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Fusobacterium nucleatum:Unraveling its potential role in gastric carcinogenesis

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World Journal of Gastroenterology 2024年第35期30卷 3972-3984页

作者： Vytenis Petkevicius Konrad Lehr Juozas Kupcinskas Alexander link Department of Gastroenterology Lithuanian University of Health SciencesKaunas 44307Lithuania Department of Gastroenterology Hepatology and Infectious DiseasesOtto-von-Guericke University HospitalMagdeburg 39120Germany Institute for Digestive Research Lithuanian University of Health SciencesKaunas 50161Lithuania

Fusobacterium nucleatum(***)is a Gram-negative anaerobic bacterium that plays a key role in the development of oral inflammation,such as periodontitis and *** the last 10 years,*** has been identified as a prevalent bacterium associated with colorectal adenocarcinoma and has also been linked to cancer progression,metastasis and poor disease *** the role of *** in colon carcinogenesis has been intensively studied,its role in gastric carcinogenesis is still poorly *** Helicobacter pylori infection has histo-rically been recognized as the strongest risk factor for the development of gastric cancer(GC),with recent advances in DNA sequencing technology,other members of the gastric microbial community,and *** in particular,have received increasing *** this review,we summarize the existing knowledge on the involvement of *** in gastric carcinogenesis and address the potential translational and clinical significance of *** in GC.

关键词： Fusobacterium nucleatum Gastric microbiota Gastric cancer Preneoplastic changes Prognosis

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PET/MRI改善癌症患儿管理

中华核医学与分子影像杂志 2024年第2期44卷 124-128页

作者： Lucia Baratto K.Elizabeth Hawk Lisa States Jing Qi Sergios Gatidis Louise Kiru Heike E.Daldrup-link 陈素芸(译) 王辉(审校) Department of Radiology Stanford UniversityStanfordCalifornia Department of Radiology Children′s Hospital of PhiladelphiaPhiladelphiaPennsylvania Department of Radiology Children′s WisconsinMilwaukeeWisconsin Department of Diagnostic and Interventional Radiology University Hospital TübingenTübingenGermany Department of Pediatrics Stanford UniversityStanfordCalifornia 上海交通大学医学院附属新华医院核医学科上海200092

一体化PET/MRI通过一站式成像提供肿瘤解剖学及功能评估,且与^(18)F-FDG PET/CT相比其辐射暴露量减少80%,因此对癌症患儿的分期与再分期具有显著临床价值。该文回顾了^(18)F-FDG PET/MRI在小儿肿瘤中的临床应用,尤其关注PET/MRI在患儿... 详细信息

一体化PET/MRI通过一站式成像提供肿瘤解剖学及功能评估,且与^(18)F-FDG PET/CT相比其辐射暴露量减少80%,因此对癌症患儿的分期与再分期具有显著临床价值。该文回顾了^(18)F-FDG PET/MRI在小儿肿瘤中的临床应用,尤其关注PET/MRI在患儿管理中的价值。来自4个不同机构的PET/MRI应用先行者分享了他们对PET/MRI技术在癌症患儿评估中特殊优势的见解。文章作者讨论了全身PET/MRI在评估某些解剖区域(如软组织和骨髓)中的价值以及儿童特殊的PET/MRI影像学特征,并强调了全身PET/MRI如何通过在不失去诊断准确性的同时减少所需放射学检查次数(因此减少辐射暴露),改善淋巴瘤、肉瘤和神经纤维瘤病患儿的临床管理。文章论述了PET/MRI如何帮助区分恶性肿瘤与感染性或炎性疾病;另外,简要探讨了PET/MRI用于接受免疫治疗的患儿疗效评估以及对不同诊疗一体化药物评估的未来研究方向。从儿童应用中所获得的经验也可拓展至成人患者的评估中。

关键词：肿瘤学儿科学 PET/MRI 癌症儿科肿瘤学

MicroRNAs as non-invasive diagnostic biomarkers for gastric cancer:Current insights and future perspectives

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World Journal of Gastroenterology 2018年第30期24卷 3313-3329页

作者： Alexander link Juozas Kupcinskas Department of Gastroenterology Hepatology and Infectious DiseasesOtto-von-Guericke University Institute for Digestive Research and Department of Gastroenterology Lithuanian University of Health Sciences

