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Hepatitis E virus in patients with acute severe liver injury

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World Journal of Hepatology 2014年第6期6卷 426-434页

作者： Claire Louise Crossan Kenneth J Simpson Darren G Craig Christopher Bellamy janice Davidson Harry R Dalton Linda Scobie Department of Life Sciences Glasgow Caledonian UniversityGlasgowG4 0BAUnited Kingdom Scottish Liver Transplant Unit Royal Infirmary of EdinburghEdinburghEH16 4SAUnited Kingdom Department of Pathology University of EdinburghEdinburghEH16 4SBUnited Kingdom Gastrointestinal Unit Royal Cornwall Hospitaland European Centre for the Environment and Human HealthUniversity of Exeter Medical SchoolTruroTR1 3HDUnited Kingdom Department of Life Sciences School of Health and Life SciencesGlasgow Caledonian UniversityGlasgowG40BAUnited Kingdom

AIM: To examine the incidence of hepatitis E(HepE) in individuals with acute liver injury severe enough to warrant treatment at a transplant ***: Hepatitis E virus(HEV) is an emerging pathogen in developed countries causing severe illness, particularly in immunocompromised patients or those with underlying chronic liver disease. HepE infection isoften under diagnosed, as clinicians can be reluctant to test patients who have not travelled to regions traditionally considered hyperendemic for HepE. There are few data regarding the significance of HEV in patients with very severe acute liver injury in developed countries. Eighty patients with acute severe liver injury attending the Scottish Liver Transplant unit were tested for HEV and anti-HEV IgG and IgM. Severe acute liver injury was defined as a sudden deterioration in liver function confirmed by abnormal liver function tests and coagulopathy or presence of hepatic encephalopathy. Eighty percent of these patients were diagnosed with paracetomol overdose. No patients had a history of chronic or decompensated chronic liver disease at time of sampling. IgG positive samples were quantified against the World Health Organization anti-HEV IgG standard. Samples were screened for HEV viral RNA by quantitative reverse transcription polymerase chain ***: Four cases of hepatitis E were identified. Three of the four cases were only diagnosed on retrospective testing and were initially erroneously ascribed to drug-induced liver injury and decompensated chronic liver disease, with the cause of the decompensation uncertain. One case was caused by HEV genotype 1 in a traveller returning from Asia, the other three were autochthonous and diagnosed on retrospective testing. In two of these cases(where RNA was detected) HEV was found to be genotype 3, the most prevalent genotype in developed countries. Three patients survived, two of whom had been misdiagnosed as having drug induced liver injury. The fourth patient

关键词： Virology Infection Acute liver injury Hepatitis E virus

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妇科学 2版

丛书名：袖珍诊疗彩色图谱系列

2002年

作者：（英）janice Rymer等孙倩等翻译

本书内容包括：妇科诊断，检验技术，月经周期，避孕，妇科感染，子宫内膜异位症，不孕症，子宫良性和恶性疾病，绝经和更年期等。

ISBN: (纸本)7543313901

本书内容包括：妇科诊断，检验技术，月经周期，避孕，妇科感染，子宫内膜异位症，不孕症，子宫良性和恶性疾病，绝经和更年期等。

关键词：妇科学图谱

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可爱的虫子

Long-Term and Immediate Impacts of Health Emergency and Disaster Risk Management(Health-EDRM) Education Interventions in a Rural Chinese Earthquake-Prone Transitional Village

丛书名：边玩边学

2000年

作者：（美）janice Vancleave 郭建玲译

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International Journal of Disaster Risk Science 2018年第3期9卷 319-330页

作者： Emily Ying Yang Chan janice Ying-en Ho Zhe Huang Jean Hee Kim Holly Ching Yu Lam Phoebe Pui Wun Chung Carol Ka Po Wong Sida Liu Sharon Chow Collaborating Centre for Oxford University and CUHK for Disaster and Medical Humanitarian Response (CCOUC) The Chinese University of Hong Kong Nuffield Department of Medicine University of Oxford The Jockey Club School of Public Health and Primary Care The Chinese University of Hong Kong Franois-Xavier Bagnoud Center for Health & Human Rights Harvard University Integrated Research on Disaster Risk (IRDR) International Centre of Excellence–CCOUC (ICoE-CCOUC) Wu Zhi Qiao (Bridge to China) Charitable Foundation

