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Protic ionic liquids/poly(vinylidene fluoride) composite membranes for fuel cell application

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Journal of Energy Chemistry 2021年第2期30卷 197-207,I0008页

作者： Isabel Vazquez-Fernandez Mohamed Raghibi Adnane Bouzina Laure Timperman janick Bigarre Meriem Anouti Laboratoire KM2E Parc de GrandmontUniversite de Tours37200ToursFrance CEA-DAM Le Ripault BP16F-37260MontsFrance

Poly(vinylidene fluoride), PVDF, membranes have attracted considerable attention as polymer electrolytes for fuel cells. This study explores the effect of solvent on the spherulite size and the crystallinity of the polymeric membranes. Based on Hansen solubility parameters theory, the mixture of DMC and DMsO was selected among a dozen of solvents for the preparation of PVDF membranes by thermally induced phase separation. The addition of two protic ionic liquids(PILs), bis(2-ethyl hexyl) ammonium hydrogen phosphate [EHNH_2][H_2PO_4], and imidazolium hexanoate [Im][Hex] to PVDF membranes at concentrations(10% s been investigated by sEM, FTIR, DsC, TGA, EIs, and DMA. The inclusion of ionic liquids into the polymer matrix influences structural parameters(degree of crystallinity and electroactive phases), thermal stability, proton conductivity and mechanical properties of the membranes. The membranes become transparent regardless type of ionic liquid employed. A small amount of ionic liquids increases the degree of crystallinity and facilitates the production of polar β and γ crystals. The proton conductivity mechanism(Grotthuss) is dependent on the ionic liquid structure(due to its selforganization in water) and the content in the PVDF membrane, as well as the membrane water *** behavior has been observed for the two ionic liquids, which stresses the challenge on selecting an appropriate cation and anion combination. The obtained composite membranes exhibited excellent mechanical performance and reduced elastic modulus, with respect to the pure polymer matrix. These results indicate that PVDF/IL composite membranes have a high potential for PEMFC applications.

关键词： PVDF Hansen solubility parameters PILs Proton conductivity

Camouflage Patterning in Maize Leaves Results from a Defect in Porphobilinogen Deaminase

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Molecular Plant 2009年第4期2卷 773-789页

作者： Mingshu Huanga Thomas L. slewinski R. Frank Baker , Diane janick-Buckner Brent Buckner Gurmukh s. Johal David M. Braun Department of Biology Pennsylvania State University University Park PA 16802 Division of science Truman State University Kirksville MO 63501 Department of Botany and Plant Pathology Purdue University West Lafayette IN 47907

Maize leaves are produced from polarized cell divisions that result in clonal cell lineages arrayed along the long axis of the leaf. We utilized this stereotypical division pattern to identify a collection of mutants that form chloroplast pigmentation sectors that violate the clonal cell lineages. Here, we describe the camouflage1 （cfl） mutant, which develops nonclonal, yellow-green sectors in its leaves. We cloned the cfl gene by transposon tagging and determined that it encodes porphobilinogen deaminase （PBGD）, an enzyme that functions early in chlorophyll and heme biosynthesis. While PBGD has been characterized biochemically, no viable mutations in this gene have been reported in plants. To investigate the in vivo function of PBGD, we characterized the cfl mutant. Histological analyses revealed that cfl yellow sectors display the novel phenotype of bundle sheath cell-specific death. Light-shift experiments determined that constant light suppressed cfl sector formation, a dark/light transition is required to induce yellow sectors, and that sectors form only during a limited time of leaf development. Biochemical experiments determined that of 1 mutant leaves have decreased PBGD activity and increased levels of the enzyme substrate in both green and yellow regions. Furthermore, the cfl yellow regions displayed a reduction in catalase activity. A threshold model is hypothesized to explain the cfl variegation and incorporates photosynthetic cell differentiation, reactive oxygen species scavenging, and PBGD function.

关键词： camouflage1 maize porphobilinogen deaminase tetrapyrrole biosynthesis variegated leaf.

Role of endoscopic ultrasound in the molecular diagnosis of pancreatic cancer

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World Journal of Gastroenterology 2014年第31期20卷 10758-10768页

作者： Barbara Bournet Marion Gayral Jérme Torrisani janick selves Pierre Cordelier Louis Buscail Department of Gastroenterology CHU Toulouse Rangueil University of Toulouse INsERM UMR 1037 CHU Toulouse Rangueil University of Toulouse Department of Pathology CHU Toulouse Purpan University of Toulouse

