检索结果-南通市图书馆

Transforming growth factor-β in stem cells and tissue homeostasis

Bone Research 2018年第1期6卷 1-31页

作者： Xin Xu Liwei Zheng Quan Yuan Gehua Zhen janet L.Crane Xuedong Zhou Xu Cao State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Cariology and Endodontics West China Hospital of StomatologySichuan University State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Pediatric Dentistry West China Hospital of Stomatology Sichuan University State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Department of Oral Implantology West China Hospital of Stomatology Sichuan University Department of Orthopedic Surgery Johns Hopkins University School of Medicine Department of Pediatrics Johns Hopkins University

TGF-β 1–3 are unique multi-functional growth factors that are only expressed in mammals, and mainly secreted and stored as a latent complex in the extracellular matrix(ECM). The biological functions of TGF-β in adults can only be delivered after ligand activation, mostly in response to environmental perturbations. Although involved in multiple biological and pathological processes of the human body, the exact roles of TGF-β in maintaining stem cells and tissue homeostasis have not been well-documented until recent advances, which delineate their functions in a given context. Our recent findings, along with data reported by others, have clearly shown that temporal and spatial activation of TGF-β is involved in the recruitment of stem/progenitor cell participation in tissue regeneration/remodeling process, whereas sustained abnormalities in TGF-β ligand activation, regardless of genetic or environmental origin, will inevitably disrupt the normal physiology and lead to pathobiology of major diseases. Modulation of TGF-β signaling with different approaches has proven effective pre-clinically in the treatment of multiple pathologies such as sclerosis/fibrosis, tumor metastasis, osteoarthritis, and immune disorders. Thus, further elucidation of the mechanisms by which TGF-β is activated in different tissues/organs and how targeted cells respond in a context-dependent way can likely be translated with clinical benefits in the management of a broad range of diseases with the involvement of TGF-β.

关键词： cells metastasis TGF-β1 ligand human lead can not

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Epidemiology of burns and scalds in children presenting to the emergency department of a regional burns unit: a 7-year retrospective study

引用

Burns & Trauma 2016年第3期4卷 245-250页

作者： Ceri Elisabeth Battle Vanessa Evans Karen James Katherine Guy janet Whitley Phillip Adrian Evans Department of Emergency Medicine NISCHR Haemostasis Biomedical Research UnitMorriston HospitalSwanseaUK Department of Physiotherapy Morriston HospitalSwanseaUK Department of Emergency Medicine NISCHR Haemostasis Biomedical Research UnitMorriston HospitalSwanseaUK Department of Physiotherapy Morriston HospitalSwanseaUK Department of Emergency Medicine Morriston HospitalSwanseaWales SA66NLUK

Background:Variation in the incidence and mechanism of thermal injury has been reported in different age groups in *** aim of this study was to report the incidence,mechanisms,and environmental factors of all burns presentations to the emergency department(ED)of a regional burns centre over a 7-year ***:A retrospective,chart review study of all burns presentations to the ED of a regional burns centre in South Wales was *** children recorded as having sustained a burn or scald,aged less than 16 years were included in the ***’demographics were analysed using descriptive statistics,and comparisons were made between patients aged less than 5 and patients aged 5-16 using chi-square test and Mann-Whitney U ***:A total of 1387 cases were included in the final *** were the most common thermal injury with 569(41.0%)reported,followed by contact burns in 563(40.6%)*** patients requiring hospitalisation were significantly younger(2 vs 3 years;p<0.001)and had a higher rate of non-accidental injury(10 vs 4;p<0.001).The most commonly injured site in both age groups was a hand or ***:Scalds and contact burns were the most commonly reported thermal injury in children aged less than *** mechanisms were hot beverages,hobs and hair straighteners,highlighting further burn prevention strategies are needed and good-quality prospective studies that investigate the effectiveness of such strategies.

