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Type XIX collagen: a promising biomarker from the basement membranes

Neural Regeneration Research 2020年第6期15卷 988-995页

作者： Ana C.Calvo Laura moreno Leticia moreno janne m.toivonen Raquel manzano Nora molina miriam de la Torre Tresa López Francisco J.miana-mena maría J.munoz Pilar Zaragoza Pilar Larrodé Alberto García-Redondo Rosario Osta Laboratory of Genetics and Biochemistry(LAGENBIO) University of ZaragozaFaculty of Veterinary SciencesInstituto de Investigación Sanitaria de Aragón(IIS)IA2CIBERNEDZaragozaSpain Hospital Clínico Universitario Lozano Blesa ZaragozaSpain Neurology Department ALS UnitCIBERER U-723Health Research InstituteMadridSpain

Among collagen members in the collagen superfamily,type XIX collagen has raised increasing interest in relation to its structural and biological *** XIX collagen is a Fibril-Associated Collagen with Interrupted Triple helices member,one main subclass of collagens in this *** collagen contains a triple helix composed of three polypeptide segments aligned in parallel and it is associated with the basement membrane zone in different *** molecular structure of type XIX collagen consists of five collagenous domains,COL1 to COL5,interrupted by six non-collagenous domains,NCI to *** most relevant domain by which this collagen exerts its biological roles is NCI domain that can be cleavage enzymatically to release matricryptins,exerting anti-tumor and anti-angiogenic effect in murine and human models of *** physiological conditions,type XIX collagen expression decreases after birth in different tissues although it is necessary to keep its basal levels,mainly in skeletal muscle and hippocampal and telencephalic interneurons in ***,in amyotrophic lateral sclerosis,altered transcript expression levels show a novel biological effect of this collagen beyond its structural role in basement membranes and its anti-tumor and anti-angiogenic *** XIX collagen can exert a compensatory effect to ameliorate the disease progression under neurodegenerative conditions specific to amyotrophic lateral sclerosis in transgenic SOD1 G93 A mice and amyotrophic lateral sclerosis *** novel biological role highlights its nature as prognostic biomarker of disease progression in and as promising therapeutic target,paving the way to a more precise prognosis of amyotrophic lateral sclerosis.

关键词： anti-tumor and anti-angiogenic properties C1 domain COL19A1 gene and protein levels compensatory effect FACIT collagens hippocampal interneurons matricryptins multiplexins NC1 domain regenerative response skeletal muscle type XIX collagen

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Tribological performance of iron- and nickel-base self-lubricating claddings containing metal sulfides at high temperature

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Friction 2022年第12期10卷 2069-2085页

作者： Hector TORRES Tugce CAYKARA Jens HARDELL janne NURmINEN Braham PRAKASH manel RODRIGUEZ RIPOLL AC2T research GmbH Viktor-Kaplan-Straße 2/CWiener Neustadt 2700Austria Department of Applied Physics and mechanical Engineering LuleåUniversity of TechnologyLuleå97187Sweden Castolin Eutectic GmbH Gutenbergstraße 10Kriftel 65830Germany Department of mechanical Engineering Tsinghua UniversityBeijing 100084China

Iron-based coatings with the incorporation of solid lubricants have been prepared by means of laser cladding,in an effort to control friction and decrease tool wear at high temperatures during metal forming *** choice of a Fe-based powder has been considered advantageous,as it can lead to decreased costs compared to nickel-based claddings previously studied by the authors,in addition to having a lower environmental *** particular,the incorporation of transition metal dichalcogenides such as moS_(2) as precursors leads to the encapsulation of silver in Fe-based self-lubricating claddings,resulting in a uniform distribution of the soft metal across the thickness of the *** tribological evaluation of the claddings at high temperatures shows that the addition of lubricious compounds leads to lower friction at room temperature and significantly decreased wear up to 600℃ compared to the unmodified iron-based reference alloy,although higher than similar self-lubricating Ni-based *** order to cast light into these observed differences,the corresponding microstructures,phase composition,and self-lubricating mechanisms have been studied and compared for Fe-and Ni-based claddings having both of them the addition of silver and moS_(2).The results suggest a key role of the formation of protective tribolayers on the counter body during high temperature sliding *** simulation of the phase evolution during solidification reveals that the formation of different chromium-and nickel-based metal sulfides in Fe-and Ni-claddings during laser cladding by the decomposition of moS_(2) plays a key role in determining their tribological behaviour at high temperatures.