Pancreatic ductal adenocarcinoma remains one of the most deadly types of tumor. Endoscopic ultrasoundguided fine-needle aspiration(EUs-FNA) is a safe, cost-effective, and accurate technique for evaluating and staging pancreatic tumors. However, EUs-FNA may be inconclusive or doubtful in up to 20% of cases. This review underlines the clinical interest of the molecular analysis of samples obtained by EUs-FNA in assessing diagnosis or prognosis of pancreatic cancer, especially in locally advanced tumors. On EUs-FNA materials DNA, mRNA and miRNA can be extracted, amplified, quantified and subjected to methylation assay. Kras mutation assay, improves diagnosis of pancreatic cancer. When facing to clinical and radiological presentations of pseudo-tumorous chronic pancreatitis, wildtype Kras is evocative of benignity. Conversely, in front of a pancreatic mass suspected of malignancy, a mutated Kras is highly evocative of pancreatic adenocarci-noma. This strategy can reduce false-negative diagnoses, avoids the delay of making decisions and reduces loss of surgical resectability. similar approaches are conducted using analysis of miRNA expression as well as Mucin or markers of invasion(s100P, s100A6, PLAT or PLAU). Beyond the diagnosis approach, the prediction of response to treatment can be also investigated form biomarkers expression within EUs-FNA materials.

关键词： Pancreatic ductal adenocarcinoma Endoscopic ultrasound-guided fine-needle aspiration solid pancreatic mass KRAs-mutation assay qPCR analysis Micro-RNA Chronic pancreatitis

Predictive factors of histological response of colorectal liver metastases after neoadjuvant chemotherapy

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World Journal of Gastrointestinal Oncology 2019年第4期11卷 295-309页

作者： Chloé serayssol Charlotte Maulat Florence Breibach Fatima-Zohra Mokrane janick selves Rosine Guimbaud Philippe Otal Bertrand suc Emilie Berard Fabrice Muscari Department of Digestive surgery and Liver Transplantation Toulouse-Rangueil University Hospital Department of Pathology Toulouse University Hospital Department of Radiology Toulouse-Rangueil University Hospital Department of Oncology Toulouse-Rangueil University Hospital The Toulouse Research Methodology support Unit Toulouse University Hospital

BACKGROUND Colorectal cancer is the third most common cancer in men and the second most common in women worldwide. Almost a third of the patients has or will develop liver metastases. Neoadjuvant chemotherapy(NAC) has recently become nearly systematic prior to surgery of colorectal livers metastases(CRLMs). The response to NAC is evaluated by radiological imaging according to morphological *** recently, the response to NAC has been evaluated based on histological criteria of the resected specimen. The most often used score is the tumor regression grade(TRG), which considers the necrosis, fibrosis, and number of viable tumor *** To analyze the predictive factors of the histological response, according to the TRG, on CRLM surgery performed after *** January 2006 to December 2013, 150 patients who had underwent surgery for CRLMs after NAC were included. The patients were separated into two groups based on their histological response, according to Rubbia-Brandt *** on their TRG, each patient was either assigned to the responder(R) group(TRG 1, 2, and 3) or to the non-responder(NR) group(TRG 4 and 5). All of the histology slides were re-evaluated in a blind manner by the same specialized pathologist. Univariate and multivariate analyses were *** seventy-four patients were classified as responders and 76 as *** postoperative mortality rate was 0.7%, with a complication rate of 38%.Multivariate analysis identified five predictive factors of histological *** were predictive of non-response: More than seven NAC sessions, the absence of a radiological response after NAC, and a repeat hepatectomy(P sponse: A rectal origin of the primary tumor and a liver-first strategy(P survival was 57% at 3 yr and 36% at 5 yr. The disease-free survival rates were 14% at 3 yr and 11% at 5 *** factors contributing to a poor prognosis for disease-free survi

关键词： Colorectal liver metastasis Tumor regression grade Neoadjuvant chemotherapy Liver surgery Histological response Hepatectomy

Early plasmapheresis and rituximab for acute humoral rejection after ABO-compatible liver transplantation

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World Journal of Gastroenterology 2009年第27期15卷 3426-3430页

作者： Nassim Kamar Laurence Lavayssière Fabrice Muscari janick selves Céline Guilbeau-Frugier Isabelle Cardeau Laure Esposito Olivier Cointault Marie Béatrice Nogier Jean Marie Peron Philippe Otal Marylise Fort Lionel Rostaing Department of Nephrology Dialysis and Multi-Organ Transplantation CHU RangueilTSA 50032 31059 Toulouse Cédex 9 France INsERM U858 IFR 31 CHU Rangueil TSA 50032 31059 Toulouse Cédex 9 France Department of Liver Transplantation CHU RangueilTSA 50032 31059 Toulouse Cédex 9 France Department of Histopathology CHU PurpanTSA 50032 31059 Toulouse Cédex 9 France Department of Histopathology CHU RangueilTSA 50032 31059 Toulouse Cédex 9 France Department of Histopathology CHU PurpanTSA 50032 31059 Toulouse Cédex 9 France Department of Radiology CHU RangueilTSA 50032 31059 Toulouse Cédex 9 France Department of Immunology CHU RangueilTSA 50032 31059 Toulouse Cédex 9 France INsERM U563 IFR 30 CHU PurpanTSA 50032 31059 Toulouse Cédex 9 France

