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Comparative utility of vestibular function tests in patients with peripheral and central vestibular dysfunction

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journal of Otology 2024年第1期19卷 5-9页

作者： Cameron B.Fattahi Christopher Zaro janice j.Chung Richard F.Lewis Divya A.Chari Department of Otolaryngology-Head and Neck Surgery UMASS Memorial Medical CenterUniversity of Massachusetts Chan Medical SchoolWorcesterMAUSA jenks Vestibular Physiology Laboratory Massachusetts Eye and EarBostonMAUSA Department of Otolaryngology-Head and Neck Surgery Massachusetts Eye and EarHarvard Medical SchoolBostonMAUSA Department of Neurology Harvard Medical SchoolBostonMAUSA

Background: Bithermal caloric irrigation, video head impulse test(vHIT), and rotational testing are commonly used to assess peripheral vestibular function, but the relative clinical utility of each test in differentiating patients with peripheral vestibulopathy is ***: To determine whether(1) the combination of two or more vestibular tests enhances diagnostic utility over a single test;(2) abnormal test results on vestibular tests correlate with one ***: Retrospective analysis of data collected from multidisciplinary vestibular clinics at two academic medical centers from 2016 to ***: 150 patients(54.10 ± 15.09 years, 88 females) were included. No individual test was significantly better at predicting the presence of peripheral vestibular damage(p > 0.05). vHIT test results improved significantly when combined with either the caloric test(p = 0.007) or rotary chair test(p = 0.039). Caloric and rotational testing had high sensitivity(74.65% and 76.06%, respectively) and specificity(83.54% and 78.48%, respectively). vHIT demonstrated excellent specificity(89.87%) but poor sensitivity(47.89%). Caloric, vHIT, and rotary chair tests results did not correlate with one another(p > 0.05).Conclusions: Vestibular function tests have comparable diagnostic utility, yet each offers unique advantages. Caloric and rotational testing may be best suited for screening peripheral damage and vHIT may function ideally as a confirmatory test.

关键词： vestibular patients specificity

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Number matters:control of mammalian mitochondrial DNA copy number

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journal of Genetics and Genomics 2009年第3期36卷 125-131页

作者： Laura L.Clay Montier janice j.Deng Department of Cellular and Structural Biology The Barshop Institute for Longevity and Aging Studies University of Texas Health Science Center at San Antonio

Regulation of mitochondrial biogenesis is essential for proper cellular functioning. Mitochondrial DNA （mtDNA） depletion and the resulting mitochondrial malfunction have been implicated in cancer, neurodegeneration, diabetes, aging, and many other human diseases. Although it is known that the dynamics of the mammalian mitochondrial genome are not linked with that of the nuclear genome, very little is known about the mechanism of mtDNA propagation. Nevertheless, our understanding of the mode of mtDNA replication has ad- vanced in recent years, though not without some controversies. This review summarizes our current knowledge of mtDNA copy number control in mammalian cells, while focusing on both mtDNA replication and turnover. Although mtDNA copy number is seemingly in excess, we reason that mtDNA copy number control is an important aspect of mitochondrial genetics and biogenesis and is essential for normal cellular function.

关键词： mitochondria DNA copy number DNA turnover replication

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Can two-dimensional graphdiyne-based materials be novel materials for perovskite solar cell applications?

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Materials Futures 2023年第2期2卷 142-151页

Two-dimensional(2D)graphdiyne(GDY)-based materials have attracted attention in the solar cell research community owing to their unique physicochemical properties and hydrophobic nature which can serve as moisture resistance from the surrounding *** from these,the performance and stability ofperovskite solar cells(PSCs)can be greatly improved via the addition of 2D GDY-based *** mini-review summarizes the recent development of 2D GDY-based materials for PSC *** roles of 2D GDY-based materials,such as hole transporting material,electron transporting material,dopant material in perovskite film and interfacial layer,are discussed in ***,we provide future perspectives in this field,aiming to help further progress efficient and stable 2D GDY-based materials in PSCs.

关键词： two-dimensional material graphdiyne perovskite solar cells power conversion efficiency stability

MRI评估的左心室心肌质量与长期心血管事件风险的关系:多种族动脉粥样硬化研究(MESA)

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国际医学放射学杂志 2019年第6期 736-737页

作者： N.K Boehm R.Kronmal j.eng A.Folsom G.Burke j.j.Carr 蒋梦迪 Department of Radiology Kantonsspital Graubuenden

摘要目前很少有基于MRI量化的左心室心肌质量提高预测长期心血管事件的多种族队列研究。目的在一项前瞻性、多种族人群队列研究中,评估左心室心肌质量增加与

关键词：左心室心肌 MRI 心血管事件动脉粥样硬化

Anemia and iron deficiency in gastrointestinal and liver conditions

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World journal of Gastroenterology 2016年第35期22卷 7908-7925页

作者： jürgen Stein Susan Connor Garth Virgin David eng Hui Ong Lisandro Pereyra Interdisciplinary Crohn Colitis Centre Rhein-Main Frankfurt am Main Department of Gastroenterology and Clinical Nutrition DGD Clinics Sachsenhausen Frankfurt am Main60594 Frankfurt Germany Department of Gastroenterology and Hepatology Liverpool Hospital South Western Clinical School University of New South Wales Vifor Pharma Flughofstrasse 61 CH-8152 Zurich Switzerland Division of Gastroenterology and Hepatology University Medicine Cluster National University Hospital Servicio de Gastroenterología y Endoscopia Hospital Alemán

