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Comparative utility of vestibular function tests in patients with peripheral and central vestibular dysfunction

journal of Otology 2024年第1期19卷 5-9页

作者： Cameron B.Fattahi Christopher Zaro janice.j.chung Richard F.Lewis Divya A.Chari Department of Otolaryngology-Head and Neck Surgery UMASS Memorial Medical CenterUniversity of Massachusetts Chan Medical SchoolWorcesterMAUSA jenks Vestibular Physiology Laboratory Massachusetts Eye and EarBostonMAUSA Department of Otolaryngology-Head and Neck Surgery Massachusetts Eye and EarHarvard Medical SchoolBostonMAUSA Department of Neurology Harvard Medical SchoolBostonMAUSA

Background: Bithermal caloric irrigation, video head impulse test(vHIT), and rotational testing are commonly used to assess peripheral vestibular function, but the relative clinical utility of each test in differentiating patients with peripheral vestibulopathy is ***: To determine whether(1) the combination of two or more vestibular tests enhances diagnostic utility over a single test;(2) abnormal test results on vestibular tests correlate with one ***: Retrospective analysis of data collected from multidisciplinary vestibular clinics at two academic medical centers from 2016 to ***: 150 patients(54.10 ± 15.09 years, 88 females) were included. No individual test was significantly better at predicting the presence of peripheral vestibular damage(p > 0.05). vHIT test results improved significantly when combined with either the caloric test(p = 0.007) or rotary chair test(p = 0.039). Caloric and rotational testing had high sensitivity(74.65% and 76.06%, respectively) and specificity(83.54% and 78.48%, respectively). vHIT demonstrated excellent specificity(89.87%) but poor sensitivity(47.89%). Caloric, vHIT, and rotary chair tests results did not correlate with one another(p > 0.05).Conclusions: Vestibular function tests have comparable diagnostic utility, yet each offers unique advantages. Caloric and rotational testing may be best suited for screening peripheral damage and vHIT may function ideally as a confirmatory test.

关键词： vestibular patients specificity

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Environmentally adaptive reshaping of plant photomorphogenesis by karrikin and strigolactone signaling

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journal of Integrative Plant Biology 2024年第5期66卷 865-882页

作者： Young-joon Park Bo Eun Nam chung-Mo Park Department of Smart Farm Science Kyung Hee UniversityYongin 17104Korea Departmentof Biological Sciences Seoul National UniversitySeoul 08826Korea Department of Chemistry Seoul National UniversitySeoul 08826Korea

Coordinated morphogenic adaptation of growing plants is critical for their survival and propagation under fluctuating *** morphogenic responses to light and warm temperatures,termed photomorphogenesis and thermomorphogenesis,respectively,have been extensively studied in recent *** photomorphogenesis,plants actively reshape their growth and developmental patterns to cope with changes in light ***,photomorphogenesis is closely associated with diverse growth hormonal ***,accumulating evidence indicates that light-directed morphogenesis is profoundly affected by two recently identified phytochemicals,karrikins(KARs)and strigolactones(SLs).KARs and SLs are structurally related butenolides acting as signaling molecules during a variety of developmental steps,including seed *** receptors and signaling mediators have been identified,and associated working mechanisms have been explored using gene-deficient mutants in various plant *** particular interest is that the KAR and SL signaling pathways play important roles in environmental responses,among which their linkages with photomorphogenesis are most comprehensively studied during seedling *** this review,we focus on how the phytochemical and light signals converge on the optimization of morphogenic *** also discuss molecular mechanisms underlying the signaling crosstalks with an aim of developing potential ways to improve crop productivity under climate changes.

关键词： karrikins morphogenic adaptation photomorphogenesis seedling establishment strigolactones

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Predicting Chemical Immunotoxicity through Data-Driven QSAR Modeling of Aryl Hydrocarbon Receptor Agonism and Related Toxicity Mechanisms

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Environment & Health 2024年第7期2卷 474-485页

作者： Nada j.Daood Daniel P.Russo Elena chung Xuebin Qin Hao Zhu Predicting Chemical Immunotoxicity through Data-Driven QSAR Modeling of Aryl Hydrocarbon Receptor Agonism and Related Toxicity Mechanisms Department of Chemistry and Biochemistry Rowan UniversityGlassboroNew Jersey 08028United States Center for Biomedical Informatics and Genomics Tulane University School of MedicineNew OrleansLouisiana 70112United States Tulane National Primate Research Center Tulane University School of MedicineCovingtonLouisiana 70433United States

