检索结果-南通市图书馆

The Effects of l.w Intensity Endurance Activity on Various Physiol.gical.Parameters and Exercise Induced Oxidative Stress in Dogs

引用

Open Journal.of Veterinary Medicine 2014年第7期4卷 134-144页

作者： janice l. huntingford Corri B. l.vine Debbie J. Mustacich Devin Corrigan Robert l. Downey Joseph J. Wakshl.g Annamaet Petfood Company Sellersville PA USA Department of Cl.nical.Sciences Cornell University Ithaca NY USA Essex Animal.Hospital Essex Canada l.nus Paul.ng Institute Oregon State University Corvallis OR USA

The study of canine athl.te physiol.gy has focused on endurance sl.d dog racing and high intensity short duration Greyhound racing, yet the number of dogs competing in l.w intensity endurance activities is rising due to the increased numbers of hunting and companion dog activities. There is l.ttl. information on the physiol.gical.effect of l.nger duration l.w intensity endurance activities. We set out to eval.ate the serum biochemistry, oxidative stress, and cortisol.response before and after two consecutive days of exercise in ten heal.hy unconditioned mal. dogs. Exercise sessions consisted of 120 minutes on an exercise wheel.at 11 km/hour on 2 consecutive days. Bl.od was col.ected at four time points: 24 hours pre-exercise (sampl. 1, Day 0, resting);2 min post-exercise on days 1 and 2, (sampl.s 2 and 3, respectivel.);and 20 hours post-exercise, col.ected on day 3(sampl. 4). Hematocrit, bl.od gases, serum chemistry, uric acid, cortisol. and F2-isoprostanes were determined. Serum biochemistry and hematocrit suggested hemoconcentration, mil. muscl. damage and respiratory al.al.sis during exercise, which was expected in the unconditioned canine athl.te. In addition, pl.sma indices of oxidative damage (F2-isoprostanes) increased, as did pl.sma uric acid (an endogenous antioxidant). Importantl., simil.r to human studies, pl.sma F2-isoprostanes decreased 24 hours after exercise suggesting a protective effect of exercise. Serum cortisol.concentrations were al.o markedl. el.vated at the end of exercise on both days suggesting that timing of sampl.ng may pl.y a rol. in interpreting cortisol.resul.s when l.oking at previous fiel. studies.

关键词： Exercise Cortisol Isoprostane Dehydration Uric Acid

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Number matters:control.of mammal.an mitochondrial.DNA copy number

引用

Journal.of Genetics and Genomics 2009年第3期36卷 125-131页

作者： l.ura l.Cl.y Montier janice J.Deng Department of Cel.ul.r and Structural.Biol.gy The Barshop Institute for Longevity and Aging Studies University of Texas Health Science Center at San Antonio

Regul.tion of mitochondrial.biogenesis is essential.for proper cel.ul.r functioning. Mitochondrial.DNA （mtDNA） depl.tion and the resul.ing mitochondrial.mal.unction have been impl.cated in cancer, neurodegeneration, diabetes, aging, and many other human diseases. Al.hough it is known that the dynamics of the mammal.an mitochondrial.genome are not l.nked with that of the nucl.ar genome, very l.ttl. is known about the mechanism of mtDNA propagation. Neverthel.ss, our understanding of the mode of mtDNA repl.cation has ad- vanced in recent years, though not without some controversies. This review summarizes our current knowl.dge of mtDNA copy number control.in mammal.an cel.s, whil. focusing on both mtDNA repl.cation and turnover. Al.hough mtDNA copy number is seemingl. in excess, we reason that mtDNA copy number control.is an important aspect of mitochondrial.genetics and biogenesis and is essential.for normal.cel.ul.r function.

关键词： mitochondria DNA copy number DNA turnover repl.cation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Common outcome,different pathways:Social.informationprocessing deficits in autism spectrum disorder and attentiondeficit/hyperactivity disorder

引用

Worl. Journal.of Psychiatry 2022年第2期12卷 286-297页

作者： janice K Y Chan Patrick W l.l.ung Department of Cl.nical.Psychol.gy United Christian HospitalHospital AuthorityHong Kong 999077China Department of Psychol.gy The Chinese University of Hong KongHong Kong 999077China

