial HospitalKeelung&Chang Gung UniversityCollege of MedicineKeelung 20445TaiwanChina Division of Medical Oncology Department of Internal MedicineChang Gung Memorial Hospital at LinkouTaoyuan 33305TaiwanChina Department of Hematology and Oncology Department of MedicineChang-Gung Memorial HospitalChiayi 61363TaiwanChina

Objective: This study aims to evaluate the impact and potential prognostic roles of the pre- and post-treatment Glasgow prognostic score (GPS) and the change thereof in patients with advanced head and neck cancer undergoing concurrent chemoradiotherapy (CCRT). Methods: We collected GPS and clinicopathological data of 139 stage III, IVA, and IVB head and neck cancer patients who underwent CCRT between 2008 and 2011. Their GPSs pre- and post-CCRT and the change thereof were analyzed for correlations with recurrence and survival. Results: The GPS changed in 72 (51.8%) patients, with worse scores observed post-CCRT in 65 (90.3%) of the GPS changed patients. Patients in the improved GPS group showed a tendency toward better survival. From the multivariate analysis, the post-CCRT GPS level was an independent prognostic factor in addition to tumor stage. Conclusions: After CCRT, a high GPS was revealed to be an important predictor of survival for advanced head and neck cancer.

关键词： Glasgow prognostic score (GPS) head and neck cancer chemoradiation inflammation cachexia nutrition

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Magnesium lithospermate B possesses inhibitory activity on Na+,K+-ATPase and neuroprotective effects against ischemic stroke

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Acta Pharmacologica Sinica 2007年第5期28卷 609-615页

作者： jason TC TZEN Tzyy-rong JINN Hank KH SHE Balance CM CHEN Vic hsieh Graduate Institute of Biotechnology Herbal Source Biotechnology Co Tainan CountyTaiwan741 China jason Life Tech Inc National Chung Hsing UniversityTaichungTaiwan 402 China

Aim:To examine if magnesium lithospermate B （MLB） extracted from Danshen,thedried roots of Salvia miltiorrhiza,may act as an active component responsible forthe cardiac therapeutic effect of this traditional Chinese herb via the same molecu-lar mechanism triggered by cardiac glycosides,such as ouabain and ***,we wanted to test if MLB may provide neuroprotection againstischemic stroke as observed for cardiac ***:Similarity in thechemical structure and molecular configuration between MLB and ouabain *** inhibition potency of MLB and ouabain on Na+,K+-ATPase activ-ity of a commercial product,as well as in purified membrane fractions from rat brainand heart tissues,was examined and *** effect of MLBagainst ischemic stroke was also evaluated using a cortical brain slice-basedassay ***:Dose-dependent inhibition on the commercial Na+,K+-ATPase equivalent to that for ouabain was observed for MLB of approximatelyhalf dosage by *** relative potency of ouabain and MLB was alsoobserved for their inhibition on Na+,K+-ATPase activity of plasma membranepurified from rat tissues,although these 2 inhibitors exhibited somewhat lowercompetence in these crude *** ischemic gerbil brains,post-treatment withMLB significantly reduced the infarct size,visualized by 2,3,5-triphenyltetrazoliumchloride staining,by approximately 55% when compared with the control ***:These results evidently suggest that the cardiac therapeutic effect ofDanshen should be at least partly attributed to the effective inhibition of Na+,K+-ATPase by MLB,and that MLB provides anti-ischemic neuroprotection in gerbilssubjected to focal ischemia and reperfusion.

关键词： cardiac glycosides magnesium lithospermate B Na~+,K~+-ATPase neuroprotection ouabain Salvia miltiorrhiza

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Regulatory signaling network in the tumor microenvironment of prostate cancer bone and visceral organ metastases and the development of novel therapeutics

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Asian Journal of Urology 2019年第1期6卷 65-81页

作者： Gina chia-Yi Chu Leland W.K.Chung Murali Gururajan chia-Ling hsieh Sajni Josson Srinivas Nandana Shian-Ying Sung Ruoxiang Wang jason Boyang Wu Haiyen E.Zhau Uro-Oncology Research Department of Medicine and Samuel Oschin Comprehensive Cancer InstituteCedars-Sinai Medical CenterLos AngelesCAUSA Bristol-Myer Squibb Company PrincetonNJUSA Department of Urology Emory University School of MedicineAtlantaGAUSA Oncoveda Cancer Research Center Genesis Biotechnology GroupHamiltonNJUSA Texas Tech University Health Sciences Center Department of Cell Biology and BiochemistryLubbockTXUSA Department of Pharmaceutical Sciences College of Pharmacy and Pharmaceutical SciencesWashington State UniversitySpokaneWAUSA

