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Aberrant adult neurogenesis in intractable epilepsy:can GABAergic progenitor transplantation normalize this process?

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Neural Regeneration Research 2024年第7期19卷 1419-1420页

作者： Muhammad N.Arshad janice R.Naegele Department of Biology Wesleyan UniversityMiddletownCTUSA Department of Neuroscience Tufts University School of MedicineBostonMAUSA

Temporal lobe epilepsy(TLE) is a common type of focal epilepsy characterized by seizure foci within the temporal *** surgical resection of the foci is an established and effective approach for controlling seizures,both temporal lobes cannot be removed,due to their prominent roles in learning and ***,seizures induce changes to the temporal lobes that contribute to hyperexcitability,including mossy fiber sprouting,astrogliosis.

关键词： epilepsy progenitor seizures

Selected dietary plant-based proteins for growth and health response of Nile tilapia Oreochromis niloticus

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Aquaculture and Fisheries 2024年第1期9卷 3-19页

作者： Tzodoq Obrero Magbanua janice Alano Ragaza Ateneo Aquatic and Fisheries Resources Laboratory Department of BiologySchool of Science and EngineeringAteneo de Manila UniversityKatipunan AvenueLoyola HeightsQuezon CityMetro Manila1108Philippines

Tilapia culture is one of the largest sectors of global *** the different species of tilapia,Nile tilapia(Oreochromis niloticus)is perhaps the top cultured *** production of Nile tilapia has been continually increasing throughout the years resulting in genetic *** tilapia strains with better growth performance and adaptive capability to survive in different culture conditions have been developed to alleviate the *** demand for Nile tilapia implies higher farming ***-based proteins are utilized as partial or complete fishmeal replacements to reduce feed ***,these proteins can adversely affect and alter growth and feed performance,carcass composition and indices,and gut and hepatic *** review discusses the use of seven plant-based proteins:namely,soybean,copra,pea,corn,palm kernel,microalgae,and seaweed as a Nile tilapia *** processing methods are employed to produce several types of plant-based *** plant-protein types,when utilized as an aquafeed ingredient,vary in its effect on the performance,hemato-immunological parameters,and gut and hepatic health of Nile *** have shown that Nile tilapia can effectively maximize plant-based protein diets based on the preparation method,type of plant source,amino acid supplementation,and inclusion levels of the plant *** readily available crops should be considered as primary protein sources for *** to the use of plant-based proteins as a main dietary protein are limiting amino acids,presence of anti-nutritional factors,and the competition between its demand as human food and as animal feed.

关键词： Nile tilapia Plant-based proteins Soybean proteins Copra proteins Pea proteins Corn proteins Palm kernel proteins Algal proteins

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World Journal of Emergency Medicine 2024年第4期15卷 256-262页

作者： Jie Er janice Soo Yuan Helen Zhang Gek Hsiang Lim Fatimah Lateef Department of Emergency Medicine Singapore General HospitalSingapore 168753Singapore Health Services Research Unit Singapore General HospitalSingapore168753Singapore

BACKGROUND:This study aimed to review bicycle-related injuries during the COVID-19 pandemic to assist with reinforcement or implementation of new policies for injury ***:This is a retrospective descriptive analysis of injuries sustained during cycling for patients 18 years old and above who presented to Singapore General Hospital from January to June *** records were reviewed and *** analyses were used to summarize patient characteristics,and differences in characteristics subgrouped by triage acuity and discharge status were ***:The study included 272 patients with a mean age of 43 years and a male predominance(71.7%).Most presented without referrals(88.2%)and were not conveyed by ambulances(70.6%).Based on acuity category,there were 24(8.8%)Priority 1(P1)patients with 7 trauma activations,174(64.0%)and 74(27.2%)P2 and P3 patients *** most common injuries were fractures(34.2%),followed by superficial abrasion/contusion(29.4%)and laceration/wound(19.1%).Thirteen(4.8%)patients experienced head injury and 85 patients(31.3%)were documented to be wearing a *** majority occurred on the roads as traffic accidents(32.7%).Forty-two patients(15.4%)were admitted with a mean length of stay of 4.1 d and 17(6.3%)undergone surgical *** of 214(78.7%)discharged patients,no re-attendances or mortality were *** the subgroup analysis,higher acuity patients were generally older,with higher proportions of head injuries leading to ***:Our study highlights significant morbidities in bicycle-related *** is also a high proportion of fractures in the young healthy male *** prevention is paramount and we propose emphasizing helmet use and road user safety.