Computational modeling has emerged as a time-saving and cost-effective alternative to traditional animal testing for assessing chemicals for their potential ***,few computational modeling studies for immunotoxicity were reported,with few models available for predicting toxicants due to the lack of training data and the complex mechanisms of *** this study,we employed a data-driven quantitative structure–activity relationship(QSAR)modeling workflow to extensively enlarge the limited training data by revealing multiple targets involved in *** this end,a probe data set of 6,341 chemicals was obtained from a high-throughput screening(HTS)assay testing for the activation of the aryl hydrocarbon receptor(AhR)signaling pathway,a key event leading to *** this probe data set against PubChem yielded 3,183 assays with testing results for varying proportions of these 6,341 compounds.100 assays were selected to develop QSAR models based on their correlations to AhR *** individual QSAR models were built for each assay using combinations of four machine-learning algorithms and three molecular fingerprints.5-fold cross-validation of the resulting models showed good predictivity(average CCR=0.73).A total of 20 assays were further selected based on QSAR model performance,and their resulting QSAR models showed good predictivity of potential immunotoxicants from external *** study provides a computational modeling strategy that can utilize large public toxicity data sets for modeling immunotoxicity and other toxicity endpoints,which have limited training data and complicated toxicity mechanisms.

关键词： Immunotoxicity QSAR Machine learning Aryl hydrocarbon receptor Data mining

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Integrating artificial intelligence and high-throughput phenotyping for crop improvement

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journal of Integrative Agriculture 2024年第6期23卷 1787-1802页

作者： Mansoor Sheikh Farooq Iqra Hamadani Ambreen Kumar A Pravin Manzoor Ikra Yong Suk chung Phenomics Laboratory Department of Plant Resources and EnvironmentJeju National UniversityJeju 63234Republic of Korea Council of Scientific&Industrial Research Indian Institute of Integrative MedicinePulwamaJ&K 192301India Animal and Dairy Science University of WisconsinMadisonWI 530706United States of America Division of Fruit Science Faculty of HorticultureSher-e-Kashmir University of Agricultural Sciences and Technology of KashmirSrinagar 190025India

Crop improvement is crucial for addressing the global challenges of food security and sustainable *** advancements in high-throughput phenotyping(HTP)technologies and artificial intelligence(AI)have revolutionized the field,enabling rapid and accurate assessment of crop traits on a large *** integration of AI and machine learning algorithms with HTP data has unlocked new opportunities for crop *** algorithms can analyze and interpret large datasets,and extract meaningful patterns and correlations between phenotypic traits and genetic *** technologies have the potential to revolutionize plant breeding programs by providing breeders with efficient and accurate tools for trait selection,thereby reducing the time and cost required for variety ***,further research and collaboration are needed to overcome the existing challenges and fully unlock the power of HTP and AI in crop *** leveraging AI algorithms,researchers can efficiently analyze phenotypic data,uncover complex patterns,and establish predictive models that enable precise trait selection and crop *** aim of this review is to explore the transformative potential of integrating HTP and AI in crop *** review will encompass an in-depth analysis of recent advances and applications,highlighting the numerous benefits and challenges associated with HTP and AI.

关键词： artificial intelligence crop improvement data analysis high-throughput phenotyping machine learning precision agriculture trait selection

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Self-polarized RGB device realized by semipolar micro-LEDs and perovskite-in-polymer films for backlight applications

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Opto-Electronic Advances 2024年第3期7卷 35-49页

作者： Tingwei Lu Yue Lin Tianqi Zhang Yue Huang Xiaotong Fan Shouqiang Lai Yijun Lu Hao-chung Kuo Zhong Chen Tingzhu Wu Rong Zhang School of Electronic Science and Engineering Fujian Engineering Research Center for Solid-State LightingXiamen UniversityXiamen 361005China Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) Xiamen 361005China Department of Photonics and Graduate Institute of Electro-Optical Engineering College of Electrical and Computer EngineeringYang Ming Chiao Tung UniversityHsinchu 30010China Semiconductor Research Center Hon Hai Research InstituteTaipei 11492China.