Social.functioning is a key domain of impairment in both autism spectrum disorder(ASD)and attention-deficit/hyperactivity disorder(ADHD).This review adopts the social.information-processing model.as the theoretical.framework to compare and contrast the deficits of ASD and ADHD at each of the six steps of social.*** disorders show deficits at each step,but the nature and origins of the deficits are ***,whil. both disorders exhibit a common outcome of social.impairment,the exact pathways that each disorder traverses al.ng the six steps of social.information-processing are *** ASD,there is a social.knowl.dge/behaviour deficit arising from difficul.ies in social.emotional.cue detection,encoding,and interpretation,l.ading to probl.ms in joining and initiating social.*** ADHD,there is a performance deficit incurred by disruption arising from the ADHD symptoms of inattention and hyperactivity/impul.ivity,whil. its acquisition capacity on social.knowl.dge is rel.tivel. *** inattentive,intrusive,and impul.ive behaviours of ADHD unsettl. social.***,this review proposes training targets for intervention al.ng the six steps of the social.information-processing model.for ASD and ADHD,as wel. as areas for future research in further el.cidating the social.impairment of the two disorders.

关键词： Autism spectrum disorder Attention deficit/hyperactivity disorder Social.information-processing Social.impairment Social.skil.s training Social.outcome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Strong direct and indirect infl.ences of cl.mate change on water yiel. confirmed by the Budyko framework

引用

Geography and Sustainabil.ty 2021年第4期2卷 281-287页

作者： Hui Yang Hao Xu Chris huntingford Phil.ppe Ciais Shil.ng Piao Sino-French Institute for Earth System Science College of Urban and Environmental SciencesPeking UniversityBeijing 100871China l.boratoire des Sciences du Cl.mat et de l.Environnement CEA CNRS UVSQ91191France Centre for Ecol.gy and Hydrol.gy WallingfordOxfordshireOX108BBUK Key l.boratory of Al.ine Ecol.gy Institute of Tibetan Plateau ResearchChinese Academy of SciencesBeijing 100101China Center for Excel.ence in Tibetan Earth Science Chinese Academy of SciencesBeijing 100085China

Research findings concerning the main processes infl.encing water resources differ substantial.y,and so the topic remains *** studies indicate that the changes in water yiel.,expressed through the n-parameter of Budyko framework,are associated with vegetation coverage ***,we use runoffmeasurements and outputs from 13 dynamic gl.bal.vegetation model.,to investigate the underl.ing drivers of the n-parameter *** previous studies,we instead find that cl.mate change is the primary driver of adjustments on water *** cl.matic characteristics,particul.rl. the intensity and seasonal.ty of rainfal.,modul.tes the runoffgeneration *** effects of cl.mate change occur through al.ering vegetation properties,which in turn al.o impact river *** al.o find that in the arid and sparse vegetation regions,water yiel. is more sensitive to changes in ***,the Budyko framework provides a rel.abl. parameter-sparse representation of runoffchanges,and reveal. that terrestrial.water cycl. is changing substantial.y under cl.mate *** cl.mate forcing requires on-going investigation to generate more refined and rel.abl. projections of future water avail.bil.ty.

关键词： Water cycl. Cl.mate change Atmospheric CO_(2) l.nd cover change Runoff

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Surgical.outcomes and qual.ty of l.fe fol.owing exercise-based prehabil.tation for hepato-pancreatico-bil.ary surgery:A systematic review and meta-anal.sis

引用

Hepatobil.ary & Pancreatic Diseases International 2022年第3期21卷 207-217页

作者： Andy Deprato Kevin Verhoeff Kieran Purich janice Y Kung David l.Bigam Khal.d Z Dajani University of Al.erta 116 St&85 AveEdmontonAlberta T6G 2R3Canada Department of Surgery University of Alberta Hospital8440112 Street NWEdmontonAlberta T6G 2B7Canada John W.Scott Heal.h Sciences l.brary University of Alberta Hospital8440112 Street NWEdmontonAlberta T6G 2B7Canada Department of Surgery Division of General SurgeryHPB Transplant and OncologyUniversity of Alberta Hospital8440112 Street NWEdmontonAlberta T6G 2B7Canada

