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小单孢菌产生的氨基糖苷类抗生素:化学与微生物学

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国外医药(抗生素分册) 1987年第3期 181-190页

作者： janos berdy ,廖福荣

引言氨基糖苷类抗生素以及β-内酰胺类、四环类与大环内酯类,都是抗细菌化疗上的主要药物。近数十年来,世界各地在寻找活性增强、毒性降低的新型氨基糖苷类方面积累了丰富的知识。应用于此项研究的主要方法有: (1)传统的微生物发酵技术;... 详细信息

引言氨基糖苷类抗生素以及β-内酰胺类、四环类与大环内酯类,都是抗细菌化疗上的主要药物。近数十年来,世界各地在寻找活性增强、毒性降低的新型氨基糖苷类方面积累了丰富的知识。应用于此项研究的主要方法有: (1)传统的微生物发酵技术; (2)包括突变合成在内的生物转化方法;

关键词：庆大霉素化合物艮他霉素氨基糖碳水化合物西索米星衍生物抗生素次要组分化学结构氨基环醇产生菌微生物学

小单孢菌产生的氨基糖苷类抗生素:化学与微生物学Ⅱ

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国外医药(抗生素分册) 1987年第6期 415-418页

作者： janos berdy ,廖福荣

Fortimicin型由日本协和发酵公司和美国阿波特实验室的研究人员共同发现的fortimicin型抗生素,是一组具有新型结构与作用方式的很有前途的氨基糖苷类。几年后,其它一些实验室也从不同的微生物中发现了类似的化合物。与全部由小单孢菌产... 详细信息

Fortimicin型由日本协和发酵公司和美国阿波特实验室的研究人员共同发现的fortimicin型抗生素,是一组具有新型结构与作用方式的很有前途的氨基糖苷类。几年后,其它一些实验室也从不同的微生物中发现了类似的化合物。与全部由小单孢菌产生的庆大霉素-西索米星型抗生素明显不同,fortimicin型假二糖是由一个脱氧氨糖(如:6-差向绛红糖胺-B)和一个定名为福提霉胺(Ⅲ)的1,4-二氨基环醇或其3,4-差向脱甲基-等衍生物组成,它们不仅由小单孢菌产生(fortimicins,lysinomycin等),而且亦可由链霉菌产生(sannamycins,istamycins),由糖多孢菌产生(sporaricins)及指孢囊菌产生(dacti-micins)。

关键词：庆大霉素生物合成艮他霉素生化反应碳水化合物氨基糖西索米星企业研究所工业实验室链霉菌微生物学抗生素阿司米星产生菌

Biofabrication of nanocomposite-based scaffolds containing human bone extracellularmatrix for the differentiation of skeletal stem and progenitor cells

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Bio-Design and Manufacturing 2024年第2期7卷 121-136页

作者： Yang-Hee Kim janos M.Kanczler Stuart Lanham Andrew Rawlings Marta Roldo Gianluca Tozzi Jonathan I.Dawson Gianluca Cidonio Richard O.C.Oreffo Faculty of Medicine Bone and Joint Research GroupCentre for Human DevelopmentStem Cells and RegenerationInstitute of Developmental SciencesUniversity of SouthamptonSouthampton SO166YDUK School of Pharmacy and Biomedical Science University of PortsmouthPortsmouth PO12DTUK School of Engineering Faculty of Engineering and ScienceUniversity of GreenwichGreenwich ME44TBUK Center for Life Nano-and Neuro-Science(CLN2S) Italian Institute of Technology00161 RomeItaly

Autograft or metal implants are routinely used in skeletal ***,they fail to provide long-term clinical resolution,necessitating a functional biomimetic tissue engineering *** use of native human bone tissue for synthesizing a biomimeticmaterial inkfor three-dimensional(3D)bioprintingof skeletal tissueis anattractivestrategyfor ***,human bone extracellular matrix(bone-ECM)offers an exciting potential for the development of an appropriate microenvironment for human bone marrow stromal cells(HBMSCs)to proliferate and differentiate along the osteogenic *** this study,we engineered a novel material ink(LAB)by blending human bone-ECM(B)with nanoclay(L,Laponite®)and alginate(A)polymers using extrusion-based *** inclusion of the nanoﬁller and polymeric material increased the rheology,printability,and drug retention properties and,critically,the preservation of HBMSCs viability upon *** composite of human bone-ECM-based 3D constructs containing vascular endothelial growth factor(VEGF)enhanced vascularization after implantation in an ex vivo chick chorioallantoic membrane(CAM)*** inclusion of bone morphogenetic protein-2(BMP-2)with the HBMSCs further enhanced vascularization and mineralization after only seven *** study demonstrates the synergistic combination of nanoclay with biomimetic materials(alginate and bone-ECM)to support the formation of osteogenic tissue both in vitro and ex vivo and offers a promising novel 3D bioprinting approach to personalized skeletal tissue repair.