Ma'an Qiao Village, a Dai and Yi ethnic minority-based community in Sichuan Province, China sustained complete infrastructure devastation during the 2008 Panzhihua earthquake. Health emergency and disaster risk management(Health-EDRM) education intervention programs were implemented in 2010 and 2011. This serial cross-sectional survey study aimed to examine the immediate and long-term impacts of the Health-EDRM interventions in this remote rural community. The findings demonstrate knowledge improvement in areas of water and sanitation, food and nutrition, and disaster preparedness immediately after the Health-EDRM education interventions. Temporal stability of knowledge retention was observed in household hygiene and waste management and smoking beliefs in 2018, 7 years after the *** important findings include knowledge uptake pattern differences of oral rehydration solution(ORS) between earthquake-prone and flood-prone communities. Usage of Internet and mobile technology for accessing disaster-related information was found to be independent of gender and income. Overall, this study demonstrated the knowledge improvement through Health-EDRM education interventions in a remote rural community. Promoting behavioral changes through interventions to raise awareness has the potential to reduce health risks in transitional post-disaster settings. Future programs should aim to identify evidence-based practices and explore how technology can support Health-EDRM education among vulnerable subgroups.

关键词： Earthquake Transitional community Disaster preparedness kit Disaster risk reduction Health emergency and disaster risk management Rural China Sichuan

A New Technique for Use in Culturing Prokaryotes Comprising the Mouse Intestinal Microbiome

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Advances in Microbiology 2023年第3期13卷 119-147页

作者： Everest Uriel Castaneda Kelly Carroll janice Speshock Jeff Brady Department of Biological Sciences Tarleton State University Stephenville Texas USA Texas A&M AgriLife Research and Extension Center Stephenville Texas USA

The microbiome has a profound impact on host fitness. pH, oxygen, nutrients, or other factors such as food or pharmaceuticals, subject the microbiome to variations in the gastrointestinal tract. This variation is a cause for concern given dysbiosis of the microbiome is correlated with various disease states. Currently, much research relies on model organisms to study microbial communities since intact microbiomes are challenging to utilize. The objective of this study is to culture an explanted colon microbiome of 4 Balb/c mice to develop an in vitro tool for future microbiome studies. We cultured homogenates of the distal colons of 4 mice in trans-well culture dishes. These dishes were incubated for 24 hours in two different oxygen concentration levels and the pH was compared before and after incubation of the cultures. To analyze the integrity of the microbiome, we utilized massively paralleled DNA sequencing with 16S metagenomics to characterize fecal and colon samples to speculate whether future studies may utilize feces in constructing an in vitro microbial community to spare animal lives. We found that pH and familial relationships had a profound impact on community structure while oxygen did not have a significant influence. The feces and the colon were similar in community profiles, which lends credence to utilizing feces in future studies. The gut microbiome is of great interest and great importance for studies in a variety of different diseases. Many laboratories do not have access to germ-free mice, which is one optimal way to study mammalian microbiomes, but this technique allowed for the in vitro culturing of a majority of the prokaryotes isolated from the colons of mice. This may allow an alternative to study the interactions of this very diverse population of microorganisms without the need for germ-free conditions.

关键词： Microbiome ex vivo Massively Paralleled Sequencing pH Oxygen

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野生稻根际微生物对栽培稻抗旱性的研究

野生稻根际微生物对栽培稻抗旱性的研究

作者： janice álvarez López 吉林农业大学

学位级别：硕士

众所周知,干旱曾经造成过几次重大的饥荒。对亚洲雨水灌溉地区的水稻产量具有重大的破坏性影响。有研究发现野生作物在恶劣环境下仍可正常的生长。野生稻在干旱、低温、盐碱等胁迫下表现出比栽培稻在生长状况方面显著的优势,有研究表明... 详细信息