In backlighting systems for liquid crystal displays,conventional red,green,and blue(RGB)light sources that lack polarization properties can result in a significant optical loss of up to 50%when passing through a *** address this inefficiency and optimize energy utilization,this study presents a high-performance device designed for RGB polarized *** device employs an array of semipolar blueμLEDs with inherent polarization capabilities,coupled with mechanically stretched films of green-emitting CsPbBr3 nanorods and red-emitting CsPbI3-Cs4PbI6 hybrid *** CsPbBr3 nanorods in the polymer film offer intrinsic polarization emission,while the aligned-wire structures formed by the stable CsPbI3-Cs4PbI6 hybrid nanocrystals contribute to substantial anisotropic emissions,due to their high dielectric *** resulting device achieved RGB polarization degrees of 0.26,0.48,and 0.38,respectively,and exhibited a broad color gamut,reaching 137.2%of the NTSC standard and 102.5%of the Rec.2020 *** compared to a device utilizing c-plane LEDs for excitation,the current approach increased the intensity of light transmitted through the polarizer by 73.6%.This novel fabrication approach for polarized devices containing RGB components holds considerable promise for advancing next-generation display technologies.

关键词： halide perovskite light-emitting-diodes polarized emission nanocrystals stability

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食物回收等级制度帮助处理剩余食物（英文）

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英语画刊(高中版) 2024年第1期 12-14页

作者： Daisy chung Ally j.Levine Clare Trainor

每天,世界各个角落都会丢弃大量的剩余食物,比如吃不完的饭菜、发霉的面包和不能吃的果皮果核等。这不仅造成食物浪费,还会导致环境问题日益严重。Humans grow and waste food at a staggering(令人吃惊的)*** devote half the earth’s...

每天,世界各个角落都会丢弃大量的剩余食物,比如吃不完的饭菜、发霉的面包和不能吃的果皮果核等。这不仅造成食物浪费,还会导致环境问题日益严重。Humans grow and waste food at a staggering(令人吃惊的)*** devote half the earth’s habitable land to food production,while ultimately tossing one-third of that food.

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Number matters:control of mammalian mitochondrial DNA copy number

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journal of Genetics and Genomics 2009年第3期36卷 125-131页

作者： Laura L.Clay Montier janice j.Deng Department of Cellular and Structural Biology The Barshop Institute for Longevity and Aging Studies University of Texas Health Science Center at San Antonio

Regulation of mitochondrial biogenesis is essential for proper cellular functioning. Mitochondrial DNA （mtDNA） depletion and the resulting mitochondrial malfunction have been implicated in cancer, neurodegeneration, diabetes, aging, and many other human diseases. Although it is known that the dynamics of the mammalian mitochondrial genome are not linked with that of the nuclear genome, very little is known about the mechanism of mtDNA propagation. Nevertheless, our understanding of the mode of mtDNA replication has ad- vanced in recent years, though not without some controversies. This review summarizes our current knowledge of mtDNA copy number control in mammalian cells, while focusing on both mtDNA replication and turnover. Although mtDNA copy number is seemingly in excess, we reason that mtDNA copy number control is an important aspect of mitochondrial genetics and biogenesis and is essential for normal cellular function.

关键词： mitochondria DNA copy number DNA turnover replication

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壮通饮通过Nrf2-SCL7A11/xCT-Gpx4通路调控铁死亡改善脑缺血再灌注损伤

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中山大学学报（医学科学版） 2024年第4期45卷 539-548页

作者：王成毅蔡粤芳宁振求邓敏贞孙景波 Sookja Kim chung 李岩程骁广州中医药大学第二临床医学院广东广州510006 深圳市人民医院、南方科技大学第一附属医院、暨南大学第二临床医学院广东深圳518020 省部共建中医湿证国家重点实验室广东广州510120 广东省中医急症研究重点实验室广东广州510120 澳门科技大学医学院中国澳门999078 广西国际壮医医院广西南宁530201

【目的】探究壮通饮通过Nrf2-SCL7A11/xCT-Gpx4通路调控铁死亡对大脑中动脉栓塞模型小鼠脑缺血再灌注损伤的保护作用及其机制。【方法】将C57BL/6j小鼠随机分为假手术组(Sham)、模型组(MCAO)、低剂量壮通饮组(ZTY-L+MCAO),高剂量壮通饮... 详细信息