关键词： high temperature laser cladding self-lubrication metal forming chromium sulphide moS_(2)

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Diarrhoea-predominant irritable bowel syndrome distinguishable by 16S rRNA gene phylotype quantification

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World Journal of Gastroenterology 2009年第47期15卷 5936-5945页

作者： Anna Lyra Teemu Rinttil janne Nikkil Lotta Krogius-Kurikka Kajsa Kajander Erja malinen Jaana mtt Laura mkel Airi Palva Department of Basic Veterinary Sciences Faculty of Veterinary Medicine University of HelsinkiHelsinki 00014Finland Alimetrics Ltd. EspooEspoo 02920Finland Valio Ltd. Research CentreHelsinki 00370 Finland Institute of Biomedicine Faculty of Medicine University of HelsinkiHelsinki 00014Finland VTT Biotechnology VTTEspoo 02044Finland The Finnish Red Cross Blood ServiceHelsinki 00310Finland Institute of Clinical medicine University of HelsinkiHelsinki 00014Finland

AIm:To study whether selected bacterial 16S ribosomal RNA(rRNA)gene phylotypes are capable of disting- uishing irritable bowel syndrome(IBS). mETHODS:The faecal microbiota of twenty volunteers with IBS,subdivided into eight diarrhoea-predominant (IBS-D),eight constipation-predominant(IBS-C)and four mixed symptom-subtype(IBS-m)IBS patients,and fifteen control subjects,were analysed at three time-points with a set of fourteen quantitative real-timepolymerase chain reaction *** assays targeted 16S rRNA gene phylotypes putatively associated with IBS,based on 16S rRNA gene library sequence analysis. The target phylotypes were affiliated with Actinobac-teria,Bacteroidetes and *** of the target phylotypes had less than 95%similarity to cultured bacterial species according to their 16S rRNA gene *** data analyses were made with repeated-measures ANCOVA-type modelling of the data and principle component analysis(PCA)with linear mixed-effects models applied to the principal component scores. RESULTS:Bacterial phylotypes Clostridium cocleatum 88%,Clostridium thermosuccinogenes 85%,Coprobacillus catenaformis 91%,Ruminococcus bromii-like, Ruminococcus torques 91%,and *** 93%were detected from all samples analysed.A multivariate analysis of the relative quantities of all 14 bacterial 16S rRNA gene phylotypes suggested that the intestinal microbiota of the IBS-D patients differed from other sample *** PCA on the first principal component(PC1),explaining 30.36%of the observed variation in the IBS-D patient group,was significantly altered from all other sample groups(IBS-D vs control, P=0.01;IBS-D vs IBS-m,P=0.00;IBS-D vs IBS-C, P=0.05).Significant differences were also observed in the levels of distinct phylotypes using relative values in proportion to the total amount of bacteria.A phy- lotype with 85%similarity to *** was quantified in significantly different quantities among the IBS-D and control subjects(-4.08±0.90 vs -

关键词： rRNA基因肠道微生物主成分分析细菌种类核糖体RNA 基因序列分析综合征 IBS

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A Common Peptidolytic mechanism for Targeting Peptide Degradation in mitochondria and Chloroplasts

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molecular Plant 2018年第2期11卷 342-345页

作者： Beata Kmiec Rui m.m. Branca monika W. murcha janne Lehtio Elzbieta Glaser Pedro F. Teixeira Department of Biochemistry and Biophysics Stockholm University Arrhenius Laboratories for Natural Sciences 106 91 Stockholm Sweden Clinical Proteomics mass Spectrometry Department of Oncology-Pathology Science for Life Laboratory and Karolinska Institutet Stockholm Sweden ARC Centre of Excellence in Plant Energy Biology University of Western Australia Crawley WA Australia School of molecular Sciences University of Western Australia Crawley WA Australia

