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A roadmap for research in octoploid strawberry

Horticulture Research 2020年第1期7卷 2300-2316页

作者： Vance M.Whitaker Steven J.Knapp Michael A.Hardigan patrick p.Edger janet p.slovin Nahla V.Bassil Timo Hytönen Kathryn K.Mackenzie Seonghee Lee Sook Jung Dorrie Main Christopher R.Barbey Sujeet Verma University of Florida Institute of Food and Agricultural SciencesGulf Coast Research and Education CenterWimaumaFlorida 33598USA Department of plant Sciences University of CaliforniaDavisCA 95616USA Department of Horticulture Michigan State UniversityEast LansingMI 48824USA USDAARS Genetic Improvement of Fruits and Vegetables Laboratory BeltsvilleMA 20705USA USDA-ARS National Clonal Germplasm Repository CorvallisOR 97333USA Department of Agricultural Sciences Viikki Plant Science CentreUniversity of HelsinkiHelsinki 00790Finland Organismal and Evolutionary Biology Research programme Faculty of Biological and Environmental SciencesViikki Plant Science CentreUniversity of HelsinkiHelsinki 00790Finland NIAB EMR Kent ME196BJUK Department of Horticulture Washington State UniversityPullmanWA 99164USA

The cultivated strawberry(Fragaria×ananassa)is an allo-octoploid species,originating nearly 300 years ago from wild progenitors from the *** that time the strawberry has become the most widely cultivated fruit crop in the world,universally appealing due to its sensory qualities and health *** recent publication of the first highquality chromosome-scale octoploid strawberry genome(***)is enabling rapid advances in genetics,stimulating scientific debate and provoking new research *** this forward-looking review we propose avenues of research toward new biological insights and applications to *** these are the origins of the genome,characterization of genetic variants,and big data approaches to *** areas of research in molecular biology will include the control of flowering,fruit development,fruit quality,and plant–pathogen *** order to realize this potential as a global community,investments in genome resources must be continually augmented.

关键词： straw cultivated looking

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Limb Lengthening and Reconstruction Society orthopedic surgeons in the United States:An analysis of geographical distribution,academic,leadership,and demographic characteristics

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World Journal of Orthopedics 2024年第2期15卷 147-155页

作者： Amir Human Hoveidaei Reza Niakan Seyed Hossein Hosseini-Asl Abijith Annasamudram janet D Conway International Center for Limb Lengthening Rubin Institute for Advanced OrthopedicsSinai Hospital of BaltimoreBaltimoreMD 21215United States Student Research Committee Shiraz University of Medical SciencesShiraz 73Iran Students’Scientific Research Center Tehran University of Medical SciencesTehran ***Iran

BACKGROUND The Limb Lengthening and Reconstruction Society(LLRS)is a premier orthopedic specialty organization that promotes limb reconstruction for all *** membership characteristics,however,are poorly *** study delineates orthopedic surgeon LLRS members’demographic traits,academic achievement,leadership attainment,and geographical distribution across the United *** To inform aspiring orthopedic professionals,as well as to promote growth and diversity in both the LLRS organization and overarching *** This cross-sectional study examined United States LLRS members’academic,leadership,demographic,and geographical *** reviewing the 2023 LLRS member directory,Google search results were matched to the listings and appended to the compiled *** and ethnicity were evaluated visually utilizing retrieved *** Hirsch index(H-index)of academic activity,residency and fellowship training,other graduate degrees,leadership positions,practice type(academic or non-academic),and spoken languages were *** members per state and capita determined geographic *** Mann Whitney U test was applied to compare H-index between males and females,as well as to assess member differences pertaining to affiliation with academic vs non-academic practice *** The study included 101 orthopedic surgeons,78(77.23%)Caucasian and 23(22.77%)non-Caucasian,79(78.22%)male and 22(21.78%)*** with DO degrees comprised only 3.96%(4)of the cohort,while the vast majority held MDs[96.04%(97)].Mean H-index was 10.55,with male surgeons having a significantly higher score(p=0.002).Most orthopedic surgeons(88.12%,)practiced in academic *** those professionals who occupied leadership positions,14%were women,while 86%were ***,19(37.25%)United States regions and the District of Columbia lacked an LLRS-member orthopedic *** per capita rate across the United States was 0.30 LLRS orthopedic

