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Status of precision medicine approaches to traumatic brain injury

Neural Regeneration Research 2022年第10期17卷 2166-2171页

作者： Sahithi Reddi Smita Thakker-Varia janet Alder Anna O.Giarratana Department of Neuroscience and Cell Biology Rutgers Robert Wood Johnson Medical SchoolPiscatawayNJUSA

Traumatic brain injury(TBI)is a serious condition in which trauma to the head causes damage to the brain,leading to a disruption in brain *** is a significant health issue worldwide,with around 69 million people suffering from TBI each *** following the trauma,damage occurs in the acute phase of injury that leads to the primary outcomes of the *** the hours-to-days that follow,secondary damage can also occur,leading to chronic *** can range in severity from mild to severe,and can be complicated by the fact that some individuals sustain multiple TBIs,a risk factor for worse long-term *** our knowledge about the pathophysiology of TBI has increased in recent years,unfortunately this has not been translated into effective clinical *** *** and Drug Administration has yet to approve any drugs for the treatment of TBI;current clinical treatment guidelines merely offer supportive *** between individuals greatly vary,which makes the treatment for TBI so challenging.A blow of similar force can have only mild,primary outcomes in one individual and yet cause severe,chronic outcomes in *** of the reasons that have been proposed for this differential response to TBI is the underlying genetic differences across the *** to this,many researchers have begun to investigate the possibility of using precision medicine techniques to address TBI *** this review,we will discuss the research detailing the identification of genetic risk factors for worse outcomes after TBI,and the work investigating personalized treatments for these higher-risk *** highlight the need for further research into the identification of higher-risk individuals and the development of personalized therapies for TBI.

关键词： apolipoprotein E biomarkers brain injury brain-derived neurotrophic factor clinical trials personalized treatments precision medicine tau translational research traumatic brain injury

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Hypotension prediction index together with cerebral oxygenation in guiding intraoperative hemodynamic management: a case report

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The Journal of Biomedical Research 2022年第1期36卷 73-77页

作者： Yun Li janet Phan Azaam Mamoor Hong Liu Department of Anesthesiology the Second Hospital of Anhui Medical UniversityHefeiAnhui 230601China Department of Anesthesiology and Pain Medicine University of California Davis HealthSacramentoCA 95817USA California Northstate University College of Medicine SacramentoCA 95757USA

Intraoperative hypotension happens in everyday clinical practice. It was suggested to have a strong association with adverse postoperative outcomes. Hypotension prediction index(HPI) was developed to predict intraoperative hypotension(mean arterial pressure <65 mmHg) in real time. However, pressure autoregulation also plays an important role in maintaining adequate organ perfusion/oxygenation during hypotension. A cerebral oxygenation monitor provides clinicians with the values of organ oxygenation. We reported a case that the cerebral oxygenation monitor was used together with HPI to guide intraoperative blood pressure management. We found that cerebral oxygenation was maintained in the event of hypotension during surgery. The patient had no intraoperative or postoperative adverse outcomes despite the hypotension. We believe this can provide an individualized intraoperative blood pressure management to avoid over-or under-treating hypotension.

关键词： hypotension prediction index cerebral oxygenation hemodynamic intraoperative

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Role of locoregional therapies in the management of patients with hepatocellular carcinoma

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Hepatoma Research 2022年第1期8卷 106-126页

作者： janet Wui Cheung Kung Kelvin Kwok Chai Ng Department of Surgery The Chinese University of Hong KongHong Kong 999077China

Hepatocellular carcinoma(HCC)was the sixth most common cancer and the third cause of cancer-related deaths worldwide in *** resection and transplantation remain the cornerstone for patients with early-stage disease and represent the only option for potential cure in ***,fewer than 10%of patients are considered suitable for surgery at the time of *** therapies,defined as minimally invasive image-guided liver tumour-directed procedures,are integral to in the management of *** review discusses the role of locoregional therapies in HCC management in the emergence of immune and systemic treatments.

关键词： Locoregional therapy hepatocellular carcinoma ablation transarterial embolization radiation therapy

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Vascular resections in minimally invasive surgery for pancreatic cancer

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Laparoscopic, Endoscopic and Robotic Surgery 2022年第1期5卷 3-9页

作者： janet W.C.Kung Rowan W.Parks Division of HBP Surgery Prince of Wales HospitalShatinHong KongChina Department of Surgery The Chinese University of Hong KongHong KongChina HPB Surgery Royal Infirmary of EdinburghEdinburghUnited Kingdom Department of Clinical Surgery University of EdinburghEdinburghUnited Kingdom

Pancreatic ductal adenocarcinoma(PDAC)is characterised by poor oncological outcome and is the seventh cause of cancer-related deaths *** the advances in surgical technology,oncological treatment,and critical care,extended pancreatic resections including vascular resections have become more frequently performed in specialised ***,the boundaries of resectability continue to be pushed in order to achieve a potentially curative approach in selected patients in combination with neoadjuvant and adjuvant treatment *** review gives an overview on the current state of venous and arterial resections in PDAC surgery with particular attention given to the minimally invasive approach.

