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建筑技艺 2010年第11期16卷 132-135页

作者： Jos van Eldonk jarno van Essen Albert de Graaf Berend Hoffmann April Kong Margon de Vries Ingenieursbureau Zonneveld Rotterdam fedde de Weert Scagliola Brakkee 吴春花 M.J.de Nijsen Zonen Warmenhuizen

CSM糖厂地址位于哈尔夫韦赫(Halfweg),处于阿姆斯特丹和哈勒姆中间.项目的挑战在于将原有的工业基地变为—个舒适的、充满生机的区域.但这里紧邻Schiphol飞机场跑道,不能作为居住区,因此不得不考虑其他功能来激发活力,达到白天与夜晚一... 详细信息

CSM糖厂地址位于哈尔夫韦赫(Halfweg),处于阿姆斯特丹和哈勒姆中间.项目的挑战在于将原有的工业基地变为—个舒适的、充满生机的区域.但这里紧邻Schiphol飞机场跑道,不能作为居住区,因此不得不考虑其他功能来激发活力,达到白天与夜晚一样,工作日和休息日一样.最终将商业、办公、商店、美食广场、宾馆、影院、体育和休闲设,广泛地混合起来,形成了充满活力的环境氛围.

关键词：荷兰糖厂工业基地工业生产基地生产基地休闲设施 CSM 阿姆斯特丹钻石岛状硅酸盐矿物冷却塔冷水塔商店服务设施充满活力宾馆旅馆哈勒储藏库

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Global wood anatomical perspective on the onset of the Late Antique Little Ice Age (LALIA) in the mid-6th century CE

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Science Bulletin 2022年第22期67卷 2336-2344页

作者： Ulf Büntgen Alan Crivellaro Dominique Arseneault Mike Baillie David Barclay Mauro Bernabei jarno Bontadi Gretel Boswijk David Brown Duncan A.Christie Olga V.Churakova Edward R.Cook Rosanne D’Arrigo Nicole Davi Jan Esper Patrick fonti Ciara Greaves Rashit M.Hantemirov Malcolm K.Hughes Alexander V.Kirdyanov Paul J.Krusic Carlos Le Quesne fredrik C.Ljungqvist Michael Mc.Cormick Vladimir S.Myglan Kurt Nicolussi Clive Oppenheimer Jonathan Palmer Chun Qin frederick Reinig Matthew Salzer Markus Stoffel Max Torbenson Mirek Trnka Ricardo Villalba Nick Wiesenberg Greg Wiles Bao Yang Alma Piermattei Department of Geography University of CambridgeCambridge CB23ENUK Swiss federal Research Institute(WSL) Birmensdorf 8903Switzerland Global Change Research Centre(CzechGlobe) Brno 60300Czech Republic Department of Geography Faculty of ScienceMasaryk UniversityBrno 61300Czech Republic forest Biometrics Laboratory Faculty of Forestry“Stefan cel Mare”University of SuceavaSuceava 720229Romania Department of Biology Chemistry and GeographyUniversity of Quebec in RimouskiRimouski Qc.G5L 3A1Canada Archaeology&Palaeoecology School of Natural and Built EnvironmentQueen’s University BelfastBelfast BT71NNUK Department of Geology State University of New York at CortlandCortland NY 13045USA CNR-IBE Institute of BioEconomyNational Research CouncilTrento 38121Italy School of Environment The University of AucklandAuckland 1010New Zealand Laboratorio de Dendrocronología y Cambio Global Universidad Austral de ChileValdivia 509000Chile Center for Climate and Resilience Research(CR) Santiago 8370449Chile Cape Horn International Center(CHIC) Punta Arenas 6200000Chile Institute of Ecology and Geography Siberian Federal UniversityKrasnoyarsk 660041Russia Tree-Ring Laboratory Lamont-Doherty Earth ObservatoryColumbia UniversityPalisades NY 10964USA Department of Environmental Science William Paterson UniversityWayne NJ 07470USA Department of Geography Johannes Gutenberg UniversityMainz 55099Germany Institute of Plant and Animal Ecology Ural BranchRussian Academy of SciencesYekaterinburg 620144Russia Ural Institute of Humanities Ural Federal UniversityYekaterinburg 620002Russia Laboratory of Tree-Ring Research University of ArizonaTucson AZ 85721USA Sukachev Institute of forest SB RAS Krasnoyarsk 660036Russia Department of Physical Geography Bolin Centre for Climate ResearchStockholm UniversityStockholm 10691Sweden Department of History Stockholm UniversityStockholm 10691Sweden Bolin Centre for Climate Research Stockholm UniversityStockholm 10691Sweden Swedish Collegium for Advanced Study