Dear Editor mitochondria are multifunctional organelles of eukaryotic cells. Biogenesis and functionality of mitochondria require the import of more than 90% of its resident proteins after synthesis by cytosolic ribos... 详细信息

关键词： PRESEQUENCES PREP

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考虑目标光谱差异的机载离散激光雷达叶面积指数反演

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遥感学报 2020年第12期24卷 1450-1463页

作者：田罗屈永华 Korhonen Lauri Korpela Ilkka Heiskanen janne 北京师范大学遥感科学国家重点实验室北京100875 北京师范大学地理科学学部遥感与工程研究院北京市陆表遥感数据产品工程技术研究中心北京100875 东芬兰大学森林科学学院东芬兰70210 赫尔辛基大学地理科学学部赫尔辛基00100 赫尔辛基大学大气与地球系统研究所赫尔辛基00100

利用间隙率模型反演LAI(Leaf Area Index),需要同时获取冠层间隙率和消光系数,后者与冠层叶倾角分布有关。基于点云数量构建激光雷达穿透指数LPI(LiDAR Penetration Index),用以代替冠层间隙率GF(Gap Fraction),并利用间隙率模型反演冠... 详细信息

利用间隙率模型反演LAI(Leaf Area Index),需要同时获取冠层间隙率和消光系数,后者与冠层叶倾角分布有关。基于点云数量构建激光雷达穿透指数LPI(LiDAR Penetration Index),用以代替冠层间隙率GF(Gap Fraction),并利用间隙率模型反演冠层LAI是利用LiDAR PCD(LiDAR Point Cloud Data)数据反演冠层LAI主要思路。冠层和背景的光谱差异是影响PCD数据中冠层和背景点云数量的重要因素,因此从LPI到GF的校正需要获取背景和冠层的后向散射系数比(μ=ρg/ρv)。本文基于PCD数据中点云强度进行μ值获取,用以实现LPI到GF的校正;在假设区域内叶倾角满足椭球形叶倾角分布的基础上,利用样地尺度下的多角度GF,采用有约束的非线性最优化方法获取椭球形叶倾角分布参数χ,实现冠层消光系数的获取;最后利用间隙率模型实现基于PCD数据的LAI反演。本文探讨了基于PCD数据进行冠层LAI反演时,样地尺度Rxy_Tile、样方尺度Rxy_Plot以及进行背景和冠层分割的高度阈值Ht对模型的影响。结果显示,由于区域内地衣植被广泛覆盖,基于点云强度的μ值接近1,符合区域特点;经过μ值校正后的GF对冠层间隙率具有较好的反映能力(R2=0.78,RmSE=0.09);对于优势种明显的区域,基于样地尺度内多角度GF的χ值反演受样地内冠间大间隙的影响,选择合适的样地尺度能够减小LAI反演过程中的系统性误差;结合地面参考数据,确定的最优Rxy_Tile、Rxy_Plot和Ht分别为950 m、10 m和2.6 m,在此基础上反演的LAI与地面测量数据具有高度的一致性(R2=0.84,RmSE=0.51);与Rxy_Plot相比,基于间隙率模型的LAI反演对Ht的选择更为敏感。

关键词：遥感叶面积指数 LiDAR 间隙率消光系数目标光谱特性

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纳米TiO_2薄膜厚度与不锈钢基体对染料敏化太阳能电池的影响

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功能材料 2008年第10期39卷 1752-1755页

作者：黄光胜 janne Halme 杨芸 Peter Lund 重庆大学材料科学与工程学院 Helsinki University of Technology FIN-02015 HUTFinland

由于用金属做光阳极基体的染料敏化太阳能电池(DSCs)可以制作成柔性电池,成本低并且有广泛的用途,受到越来越多的关注。用导电玻璃和304不锈钢作为基体制作了DSCs,研究了纳米TiO2薄膜厚度和不锈钢基体对DSCs光电转换性能以及稳定性的影... 详细信息