关键词： Pancreatic adenocarcinoma Minimally invasive surgery Extended pancreatic resection Vascular resection Vascular reconstruction Neoadjuvant therapy

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Phase equilibria and microstructure investigation of Mg-Gd-Y-Zn alloy system

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Journal of Magnesium and Alloys 2022年第3期10卷 746-755页

作者： janet M.Meier Jiashi Miao Song-Mao Liang Jun Zhu Chuan Zhang Josh Caris Alan A.Luo Department of Materials Science and Engineering The Ohio State UniversityColumbusOH 43210USA CompuTherm LLC MiddletonWI 53562 USA Terves LLC EuclidOH 44117USA Department of Integrated Systems Engineering The Ohio State UniversityColumbusOH 43210USA

In order to develop high strength Mg-Gd-Y-Zn alloys,key experiments coupled with CALPHAD(CALculation of PHAse Diagrams)calculations were carried out in the current work to provide critical understanding of this important alloy *** Mg-10 Gd-xY-yZn(x=4 or 5,y=3 or 5,wt.%) were mapped on Mg-Gd-Y-Zn phase diagrams for phase equilibria and microstructure *** microscopy was performed for phase identification and phase fraction determination in as-cast and solution treated *** all three alloys,the major phases were Mg-matrix and long period stacking order(LPSO) 14 H *** ST at 400 and 500℃,the phase fraction of LPSO 14 H increased,particularly the fine lamellar morphology in the Mg *** as-cast and 400℃ Mg10 Gd5 Y3 Zn samples had Mg(Gd,Y) *** 500℃,Mg(Gd,Y) is not stable and transforms into LPSO 14 *** Mg 10 Gd5 Y5 Zn alloy included the WPhase,which showed a reduction in phase fraction with solution *** experimental results were used to validate and improve the thermodynamic database of the Mg-Gd-Y-Zn *** calculations using the improved database can well describe the available experimental results and make accurate predictions to guide the development of promising high-strength Mg-Gd-Y-Zn alloys.

关键词： Long period stacking order(LPSO) Microstructure Magnesium alloys CALPHAD Alloy development.

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Understanding Lithium-ion Transport in Sulfolane- and Tetraglyme-Based Electrolytes Using Very Low-Frequency Impedance Spectroscopy

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Energy & Environmental Materials 2023年第1期6卷 368-376页

作者： janet SHo Oleg A.Borodin Michael SDing Lin Ma Marshall A.Schroeder Glenn R.Pastel Kang Xu Energy Sciences Division Sensors and Electron Devices DirectorateUS Army Research LaboratoryAdelphi MD 20783USA

With the increasing interest in highly concentrated electrolyte systems,correct determination of the cation transference number is ***-field gradient NMR technique,which measures self-diffusion coefficients,is often applied on liquid electrolytes because of the wide accessibility and simple sample ***,since the assumptions of this technique,that is,complete salt dissociation,all ions participating in motion,and all of them moving independently,no longer hold true in concentrated solutions,the transference numbers,thus obtained are often *** the present work,impedance spectroscopy at a frequency range of 1 MHz to 0.1 mHz was used to examine the concentration effect on lithium-ion transference number under anion-blocking conditions T abc Liþfor two electrolytes:lithium bis(fluorosulfonyl)imide(LiFSI)in sulfolane(SL)and lithium bis(trifluorosulfonyl)imide(LiTFSI)in tetraglyme(G4).The T abc Liþof the former was almost an order of magnitude higher than that of the *** also appeared to increase with increasing concentration while the latter followed an opposite *** faster Li^(+)transport in the SL system is attributed to the formation of a liquid structure consisting of extended chains/bridges of SL molecules and the anions,which facilitate a cation-hopping/ligand-exchanged-typed diffusion mechanism by partially decoupling the cations from the anions and solvent *** G4 system,in contrast,is dominated by the formation of long-lived,stable[Li(G4)]+solvation cages that results in a sluggish Li+*** difference between the two transport mechanisms is discussed via comparison of the bulk ionic conductivity,viscosity,ion self-diffusion coefficients,and the Onsager transport coefficients.

关键词： anion-blocking conditions ion correlations low-frequency impedance spectroscopy transference number

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Quickbooks Pro 2002 a complete course janet Horne.

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2003年

作者： janet Horne.

