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Effects of testosterone and estradiol on anxiety and depressive-like behavior via a non-genomic pathway

Neuroscience Bulletin 2015年第3期31卷 288-296页

作者： Barbora Filova Maria Malinova janka babickova Lubomira Tothova Daniela Ostatnikova Peter Celec Julius Hodosy Institute of Molecular Biomedicine Faculty of Medicine Comenius University Center for Molecular Medicine Slovak Academy of Sciences Institute of Physiology Faculty of Medicine Comenius University Institute of Pathophysiology Faculty of Medicine Comenius University Department of Molecular Biology Faculty of Natural Sciences Comenius University

Besides their known slow genomic effects, testosterone and estradiol have rapid effects in the brain. However, their impact on mood-related behavior is not clear. The aim of this study was to investigate the non-genomic pathway of testosterone and estradiol in the amygdala in relation to anxiety and depressive-like behavior. Sham-operated and gonadectomized male rats （GDX） supplemented with testosterone propionate, estradiol, or olive oil were used. Five minutes after administration, anxiety and depression-like behavior were tested. Estradiol increased anxiolytic behavior in the open-field test compared to the GDX group, but administration of testosterone had no significant effect. Besides, c-Fos expression in the medial nucleus of the amygdala significantly increased after testosterone treatment compared to the GDX group, while no significant difference was observed in the central and the basolateral nuclei of the amygdala in the testosterone-treated group compared to the GDX group. In conclusion, estradiol had an anxiolytic effect via a rapid pathway, but no rapid effect of testosterone on anxiety was found. Further studies elucidating whether the rapid effect is mediated by a non-genomic pathway are needed.

关键词： non-genomic effects steroids anxiety depression c-Fos amygdala

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Pathological and therapeutic interactions between bacteriophages,microbes and the host in inflammatory bowel disease

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World Journal of Gastroenterology 2015年第40期21卷 11321-11330页

作者： janka babickova Roman Gardlik Institute of Molecular Biomedicine Faculty of MedicineComenius University Center for Molecular Medicine Slovak Academy of Sciences

The intestinal microbiome is a dynamic system of interactions between the host and its microbes. Under physiological conditions,a fine balance and mutually beneficial relationship is present. Disruption of this balance is a hallmark of inflammatory bowel disease(IBD). Whether an altered microbiome is the consequence or the cause of IBD is currently not fully understood. The pathogenesis of IBD is believed to be a complex interaction between genetic predisposition,the immune system and environmental factors. In the recent years,metagenomic studies of the human microbiome have provided useful data that are helping to assemble the IBD puzzle. In this review,we summarize and discuss current knowledge on the composition of the intestinal microbiota in IBD,hostmicrobe interactions and therapeutic possibilities using bacteria in IBD. Moreover,an outlook on the possible contribution of bacteriophages in the pathogenesis and therapy of IBD is provided.

关键词： Microbiota Inflammatory bowel disease Gut Bacterio

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