由于用金属做光阳极基体的染料敏化太阳能电池(DSCs)可以制作成柔性电池,成本低并且有广泛的用途,受到越来越多的关注。用导电玻璃和304不锈钢作为基体制作了DSCs,研究了纳米TiO2薄膜厚度和不锈钢基体对DSCs光电转换性能以及稳定性的影响。结果表明,TiO2薄膜厚度在20μm左右,玻璃DSCs具有较高的光电转化效率和稳定性。而不锈钢DSCs的稳定性较差,特别是不锈钢做光阳极基体的DSCs。

关键词：太阳能电池染料敏化不锈钢基体稳定性

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Relative importance of spatial processes and environmental factors in shaping alpine meadow communities

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Journal of Plant Ecology 2011年第4期4卷 249-258页

作者： Qi Li Xue Yang janne Soininen Cheng-Jin Chu Jie-Qi Zhang Kai-Liang Yu Gang Wang mOE Key Laboratory of Arid and Grassland Ecology Lanzhou UniversityLanzhou 730000China Department of Environmental Sciences University of HelsinkiHelsinkiPO Box 65FI 00014Finland

Spatial processes and environmental control are the two distinct,yet not mutually exclusive forces of community structuring,but the relative importance of these factors is controversial due to the speciesspecific dispersal ability,sensitivity towards environmental variables,organism’s abundance and the effect of spatial *** the present paper,we explored spatial versus environmental control in shaping community composition(i.e.b-diversity)and species turnover(*** of b-diversity)at an alpine meadow along a slope aspect gradient on the Qinghai–Tibetan Plateau at different spatial scales of sampling(quadrats and plots),by taking account of seed dispersal mode and *** We examined the relative importance of spatial processes and environmental factors using all species and four additional subsets of selected ***,we attempted to explore the effect of scale(quadrat refers to scale of;0.3 m and plot of;8 m)on their counter *** data were analyzed both by variation partitioning and multiple regressions on distance *** spatial structure was modelled using moran’s eigenvector maps(mEm).Important Findings Both spatial processes and environmental factors were important determinants of the community composition and species *** community composition in the alpine meadow was controlled by spatially structured environment(17.6%),space independent of environment(18.0%)and a negligible effect of environment independent of space(4.4%)at the scale of *** three components contributed 21.8,9.9 and 13.9%,respectively,at the scale of *** balance between the forces at different spatial scales drove community structures along the slope aspect *** importance of environmental factors on b-diversity at alpine meadow increased with scale while that of spatial processes decreased or kept steady,depending on dispersal mode and abundance of species comprising the *** the‘pure’effect of spatial processes on

关键词： alpine meadow dispersal environmental factor slope aspect spatial process spatial scale

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Carbon nanotube micropillars trigger guided growth of complex human neural stem cells networks

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Nano Research 2019年第11期12卷 2894-2899页

作者： Gabriela S.Lorite Laura Yla-Outinen Lauriane Janssen Olli Pitkanen Tiina Joki janne T.Koivisto minna Kellomaki Robert Vajtai Susanna Narkilahti Krisztian Kordas microelectronics Research Unit University of OuluOuluPO BOX 4500FI 90014Finland NeuroGroup BioMediTech and Faculty of Medicine and Health technologyTampere UniversityArvo Ylpön katu 34TampereFI 33520Finland Biomaterials&Tissue Engineering Group BioMediTechFaculty of Medicine and Health TechnologyTampere UniversityPO Box 527TampereFI 33101Finland Department of materials Science and Nanoengineering Rice UniversityP.O.Box 1892HoustonTX77251-1892USA