Linked to major volcanic eruptions around 536 and 540 CE, the onset of the Late Antique Little Ice Age has been described as the coldest period of the past two millennia. The exact timing and spatial extent of this exceptional cold phase are, however, still under debate because of the limited resolution and geographical distribution of the available proxy archives. Here, we use 106 wood anatomical thin sections from 23forest sites and 20 tree species in both hemispheres to search for cell-level fingerprints of ephemeral summer cooling between 530 and 550 CE. After cross-dating and double-staining, we identified 89Blue Rings(lack of cell wall lignification), nine frost Rings(cell deformation and collapse), and 93Light Rings(reduced cell wall thickening) in the Northern Hemisphere. Our network reveals evidence for the strongest temperature depression between mid-July and early-August 536 CE across North America and Eurasia, whereas more localised cold spells occurred in the summers of 532, 540–43, and548 CE. The lack of anatomical signatures in the austral trees suggests limited incursion of stratospheric volcanic aerosol into the Southern Hemisphere extra-tropics, that any forcing was mitigated by atmosphere-ocean dynamical responses and/or concentrated outside the growing season, or a combination of factors. Our findings demonstrate the advantage of wood anatomical investigations over traditional dendrochronological measurements, provide a benchmark for Earth system models, support cross-disciplinary studies into the entanglements of climate and history, and question the relevance of global climate averages.

关键词： Blue Rings Climate extremes Dendrochronology Late Antiquity Tree rings Volcanic eruptions

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Gene expression differences between stroke-associated and asymptomatic carotid plaques

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世界最新医学信息文摘 2015年第5期 7-7页

作者： Jani Saksi Petra Ij s Krista Nuotio Riitta Sonninen Lauri Soinne Oili Salonen Eija Saimanen jarno Tuimala Erno M.Lehtonen-Smeds Markku Kaste Petri T.Kovanen Perttu J.Lindsberg

Atherosclerotic carotid stenosis is an important risk factor for stroke. Carotid plaques(CPs) causing stroke may present a distinct type of molecular pathology compared with transient ischemic attack( TIA)-associated or asymptomatic plaques. We compared the gene expression profiles of CPs from stroke patients( n =12) and asymptomatic patients( n =9),both with similar risk factors and severity of carotid stenosis(>70%). Sixty probes showed over 1.5-fold expression difference at 5% false discovery rate. functional clustering showed enrichment of genes in 51 GO categories and seven pathways, the most significant of which relate to extracellular-matrix interaction, PPAR gamma signaling, scavanger receptor activity, and lysosomal activity. Differential expression of ten genes was confirmed in an extended replication group(n=43), where the most significant expression differences were found in CD36( 2.1-fold change, p =0.005), CD163( 1.7-fold change, p =0.007) and fABP4(2.2-fold change, p=0.015). These include four genes not previously linked to plaque destabilization: GLUL(2.2-fold change,p=0.016), fUCA1(2.2-fold change, p=0.025), IL1RN(1.6-fold change, p=0.034), and S100A8(2.5-fold change, p=0.047). Strong correlations were found to plaque ulceration, plaque hemorrhage, and markers of apoptosis and proliferation(activated caspase 3, TUNEL, and Ki67). Protein expression of these genes was confirmed by immunohistochemistry and was found in the atheromatous areas of CPs critical for plaque destabilization. This study presents a comprehensive transcriptional analysis of stroke-associated CPs and demonstrates a significant transcriptome difference between stroke-associated and asymptomatic CPs. followup studies on the identified genes are needed to define whether they could be used as biomarkers of symptomatic CPs or have a role in plaque destabilization.

关键词： Stroke Atherosclerosis Microarray Cerebrovascular Real-time PCR

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