众所周知,干旱曾经造成过几次重大的饥荒。对亚洲雨水灌溉地区的水稻产量具有重大的破坏性影响。有研究发现野生作物在恶劣环境下仍可正常的生长。野生稻在干旱、低温、盐碱等胁迫下表现出比栽培稻在生长状况方面显著的优势,有研究表明胁迫下野生稻内部及根际有些优势菌群辅助了植物抵抗逆境。鉴于此,我们在干旱胁迫下对东乡野生稻根际微生物和内生微生物进行了分离和筛选,制备成菌剂,作用于栽培稻东稻4,期望能有助于栽培稻在干旱条件下的生长和生存。研究结果如下:1.我们种植了东乡野生稻,并给予干旱胁迫,然后筛选分离抗旱的内生菌和根际菌。利用PEG 6000模拟干旱胁迫,浓度分别为30.3%(-1 MPa)和43.8%(-2 MPa),筛选出多株具有研究潜力的菌株。测定各种抗逆指标后,选择3株优良菌种,分别命名为P1、N1g和N2。通过形态学、生理生化和分子生物学鉴定手段,P1鉴定为卡贝肠杆菌Enterobacter kobei,N1g鉴定为丰盈芽孢杆菌Bacillus toyonensis,N2鉴定为阿斯氏肠杆菌Enterobacter asburiae。经过测试,发现这些菌株在促进植物生长方面也具有一定的研究潜力,如具有ACC脱氨酶活性、溶解磷酸盐(P)和钾盐(K)、产氨(NH)、产铁载体和氢氰酸(HCN)等。2.以东稻4号栽培稻为研究材料,自制菌剂采用叶面喷施,研究其对水稻抗旱性和促生长的影响。盆栽实验设置为常规栽培组CK(+)、干旱对照组CK(-)、N1g+N2处理组、P1处理组。研究结果表明,菌剂处理组与干旱对照组CK(-)相比,植株的形态、生理生化指标均有显著提高,表现在地上部分高度、地上部分和根的鲜重、叶片相对含水量、叶面积指数、光合色素、抗氧化等指标上,同时发现MDA含量显著降低。在干旱胁迫下的两组实验中,接种菌株P1和N1g+N2的处理与常规栽培组CK(+)之间的一些指标没有显著差异,表明菌剂的抗旱能力非常强。与干旱对照组CK(-)相比,P1组叶片相对含水量增加297.8%。与常规栽培组CK(+)相比栽培稻根系鲜重和干重也有显著增加,接种N1g+N2的水稻根系鲜重增加了42.9%;干重增加了34.1%。结论,N1g+N2菌株组合和P1菌株单独叶面喷施在干旱条件下都能够很好地帮助栽培稻抗逆和促生。进而表明野生稻根际微生物和内生微生物在干旱条件下用于促进植物生长发育很有前景、很有意义。

关键词：野生稻细菌干旱胁迫栽培稻促生

多蒴灰藓(苔藓植物门：藓纲)对短期极端温度的生理响应(英文)

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植物研究 2011年第1期31卷 40-48页

作者：沈蕾郭水良杨武曹同 janice M.Glime 上海师范大学生命与环境科学学院上海200234 浙江师范大学化学与生命科学学院金华321004 Department of biological Sciences Michigan Technological UniversityHoughtonMI 49931U.S.A.

近年来,藓类植物作为一类模式植物,在分子生物学、抗性生理学研究中受到重视,因此,开展逆境条件下藓类植物渗透调节物质和膜保护系统相关指标变化的研究,将为了解藓类植物对逆境条件适应的生理机制提供基础资料。多蒴灰藓(Hypnum fertil... 详细信息

近年来,藓类植物作为一类模式植物,在分子生物学、抗性生理学研究中受到重视,因此,开展逆境条件下藓类植物渗透调节物质和膜保护系统相关指标变化的研究,将为了解藓类植物对逆境条件适应的生理机制提供基础资料。多蒴灰藓(Hypnum fertile Senden.)分布广泛,生境多样,本文研究了低温(5℃)和高温(40℃和60℃)在不同胁迫时间(0、1、2、4、6、8 h)下多蒴灰藓体内可溶性糖、游离脯氨酸、丙二醛(MDA)含量和过氧化物酶(POD)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)活性的变化,以期了解多蒴灰藓对不同温度条件的适应能力和响应的生理机制。结果表明:在5℃低温处理下,随处理时间延长,多蒴灰藓的可溶性糖含量逐渐增加,在高温处理下,呈现先升高后降低的趋势;游离脯氨酸、MDA在低温和高温胁迫下随处理时间延长都逐渐升高。CAT在5℃低温处理下活性逐渐升高,在40℃高温处理下先升高后降低,在60℃高温处理下则迅速降低,6 h后酶完全丧失活性。SOD的活性在5℃低温处理下随处理时间延长逐渐降低,在高温处理下则表现出先升高后降低趋势,40℃高温胁迫下6 h达到最大值,60℃胁迫下0.5 h达到最大值。POD在5℃和40℃处理下活性随处理时间延长逐渐升高,在60℃高温处理下则先升高后降低。这些结果表明,多蒴灰藓适生于20℃左右的温度条件下,60℃高温对多蒴灰藓的伤害明显,与高温相比,多蒴灰藓更适合生长于低温环境;多蒴灰藓通过增加游离脯氨酸以提高对温度逆境的适应;POD和CAT在多蒴灰藓抵御低温胁迫时可能起着主要作用,而SOD则在其抵御高温胁迫时起一定的作用。

关键词：多蒴灰藓温度胁迫抗氧化酶渗透调节物质

Same day yttrium-90 radioembolization with single photon emission computed tomography/computed tomography: An opportunity to improve care during the COVID-19 pandemic and beyond

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World Journal of Gastrointestinal Oncology 2021年第5期13卷 440-452页

