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Treatment of osteoarthritis by implantation of Mg- and WE43-cylinders - A preclinical study on bone and cartilage changes and their influence on pain sensation in rabbits

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Bioactive Materials 2024年第10期40卷 366-377页

作者： Nina Angrisani Christin von der Ahe Regine Willumeit-R¨omer Henning Windhagen Verena Scheper Michael Schwarze Bj¨orn Wiese Heike Helmholz janin reifenrath Hannover Medical School Clinic for Orthopaedic SurgeryLower Saxony Centre for Biomedical EngineeringImplant Research and Development(NIFE)HannoverLower SaxonyGermany Helmholtz-Zentrum Hereon Institute of Metallic BiomaterialsGeesthachtGermany Hannover Medical School Department of OtolaryngologyLower Saxony Centre for Biomedical EngineeringImplant Research and Development(NIFE)HannoverLower SaxonyGermany Hannover Medical School Clinic for Orthopaedic SurgeryLaboratory for Biomechanics and BiomaterialsHannoverLower SaxonyGermany

With its main features of cartilage degeneration, subchondral bone sclerosis and osteophyte formation, osteoarthritisrepresents a multifactorial disease with no effective treatment options. As biomechanical shift in thetrabecular network may be a driver for further cartilage degeneration, bone enhancement could possibly delayOA progression. Magnesium is known to be osteoconductive and already showed positive effects in OA *** aimed to use magnesium cylinders to enhance subchondral bone quality, condition of cartilage and painsensation compared to sole drilling in vivo. After eight weeks of implantation in rabbits, significant increase insubchondral bone volume and trabecular thickness with constant bone mineral density was found indicatingfavored biomechanics. As representative for pain, a higher number of CD271+ vessels were present in controlsamples without magnesium. However, this result could not be confirmed by sensitive, objective lamenessevaluation using a pressure sensing mat and no positive effect could be shown on either cartilage degenerationevaluated by OARSI score nor the presence of regenerative cells in CD271-stained samples. The presented resultsshow a relevant impact of implanted magnesium on key structures in OA pain with missing clinical relevanceregarding pain. Further studies with shifted focus should examine additional structures as joint capsule orosteophytes.

关键词： Magnesium Subchondral bone In vivo Gait analysis μ-computed tomography CD271

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