关键词： Cycling Injuries Emergency department

Comparative utility of vestibular function tests in patients with peripheral and central vestibular dysfunction

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Journal of Otology 2024年第1期19卷 5-9页

作者： Cameron B.Fattahi Christopher Zaro janice J.Chung Richard F.Lewis Divya A.Chari Department of Otolaryngology-Head and Neck Surgery UMASS Memorial Medical CenterUniversity of Massachusetts Chan Medical SchoolWorcesterMAUSA Jenks Vestibular Physiology Laboratory Massachusetts Eye and EarBostonMAUSA Department of Otolaryngology-Head and Neck Surgery Massachusetts Eye and EarHarvard Medical SchoolBostonMAUSA Department of Neurology Harvard Medical SchoolBostonMAUSA

Background: Bithermal caloric irrigation, video head impulse test(vHIT), and rotational testing are commonly used to assess peripheral vestibular function, but the relative clinical utility of each test in differentiating patients with peripheral vestibulopathy is ***: To determine whether(1) the combination of two or more vestibular tests enhances diagnostic utility over a single test;(2) abnormal test results on vestibular tests correlate with one ***: Retrospective analysis of data collected from multidisciplinary vestibular clinics at two academic medical centers from 2016 to ***: 150 patients(54.10 ± 15.09 years, 88 females) were included. No individual test was significantly better at predicting the presence of peripheral vestibular damage(p > 0.05). vHIT test results improved significantly when combined with either the caloric test(p = 0.007) or rotary chair test(p = 0.039). Caloric and rotational testing had high sensitivity(74.65% and 76.06%, respectively) and specificity(83.54% and 78.48%, respectively). vHIT demonstrated excellent specificity(89.87%) but poor sensitivity(47.89%). Caloric, vHIT, and rotary chair tests results did not correlate with one another(p > 0.05).Conclusions: Vestibular function tests have comparable diagnostic utility, yet each offers unique advantages. Caloric and rotational testing may be best suited for screening peripheral damage and vHIT may function ideally as a confirmatory test.

关键词： vestibular patients specificity

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顶级跨国公司陆续从非洲撤退

商业周刊（中文版） 2024年第6期 10-12页

作者： janice Kew David Herbling 竹西(译) 不详

雀巢2023年8月以需求下降为由,关停了雀巢巧克力奶粉在南非的生产。一年前,联合利华公司为了“维持盈利”,停止了在尼日利亚生产家用护理和皮肤清洁产品。制药巨头拜耳和葛兰素史克已经将其产品分销外包给肯尼亚和尼日利亚的独立公司。

关键词：跨国公司尼日利亚葛兰素史克雀巢联合利华公司需求下降肯尼亚巧克力

Epidemiological, Clinical Progress Aspects of Congenital Heart Disease with Neonatal Revelation at the Mother-Child Hospital of Bingerville (HME) Concerning 98 Cases from January 2021 to December 2022 (Côte d’Ivoire)

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Open Journal of Pediatrics 2024年第1期14卷 89-100页

作者： Adja Evelyne Akaffou-Gbery Richard Azagoh-Kouadio Anne-Lise Laetitia Mobio Jean-Jacques Yao Atteby Serenah Marie janice N’vrah Anoh Kouassi Raoul Yao Department of Paediatrics and Neonatology H&#244pital Mère-Enfant de Bingerville (HME) Bingerville C&#244te d’Ivoire Department of Medical Pediatrics and Specialties CHU de Angré Abidjan C&#244te d’Ivoire

