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作者： Weber janet.

来源：畅想之星图书光盘版（南... 评论

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畅想之星图书光盘版（南通市图书馆镜像）

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站在时代的十字路口伦敦半岛依然是传奇

旅行者 2023年第6期 30-37页

作者： janet(文/图) 不详

让人不想出门的房间。半岛的房间有一种让人不想出门的魔力。站在伦敦半岛酒店房间的落地玻璃窗前,窗外是伦敦初冬的典型气候,时阴时雨,阳光来去无踪。眼前是为纪念第一代惠灵顿公爵阿瑟·韦尔斯利打败拿破仑的胜利与历史之门(Wellingto... 详细信息

让人不想出门的房间。半岛的房间有一种让人不想出门的魔力。站在伦敦半岛酒店房间的落地玻璃窗前,窗外是伦敦初冬的典型气候,时阴时雨,阳光来去无踪。眼前是为纪念第一代惠灵顿公爵阿瑟·韦尔斯利打败拿破仑的胜利与历史之门(Wellington Arch),还有川流不息的宪法山(Constitution Hill)大道。

关键词：落地玻璃半岛酒店韦尔斯利十字路口拿破仑房间魔力伦敦

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年轻时来悉尼

旅行者 2023年第5期 28-35页

作者： janet(图/文) 不详

上海盛夏,悉尼暖冬。踏上悉尼的旅程,因为备受瞩目的2023年FIFA女足世界杯,亲临现场观看半决赛,虽然不是铁杆球迷,但是现场带来的震撼和之后几天旅途中的惊喜,都让我刷新了对悉尼的认知。悉尼的蓝,悉尼的海,悉尼的活力与自然,都值得一... 详细信息

上海盛夏,悉尼暖冬。踏上悉尼的旅程,因为备受瞩目的2023年FIFA女足世界杯,亲临现场观看半决赛,虽然不是铁杆球迷,但是现场带来的震撼和之后几天旅途中的惊喜,都让我刷新了对悉尼的认知。悉尼的蓝,悉尼的海,悉尼的活力与自然,都值得一颗年轻澎湃的心去发现探索。

关键词：女足世界杯半决赛悉尼年轻

Three-dimensional impact kinetics with foot-strike manipulations during running

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Journal of Sport and Health Science 2017年第4期6卷 489-497页

作者： Andrew D. Nordin janet S. Dufek John A. Mercer Department of Kinesiology and Nutrition Sciences University of Nevada Las Vegas NV 89154 USA

Background: Lack of an observable vertical impact peak in fore/mid-foot running has been suggested as a means of reducing lower extremity impact forces, although it is unclear if impact characteristics exist in other axes. The purpose of the investigation was to compare three-dimensional(3 D) impact kinetics among foot-strike conditions in over-ground running using instantaneous loading rate–time ***: Impact characteristics were assessed by identifying peak loading rates in each direction(medial–lateral(ML), anterior–posterior(AP),vertical, and 3 D resultant) following foot-strike instructions(fore-foot, mid-foot, subtle heel, and obvious heel strike). Kinematic and kinetic data were analyzed among 9 male participants in each foot-strike ***: Loading rate peaks were observed in each direction and foot-strike condition, differing in magnitude by direction(3 D resultant and vertical > AP > ML, p ≤ 0.031) and foot-strike: ML(fore-foot and mid-foot strike > obvious heel strike, p ≤ 0.032), AP(fore-foot and mid-foot strikes > subtle-heel and obvious heel strikes, p ≤ 0.023). In each direction, the first loading rate peak occurred later during heel strike running relative to fore-foot(p ≤ 0.019), with vertical and 3 D resultant impact durations exceeding shear(ML and AP, p ≤ 0.007) in each ***: Loading rate–time assessment identified contrasting impact characteristics in each direction and the 3 D resultant following foot-strike manipulations, with potential implications for lower extremity structures in running.