Non-invasive diagnostic biomarkers may contribute to an early identification of gastric cancer(GC) and improve the clinical ***,no sensitive and specific screening biomarkers are available yet and the currently available approaches are limited by the nature of the *** is a heterogenic disease with various distinct genetic and epigenetic events that occur during the multifactorial cascade of *** RNAs(mi RNAs) are commonly deregulated in gastric mucosa during the Helicobacter pylori infection and in stepwise manner from chronic gastritis,through preneoplastic conditions such as atrophic gastritis and intestinal metaplasia,to early dysplasia and invasive *** of mi RNAs in blood in 2008 led to a great interest on mi RNA-based diagnostic,prognostic biomarkers in *** this review,we provide the most recent systematic review on the existing studies related to mi RNAs as diagnostic biomarkers for ***,we systematically evaluate 75 studies related to differential expression of circulating mi RNAs in GC patients and provide novel view on various heterogenic aspects of the existing data and summarize the methodological ***,we highlight several important aspects crucial to improve the future translational and clinical research in the field.

关键词： microRNA biomarkers screening stomach gastric cancer systematic review blood serum plasma

Characteristics of developing scour-holes at a sand-embedded cylinder

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International Journal of Sediment Research 2008年第3期23卷 258-266页

作者： Oscar link Florian PFLEGER Ulrich ZANKE Dept. of Civil Engineering University of Concepción Edmundo Larenas 270 Concepción Chile.Dr.-Ing. Assistant Prof. Doctoral Research Fellow Institute for Hydromechanics Technische Universitt München Arcisstrasse 21 80333 München Germany. Institute for Hydraulic and Water Resources Engineering Darmstadt University of Technology Rundeturmstraβe 1 64283 Germany.Full Prof.

Characteristics of developing scour-holes at a sand-embedded 0.2 m diameter circular cylinder are presented. Non-intrusive, high-resolution topographic measurements of developing scour-holes were made with an experimental installation using a laser distance sensor (LDS) and precision step-motors. A clear-water experiment was conducted with bed shear stress equal to 95% of the critical bed shear stress for the initiation of sediment motion at the undisturbed plane sand bed with a d50 of 0.26 mm. During the running experiment of 21 hours duration, measurements were taken by the LDS in different azimuthal half-planes with θ = 0, 15, 30, 45, 60, 75, 90, 105, 120, 135, 150, 165 and 180o in order to study the spatio-temporal variation of geometric properties in developing scour-holes. After 21 hours, the equilibrium condition was approached, with a scour rate less than d50 per hour. Measurement of maximum scour depth in different azimuthal half-planes at different points in time during the experiment show that scour started at the cylinder side and surrounded the cylinder after about 20% of experiment time. Slopes of developing scour-holes presented three regions with different inclinations, which were attributed to vortex action. Both maximum scour depth and maximum scour radius at different azimuthal half-planes are well correlated with the maximum scour depth at plane with θ = 0o. When providing maximum scour depth at the cylinder front, the presented correlations are useful for simple calculation of scour-hole topography. This work provides an experimental database for advanced numerical simulation for loose sediment hydraulics.

关键词： Scour Bridges Piers Sediment transport Loose sediment hydraulics

Performance of Different Orthodontic Brackets after Exposure to Dietary Components: An <i>in Vitro</i>Pilot Study

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Open Journal of Stomatology 2021年第9期11卷 341-348页

作者： Anthony Fusco Syed Ahmed jared link Tanya Al-Talib Neamat Hassan Abubakr DMD School of Dental Medicine University of Nevada Las Vegas NV USA Department of Clinical Sciences School of Dental Medicine University of Nevada Las Vegas NV USA Department of Biomedical Sciences School of Dental Medicine University of Nevada Las Vegas NV USA

Introduction: The aim of this study was to determine whether there was a significant difference in shear bond strength between metal and ceramic brackets when exposed to acidic dietary components (beverages) and to observe the chromogenic potential of each in vitro. Methods: Metal and clear orthodontic brackets were placed on extracted maxillary second premolars and exposed to select beverages three times daily for four weeks. Shade was taken using a colorimeter device at seven intervals and the shear bond strength of each bracket was recorded. Results: There was a variable change in tooth shade with respect to the various beverages in which they were submerged. Coffee and Dr. Pepper had the most pronounced change, whereas Red Bull and water produced little to none, respectively. Compared to controls, brackets submerged in coffee had the greatest reduction in shear bond strength, followed by Dr. Pepper, then Red Bull. Overall, clear brackets showed higher shear bond strength than metal brackets. Conclusion: Acidic dietary components have a negative effect on the shear bond strength of orthodontic brackets, and more pigmented beverages have a higher chromogenic staining potential.