Introduction The distribution of congenital heart disease (CHD) in sub-Saharan Africa is highly imprecise and varies from one region to another due to the inequality of diagnostic facilities. The aim of this study was to determine the in-hospital prevalence of congenital heart disease in children at the Mother-Child hospital of Bingerville (HME) by specifying the diagnostic, therapeutic and evolutionary aspects. Materials and methods We conducted a retrospective, descriptive, cross-sectional study at HME of Bingerville from January 2021 to December 2022. All newborns with congenital heart disease confirmed by echocardiography were included in the study. Results Of 656 admissions to the neonatology department over the study period, congenital heart disease accounted for 14.9% (98/656) of cases. In our series, 76.7% were diagnosed before the 1st week of life, with a mean chronological age of 5.18 days and extremes of 0 and 46 days. There were as many male patients (50%) as female (50%), i.e. a sex ratio of 1. These newborns were premature in 60.2% of cases, with a mean and median gestational age of 34 weeks’ amenorrhea. Most were left-right shunts (90.8%). Persistent ductus arteriosus (PDA) (48.9%) predominated, followed by atrial septal defect (38.7%), ventricular septal defect (13.3%), common trunk artery (CTA) (3.1%) and open septal pulmonary atresia (OSPA) (1%) as the primary cyanogenic heart disease. Pulmonary arterial hypertension (PAH) (50%) was primary in 38.8% and secondary (61.2%). The mortality rate was 30.6%, and all CTA patients died (100%), with a significant statistical relationship (p = 0.027). Progression under treatment was marked by clinical stabilization (68/98) in 69.4% of cases. Conclusion: Congenital heart disease is relatively common at the Bingerville HME. Access to echocardiography should be facilitated in neonatology departments for rapid diagnosis and optimal management of congenital heart disease in newborns.

关键词： Newborn Congenital Heart Disease Côte d’Ivoire

基于注意力机制与自适应特征融合的群养猪身份识别

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软件导刊 2024年第6期23卷 25-31页

作者：韩丁磊陈晨 Steibel Juan Siegford janice 韩俊杰王梦凡徐雷钧 Norton Tomas 江苏大学电气信息工程学院江苏镇江212013 Department of Animal Science Iowa State UniversityAmesIA 50010USA Animal Behaviour and Welfare Group Department of Animal ScienceMichigan State UniversityEast Lansing 48824USA Animal Behaviour and Welfare Group Department of Computational MathematicsScience and EngineeringMichigan State UniversityEast Lansing 48824USA Division of Measure Model&Manage Bioresponses(M3-Biores)KU LeuvenLeuven 30001Belgium

针对群养猪攻击过程中身体形变和重叠影响猪身份识别精度的问题,开发一种基于注意力机制和自适应特征融合的深度学习方法以提高猪身份识别精度。录制猪栏中8只猪每天8小时共3天的视频,并筛选含攻击的16830帧作为数据集。首先,采用ResNe... 详细信息

针对群养猪攻击过程中身体形变和重叠影响猪身份识别精度的问题,开发一种基于注意力机制和自适应特征融合的深度学习方法以提高猪身份识别精度。录制猪栏中8只猪每天8小时共3天的视频,并筛选含攻击的16830帧作为数据集。首先,采用ResNet50提取猪的卷积神经网络(CNN)特征;然后,采用特征金字塔网络(FPN)在ResNet50中选择3层不同尺度的特征,以优化这些特征的定位和语义信息;接着,采用自注意力机制提高这些特征的区分度,并采用自适应空间特征融合(ASFF)以融合不同尺度的特征;最后,利用卷积和Sigmoid函数相结合的检测器对猪身份进行识别。使用该方法后,猪身份识别的均值平均精度(mAP)达到95.59%,速度达到37.6 f/s。结果表明,该方法能够在攻击场景下有效识别猪身份,有助于将攻击识别从群体级细化为个体级。

关键词：群养猪身份识别注意力机制特征融合深度学习

Effects of Imazethapyr-Based Herbicide Formulation in the Zebrafish (Danio rerio) Hepatocyte Cell Line (ZF-L): Cytotoxicity and Oxidative Stress

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Journal of Environmental Protection 2024年第6期15卷 747-765页