关键词： Fore-foot Heel strike Loading rate Mid-foot Overground Resultant

Applying the Hidden Markov Model to Analyze Urban Mobility Patterns: An Interdisciplinary Approach

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Chinese Geographical Science 2021年第1期31卷 1-13页

作者： LOO Becky P Y ZHANG Feiyang HSIAO janet H CHAN Antoni B LAN Hui Department of Geography the University of Hong KongHong Kong 999077China Department of Psychology the University of Hong KongHong Kong 999077China Department of Computer Science the City University of Hong KongHong Kong 999077China

With the emergence of the Internet of Things(IoT), there has been a proliferation of urban studies using big data. Yet, another type of urban research innovations that involve interdisciplinary thinking and methods remains underdeveloped. This paper represents an attempt to adopt a Hidden Markov Model(HMM) toolbox developed in Computer Science for the analysis of eye movement patterns in Psychology to answer urban mobility questions in Geography. The main idea is that both people’s eye movements and travel behavior follow the stop-travel-stop pattern, which can be summarized using HMM. Methodological challenges were addressed by adjusting the HMM to analyze territory-wide travel survey data in Hong Kong, China. By using the adjusted toolbox to identify the activitytravel patterns of working adults in Hong Kong, two distinctive groups of balanced(38.4%) and work-oriented(61.6%) lifestyles were identified. With some notable exceptions, working adults living in the urban core were having a more work-oriented lifestyle. Those with a balanced lifestyle were having a relatively compact zone of non-work activities around their homes but a relatively long commuting distance. Furthermore, working females tend to spend more time at home than their counterparts, regardless of their marital status and lifestyle. Overall, this interdisciplinary research demonstrates an attempt to integrate spatial, temporal, and sequential information for understanding people’s behavior in urban mobility research.

关键词： activity-travel pattern urban mobility activity sequences cluster analysis Hidden Markov Model

Tertiary lymphoid structures in cancer – considerations for patient prognosis

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Cellular & Molecular Immunology 2020年第6期17卷 570-575页

作者： Luis Munoz-Erazo janet L.Rhodes Valentine C.Marion Roslyn A.Kemp Department of Microbiology and Immunology University of OtagoDunedinNew Zealand Ecole Normale Superieure de Lyon LyonFrance and Universite Claude Bernard Lyon 1LyonFrance

Tertiary lymphoid structures(TLS)are ectopic lymphoid formations that form within nonlymphoid *** share structural and functional characteristics with secondary lymphoid structures such as lymph nodes and can contain B-cell follicles and germinal centers surrounded by a T-cell *** have been described in several types of cancers and are usually associated with positive patient ***,TLS differ vastly in cellular composition and location within tissue *** this review,we discuss factors confounding the interpretation of the evidence for a prognostic role for TLS in cancer and frame these factors in the context of translation to regular clinical use.

关键词： tertiary lymphoid structure prognosis cancer tissue

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基于熵函数的流水车间小批生产信息量测度

自动化学报 2020年第10期46卷 2221-2228页

作者：张志峰 janet David 南昌航空大学经济管理学院南昌330063 内蒙古科技大学经济管理学院包头014010 牛津大学工程科学系牛津 OX13PJ英国

流水车间生产中,批量及批次的信息量测度意味着对描述不同批量及批次在工作站的状态所需信息量的度量,即求解批量及批次的信息熵表达.现有批量及批次信息控制研究主要集中在批量调度问题上,鲜有针对生产中的批量及批次与管理生产所需信... 详细信息

流水车间生产中,批量及批次的信息量测度意味着对描述不同批量及批次在工作站的状态所需信息量的度量,即求解批量及批次的信息熵表达.现有批量及批次信息控制研究主要集中在批量调度问题上,鲜有针对生产中的批量及批次与管理生产所需信息量关系的研究,造成研究结论很难为决策者从信息管理角度选择生产方式提供理论依据.针对上述问题,在分析信息熵度量特性基础上,理论上首次建立流水车间生产线不同批次相同加工时间条件下的批量及批次的信息熵函数,作为度量生产系统状态所需信息量的基础,并由此提出生产批次与熵函数变化关系两个定理,即:生产批次的信息熵函数单调递减;批次趋于无穷大时,系统信息熵趋于零.采用求导法与极值法分别对所提定理给予充分证明,从而理论上证明了流水车间的加工批次增加(或批量减小),则系统的信息熵降低.分别取工作站数量为10和20进行实证研究,以图示表达的结果再次验证了所提定理的正确性.批量与批次的信息量测度理论研究,对实际流水车间生产批量与批次的作业安排及最终生产方式的选择,都具有重要的理论支撑和现实指导意义.