关键词： Limb lengthening and reconstruction Orthopedic surgeon demographics Orthopedic surgeon societal membership Orthopedic fellowships

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Characterization of Extended Spectrum Beta-lactamase and Carbapenamase producing Enterobacteriaceae Causing Urinary Tract Infection among Children in Kenya: A Cross-Sectional Study

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Advances in Microbiology 2024年第7期14卷 351-365页

作者： Rachael Wangeci Waithaka janet Kerubo Maranga Celestine Khalechi Makobe Department of Microbiology Jomo Kenyatta University of Agriculture and Technology Juja Kenya Gertrudes Childrens Hospital Nairobi Kenya

Introduction: Enterobacteriaceae causing urinary tract infections (UTI) have developed resistance to the commonly used antibiotics due to emergence of Extended Spectrum Beta-Lactamases (ESBLs) and Carbapenamase producing Enterobactericeae which are a public health problem worldwide. This study aims to determine the prevalence and characterize ESBLs and carbapenamase producing Enterobactericeae. Method: A cross-sectional study was carried out in Gertrude’s Children’s Hospital, Nairobi. 238 urine samples were collected from patients with urinary symptoms attending the outpatient department within the period 2020-2021. The urine were examined macroscopically and microscopically. Identification and antimicrobial susceptibility testing were done using VITEK® 2 Compact system (BioMérieux). Double disc synergy test and modified hodge tests were done as confirmatory tests for ESBLs and Carbapenamase phenotypes respectively. polymerase Chain Reaction was used for the detection of blaCTX-M, blaTEM, blaSHV, blaKpC and blaOXA-48 genes. Results: From the 238 children sampled the prevalence of UTI caused by Enterobactericeae was 22.3%. The Enterobacteriaceae species isolated were Escherichia coli (84.9%), Klebsiella pneumoniae (5.66%), proteus mirabillis (5.66%), Enterobacter aerogenes (1.89%) and Morganella morganii (1.89%). The isolated species were resistant to ampicillin. Meropenem had the highest susceptibility. Only E. coli species had the ESBLs (26.4%) and carbapenamase (1.9%) phenotypes. 100% had BlaCTX-M while 50% had blaTEM resistant gene. There was a significant association (p Conclusion: Ampicillin resistance resulted to use of alternative drugs and Meropenem was the drug of choice where increased resistance to the recommended drugs was noted. Further research on resistant genes is recommended.

关键词： Enterobactericeae Urinary Tract Infection prevalence Beta Lactamases polymerase Chain Reaction Children Outpatient Antimicrobial Resistance phenotypes Escherichia coli

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Establishing Fragaria vesca,a Diploid Strawberry,as a Model for Studying Flower and Fruit Development

Establishing Fragaria vesca,a Diploid Strawberry,as a Model ...

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第二届国际整合植物生物学学术研讨会

作者： Hollender Courtney A Kang Chunying Geretz Aviva Currie Alyssa-Marie slovin janet Dept.of Cell Biology and Molecular Genetics University of MarylandCollege ParkUSA Genetic Improvement of Fruit and Vegetables Laboratory USDA/ARSBeltsvilleUSA

＜正＞The diploid strawberry Fragaria vesca is becoming an ideal model for studying flower and fruit development.F vesca can be easily grown in the lab,has a life cycle of only 3.5 months,can be propagated both sexually and asexually,and is amenable to transformation and genetic analyses. In addition,its～200 Mb genome has recently been sequenced.F vesca can also serve as a model for other Rosaceae species that possess larger genomes and/or longer juvenile phases. Using a 7th generation diploid inbred line,*** 5AF7,we characterized developmental stages of strawberry flower and fruit development using histological sections and scanning electron *** description of morphological landmarks during flower and fruit development provides reference points for subsequent molecular,genetic,and genomic studies that included in situ hybridization of organ and meristem markers such as FvAGAMOUS and FvWUSCHEL and stage-,tissue-,and floral organ-specific transcriptiomes using next-generation *** stage and tissue-specific reproductive tissues are dissected either manually or via laser capture *** of auxin-inducible reporters into the F vesca is being carried out. Finally,a mutagenized population of 5AF7 has been generated with the ultimate goal of isolating developmental mutants and creating a tilling library for both forward and reverse genetic analyses.