Acute humoral rejection （AHR） is uncommon after ABO- compatible liver transplantation. Herein, we report two cases of AHR treated with plasmapheresis and rituximab in two ABO-compatible liver-transplant patients with preformed anti-human leukocyte antigen donor-specific antibodies. Patient 1 experienced a biopsy-proven AHR at day 10 post-transplant. she was treated by steroid pulses, and OKT3. Because of persisting signs of biopsy-proven AHR at day 26, she was treated by plasmapheresis and rituximab. Uver enzyme levels did not improve, and she died on day 41. Patient 2 experienced a biopsy-proven AHR on day 10 post-transplant. she was treated by steroid pulses, plasmapheresis, and rituximab. Liver enzymes returned to within normal range 18 d after diagnosis. Uver biopsies, at 3 and 9 mo post-transplant, showed complete resolution of AHR. We conclude that plasmapheresis should be started as soon as AHR is diagnosed, and be associated with a B-cell depleting agent. Rituximab may be considered as a first-line therapy.

关键词： Acute humoral rejection Liver transplantation Donor-specific antibodies Rituximab Plasmapheresis

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极限负荷

电力安全技术 2002年第12期4卷 41-42页

作者： Mark janick 本刊编辑部美国

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摩洛哥香蕉的大棚栽培

国外农学（果树） 1989年第3期 28-30页

作者： janick J. 胡国谦

摩洛哥位于非洲西北部与欧洲相邻,气候条件与美国加州和墨西哥北部相似。摩洛哥以在冬季供应欧洲市场蔬菜和柑桔而在园艺界久负盛名。近年来。在塑料大棚中大力发展香蕉生产是该国园艺业中独具一格的成就。发展历史早在1940年,摩洛哥就... 详细信息

摩洛哥位于非洲西北部与欧洲相邻,气候条件与美国加州和墨西哥北部相似。摩洛哥以在冬季供应欧洲市场蔬菜和柑桔而在园艺界久负盛名。近年来。在塑料大棚中大力发展香蕉生产是该国园艺业中独具一格的成就。发展历史早在1940年,摩洛哥就开始引种香蕉,但其生产区域仅局限于大西洋沿岸的阿加迪尔北部。

关键词：香蕉塑料大棚栽培摩洛哥

Outcomes of nonresected main-duct intraductal papillary mucinous neoplasms of the pancreas

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World Journal of Gastroenterology 2015年第9期21卷 2658-2667页

作者： Mathieu Daudé Fabrice Muscari Camille Buscail Nicolas Carrère Philippe Otal janick selves Louis Buscail Barbara Bournet Department of Gastroenterology CHU Toulouse RangueilUniversity of Toulouse31059 ToulouseFrance Department of Digestive surgery CHU Toulouse Rangueil and PurpanUniversity of Toulouse31059 ToulouseFrance Department of Public Health and Epidemiology CHU Rennes PontchaillouUniversity of Rennes35033 RennesFrance Department of Radiology CHU Toulouse RangueilUniversity of Toulouse31059 ToulouseFrance Department of Pathology CHU Toulouse PurpanUniversity of Toulouse31300 ToulouseFrance

AIM:To compare characteristics and outcomes of resected and nonresected main-duct and mixed intraductal papillary mucinous neoplasms of the pancreas(IPMN).METHODs:Over a 14-year period,50 patients who did not undergo surgery for resectable main-duct or mixed IPMN,for reasons of precluding comorbidities,age and/or refusal,were compared with 74 patients who underwent resection to assess differences in rates of survival,recurrence/occurrence of malignancy,and prognostic *** study participants had dilatation of the main pancreatic duct by ≥ 5 mm,with or without dilatation of the branch *** of the nonsurgical patients showed evidence of mucus upon perendoscopic retrograde cholangiopancreatography or endoscopic ultrasound and/or after fine needle *** the surgical patients,pathologic analysis of resected specimens confirmed a diagnosis of IPMN with involvement of the main pancreatic duct or of both branch ducts as well as the main pancreatic *** and biologic follow-ups were conducted for all patients at least annually,through hospitalization or consultation every six months during the first year of follow-up,together with abdominal imaging analysis(magnetic resonance cholangiopancreatography or computed tomography) and,if necessary,endoscopic ultrasound with or without fine needle ***:The overall five-year survival rate of patients who underwent resection was significantly greater than that for the nonsurgical patients(74% vs 58%; P =0.019).The parameters of age(s) and absence of a nodule were associated with better survival(P s of main pancreatic duct diameter > 10 mm,branch ductdiameter > 30 mm,or presence of extra pancreatic cancers did not significantly influence the *** the nonsurgical patients,pancreatic malignancy occurred in 36% of cases within a mean time of 33 mo(median:29 mo; range:8-141 mo).Comparison of the nonsurgical patients who experienced disease progression

关键词： Main-duct intraductal papillary mucinous neoplasms

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摩洛哥的香蕉温室生产

世界热带农业信息 1989年第5期 24-26页

作者： Jules janick 陆锋

本文介绍了摩洛哥香蕉温室生产的发展历史、现状和未来。

关键词：摩洛哥香蕉温室生产薄膜温室杀线虫剂拉姆种植者每公顷产量塑料薄膜美元