【目的】探究壮通饮通过Nrf2-SCL7A11/xCT-Gpx4通路调控铁死亡对大脑中动脉栓塞模型小鼠脑缺血再灌注损伤的保护作用及其机制。【方法】将C57BL/6j小鼠随机分为假手术组(Sham)、模型组(MCAO)、低剂量壮通饮组(ZTY-L+MCAO),高剂量壮通饮组(ZTY-H+MCAO),每组5只。其中MCAO组采用硅胶线栓法进行造模,小鼠大脑中动脉栓塞1h,拔出线栓再灌注72h后进行心脏灌注取脑,Sham组除了不插入线栓其余操作同MCAO组。采用Zea-Longa法对小鼠神经功能进行评分;采用TTC染色评估小鼠脑梗死体积;采用HE染色、尼氏染色评估脑损伤程度;采用普鲁士蓝染色评价三价铁离子蓄积水平;qPCR检测铁离子转运相关载体受体TfR1和DMT1、脂质过氧化相关基因ACSL4以及铁死亡标志物PTGS2 mRNA表达;ELISA试剂盒检测4-HNE的含量评估小鼠大脑脂质过氧化水平;Western-blot、免疫荧光检测小鼠脑组织中Nrf2、SCL7A11/xCT、Gpx4蛋白水平。【结果】①壮通饮改善了MCAO/R后小鼠神经功能(P<0.05)和大脑梗死体积(P<0.05)及缓解MCAO/R后大脑皮层细胞病理损伤。②壮通饮减弱了MCAO/R后小鼠大脑组织的三价铁离子蓄积状态;减少MCAO/R后小鼠大脑中与铁离子转运入细胞内相关载体TfR1和DMT1 mRNA的表达(P<0.001);下调MCAO/R后小鼠大脑脂质过氧化物4-HNE含量和组织脂质过氧化物酶ACSL4 mRNA表达(P<0.001);降低MCAO/R后小鼠大脑铁死亡标志物PTGS2 mRNA表达(P<0.001)。③壮通饮增加MCAO/R后Nrf2入核表达(P<0.001),以及增加xCT和Gpx4在神经元中的表达(P<0.001)。【结论】壮通饮能够改善MCAO/R小鼠神经功能和脑梗死体积,缓解大脑皮层细胞病理损伤,影响Nrf2-SCL7A11/xCT-Gpx4通路关键信号分子表达,所以壮通饮改善小鼠MCAO/R损伤的作用机制可能是通过Nrf2-SCL7A11/xCT-Gpx4通路调节铁死亡水平达到的。

关键词：缺血性脑卒中铁死亡壮通饮 Nrf2-SCL7A11/xCT-Gpx4通路机制研究

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Development of a group support system to support collaborative works in value management workshops

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journal of Harbin Institute of Technology(New Series) 2004年第1期11卷 91-97页

作者： chung j K H Dept. of Building and Real Estate Hong Kong Polytechnic University Kowloon Hong Kong China

Value Management (VM) is a rigorous and systematic approach to improve the value and optimise the overall cost of a facility. It identifies opportunities to remove unnecessary costs while assuring that quality, reliability, performance, and other critical factors will meet or exceed the customers’ expectations. It has been widely used in the construction industry in a number of countries. A recent survey, however, revealed several problems that hinder the wider use of this methodology in the industry. To overcome these problems, a feasibility study has been conducted to investigate whether or not a Group Support System (GSS) can support collaborative works in VM workshops. This paper introduces the development and structure of a prototype GSS which is designed to support the collaborative works of stakeholders in VM workshops. It begins with an introduction to the conceptual GSS framework and job plan, illustrating what GSS supports can be provided to VM workshops. This is followed by a detailed description of the GSS prototype system to demonstrate how these supports can be performed as an integrated computer system. The testing of the system is also discussed. The research findings provide strong evidence in supporting the notion of using GSS to improve VM implementation. The information support of GSS has been ranked to be the most useful GSS functions and most of the practitioners interviewed are highly interested in applying GSS to support VM workshops in the future.

关键词： group support system value management workshops construction

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Surface diffusivity of atomic deuterium on Ni_3(Al, Ti)(110) surface with and without boron

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中国有色金属学会会刊：英文版 2002年第4期12卷 649-652页

作者： j.L.Wang Y.W.chung DepartmentofMaterialsScienceandEngineering RobertR.McCormickSchoolofEngineeringandAppliedScienceNorthwesternUniversityEvanstonIL60208USA DepartmentofMaterialsScienceandEngineering RobertR.McCormic

The electron stimulated desorption was used to measure the surface diffusivity of atomic deuterium on clean and boron modified Ni 3(Al, Ti)(110) surfaces. Boron dosing was performed using a solid state boron ion source. Earlier studies showed that boron dissociates water readily at temperatures as low as 130?K and that the resulting atomic hydrogen is bound to the surface strongly. The surface diffusion coefficient of atomic D on 0.05 monolayer boron modified surface was measured to be about 10 times smaller than that on the clean surface. This slower diffusion of atomic hydrogen may explain why boron improves the ductility of polycrystalline Ni 3Al in moist environments.

关键词：氘原子表面扩散硼 Ni3Al Ni3Ti 金属间化合物

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