New strategies for spatially controlled growth of human neurons may provide viable solutions to treat and recover peripheral or spinal cord *** topography cues are known to promote attachment and direct proliferation of many cell types,guided outgrowth of human neurites has been found difficult to achieve so ***,three-dimensional(3D)micropatterned carbon nanotube(CNT)templates are used to effectively direct human neurite stem cell *** exploiting the mechanical flexibility,electrically conductivity and texture of the 3D CNT micropillars,a perfect environment is created to achieve specific guidance of human neurites,which may lead to enhanced therapeutic effects within the injured spinal cord or peripheral *** is found that the 3D CNT micropillars grant excellent anchoring for adjacent neurites to form seamless neuronal networks that can be grown to any arbitrary shape and *** from clear practical relevance in regenerative medicine,these results using the CNT based templates on Si chips also can pave the road for new types of microelectrode arrays to study cell network electrophysiology.

关键词： carbon nanotubes multiple cues guided neurite outgrowth human neural stem cells neuronal networks

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Coating doxycycline on titanium-based implants: Two in vivo studies

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Bioactive materials 2020年第4期5卷 787-797页

作者： maryam Rahmati Ståle Petter Lyngstadaas janne E.Reseland Ingrid Andersbakken Heidi Straume Haugland mónica López-Peña Antonio Gonzalez Cantalapiedra Fernando maria Guzon muñoz Håvard Jostein Haugen Department of Biomaterials Institute of Clinical DentistryUniversity of Oslo0317OsloNorway Universidade de Santiago de Compostela Facultad de Veterinaria Campus Universitarios/n27002LugoSpain

Regardless of the substantial progress in designing titanium-based dental implants and aseptic techniques,infection remains as the most common complication after implantation ***,having a weakened immune system or systematic diseases is not seen as contraindicated for dental implants anymore,controlling the immune system is required to avoid surgical site infections after *** patients have to control the surgical site infections by taking a high daily dose of oral antibiotics after dental *** antibiotics oral administration has many side effects such as gastrointestinal symptoms,skin rashes and *** antibiotics on the biomaterials surface could be a promising solution to reduce these disadvantages through locally releasing antibiotics in a controlled *** aim of this study was to investigate the effects of doxycycline coating layer on titanium-zirconium alloy surfaces in vitro and in *** our previous studies,we demonstrated the chemical presence of doxycycline layer in *** this study,we examined its physical presence using field emission scanning electron microscope and confocal *** also analyzed its controlled released manner using Nano-Drop UV Vis *** in vitro characterization of the coating layer,we evaluated its effects on the implant osseointegration in dogs and *** histological and histomorphometrical results exhibited no significant difference between doxycycline coated and uncoated groups regarding the implants osseointegration and biocompatibility for dental ***,coating a doxycycline layer on TiZr implants could be favorable for reducing or removing the antibiotics oral administration after the implantation surgery.

关键词： Titanium-zirconium Doxycycline Antibiotic Coating SLActive

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Why obese women feel better about their“big”condition when they are pregnant:A qualitative study performed in Sweden

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Open Journal of Obstetrics and Gynecology 2013年第7期3卷 544-552页

作者： Annsofie Adolfsson janne Finnerup Andresen Kristin Brattstrom Edgren School of Health and medical Sciences Orebro UniversityOrebroSweden

Overweight and obesity as measured by the body mass index (BmI) is an increasing problem worldwide according to the World Health Organization (WHO) [1]. Women having a body mass index greater than or equal to30 kg/m2 are considered to be obese and they run a greater risk of complications when they are pregnant. Complications such as high blood pressure, gestational diabetes, risk of intrauterine fetal death and slower delivery when giving birth to the baby are risks that can affect the well being of the woman and the child. According to the study on the women, the midwife’s most important role when meeting with the pregnant obese woman is to inform them about potential risks during pregnancy. The midwife must withhold judgment. For many women living with obesity means that they are not seen as the person they actually are. Obese women feel that they do not conform to the societal ideal of an attractive woman because of their size and because of other people’s prejudices regarding their obesity. When an obese woman becomes pregnant they may feel more comfortable with their standing in society because there is a happy explanation for the size of their abdomen. They experience that they are happy and proud about their stomach and this gives them a sense of relief and belonging.

关键词： Obesity Pregnancy Support midwife

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