来源：畅想之星图书光盘版（南... 评论

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Development and psychometric evaluation of the nurse behavior toward confirmed and suspected HIV/AIDS patients (NB-CSHAP) scale

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Frontiers of Nursing 2022年第1期9卷 103-113页

作者： janet Alexis De los Santos Norberto Milla Cyruz Tuppal Leodoro Labrague Department of Nursing Visayas State UniversityViscaLeyte 6521Philippines Graduate School St Paul University PhilippinesTuguegaraoCagayan Valley 3500Philippines Department of Statistics Visayas State UniversityViscaLeyte 6521Philippines College of Health Allied and Medical Professions University of San AgustinTuguegaraoIloiloVisayas 5000Philippines Fundamentals and Administration Department Sultan Qaboos UniversityMuscatMuscat 112Oman

There is a scarcity of literature discussing nurses’ behaviors toward caring for suspected or confirmed human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients. The development of a scale specific to measure nurses’ behaviors will allow health institutions to assess the disposition of their nurses in terms of HIV care. This study aims to present the rigors of developing and validating a reliable instrument to contextualize these nurses’ behaviors. This study utilized a sequential exploratory mixed method design to develop the NB-CSHAP scale. Thematic analysis was done on the qualitative data from the interviews with persons living with HIV/AIDS (PLHA) from which items were selected to be included in the scale. Exploratory factor analysis was utilized to extract the factors and Cronbach’s alpha was used to assess the reliability of the instrument. Four factors were extracted and are categorized as either caring or discriminatory behaviors. These include: (1) service-oriented, (2) openhanded, (3) perceptive, and (4) discriminatory. The scale has an internal consistency of 0.73. The scale shows acceptable psychometric properties, hence can be used to assess the nurses’ behaviors in caring for confirmed or suspected HIV clients. The scale may be used by health institutions to determine the quality of the patient care provided by their nurses to clients with confirmed or suspected HIV .

关键词： caring behaviors HIV/AIDS care nursing scale development sequential exploratory mixed method design

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Materials and technology of Chinese jades dating to the Western Zhou period (1050―771 BCE)

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Science China(Technological Sciences) 2008年第4期51卷 467-480页

作者： janet G DOUGLAS Department of Conservation and Scientific Research Freer Gallery of Art / Arthur M. Sackler Gallery Smithsonian Institution

Excavated jades dating to the Western Zhou period (1050―771 BCE) from the Xi’an area in Shaanxi Province, China, and contemporaneous jades in the collections of the Arthur M. Sackler Gallery at the Smithsonian Institution have been studied to learn about the jade and stone materials and how they were worked during the Western Zhou period. Materials identification was carried out using a combination of techniques such as Fourier-transform infrared spectroscopy and X-ray diffraction. Tool marks were studied using stereomicroscopy and examination of mold impressions using scanning electron microscopy. All of these objects were pro- duced through simple processes involving solid drilling, riffling, and sharp point abrasion; and no evidence was found for the use of rotary tools for incising or sawing.

关键词： jade nephrite stone China Western Zhou scanning electron microscopy materials technology tool marks

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The"weekend effect"does not impact on outcome of trauma laparotomy–Experience from a level 1 trauma centre in New Zealand

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中华创伤杂志：英文版 2023年第2期26卷 73-76页

作者： Jonathan Ko Victor Kong janet Amey Damien Ah Yen Damian Clarke Grant Christey Department of Surgery University of AucklandAucklandNew Zealand Department of Trauma Waikato HospitalHamiltonNew Zealand Department of Surgery University of the WitwatersrandJohannesburgSouth Africa Te Manawa Taki Trauma System WaikatoNew Zealand

Purpose:Trauma centres have been proven to provide better outcomes in developed countries for overall trauma,but there is limited literature on the systematic factors that describe any discrepancies in outcomes for trauma laparotomies in these *** study was conducted to examine and interrogate the effect of systematic factors on patients undergoing a trauma laparotomy in a developed country,intending to identify potential discrepancies in the ***:This was a retrospective study of all laparotomies performed for trauma at a level 1 trauma centre in New *** adult patients who had undergone an index laparotomy for trauma between February 2012 and November 2020 were identified and laparotomies for both blunt and penetrating trauma were *** laparotomies and trauma laparotomies in children were *** primary clinical outcomes reviewed included morbidity,length of hospital stay,and *** statistical analysis was performed using R ***:During the 9-year study period,204 trauma laparotomies were performed at Waikato *** majority(83.3%)were performed during office hours(170/204),and the remaining 16.7%were performed after hours(34/204).And 61.3%were performed on a weekday(125/204),whilst 38.7%were performed on the weekend/public holiday(79/204).Most of the parameters in office hours and after hours groups had no statistically significant difference,except lactate(p=0.026).Most of the variables in weekday and weekend groups had no statistically significant difference,except pH,lactate,length of stay,and gastrointestinal complications(p=0.012,p<0.001,p=0.003,p=0.020,respectively).Conclusion:The current trauma system at Waikato hospital is capable of delivering care for trauma laparotomy patients with the same outcome regardless of working hours or after hours,weekday or *** confirms the importance of a robust trauma system capable of responding to the sudden demands placed on it.

关键词： Wounds and injuries General surgery Trauma surgery Abdominal trauma Systematic factors

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