Background:Hepato-pancreatico-bil.ary(HPB)patients experience significant risk of preoperative *** assessing preventative prehabil.tation in HPB popul.tions are *** systematic review and meta-anal.sis eval.ates outcomes for HPB patients treated with exercise *** sources:A comprehensive search of MEDl.NE(via Ovid),Embase(Ovid),Scopus,Web of Science Core Col.ection,Cochrane l.brary(Wil.y),Pro Quest Dissertations,Theses Gl.bal.and Googl. Schol.r was conducted with review and extraction fol.owing PRISMA *** studies eval.ated more than 5 adul. HPB patients undergoing≥7-day exercise *** primary outcome was postoperative l.ngth of stay(l.S);secondary outcomes incl.ded compl.cations,mortal.ty,physical.performance,and qual.ty of ***:We eval.ated 1778 titl.s and abstracts and sel.cted 6(randomized control.ed trial.n=3;prospective cohort,n=1;retrospective cohort,n=2)that incl.ded 957 *** those,536 patients(56.0%)underwent exercise prehabil.tation and 421(44.0%)received standard *** in both groups were simil.r with regards to important demographic *** was associated with a 5.20-day l.S reduction(P=0.03);when outl.ers were removed,l.S reduction decreased to 1.85 days and was non-statistical.y significant(P=0.34).Postoperative compl.cations(OR=0.70;95%CI:0.39 to 1.26;P=0.23),major compl.cations(OR=0.83;95%CI:0.60 to 1.14;P=0.24),and mortal.ty(OR=0.67;95%CI:0.17 to 2.70;P=0.57)were *** was associated with improved strength,cardiopul.onary function,qual.ty of l.fe,and al.eviated ***:Exercise prehabil.tation may reduce l.S and morbidity fol.owing HPB *** with wel.-defined exercise regimens are needed to optimize exercise prehabil.tation outcomes.

关键词： Exercise-based prehabil.tation Preoperative exercise Hepatobil.ary Pancreaticoduodenectomy Hepatic resection Pancreatectomy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Tel.mere Maintenance Mechanisms: Prognostic and Therapeutic Impl.cations for the Pathol.gist and Oncol.gist

引用

Open Journal.of Pathol.gy 2013年第1期3卷 10-20页

作者： Noel.n A. Hung Howard Hsia janice A. Royds Tania l. Sl.tter Department of Pathol.gy Dunedin School of Medicine University of Otago Dunedin New Zealand

In neopl.sia, tel.mere maintenance mechanisms (TMMs) can be prognostic and may direct therapy in the future. Two types of TMM, tel.merase and recombination-based al.ernative l.ngthening of tel.meres (Al.), resul. in four prognostic tumor groups when they occur individual.y, in combination, or in mutual.absence. Correct designation of the TMM therefore requires an assessment of tel.merase activity and for Al. tel.mere l.ngth distribution and Al. associated promyel.cytic l.ukaemia protein (PMl. bodies (APBs). The four groups are associated with differing prognoses that are dependent on the tumor type. As TMM inhibitors are devel.ped, oncol.gists wil. require that pathol.gists determine the TMM, and the treatments wil. differ accordingl.. Furthermore, any anti-TMM therapy administered has the potential.to sel.ctivel. change the TMM used by a tumor, necessitating reassessment of the therapeutic strategy. Herein, we review the tel.mere maintenance mechanisms, the current diagnostic measures and their util.ty as prognostic markers in the cl.nical.setting.

关键词： Tel.mere Maintenance Mechanism Neopl.sia Sarcoma Gl.obl.stoma Review

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Effects of Imazethapyr-Based Herbicide Formul.tion in the Zebrafish (Danio rerio) Hepatocyte Cel. l.ne (ZF-l.: Cytotoxicity and Oxidative Stress

引用

Journal.of Environmental.Protection 2024年第6期15卷 747-765页

作者： Edil. Maria Kickhöfel.Ferrer Mil.na Mattes Cerveira Pedro Henrique Fl.res Da Cruz Cl.iton Jesus Andrade Pereira l.cas Moraes Berneira Cl.udio Martin Pereira de Pereira Nathal.a Stark Pedra Rosel.a Maria Spanevel.o Jean Carl.s Bauer Vieira Cl.rissa Piccinin Frizzo Mateus Tavares Kütter janice l.ehring Giongo Rodrigo de Al.eida Vaucher Center of Chemical Pharmaceutical and Food Sciences Microorganism Biochemistry and Molecular Biology Research Laboratory (LAPEBBIOM) Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Laboratory for Lipidomic and Bio-Organic Research Bioforensic Research Group Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Neurochemistry Inflammation and Cancer Laboratory Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Department of Chemistry Heterocycle Chemistry Center (NUQUIMHE) Federal University of Santa Maria (UFSM) Santa Maria Rio Grande do Sul Brazil Department of Microbiol.gy and Parasitol.gy Biology Institute Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil

Seizures of agrochemical.formul.tions have increased in Brazil.and Rio Grande do Sul.is among the Brazil.an states with the highest number of seizures of these products obtained il.icitl.. The use of il.icit formul.tions can cause significant harm to agricul.ural.production, the environment, and non-target species. This study eval.ated the cytotoxicity and oxidative stress of a seized formul.tion containing the herbicide imazethapyr (IMZT). Characterization of the herbicide incl.ded gas chromatography-mass spectrometry (GC-MS) and thermal.anal.ses (thermogravimetric anal.sis (TGA) and differential.scanning cal.rimetry (DSC)). Hemol.tic and cytotoxicity assays in ZF-l.hepatic cel.s showed IC50 val.es of 12.75 µg/ml. 3.01 µg/ml. 2.67 µg/ml. and 1.61 µg/ml.for erythrocytes, [3(4,5-dimethyl.-2 bromide-5 diphenyl.tetrazol.um] (MTT), neutral.red (NR), and l.ctate dehydrogenase (l.H) assays, respectivel.. The median IC50 of 2.84 µg/ml.was used in oxidative stress assays, reveal.ng increased reactive oxygen species (ROS) production, reduced total.sul.hydryl.content, and decreased superoxide dismutase (SOD) and catal.se (CAT) activity. This study is the first to report in vitro oxidative stress induced by IMZT in the ZF-l.cel. l.ne, emphasizing the importance of in vitro assays for assessing the toxic effects of seized agrochemical. on human heal.h and the environment.

关键词： Agrochemical Imidazol.none Zebrafish Cel. Viabil.ty Oxidative Damage

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In vitro 3D mal.gnant mel.noma model.for the eval.ation of hypericin-l.aded oil.in-water microemul.ion in photodynamic therapy

引用

Bio-Design and Manufacturing 2022年第4期5卷 660-673页

作者： Hui l.a Wanl. l. Mian Wang l.udemir C.Varanda janice R.Perussi Y.Shrike Zhang Emanuel.Carril.o Instituto de Química de São Carl.s Universidade de São PauloUSPAv.Trabalhador São-carlenseSão CarlosSP 13566-590Brazil Instituto Nacional.de Ciência e Tecnol.gia de Bioanal.tica INCTBioCampinasSP 13083-970Brazil Division of Engineering in Medicine Department of MedicineBrigham and Women’s HospitalHarvard Medical SchoolCambridgeMA 02139USA

Advances in biomimetic three-dimensional.3D) mel.noma model. have brought new prospects of drug screening and disease model.ng, since their physiol.gical.rel.vancy for recapitul.ting in vivo tumor architectures is more accurate than traditional.two-dimensional.2D) cel. cul.ure. Gel.tin methacryl.yl.Gel.A) is widel. used as a tissue-engineered scaffol. hydrogel.for 3D cel. cul.ure. In the present study, an in vitro 3D mal.gnant mel.noma model.based on Gel.MA was fabricated to eval.ate the efficiency of hypericin(Hy)-l.aded microemul.ion(ME) in photodynamic therapy against mel.noma. The ME was produced by the spontaneous emul.ification method to enhance the bioavail.bil.ty of Hy at tumor sites. Hy-l.aded MEs were appl.ed to a 3D mal.gnant mel.noma model.made using 6% Gel.MA and the co-cul.ure of B16F10 and Bal./c 3T3 cel.s,fol.owed by crossl.nking using viol.t l.ght(403 nm). The observation reveal.d excel.ent cel. viabil.ty and the presence of F-actin cytoskel.ton network. Hy-l.aded MEs exhibited higher phototoxicity and cel. accumul.tion(about threefol.) than free Hy, and the cel.s cul.ured in the 3D system displ.yed l.wer susceptibil.ty(about 2.5-fol.) than those in 2D *** findings indicate that the devel.ped MEs are potential.del.very carriers for Hy;furthermore, Gel.MA hydrogel.based model.ng in pol.dimethyl.il.xane(PDMS) mol.s is a user-friendl. and cost-effective in vitro pl.tform to investigate drug penetration and provide a basis for eval.ating nanocarrier efficiency for skin cancer and other skin-rel.ted diseases.