关键词： Bracket Shear Bond Strength Orthodontics Tooth Shade

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D-link无线校园网络解决方案

教育信息化 2004年第10期 9-9,8页

作者： D-link D-link

无线网络的优势分析校园内部铺设网络的工程涉及面很广,无论是在室内还是在室外,均会对现有的校园环境产生不少影响,这一点在发展历史较长、校内新老建筑并举的校园内表现的尤为明显.从投资、施工周期、网络维护、升级等多个方面着眼,... 详细信息

无线网络的优势分析校园内部铺设网络的工程涉及面很广,无论是在室内还是在室外,均会对现有的校园环境产生不少影响,这一点在发展历史较长、校内新老建筑并举的校园内表现的尤为明显.从投资、施工周期、网络维护、升级等多个方面着眼,学校需要一整套能够多快好省建设校园网络的方案.

关键词： D-link 无线校园网解决方案教育信息化

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D-link推出中型校园网解决方案

教育信息化 2004年第8期 15-16页

作者： D—link D-link

教学资源整合,信息化担纲随着我国教育信息化水平不断提高,教学资源的整合利用水平日渐上升,建设各级校园网和教育城域网成为我国进行素质教育的重要举措.据悉,教育部还将进一步加大校园网等信息化工程的推进力度.今天的校园网(Campus N... 详细信息

教学资源整合,信息化担纲随着我国教育信息化水平不断提高,教学资源的整合利用水平日渐上升,建设各级校园网和教育城域网成为我国进行素质教育的重要举措.据悉,教育部还将进一步加大校园网等信息化工程的推进力度.今天的校园网(Campus Network)已经成为学校发展的重要基础设施,是提高学校教学和科研水平不可缺少的支撑环境,也是衡量学校学术水平和管理水平的重要标志.校园网的概念已经得到丰富的延伸,超出了单纯的校园范围,代表了一类网络的结构.作为教育信息化进程重要的支持力量,国际著名网络设备和解决方案提供商D-link推出了一系列具有定制化特色的校园网解决方案,其中之一就是D-link中型校园网解决方案.

关键词： D-link 中型校园网解决方案教学资源整合素质教育

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D-link推出大型校园网解决方案

教育信息化 2005年第6期 21-22页

作者： D-link D-link

建设背景

关键词：解决方案 link 校园网提高教学质量教育资源共享教务管理系统信息化程度网络化管理建设背景教学手段网络建设网络流量视频点播网络系统学校规模基础设施覆盖范围高校扩招

将宽带应用落实到每个细节——D-link网络方案在焦作工学院校园网中的应用

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教育信息化 2004年第1期 10-11页

作者： D—link D-link

校园网作为学校信息化工程建设的基础,肩负着为学校师生提供教学、研究和综合信息等多项服务.对焦作工学院而言,随着教学科研任务的增加,管理工作的日益繁杂,建立一个宽带多媒体网络成为了必然,而通常这样校园网络要同时兼具教学(科研)... 详细信息

校园网作为学校信息化工程建设的基础,肩负着为学校师生提供教学、研究和综合信息等多项服务.对焦作工学院而言,随着教学科研任务的增加,管理工作的日益繁杂,建立一个宽带多媒体网络成为了必然,而通常这样校园网络要同时兼具教学(科研)、管理和通讯三大功能.其中,教学和科研功能是整个校园网应用的最基本功能,该功能的实现要求校园网络必须具备高宽带、可交互等功能,这样才能实现多媒体课件制作、多媒体教学、多媒体电子图书馆等.在管理功能中还包括师生信息查询管理、文件管理、财务管理等.而通讯功能就要求实现互联网的基本功能,包括能够支持Internet访问、电子邮件、远程访问、信息发布与交流等工作.

关键词：校园网焦作工学院 D-link 网络设备教育信息化