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Traumatic axonal injury of the cingulum in patients with mild traumatic brain injury: a diffusion tensor tractography study

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Neural Regeneration Research 2019年第9期14卷 1556-1561页

作者： Sung Ho jang Seong Ho Kim han Do Lee Department of Physical Medicine and Rehabilitation College of MedicineYeungnam UniversityNamkuDaeguRepublic of Korea Department of Neurosurgery College of MedicineYeungnam UniversityNamkuDaeguRepublic of Korea

The cingulum,connecting the orbitofrontal cortex to the medial temporal lobe,involves in diverse cognition functions including attention,memory,and *** investigate the relationship between the cingulum injury and cognitive impairment in patients with chronic mild traumatic brain injury,we evaluated the integrity between the anterior cingulum and the basal forebrain using diffusion tensor tractography in 73 patients with chronic mild traumatic brain injury(39 males,34 females,age 43.29±11.42 years)and 40 healthy controls(22 males,18 females,age 40.11±16.81 years).The patients were divided into three subgroups based on the integrity between the anterior cingulum and the basal forebrain on diffusion tensor tractography:subgroup A(n=19 patients)– both sides of the anterior cingulum were intact;subgroup B(n=36 patients)– either side of the anterior cingulum was intact;and subgroup C(18 patients)– both sides of the anterior cingulum were *** were significant differences in total Memory Assessment Scale score between subgroups A and B and between subgroups A and *** were no significant differences in diffusion tensor tractography parameters(fractional anisotropy,apparent diffusion coefficient,and fiber volume)between patients and *** findings suggest that the integrity between the anterior cingulum and the basal forebrain,but not diffusion tensor tractography parameter,can be used to predict the cognitive function of patients with chronic mild traumatic brain *** study was approved by Yeungnam University Hospital Institutional Review Board(approval ***-2014-01-425-010)on August 16,2017.

关键词： mild traumatic brain injury brain trauma diffusion tensor tractography diffusion tensor imaging cognitive impairment cingulum memory Glasgow Coma Scale neural regeneration

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Effects of Wind Fences on the Wind Environment around jang Bogo Antarctic Research Station

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Advances in Atmospheric Sciences 2017年第12期34卷 1404-1414页

作者： jang-Woon WANG Jae-Jin KIM Wonsik CHOI Da-Som MUN jung-Eun KANG Hataek KWON Jin-Soo KIM Kyung-Soo han Department of Environmental Atmospheric Sciences Pukyong National University 45Yongso-ro Korea Polar Research Institute 26 Songdomirae-ro Yeonsu-gu Department of Spatial Information Engineering Pukyong National University 45Yongso-ro

This study investigated the flow characteristics altered by jang Bogo Antarctic Research Station using computational fluid dynamics(CFD) modeling. The topography and buildings around jang Bogo Station were constructed with computeraided-design data in the CFD model domain. We simulated 16 cases with different inflow directions, and compared the flow characteristics with and without jang Bogo Station for each inflow direction. The wind data recorded by the site’s automatic weather station(AWS) were used for comparison. Wind rose analysis showed that the wind speed and direction after the construction of jang Bogo Station were quite different from those before construction. We also investigated how virtual wind fences would modify the flow patterns, changing the distance of the fence from the station as well as the porosity of the fence. For westerly inflows, when the AWS was downwind of jang Bogo Station, the decrease in wind speed was maximized(-81% for west-northwesterly). The wind speed reduction was also greater as the distance of the fence was closer to jang Bogo Station. With the same distance, the fence with medium porosity(25%–33%) maximized the wind speed *** results suggest that the location and material of the wind fence should be selected carefully, or AWS data should be interpreted cautiously, for particular prevailing wind directions.

关键词： jang Bogo Antarctic Research Station CFD model observation environment wind fence porosity

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Sodium-Coordinated Polymeric Phthalocyanines as Stable High-Capacity Organic Anodes for Sodium-Ion Batteries

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Energy & Environmental Materials 2023年第4期6卷 22-30页