作者： Edila Maria Kickhöfel Ferrer Milena Mattes Cerveira Pedro Henrique Flores Da Cruz Cleiton Jesus Andrade Pereira Lucas Moraes Berneira Claudio Martin Pereira de Pereira Nathalia Stark Pedra Roselia Maria Spanevello Jean Carlos Bauer Vieira Clarissa Piccinin Frizzo Mateus Tavares Kütter janice Luehring Giongo Rodrigo de Almeida Vaucher Center of Chemical Pharmaceutical and Food Sciences Microorganism Biochemistry and Molecular Biology Research Laboratory (LAPEBBIOM) Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Laboratory for Lipidomic and Bio-Organic Research Bioforensic Research Group Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Center of Chemical Pharmaceutical and Food Sciences Neurochemistry Inflammation and Cancer Laboratory Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil Department of Chemistry Heterocycle Chemistry Center (NUQUIMHE) Federal University of Santa Maria (UFSM) Santa Maria Rio Grande do Sul Brazil Department of Microbiology and Parasitology Biology Institute Federal University of Pelotas (UFPEL) Pelotas Rio Grande do Sul Brazil

Seizures of agrochemical formulations have increased in Brazil and Rio Grande do Sul is among the Brazilian states with the highest number of seizures of these products obtained illicitly. The use of illicit formulations can cause significant harm to agricultural production, the environment, and non-target species. This study evaluated the cytotoxicity and oxidative stress of a seized formulation containing the herbicide imazethapyr (IMZT). Characterization of the herbicide included gas chromatography-mass spectrometry (GC-MS) and thermal analyses (thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC)). Hemolytic and cytotoxicity assays in ZF-L hepatic cells showed IC50 values of 12.75 µg/mL, 3.01 µg/mL, 2.67 µg/mL, and 1.61 µg/mL for erythrocytes, [3(4,5-dimethyl)-2 bromide-5 diphenyl tetrazolium] (MTT), neutral red (NR), and lactate dehydrogenase (LDH) assays, respectively. The median IC50 of 2.84 µg/mL was used in oxidative stress assays, revealing increased reactive oxygen species (ROS) production, reduced total sulfhydryl content, and decreased superoxide dismutase (SOD) and catalase (CAT) activity. This study is the first to report in vitro oxidative stress induced by IMZT in the ZF-L cell line, emphasizing the importance of in vitro assays for assessing the toxic effects of seized agrochemicals on human health and the environment.

关键词： Agrochemical Imidazolinone Zebrafish Cell Viability Oxidative Damage

Modeling, simulation, and prediction of global energy indices: a differential approach

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Frontiers in Energy 2022年第2期16卷 375-392页

作者： Stephen Ndubuisi NNAMCHI Onyinyechi Adanma NNAMCHI janice Desire BUSINGYE Maxwell Azubuike IJOMAH Philip Ikechi OBASI Department of Mechanical Engineering Kampala International University20000 KampalaUganda Department of Agricultural Engineering and Bio Resources Michael Okpara University of AgricultureUmudikeUmuahiaNigeria Directorate of Human Resource/Finance Kampala International University20000 KampalaUganda Department of Mathematics and Statistics Faculty of SciencesUniversity of Port HarcourtPMB 5323 Choba Port HarcourtNigeria Department of Macroeconomic Analysis(Ministry of Finance) Budget and National PlanningAbujaNigeria

Modeling, simulation, and prediction of global energy indices remain veritable tools for econometric, engineering, analysis, and prediction of energy indices. Thus, this paper differentially modeled, simulated, and non-differentially predicated the global energy indices. The state-of-the-art of the research includes normalization of energy indices, generation of differential rate terms, and regression of rate terms against energy indices to generate coefficients and unexplained terms. On imposition of initial conditions, the solution to the system of linear differential equations was realized in a Matlab environment. There was a strong agreement between the simulated and the field data. The exact solutions are ideal for interpolative prediction of historic data. Furthermore, the simulated data were upgraded for extrapolative prediction of energy indices by introducing an innovative model, which is the synergy of deflated and inflated prediction factors. The innovative model yielded a trendy prediction data for energy consumption, gross domestic product, carbon dioxide emission and human development index. However, the oil price was untrendy, which could be attributed to odd circumstances. Moreover, the sensitivity of the differential rate terms was instrumental in discovering the overwhelming effect of independent indices on the dependent index. Clearly, this paper has accomplished interpolative and extrapolative prediction of energy indices and equally recommends for further investigation of the untrendy nature of oil price.

关键词： energy indices differential model normalization simulation inflation deflation predictive factor and prediction rate