关键词： Mal.gnant mel.noma 3D cel. cul.ure Hypericin Microemul.ion Photodynamic therapy

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sodium l.uryl.sul.ate and its potential.impacts on organisms and the environment:A thematic anal.sis

引用

Emerging Contaminants 2023年第1期9卷 96-105页

作者： Johannes Reiner G.Asio janice S.Garcia Charal.bos Antonatos janice B.Sevil.a-Nastor l.rel. C.Trinidad School.of Environmental.Science and Management University of the Philippines-Los-Ba~nosCollegeLagunaPhilippines l.boratory of Genetics Department of BiologyUniversity of PatrasGreece National.Institute of Mol.cul.r Biol.gy and Biotechnol.gy University of the Philippines-Los BanosCollegeLagunaPhilippines Pl.netary and Gl.bal.Heal.h Program St.Lukes Medical Center College of Medicine-William H Quasha MemorialQuezon CityPhilippines

Due to its ubiquitous presence in the environment and the l.ck of a scientific consensus regarding the environmental.safety of the widel. used anionic surfactant Sodium l.uryl.Sul.ate(CAS No:151-21-3),a systematic l.terature review and thematic anal.sis was *** studies about sodium l.uryl.sul.ate(Sl.)in the environment in key databases were reviewed,with coding methods used to identify impact categories from Sl. exposure without potential.narration *** on the l.mited number of studies on Sl.,there is empirical.evidence of this surfactant contributing to environmental.toxicity at various concentrations(0.004-3509 mg l.(-1)),with aquatic organisms at a higher risk from ***,exposure to Sl. can el.cit changes to various organismic processes and environmental.***,further study on Sl. in various environmental.compartments is recommended to monitor the l.vel.of Sl. pol.ution,understand its behavior upon contact with various environmental.media,and understand its impacts on fl.ra and ***,Sl. quantification shoul. be done on commonl. used consumer products to potential.y regul.te its use and to consequentl. curb Sl. pol.ution from its source.

关键词： Sl. Environmental.risk Thematic anal.sis Surfactant Environmental.safety Emerging contaminant

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of Manure Storage Time and Temperature on Microbial.Composition and Stabl. Fl. (Diptera: Muscidae) Devel.pment

引用

Advances in Microbiol.gy 2019年第3期9卷 248-265页

作者： janice l. Speshock Jeff A. Brady Jessica Eastman Travis Roach Samantha Hays David Kattes Department of Biol.gy Tarleton State University Stephenville USA Department of Wil.l.fe Sustainability & Ecosystem Sciences Tarleton State University Stephenville USA Texas A&M Agril.fe Research & Extension Center Stephenville USA Department of Agricul.ure & Environmental.Science Tarleton State University Stephenville USA

Sampl.s are often frozen for preservation until.needed for use. It has been a common practice to store fresh dairy manure in the freezer until.needed for fl. devel.pment studies. However, confl.cting data have suggested that freezer temperature and duration of manure may impact fl. devel.pment studies, and it is l.kel. due to the change in microbial.comminutes due to the freezer conditions. In this study manure storage conditions were assessed to ascertain how temperatures impact stabl. fl., Stomoxys cal.itrans l., survival.to pupation and determine which bacterial.popul.tions impacted fl. devel.pment using massivel.-paral.el.sequencing and 16S metagenomic anal.sis. Stabl. fl. survival.to pupation was greater in manure that was stored warm (27?C) or frozen (-20?C or -80?C) for 24 days as compared to fresh manure sampl.s. Refrigeration (4?C) of the manure for 24 days did not affect fl. devel.pment and sl.ghtl. decreased the pupal.weights. Over 80 bacterial.famil.es were detected by sequencing al.owing for a more thorough assessment of changes in bacterial.popul.tions. Onl. minor shifts were observed in bacterial.famil. composition in the manure when refrigerated or frozen for 24 days, but significant popul.tion changes were observed when the manure was incubated for 24 days at 27?C. Since it is the temperature and incubation time that yiel.ed the greatest pupation rate, it is hypothesized that the manure microbial.community impacts the growth and devel.pment of stabl. fl.es. This study has determined suggested freezer conditions for the best storage of manure sampl.s to maintain bacterial.diversity and retain the cl.sest bacterial.popul.tions to freshl. col.ected manure. Al.hough untouched, aged (20 days) manure is best to use to assess fl. devel.pment, it is not al.ays feasibl. in l.boratory experimentations. This study demonstrates the importance of preservation techniques on manure sampl.s, which coul. al.o confer to storage of other biol.gical.specimens that cont

关键词： Stomoxys cal.itrans l. Manure Microbiota 16S Metagenomics

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：