This article describes cell signaling network of metastatic prostate cancer(PCa)to bone and visceral organs in the context of tumor microenvironment and for the development of novel *** article focuses on our recent progress in the understanding of:1)The plasticity and dynamics of tumorestroma interaction;2)The significance of epigenetic reprogramming in conferring cancer growth,invasion and metastasis;3)New insights on altered junctional communication affecting PCa bone and brain metastases;4)Novel strategies to overcome therapeutic resistance to hormonal antagonists and chemotherapy;5)Geneticbased therapy to co-target tumor and bone stroma;6)PCa-bone-immune cell interaction and TBX2-WNTprotein signaling in bone metastasis;7)The roles of monoamine oxidase and reactive oxygen species in PCa growth and bone metastasis;and 8)Characterization of imprinting cluster of microRNA,in tumorestroma *** article provides new approaches and insights of PCa metastases with emphasis on basic science and potential for clinical *** article referenced the details of the various approaches and discoveries described herein in peer-reviewed *** dedicate this article in our fond memory of *** *** who taught us the spirit of sharing and the importance of focusing basic science discoveries toward translational medicine.

关键词： Prostate cancer Castration resistance Metastasis Cancer-stromal interaction Targeted therapy

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Levels of Chemical Toxicants in Waterpipe Tobacco and Waterpipe Charcoal Solid Waste

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Journal of Environmental Protection 2021年第11期12卷 913-938页

作者： jason R. hsieh Megan L. Mekoli Ronald L. Edwards Jr. Office of Science Center for Tobacco Products U.S. Food and Drug Administration Calverton MD USA

This work provides insights on waterpipe tobacco and waterpipe charcoal as potential sources of environmental toxicants. Selected harmful and potentially harmful constituents (HPHCs) from ten U.S. commercial waterpipe tobacco filler products (before and after electric heating) and five waterpipe charcoal products (before and after burning) were investigated. The differences in quantities of HPHCs between the evaluated products appear to be affected by raw material properties and/or the manufacturing processes involved in product production. Trace metal quantities in waterpipe tobacco and charcoal products were observed after heating or burning conditions compared to unheated or unburned conditions, which could impact the environment through the generation of toxic tobacco product waste. This study demonstrates that waterpipe tobacco and waterpipe charcoal contain substantial quantities of benzo[a]pyrene (B[a]P) and trace metals (i.e., selenium, arsenic, cadmium, chromium, cobalt, lead, nickel) before use and that extensive and varied changes in trace metal quantities take place as a result of heating, and more studies are needed to estimate the magnitude of the environmental impact of waterpipe tobacco use.

关键词： Harmful and Potentially Harmful Constituents Charcoal Waterpipe Metals Tobacco Product Waste

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Transient plasma-enhanced remediation of nanoscale particulate matter in restaurant smoke emissions via electrostatic precipitation

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Particuology 2021年第2期19卷 43-47页

作者： Sisi Yang Patrick Ford Sriram Subramanian Dan Singleton jason Sanders Stephen B.Cronin Department of Physics and Astronomy University of Southern CaliforniaLos AngelesCA 90089USA Ming hsieh Department of Electrical Engineering University of Southern CaliforniaLos AngelesCA 90089USA Daniel J.Epstein Department of Industrial&System Engineering University of Southern CaliforniaLos AngelesCA 90089USA Transient Plasma Systems Inc.TorranceCA 90501USA

It is now recognized that nanoscale particulate matter(PM)represents a substantial health hazard for our society,including PM from restaurant *** this study,we explored the use of a transient pulsed plasma in conjunction with an applied DC bias to treat oil aerosols that closely resemble restaurant(i.e.,charbroiler)smoke *** polyaromatic olefin PAO-4 and soybean oil,we found that a three-order-of-magnitude reduction in particulates(i.e.,99.9%remediation)could be achieved with this ***,the plasma discharge was produced in a 4-in.-diameter cylindrical reactor with a 5-10 ns high voltage(30 kV)pulse generator together with applied DC bias voltages up to 10 *** distribution of nanoparticle sizes was measured using a scanning mobility particle sizer(SMPS)with diameter centered around 225 ***,the main mechanism of remediation occurs in a two-step process in which the oil nanoparticles are first ionized by the free electrons and free radicals in the plasma and then the charged particles are swept out to the sidewalls of the reactor by the applied DC *** believe this general approach opens up new degrees of freedom in the design of electrostatic oil aerosol pollution control devices.

关键词： Nanoparticles Transient plasma Charbroiler emission DC bias Remediation

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