关键词： Diploid strawberry flower fruit transcriptome mutant screen model system

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Applying the Hidden Markov Model to Analyze Urban Mobility patterns: An Interdisciplinary Approach

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Chinese Geographical Science 2021年第1期31卷 1-13页

作者： LOO Becky p Y ZHANG Feiyang HSIAO janet H CHAN Antoni B LAN Hui Department of Geography the University of Hong KongHong Kong 999077China Department of psychology the University of Hong KongHong Kong 999077China Department of Computer Science the City University of Hong KongHong Kong 999077China

With the emergence of the Internet of Things(IoT), there has been a proliferation of urban studies using big data. Yet, another type of urban research innovations that involve interdisciplinary thinking and methods remains underdeveloped. This paper represents an attempt to adopt a Hidden Markov Model(HMM) toolbox developed in Computer Science for the analysis of eye movement patterns in psychology to answer urban mobility questions in Geography. The main idea is that both people’s eye movements and travel behavior follow the stop-travel-stop pattern, which can be summarized using HMM. Methodological challenges were addressed by adjusting the HMM to analyze territory-wide travel survey data in Hong Kong, China. By using the adjusted toolbox to identify the activitytravel patterns of working adults in Hong Kong, two distinctive groups of balanced(38.4%) and work-oriented(61.6%) lifestyles were identified. With some notable exceptions, working adults living in the urban core were having a more work-oriented lifestyle. Those with a balanced lifestyle were having a relatively compact zone of non-work activities around their homes but a relatively long commuting distance. Furthermore, working females tend to spend more time at home than their counterparts, regardless of their marital status and lifestyle. Overall, this interdisciplinary research demonstrates an attempt to integrate spatial, temporal, and sequential information for understanding people’s behavior in urban mobility research.

关键词： activity-travel pattern urban mobility activity sequences cluster analysis Hidden Markov Model

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Tight Focusing properties of Azimuthally polarized pair of Vortex Beams through a Dielectric Interface

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Chinese physics Letters 2017年第7期34卷 109-113页

作者： C. A. p. janet M. Lavanya K. B. Rajesh M. Udhayakumar Z. Jaroszewicz D. Velauthapillai Department of physics St.Xavier's Catholic College of Engineering Nagercoil Tamilnadu India Department of physics PSGR Krishnammal College for Women Coimbatore Tamilnadu India Department of physics Chikkanna Government Arts College Tiruppur Tamilnadu India Institute of Applied Optics Department of Physical Optics Warsaw Poland and National Institute of Telecommunications Warsaw Poland Faculty of Engineering and Business Administration Bergen University College Bergen Norway

Tight focusing properties of an azimuthally polarized Gaussian beam with a pair of vortices through a dielectric interface is theoretically investigated by vector diffraction theory. For the incident beam with a pair of vortices of opposite topological charges, the vortices move toward each other, annihilate and revive in the vicinity of focal plane, which results in the generation of many novel focal patterns. The usable focal structures generated through the tight focusing of the double-vortex beams may find applications in micro-particle trapping, manipulation, and material processing, etc.

关键词： Tight Focusing properties of Azimuthally polarized pair of Vortex Beams through a Dielectric Interface

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Enhanced but hypofunctional osteoclastogenesis in an autosomal dominant osteopetrosis type II case carrying a c.1856C＞T mutation in CLCN7

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Bone Research 2016年第4期4卷 232-240页

作者： Xiang Chen Kun Zhang janet Hock Chunyu Wang Xijie Yu Laboratory of Endocrinology and Metabolism Department of Endocrinology State Key Laboratory of Biotherapy West China Hospital Sichuan University Chengdu China The polis Center Indiana University-Purdue University Indianapolis Indianapolis IN USA