作者： Jeongyeon Lee Yoonbin Kim Soyong Park Kang Ho Shin Gun jang Min Jun Hwang Daekyu Kim Kyung-Ah Min Ho Seok Park Byungchan han Dennis K.P.Ng Lawrence Yoon Suk Lee Department of Applied Biology and Chemical Technology and Research Institute for Smart Energy The Hong Kong Polytechnic UniversityHung HomKowloon Hong Kong SAR China Department of Chemistry The Chinese University of Hong KongShatinNew Territories Hong Kong SAR China Convergence Research Center for Energy and Environmental Sciences Sungkyunkwan UniversitySuwon Korea Department of Chemical and Biomolecular Engineering Yonsei UniversitySeoul Korea School of Chemical Engineering Sungkyunkwan UniversitySuwon Korea

Sodium-ion batteries(SIBs)have attracted considerable interest as an alternative to lithium-ion batteries owing to their similar electrochemical performance and superior long-term cycle *** materials are regarded as promising anode materials for constructing SIBs with high capacity and good ***,utilization of organic materials is rather limited by their low energy density and poor stability at high current *** overcome these limitations,we utilized a novel polymeric disodium phthalocyanines(pNaPc)as SIB anodes to provide stable coordination sites for Na ions as well as to enhance the stability at high current *** varying the linker type during a one-pot cyclization and polymerization process,two pNaPc anodes with O-(O-pNaPc)and S-linkers(S-pNaPc)were prepared,and their structural and electrochemical properties were *** O-pNaPc binds Na ions with a lower binding energy compared with S-pNaPc,which leads to more facile Na-ion coordination/dissociation when engaged as SIB *** use of O-pNaPc significantly improves the redox kinetics and cycle stability and allows the fabrication of a full cell against Na_(3)V_(2)(PO_(4))_(2)F_(3)/C cathode,which demonstrates its practical application with high energy density(288 Wh kg^(-1))and high power density(149 W kg^(-1)).

关键词： coordination chemistry organic anode phthalocyanine polymerization sodium ion battery

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A new precision medicine initiative at the dawn of exascale computing

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Signal Transduction and Targeted Therapy 2021年第2期6卷 215-222页

作者： Ruth Nussinov Hyunbum jang Guy Nir Chung-jung Tsai Feixiong Cheng Computational Structural Biology Section Frederick National Laboratory for Cancer Research in the Laboratory of Cancer ImmunometabolismNational Cancer InstituteFrederickMD 21702USA Department of Human Molecular Genetics and Biochemistry Sackler School of MedicineTel Aviv UniversityTel Aviv 69978Israel Department of Genetics Harvard Medical SchoolBostonMA 02115USA Wyss Institute for Biologically Inspired Engineering Harvard UniversityBostonMA 02115USA Genomic Medicine Institute Lerner Research InstituteCleveland ClinicClevelandOH 44106USA Department of Molecular Medicine Cleveland Clinic Lerner College of MedicineCase Western Reserve UniversityClevelandOH 44195USA

Which signaling pathway and protein to selea to mitigate the patient's expected drug resistance?The number of possibilities facing the physician is massive,and the drug combination should fit the patient ***,we briefly review current approaches and data and map an innovative patient-specific strategy to forecast drug resistance targets that centers on parallel(or redundant)proliferation pathways in specialized *** considers the availability of each protein in each pathway in the specific cell,its activating mutations,and the chromatin accessibility of its encoding *** construction of the resulting Proliferation Pathway Network Atlas will harness the emerging exascale computing and advanced artificial intelligence(Al)methods for therapeutic *** the resulting set of targets,pathways,and proteins,with current strategies will augment the choice for the attending physicians to thwart resistance.

关键词： computing Atlas artificial

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Usefulness of the acromioclavicular joint cross-sectional area as a diagnostic image parameter of acromioclavicular osteoarthritis

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World Journal of Clinical Cases 2022年第7期10卷 2087-2094页

作者： Young Joo Jee Youn Moon jung Youn han Yun-Sic Bang Keum Nae Kang Young Su Lim Young-SoonChoi Young-Uk Kim Department of Anesthesiology and Pain Medicine CHA Ilsan Medical CenterSchool of MedicineCHA UniversityIlsanGyeonggi-do 10414South Korea Department of Anesthesiology and Pain Medicine Seoul National University Hospital College of MedicineSeoul 03080South Korea Department of Anesthesiology and Pain Medicine CHA Bundang Medical CenterSchool of MedicineSeongnamGyeonggi-do 13496South Korea Department of Anesthesiology and Pain Medicine National Police HospitalSeoul 05715South Korea Department of Anesthesiology and Pain Medicine Catholic Kwandong UniversityCollege of MedicineInternational St.Mary’s HospitalIncheon 22711South Korea