关键词： Extracellular matrix Nanoclay Bone 3D bioprinting

Non-crossing Quantile Regression Neural Network as a Calibration Tool for Ensemble Weather Forecasts

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Advances in Atmospheric Sciences 2024年第7期41卷 1417-1437页

作者： Mengmeng SONG Dazhi YANG Sebastian LERCH Xiang'ao XIA Gokhan Mert YAGLI Jamie M.BRIGHT Yanbo SHEN Bai LIU Xingli LIU Martin janos MAYER School of Electrical Engineering and Automation Harbin Institute of TechnologyHarbin150001China Heidelberg Institute for Theoretical Studies Schloss-Wolfsbrunnenweg 3569118HeidelbergGermany Chair of Statistical Methods and Econometrics Karlsruhe Institute of Technology(KIT)Bluecherstr.1776185KarlsruheGermany Key Laboratory of Middle Atmosphere and Global Environment Observation Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing100029China Solar Energy Research Institute of Singapore(SERIS) National University of Singapore(NUS)Singapore117574Singapore UK Power Networks LondonSE61NPUK China Meteorological Administration Beijing100081China Heilongjiang Meteorological Bureau Harbin150001China Department of Energy Engineering Faculty of Mechanical EngineeringBudapest University of Technology and EconomicsMűegyetem rkp.3H-1111BudapestHungary

Despite the maturity of ensemble numerical weather prediction(NWP),the resulting forecasts are still,more often than not,*** such,forecast calibration tools have become *** those tools,quantile regression(QR)is highly competitive in terms of both flexibility and predictive ***,a long-standing problem of QR is quantile crossing,which greatly limits the interpretability of QR-calibrated *** this point,this study proposes a non-crossing quantile regression neural network(NCQRNN),for calibrating ensemble NWP forecasts into a set of reliable quantile forecasts without *** overarching design principle of NCQRNN is to add on top of the conventional QRNN structure another hidden layer,which imposes a non-decreasing mapping between the combined output from nodes of the last hidden layer to the nodes of the output layer,through a triangular weight matrix with positive *** empirical part of the work considers a solar irradiance case study,in which four years of ensemble irradiance forecasts at seven locations,issued by the European Centre for Medium-Range Weather Forecasts,are calibrated via NCQRNN,as well as via an eclectic mix of benchmarking models,ranging from the naïve climatology to the state-of-the-art deep-learning and other non-crossing *** and stringent forecast verification suggests that the forecasts post-processed via NCQRNN attain the maximum sharpness subject to calibration,amongst all ***,the proposed conception to resolve quantile crossing is remarkably simple yet general,and thus has broad applicability as it can be integrated with many shallow-and deep-learning-based neural networks.

关键词： ensemble weather forecasting forecast calibration non-crossing quantile regression neural network CORP reliability diagram post-processing

A remark on density theorems for Riemann's zeta-function

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Science China Mathematics 2023年第12期66卷 2795-2802页

作者： janos Pintz ELKH Alfréd Rényi Mathematical Institute Budapest H-1053Hungary

The goal of this paper is to give a relatively simple proof of some known zero density estimates for Riemann's zeta-function which are sufficiently strong to break the density hypothesis for Re s>7/*** from a simple but ingenious idea of Halász the proof uses only classical knowledge about the zeta-function,results known for at least hundred years.

关键词： Riemann's zeta-function density hypothesis density theorems

Double balloon enteroscopy examinations in general anesthesia

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World Journal of Gastroenterology 2010年第27期16卷 3418-3422页

作者： Laszlo Zubek Lena Szabo Peter Laszlo Lakatos janos Papp janos Gal Gabor Elo Department of Anaesthesiology and Intensive Therapy Semmelweis University 2nd Department of Pediatrics Semmelweis University 1st Department of Medicine Semmelweis University