Type II autosomal dominant osteopetrosis(ADO2), which is the most common form of osteopetrosis, is caused by heterozygous mutations in the chloride channel 7(CLCN7) gene. The osteopetrosis of ADO2 has been attributed to hypofunctional osteoclasts. The mechanism underlying the abnormality in osteoclast function remains largely unknown. This study was designed to investigate gene mutations and osteoclast function in a case that was clinically diagnosed as ADO2. Genomic DNA was extracted from blood samples of this patient, and the 25 exons of CLCN7 were amplified. peripheral blood from the ADO2 subject and a healthy age- and sex-matched control was used to evaluate osteoclastogenesis, osteoclast morphology, and bone resorption. Analysis of DNA from the patient showed a germline heterozygous missense mutation,c.1856C>T(p.p619L), in exon 20 of CLCN7. A similar homozygous mutation at this site was previously reported in a patient with autosomal recessive osteopetrosis. When cultured, the peripheral blood mononuclear cells(pBMCs) from the ADO2 patient spontaneously differentiated into mature osteoclasts in vitro. The ADO2 patient’s pBMCs formed enhanced, but heterogeneous, osteoclasts in both the presence and absence of macrophage-colony stimulating factor, and nuclear factor-?B ligand. Bone resorption was reduced in the ADO2 patient’s osteoclasts, which exhibited aberrant morphology and abnormal distribution of integrin avβ3. Gene analysis found increased c-fos expression and reduced Rho A and integrin beta 3expression in ADO2 cells. In conclusion, our data suggest that enhanced, heterogeneous osteoclast induction may be an intrinsic characteristic of ADO2.

关键词： ADO T mutation in CLCN7 Enhanced but hypofunctional osteoclastogenesis in an autosomal dominant osteopetrosis type II case carrying a c.1856C case type II

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productive performance of commercial growing and finishing pigs supplemented with a Buttiauxella phytase as a total replacement of inorganic phosphate

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Animal Nutrition 2018年第4期4卷 351-357页

作者： Yueming Dersjant-Li peter plumstead Ajay Awati janet Remus Danisco Animal Nutrition DuPont Industrial Biosciences Marlborough SN8 1XN United Kingdom Department of Animal and Wildlife Sciences Faculty of Agricultural and Natural Sciences University of Pretoria Hatfield Pretoria 0028 South Africa Danisco Animal Nutrition DuPont Industrial Biosciences St. Louis MO 63167 USA

The objective of this study was to test if a novel phytase from Buttiauxella sp. can replace all added inorganic phosphate in a diet with reduced Ca and metabolizable energy(ME) fed to commercial pigs from12 kg body weight(BW) until slaughter, whilst maintaining performance and carcass quality *** dietary treatments were tested in a completely randomized design with 9 replicate pens, each containing 31 mixed sex Newsham Choice pigs. Diets included a positive control(pC) based on corn,soybean meal, wheat middling and bakery meal, meeting all nutrient requirement of pigs; a negative control(NC) excluded inorganic phosphate and with reduced Ca(-0.13%) and ME(-0.15 MJ/kg); and NC supplemented with Buttiauxella phytase at 500 or 1,000 FTU/kg feed. Diets were fed ad libitum in mash form in 5 phases: starter(12 to 25 kg BW), grower 1(25 to 50 kg BW) and 2(50 to 75 kg BW), and finisher1(75 to 100 kg BW) and 2(100 kg BW to slaughter). The NC group showed lower(p phases, lower gain to feed ratio(G:F)in starter and grower 1 compared with pC. pigs receiving the high dose of phytase of 1,000 FTU/kg had improved performance vs. the 500 FTU/kg phytase treatment in starter and grower 1 phase compared with the pC in grower 1 phase. Increasing phytase dose resulted in a linear increase in ADG(12 to120 kg BW) and G:F(50 to 75 kg BW). A comparison of treatment groups over the full production period from 12 kg BW until slaughter showed that both 500 and 1,000 FTU/kg phytase treatments were able to maintain growth performance and carcass characteristics compared with pC. The application of Buttiauxella phytase could therefore be used as an effective strategy to replace all inorganic phosphate in diets of pigs fed corn, soybean meal, wheat middling and bakery meal based diets from 12 kg BW. An economic analysis showed greater return from both phytase treatments vs. the pC and favored the

关键词： Buttiauxella phytase Carcass pigs phosphorus productive performance

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High-dose infliximab for treatment of pediatric ulcerative colitis:A survey of clinical practice