BACKGROUND Acromioclavicular joint(ACJ)space narrowing has been considered to be an important diagnostic image parameter of ACJ osteoarthritis(ACJO).However,the morphology of the ACJ space is irregular because of osteophyte formation,subchondral irregularity,capsular distention,sclerosis,and ***,we created the ACJ cross-sectional area(ACJCSA)as a new diagnostic image parameter to assess the irregular morphologic changes of the *** To hypothesize that the ACJCSA is a new diagnostic image parameter for *** ACJ samples were obtained from 35 patients with ACJO and 30 healthy individuals who underwent shoulder magnetic resonance(S-MR)imaging that revealed no evidence of *** coronal,T2-weighted,fat-suppressed SMR images were acquired at the ACJ level from the two *** measured the ACJCSA and the ACJ space width(ACJSW)at the ACJ on the S-MR images using our imaging analysis *** ACJCSA was measured as the cross-sectional area of the *** ACJSW was measured as the narrowest point between the acromion and the *** The average ACJCSA was 39.88±10.60 mm;in the normal group and 18.80±5.13 mm;in the ACJO *** mean ACJSW was 3.51±0.58 mm in the normal group and 2.02±0.48 mm in the ACJO *** individuals had significantly lower ACJCSA and ACJSW than the healthy *** operating characteristic curve analyses demonstrated that the most suitable ACJCSA cutoff score was 26.14 mm^(2),with 91.4%sensitivity and 90.0%*** The optimal ACJSW cutoff score was 2.37 mm,with 88.6%sensitivity and 96.7%*** though both the ACJCSA and ACJSW were significantly associated with ACJO,the ACJCSA was a more sensitive diagnostic image parameter.

关键词： Acromioclavicular joint Osteoarthritis Cross-sectional area Diagnosis

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Injury of the arcuate fasciculus in a patient with progressive bulbar palsy

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Neural Regeneration Research 2016年第12期11卷 2031-2032页

作者： Min Cheol Chang han Do Lee Sung Ho jang Department of Physical Medicine and Rehabilitation College of MedicineYeungnam University

The arcuate fasciculus is the neural tract connecting the two major speech centers（Broca’s and Wernicke’s areas）and plays a critical role in language function（Catani and Mesulam,2008）.Injury of this tract can lead to several types of language impairment,including conduction aphasia,Broca’s aphasia,anomic aphasia,and apraxia of speech（Anderson et al.,1999;Bartha and Benke,2003;Catani and Mesulam,2008;Bernal and Ardila,2009;Kim et al.,2011）.

关键词： arcuate patient progressive

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Improvement of hydrogen embrittlement and stress corrosion cracking by annealing for Al-4.4Mg-0.6Mn alloy

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Transactions of Nonferrous Metals Society of China 2011年第A1期21卷 17-22页

作者： Seong-Jong KIM Min-Su han Seong-Kweon KIM Seok-Ki jang Division of Marine Engineering Mokpo National Maritime University Media Engineering Seoul National University of Technology

With no annealing treatment, cathodic polarization trends in 5083F Al alloy revealed concentration polarization and activation polarization. However, the annealed specimens have lower current densities at corrosion protection potential compared to the non-annealed specimen. The results of SSRTs conducted in seawater at the applied potential range of -1.8 V to -0.5 V indicated that the maximum tensile strength, elongation, and time-to-fracture had high values at applied potentials of –0.7 to –1.4 V. The maximum tensile strength, elongation, and time-to-fracture decreased when the potential values were beyond this range in either anodic or cathodic direction. In general, the increased shear lip caused by annealing treatment indicates elongation. Time-to-fracture would likely increase with elongation. Potentials between –0.5 V to –0.6 V were found to be in the region of stress corrosion cracking. The corrosion protection zone was determined to be –0.7 V to –1.4 V because these potential ranges produced good mechanical properties. Potential less than –1.4 V produced a fractured surface with a mixture of dimples (ductile fractures) and a quasi-cleavage pattern resulting from the effects of hydrogen gas.