作者： Mohammad Elsayed Mohammad Loya James Galt David M Schuster Zachary L Bercu janice Newsome David Brandon Sonia Benenati Keywan Behbahani Richard Duszak Ila Sethi Nima Kokabi Division of Interventional Radiology and Image-Guided Medicine Department of Radiology and Imaging SciencesEmory University School of MedicineAtlantaGA 30322United States Division of Nuclear Medicine and Molecular Imaging Department of Radiology and Imaging SciencesEmory University School of MedicineAtlantaGA 30322United States

BACKGROUND The coronavirus disease 2019(COVID-19)pandemic has made it more challenging for patients to undergo yttrium-90(Y-90)radioembolization(RE).Same day Y-90 RE provides an opportunity to minimize logistical challenges and infection risk associated with COVID-19,thus improving patient *** To describe the use of same day Y-90 RE with routine single photon emission computed tomography/computed tomography(SPECT/CT)in order to optimize *** All patients were selected for Y-90 RE through a multidisciplinary tumor board,and were screened and tested for COVID-19 infection per institutional protocol.A same day procedure was developed,consisting of angiography,imaging,and Y-90 resin particle *** SPECT/CT after technetium-99m macroaggregated albumin(Tc-99m MAA)administration was performed for assessment of arterial supply,personalized dosimetry,and extrahepatic ***-treatment Y-90 bremsstrahlung SPECT/CT was performed for confirmation of particle delivery,by utilization of energy windowing to limit signal from previously administered Tc-99m MAA *** A total of 14 patients underwent same day Y-90 RE between March and June *** lung shunt fraction was 6.13%(range 3.5%-13.1%).Y-90 RE was performed for a single lesion in 7 patients,while the remaining 7 patients had treatment of multifocal *** largest lesion measured 8.3 *** patients tolerated the procedure well and were discharged the same *** Same day Y-90 RE with resin-based microspheres is feasible,and provides an opportunity to mitigate infection risk and logistical challenges associated with the COVID-19 pandemic and *** recommend consideration of SPECT/CT,especially among patients with complex malignancies,for the potential to improve outcomes and eligibility of patients to undergo same day Y-90 RE.

关键词： Yttrium-90 radioembolization Same day Selective internal radiotherapy Transarterial radioembolization Single photon emission computed tomography/computed tomography Dosimetry COVID-19

Electro-tactile stimulation (ETS) enhances cochlear-implant Mandarin tone recognition

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2017年第4期3卷 219-223页

作者： Juan Huang janice Chang Fan-Gang Zeng Mind and Brain Institute Department of Biomedical Engineering Johns Hopkins UniversityBaltimore MD 21218 USA Department of Otorhinolaryngology Head and Neck Surgery University of California Los Angeles CA90095 USA Department of Anatomy and Neurobiology Center for Hearing Research 110 Medical Science EUniversity of California Irvine CA 92697-5320 USA Biomedical Engineering Center for Hearing Research 110 Medical Science E University of CaliforniaIrvine CA 92697-5320 USA Cognitive Sciences Center for Hearing Research 110 Medical Science E University of CaliforniaIrvine CA 92697-5320 USA Otorhinolaryngology Head and Neck Surgery Center for Hearing Research 110 Medical Science EUniversity of California Irvine CA 92697-5320 USA

Objective:Electro-acoustic stimulation (EAS) is an effective method to enhance cochlear-implant performance in individuals who have residual low-frequency acoustic *** help the majority of cochlear implant users who do not have any functional residual acoustic hearing,electro-tactile stimulation (ETS) may be used because tactile sensation has a frequency range and perceptual capabilities similar to that produced by acoustic stimulation in the EAS ***:Following up the first ETS study showing enhanced English sentence recognition in noise,1 the present study evaluated the effect of ETS on Mandarin tone recognition in noise in two groups of adult Mandarin-speaking *** first group included 11 normalhearing individuals who listened to a 4-channel,noise-vocoded,cochlear-implant *** second group included 1 unilateral cochlear-implant user and 2 bilateral users with each of their devices being tested *** groups participated in a 4-alternative,forced-choice task,in which they had to identify a tone that was presented in noise at a 0-dB signal-to-noise ratio via electric stimulation (actual or simulated cochlear implants),tactile stimulation or the combined ***:While electric or tactile stimulation alone produced similar tone recognition (～40％ correct),the ETS enhanced the cochlear-implant tone recognition by 17-18 percentage *** size of the present ETS enhancement effect was similar to that of the previously reported EAS effect on Mandarin tone *** analysis on tactile sensation showed an important role of frequency discrimination in the ETS ***:Tactile stimulation can potentially enhance Mandarin tone recognition in cochlear-implant users who do not have usable residual acoustic *** optimize this potential,high fundamental frequencies need to be transposed to a 100-200 Hz range.

关键词： Tactile aid Cochlear implant Electro-acou sticstimulation (EAS) Electro-tactile stimulation (ETS) Mandarin Tones