关键词：熵函数小批生产流水车间信息量

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基于信息熵的单元化制造系统状态度量

上海交通大学学报 2015年第1期49卷 109-115页

作者：张志峰 DAVID janet 南昌航空大学经济管理学院南昌330063 牛津大学工程科学系

将描述单元化制造系统状态所需信息量分为结构熵和运行熵2种形式并予以定义;在信息熵理论基础上,构建了单元化制造系统的结构熵与运行熵函数,并对制造资源的状态认定进行说明;根据调度理论,分别建立最大可能调度时限和调度符合度模型.... 详细信息

将描述单元化制造系统状态所需信息量分为结构熵和运行熵2种形式并予以定义;在信息熵理论基础上,构建了单元化制造系统的结构熵与运行熵函数,并对制造资源的状态认定进行说明;根据调度理论,分别建立最大可能调度时限和调度符合度模型.以实施单元化制造的某加工车间为背景,依据其在不同状态下制造资源的状态信息,实证分析并绘制了系统状态随调度变化的示意图,利用所建熵函数及调度模型对系统状态进行度量,以验证所提出方法的科学性与有效性.结果表明,通过所构建的信息熵模型,可实现对单元化制造系统状态的度量与监控,并为提高系统的运行效率提供有效途径.

关键词：单元化制造系统信息熵调度

Multiparametric analysis of colorectal cancer immune responses

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World Journal of Gastroenterology 2018年第27期24卷 2995-3005页

作者： Julia KH Leman Sarah K Sandford janet L Rhodes Roslyn A Kemp Department of Microbiology and Immunology University of Otago

Colorectal cancer(CRC) is a heterogeneous disease, with a diverse and plastic immune cell infiltrate. These immune cells play an important role in regulating tumour growth-progression or elimination. Some populations of cells have a strong correlation with disease-free survival, making them useful prognostic markers. In particular, the infiltrate of CD3^+ and CD8^+ T cells into CRC tumours has been validated worldwide as a valuable indicator of patient prognosis. However, the heterogeneity of the immune response, both between patients with tumours of different molecular subtypes, and within the tumour itself, necessitates the use of multiparametric analysis in the investigation of tumour-specific immune responses. This review will outline the multiparametric analysis techniques that have been developed and applied to studying the role of immune cells in the tumour, with a focus on colorectal cancer. Because much of the data in this disease relates to T cell subsets and heterogeneity, we have used T cell populations as examples throughout. Flow and mass cytometry give a detailed representation of the cells within the tumour in a single-cell suspension on a per-cell basis. Imaging technologies, such as imaging mass cytometry, are used to investigate increasing numbers of markers whilst retaining the spatial and structural information of the tumour section and the infiltrating immune cells. Together, the analyses of multiple immune parameters can provide valuable information to guide clinical decision-making in CRC.

关键词： Colorectal cancer Flow cytometry Immune cells Multiparametric analysis Immunohistochemistry Mass cytometry Microscopy

IGF-I induced phosphorylation of PTH receptor enhances osteoblast to osteocyte transition

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Bone Research 2018年第1期6卷 60-71页

作者： Tao Qiu janet L.Crane Liang Xie Lingling Xian Hui Xie Xu Cao Department of Orthopaedic Surgery Johns Hopkins University School of Medicine Department of Pediatrics Johns Hopkins University School of Medicine State Key Laboratory of Oral Diseases West China Hospital of Stomatology Sichuan University

Parathyroid hormone(PTH) regulates bone remodeling by activating PTH type 1 receptor(PTH1R) in osteoblasts/osteocytes. Insulinlike growth factor type 1(IGF-1) stimulates mesenchymal stem cell differentiation to osteoblasts. However, little is known about the signaling mechanisms that regulates the osteoblast-to-osteocyte transition. Here we report that PTH and IGF-I synergistically enhance osteoblast-to-osteocyte differentiation. We identified that a specific tyrosine residue, Y494, on the cytoplasmic domain of PTH1R can be phosphorylated by insulin-like growth factor type I receptor(IGF1R) in vitro. Phosphorylated PTH1R localized to the barbed ends of actin filaments and increased actin polymerization during morphological change of osteoblasts into *** of the phosphorylation site reduced actin polymerization and dendrite length. Mouse models with conditional ablation of PTH1R in osteoblasts demonstrated a reduction in the number of osteoctyes and dendrites per osteocyte, with complete overlap of PTH1R with phosphorylated-PTH1R positioning in osteocyte dendrites in wild-type mice. Thus, our findings reveal a novel signaling mechanism that enhances osteoblast-to-osteocyte transition by direct phosphorylation of PTH1R by IGF1R.

关键词： Parathyroid hormone Phosphorylated PTH1R phosphorylated-PTH1R