关键词：应力腐蚀开裂退火处理合金氢脆浓度极化阴极极化保护电位拉伸强度

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The influence of thermohaline fronts on chlorophyll a concentrations during spring and summer in the southeastern Yellow Sea

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Acta Oceanologica Sinica 2013年第9期32卷 82-90页

作者： jang Pung-Guk LEE Tong Sup KANG jung-Hoon SHIN Kyoungsoon Korea Institute of Ocean Science and Technology/South Sea Institute Department of Oceanography College of Natural SciencesPusan National University

A spatial and temporal variation in physiochemical parameters in the southeastern Yellow Sea （YS） is in- vestigated in the spring and summer of 2009 to 2011. Nutrient show a strong negative relationship with chlorophyll a （Chl a） concentration in spring, and the subsurface chlorophyll a maxima （SCM） layer was associated with the nitracline in summer. In summer, the SCM was usually found within or above the pyc- nocline and at the depths of shoals from the open sea to the coastal sea due to tidal and/or topographical fronts in the southernmost study area. High Chl a concentrations were found in the central southern YS, where the YS cold water layer expanded under the pycnocline and encountered water masses during spring and summer. After a typhoon in the summer of2011, Chl a concentration increased, especially in the central southern YS, where cold waters occurred below the pycnocline. The results suggest that the development of thermohaline fronts may play an important role in the growth and accumulation of phytoplankton biomass in the upper layer of the southeastern YS during spring and summer.

关键词： Yellow Sea Cold Water nutrient chorophyll a thermohaline front

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Iterative learning-based many-objective history matching using deep neural network with stacked autoencoder

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Petroleum Science 2021年第5期18卷 1465-1482页

作者： Jaejun Kim Changhyup Park Seongin Ahn Byeongcheol Kang Hyungsik jung Ilsik jang Department of Energy Systems Engineering Seoul National UniversitySeoul08826Republic of Korea Department of Energy and Resources Engineering Kangwon National UniversityChuncheonKangwon24341Republic of Korea Geo-ICT Convergence Research Team Korea Institute of Geoscience and Mineral ResourcesDaejeon34132Republic of Korea Department of Energy and Resources Engineering Chosun UniversityGwangju61452Republic of Korea

This paper presents an innovative data-integration that uses an iterative-learning method,a deep neural network(DNN)coupled with a stacked autoencoder(SAE)to solve issues encountered with many-objective history *** proposed method consists of a DNN-based inverse model with SAE-encoded static data and iterative updates of supervised-learning data are based on distance-based clustering *** functions as an inverse model and results in encoded flattened data,while SAE,as a pre-trained neural network,successfully reduces dimensionality and reliably reconstructs *** iterative-learning method can improve the training data for DNN by showing the error reduction achieved with each iteration *** proposed workflow shows the small mean absolute percentage error below 4%for all objective functions,while a typical multi-objective evolutionary algorithm fails to significantly reduce the initial population *** learning-based manyobjective history matching estimates the trends in water cuts that are not reliably included in dynamicdata *** confirms the proposed workflow constructs more plausible *** workflow would be a reliable alternative to overcome the less-convergent Pareto-based multi-objective evolutionary algorithm in the presence of geological uncertainty and varying objective functions.

关键词： Deep neural network Stacked autoencoder History matching Iterative learning Clustering Many-objective

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Prediction of high thermoelectric performance in the lowdimensional metal halide Cs_(3)Cu_(2)I_(5)

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npj Computational Materials 2021年第1期7卷 476-481页

作者： Young-Kwang jung In Taek han Yong Churl Kim Aron Walsh Department of Materials Science and Engineering Yonsei UniversitySeoulSouth Korea Samsung Advanced Institute of Technology(SAIT) Samsung Electronics Materials Research ComplexYoungtongSuwonSouth Korea Department of Materials Imperial College LondonLondonUK

Metal halides have emerged as a new generation of semiconductors with applications ranging from solar cells to chemical *** assess the thermoelectric potential of Cs_(3)Cu_(2)I_(5),which has a crystal structure formed of zero-dimensional[Cu_(2)I_(5)]3−anionic clusters that are separated by Cs+counter *** find the compound exhibits the characteristics of a phonon-glass electroncrystal with a large imbalance in the conduction of heat and electrons predicted from first-principles transport *** anharmonic phonon–phonon scattering results in short-lived acoustic vibrations and an ultra-low lattice thermal conductivity(10 cm^(2)V^(−1)s^(−1)).For an n-type crystal at 600 K,a thermoelectric figure-of-merit ZT of 2.6 is found to be accessible,which for a cold source of 300 K corresponds to a thermodynamic heat-to-electricity conversion efficiency of 15%.

关键词： theory phonon crystal

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