Iron deficiency anemia(IDA) is associated with a number of pathological gastrointestinal conditions other than inflammatory bowel disease, and also with liver disorders. Different factors such as chronic bleeding, malabsorption and inflammation may contribute to IDA. Although patients with symptoms of anemia are frequently referred to gastroenterologists, the approach to diagnosis and selection of treatment as well as follow-up measures is not standardized and suboptimal. Iron deficiency, even without anemia, can substantially impact physical and cognitive function and reduce quality of life. Therefore, regular iron status assessment and awareness of the clinical consequences of impaired iron status are critical. While the range of options for treatment of IDA is increasing due to the availability of effective and well-tolerated parenteral iron preparations, a comprehensive overview of IDA and its therapy in patients with gastrointestinal conditions is currently lacking. Furthermore, definitions and assessment of iron status lack harmonization and there is a paucity of expert guidelines on this topic. This review summarizes current thinking concerning IDA as a common co-morbidity in specific gastrointestinal and liver disorders, and thus encourages a more unified treatment approach to anemia and iron deficiency, while offering gastroenterologists guidance on treatment options for IDA in everyday clinical practice.

关键词： Iron deficiency anemia Gastrointestinal bleeding Nonsteroidal anti-inflammatory drugs Gastritis Infection Bariatric surgery Celiac disease Gastrointestinal neoplasm Chronic hepatitis Nonalcoholic fatty liver disease

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从羊的结肠提取和纯化血管活性肠肽

中国生物化学与分子生物学报 1987年第3期 285-287页

作者：杜宝恒,j.eng,R.S.Yalow 天津医学院附属医院消化科 Solomon A.Berson Research Laboratory.VAMC.New York USA Solomon A.Berson Research Laboratory.VAMC.New York USA

1972年Said和Mutt二氏从猪的肠组织中发现一种能使周围和内脏血管强烈扩张的多肽,命名为血管活性肠肽(Vasoactive Intestinal Peptide,简称VIP),由28个氨基酸组成。其中以精氨酸和赖氨酸占优势,属于碱性多肽,与胰泌素、胰高糖素和肠抑... 详细信息

1972年Said和Mutt二氏从猪的肠组织中发现一种能使周围和内脏血管强烈扩张的多肽,命名为血管活性肠肽(Vasoactive Intestinal Peptide,简称VIP),由28个氨基酸组成。其中以精氨酸和赖氨酸占优势,属于碱性多肽,与胰泌素、胰高糖素和肠抑胃肽同属一族。近来发现VIP是一种重要的脑肠肽,在神经系统传导和胃肠胰的生理、病理活动中占有

关键词： TFA 提取液 VIP 活性物肠组织结肠大肠

高级影像检查在老年人X线隐匿性髋部骨折中的应用:系统综述及荟萃分析

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国际医学放射学杂志 2020年第6期 731-732页

作者：董力宁 A.Haj-Mirzaian j.eng R.Khorasani A.S.Raja A.S.Levin S.E.Smith The Russell H.Morgan Department of Radiology and Radiological Science Johns Hopkins University School of Medicine

摘要临床上怀疑有髋部骨折的老年病人中,X线摄影未发现但需行手术治疗的髋部骨折(即外科髋部骨折)的总发生率仍不清楚。此外,对这些病人进一步行高级影像检查的

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大腿肌肉变化在膝关节骨关节炎预后中的作用：骨关节炎倡议计划数据

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国际医学放射学杂志 2022年第6期45卷 736-737页

作者： B.Mohajer M.Dolatshahi K.Moradi N.Najafzadeh j.eng B.Zikria 王明月

摘要关于定量大腿肌肉 MRI 标志物与膝关节骨关节炎（KOA）结局之间关系的纵向数据很少，其相关性对于大腿肌肉主导的干预措施具有重要临床意义。目的测量与 KOA

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The effects of exercise on cognition in Parkinson’s disease: a systematic review

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Translational Neurodegeneration 2014年第1期3卷 21-33页

作者： Danielle K Murray Matthew A Sacheli janice j.eng A jon Stoessl Pacific Parkinson’s Research Centre and Department of Medicine Division of NeurologyUniversity of British Columbia&Vancouver Coastal HealthVancouverBC V6T 2B5Canada Department of Physical Therapy University of British ColumbiaVancouverBC V6T 1Z3Canada

Cognitive impairments are highly prevalent in Parkinson’s disease(PD)and can substantially affect a patient’s quality of *** impairments remain difficult to manage with current clinical therapies,but exercise has been identified as a possible *** objective of this systematic review was to accumulate and analyze evidence for the effects of exercise on cognition in both animal models of PD and human *** systematic review was conducted according to the Preferred Reporting Items for Systematic reviews and Meta-Analyses(PRISMA)*** original reports were identified,including six pre-clinical animal studies and eight human clinical *** studies used various exercise interventions and evaluated many different outcome measures;therefore,only a qualitative synthesis was *** evidence from animal studies supports the role of exercise to improve cognition in humans through the promotion of neuronal proliferation,neuroprotection and *** findings warrant more research to determine what roles these neural mechanisms play in clinical *** reports on cognitive changes in clinical studies demonstrate that a range of exercise programs can improve cognition in *** each clinical study demonstrated improvements in a marker of cognition,there were limitations in each study,including non-randomized designs and risk of *** Grading of Recommendations Assessment,Development and Evaluation(GRADE)system was used and the quality of the evidence for human studies were rated from“low”to“moderate”and the strength of the recommendations were rated from“weak”to“strong”.Studies that assessed executive function,compared to general cognitive abilities,received a higher GRADE ***,this systematic review found that in animal models exercise results in behavioral and corresponding neurobiological changes in the basal ganglia related to *** clinical studies showed that various types of exerc

关键词： Parkinson’s disease Exercise Cognition Humans Animals