AIM:To demonstrate that the double balloon enteroscopy(DBE) can be safely performed in general anesthesia with ***:We performed a retrospective examination between August 2005 and November 2008 amongpatients receiving intubation narcosis due to DBE *** patients were grouped based on sex,age and physical *** records includedduration of anesthesia,quantity of medication usedand anesthesia-related *** determinedthe frequency of complications in the different groupsand their relation with the quantity of medication usedand the duration of ***:We compiled data for 108 cases of general anesthesia with *** did not observeany permanent anesthesia-related complications;themost frequent side effects of anesthesia were hypo-tension(30.55%),desaturation(21.29%),and apnea(17.59%).These complications were significantly more frequent among patients with multiple additional diseases [hypotension(23.1% vs 76.9%,P = 0.005),desaturation(12.3% vs 69.2%,P < 0.001) and apnea(7.7% vs 53.8%,P = 0.001)],however,their incidence was not proportional to the quantity of medication used or the duration of ***:General anesthesia with intubation is definitely a viable option among DBE *** is highly recommended in patients with multiple additional diseases.

关键词： Double balloon enteroscopy General anesthesia Intubation Sedation Patient autonomy

Semi-stable Extensions Over 1-dimensional Bases

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Acta Mathematica Sinica,English Series 2018年第1期34卷 103-113页

作者： janos KOLLAR Johannes NICAISE Chen Yang XU Department of Mathematics Princeton University Department of Mathematics Imperial CollegeSouth Kensington Campus Beijing International Center of Mathematics Research

Given a family of Calabi-Yau varieties over the punctured disc or over the field of Laurentseries, we show that, after a finite base change, the family can be extended across the origin while keeping the canonical class trivial. More generally, we prove similar extension results for families whose log-canonical class is semi-ample. We use these to show that the Berkovich and essential skeleta agree for smooth varieties over C（（t）） with semi-ample canonical class.

关键词： Semi-stable extension Laurent series essential skeleton

Rheology of rock salt for salt tectonics modeling

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Petroleum Science 2016年第4期13卷 712-724页

作者： Shi-Yuan Li janos L.Urai School of Petroleum Engineering China University of PetroleumBeijing Endogene Dynamik Faculty of Geo-Resources and Materials Technology RWTH Aachen University

Numerical modeling of salt tectonics is a rapidly evolving field; however, the constitutive equations to model long-term rock salt rheology in nature still remain controversial. Firstly, we built a database about the strain rate versus the differential stress through collecting the data from salt creep experiments at a range of temperatures（20–200 ℃） in laboratories. The aim is to collect data about salt deformation in nature, and the flow properties can be extracted from the data in laboratory ***, as an important preparation for salt tectonics modeling, a numerical model based on creep experiments of rock salt was developed in order to verify the specific model using the Abaqus package. Finally, under the condition of low differential stresses, the deformation mechanism would be extrapolated and discussed according to microstructure research. Since the studies of salt deformation in nature are the reliable extrapolation of laboratory data, we simplified the rock salt rheology to dislocation creep corresponding to power law creep（n = 5） with the appropriate material parameters in the salt tectonic modeling.

关键词： Rock salt rheology Power law creep Dislocation creep Modeling

Catalytic behavior in propane aromatization using GA-MFI catalyst

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Chinese Journal of Chemical Engineering 2017年第12期25卷 1863-1870页

作者： Alfredo Aloise Enrico Catizzone Massimo Migliori janos B.Nagy Girolamo Giordano University of Calabria Department of Environmental and Chemical Engineering Via P. Bucci 1-87036 Rende CS Italy

Ga-Al-MFI samples were synthesized in hydrothermal conditions from gels of composition 1.08CH3NH2- 0.134TPABr-1SiO2-xAl2O3-yGa2O3-40H2O at 175 ℃ for 7 days, with x = 0.005 and 0.0025, y = 0.005, 0,010 and 0.020. The samples were characterized by XRD, BET measurements, thermal analysis （TGA-DTA） atomic absorption and high resolution solid state MAS 27Al and 71Ga NMR measurements. The aromatization of propane was studied as catalytic test. The activity and selectivity of the catalysts were determined for benzene, toluene and xylenes on the one hand and for methane and ethane on the other hand. The most active sample was obtained with the highest Ga/AI ratio. For this sample, the BTX selectivity obtained by aromatization was always higher than the hydrocracking selectivity leading to methane and ethane. The relative amount of toluene was higher than that of benzene and ofxylenes. The samples were deactivated by coke formation that was revealed more severe for the most active sample,

关键词： Propane aromatization Gallium ZSM-5 Coke formation Catalyst deactivation