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World Journal of Gastroenterology 2012年第11期18卷 1229-1234页

作者： Roy Nattiv janet M Wojcicki Elizabeth A Garnett Neera Gupta Melvin B Heyman Department of pediatrics UCSF Benioff Children's HospitalUniversity of CaliforniaSan FranciscoCA 94143-0136United States

AIM:To assess attitudes and trends regarding the use of high-dose infliximab among pediatric gastroenterologists for treatment of pediatric ulcerative colitis(UC).METHODS:A 19-item survey was distributed to subscribers of the pediatric gastroenterology(pEDSGI) *** were submitted anonymously and results compiled in a secure ***:A total of 113 subscribers(88% based in the United States) responded(101 pediatric gastroenterology attendings and 12 pediatric gastroenterology fellows).There were 46% in academic medical institutions and 39% in hospital-based *** majority(91%) were treating >10 patients with UC;13% were treating >100 patients with UC;91% had prescribed infliximab(IFX) 5 mg/kg for UC;72% had prescribed IFX 10 mg/kg for *** a 5-point Likert scale,factors that influenced the decision not to increase IFX dosing in patients with UC included:"improvement on initial dose of IFX"(mean:3.88) and "decision to move to colectomy"(3.69).Lowest mean Likert scores were:"lack of guidelines or literature regarding increased IFX dosing"(1.96) and "insurance authorization or other insurance issues"(2.34)."Insurance authorization or other insurance issues" was identified by 39% as at least somewhat of a factor(Likert score ≥ 3) in their decision not to increase the IFX *** 10 mg/kg was more commonly used for the treatment of pediatric UC among responders based in the United States(75/100) compared to non-United States responders(6/13,p = 0.047).Induction of remission was reported by 78% of all responders and 81% reported maintenance of remission with IFX 10 mg/*** responder reported one death with IFX 10 mg/***:IFX 10 mg/kg is more commonly used in the United States to treat pediatric *** and safety data are required to avoid insurance barriers for its use.

关键词： Immunosuppression Inflammatory boweldisease Ulcerative colitis Children pharmacology

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Mixture models detect large effect QTL better than GBLUp and result in more accurate and persistent predictions

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Journal of Animal Science and Biotechnology 2016年第4期7卷 468-473页

作者： Anna Wolc Jesus Arango petek Settar janet E.Fulton Neil p.O'Sullivan Jack C.M.Dekkers Rohan Fernando Dorian J.Garrick Department of Animal Science Iowa State University Hy-Line International Dallas Center

Background： Accurate evaluation of SNp effects is important for genome wide association studies and for genomic prediction. The genetic architecture of quantitative traits differs widely, with some traits exhibiting few if any quantitative trait loci （QTL） with large effects, while other traits have one or several easily detectable QTL with large effects. Methods： Body weight in broilers and egg weight in layers are two examples of traits that have QTL of large effect A commonly used method for genome wide association studies is to fit a mixture model such as BayesB that assumes some known proportion of SNp effects are zero. In contrast, the most commonly used method for genomic prediction is known as GBLUp, which involves fitting an animal model to phenotypic data with the variance-covariance or genomic relationship matrix among the animals being determined by genome wide SNp genotypes. Genotypes at each SNp are typically weighted equally in determining the genomic relationship matrix for GBLUp. We used the equivalent marker effects model formulation of GBLUp for this study. We compare these two classes of models using egg weight data collected over 8 generations from 2,324 animals genotyped with a 42 K SNp ***： Using data from the first 7 generations, both BayesB and GBLUp found the largest QTL in a similar well-recognized QTL region, but this QTL was estimated to account for 24 % of genetic variation with BayesB and less than 1% with GBLUp. When predicting phenotypes in generation 8 BayesB accounted for 36 % of the phenotypic variation and GBLUp for 25 %. When using only data from any one generation, the same QTL was identified with BayesB in all but one generation but never with GBLUp. predictions of phenotypes in generations 2 to 7 based on only 295 animals from generation 1 accounted for 10 % phenotypic variation with BayesB but only 6 % with GBLUp. predicting phenotype using only the marker effects in the 1 Mb region that accounted for the largest e

关键词： Bayesian methods Bias QTL

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