关键词： Burns epidemiology Paediatrics Emergency department

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

New Hypoxylon species from Martinique and new evidence on the molecular phylogeny of Hypoxylon based on ITS rDNA and β-tubulin data

引用

Fungal Diversity 2014年第1期64卷 181-203页

作者： Eric Kuhnert Jacques Fournier Derek Peršoh janet Jennifer Divinagracia Luangsa-ard Marc Stadler Department of Microbial Drugs Helmholtz-Zentrum für Infektionsforschung GmbHInhoffenstrasse 738124 BraunschweigGermany Las Muros 09420 RimontFrance Department of Mycology University of BayreuthUniversitätsstraße 3095540 BayreuthGermany National Center for Genetic Engineering and Biotechnology(BIOTEC) 113 Thailand Science ParkPhaholyothin RoadKlong LuangPathumthani 12120Thailand

Three new species of Hypoxylon(Xylariaceae)collected from Martinique in the French Caribbean are recognised by new combinations of morphological *** status as undescribed taxa was supported by secondary metabolite profiling based on High performance liquid chromatography with diode array and mass spectrometric detection(HPLC/DAD-MS)as well as by comparison of ITS and partialß-tubulin DNA sequences with related *** the course of this study,the teleomorph of Nodulisporium griseobrunneum was found,and this species could be transferred to ***,several names in Hypoxylon are epitypified by selecting recently collected specimens from the same geographic areas as the holotypes came *** the fact that our study used the hitherto most extensive taxon sampling,the phylogenetic analyses inferred from ITS andß-tubulin sequences remain contradictory to each other,and neither genealogy was found fully in agreement with phenotype-derived *** conclude that the right gene(or multi-gene genealogies)to reflect the phylogeny and evolution of Hypoxylon still remains to be *** the time being,we recommend that the application of polyphasic taxonomic concepts should be continued in taxonomic studies of Hypoxylon.

关键词： Biodiversity Chemotaxonomy Epitypification Phylogeny Systematics Xylariaceae

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Development and psychometric evaluation of the nurse behavior toward confirmed and suspected HIV/AIDS patients (NB-CSHAP) scale

引用

Frontiers of Nursing 2022年第1期9卷 103-113页

作者： janet alexis De los Santos Norberto Milla Cyruz Tuppal Leodoro Labrague Department of Nursing Visayas State UniversityViscaLeyte 6521Philippines Graduate School St Paul University PhilippinesTuguegaraoCagayan Valley 3500Philippines Department of Statistics Visayas State UniversityViscaLeyte 6521Philippines College of Health Allied and Medical Professions University of San AgustinTuguegaraoIloiloVisayas 5000Philippines Fundamentals and Administration Department Sultan Qaboos UniversityMuscatMuscat 112Oman

There is a scarcity of literature discussing nurses’ behaviors toward caring for suspected or confirmed human immunodeficiency virus (HIV)/acquired immunodeficiency syndrome (AIDS) patients. The development of a scale specific to measure nurses’ behaviors will allow health institutions to assess the disposition of their nurses in terms of HIV care. This study aims to present the rigors of developing and validating a reliable instrument to contextualize these nurses’ behaviors. This study utilized a sequential exploratory mixed method design to develop the NB-CSHAP scale. Thematic analysis was done on the qualitative data from the interviews with persons living with HIV/AIDS (PLHA) from which items were selected to be included in the scale. Exploratory factor analysis was utilized to extract the factors and Cronbach’s alpha was used to assess the reliability of the instrument. Four factors were extracted and are categorized as either caring or discriminatory behaviors. These include: (1) service-oriented, (2) openhanded, (3) perceptive, and (4) discriminatory. The scale has an internal consistency of 0.73. The scale shows acceptable psychometric properties, hence can be used to assess the nurses’ behaviors in caring for confirmed or suspected HIV clients. The scale may be used by health institutions to determine the quality of the patient care provided by their nurses to clients with confirmed or suspected HIV .

关键词： caring behaviors HIV/AIDS care nursing scale development sequential exploratory mixed method design

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

工艺参数扰动下互连线时延的随机点匹配评估算法

引用

物理学报 2009年第6期58卷 3603-3610页

作者：李鑫 janet M.Wang 唐卫清南京理工大学计算机科学与技术学院南京210094 亚利桑那大学电子工程系中国科学院计算技术研究所北京100190

提出了一种基于工艺参数扰动的随机点匹配时延评估算法.该算法通过Cholesky分解将具有强相关性的工艺随机扰动转化为独立随机变量,并结合随机点匹配方法和多项式混沌理论对耦合随机互连线模型进行时延分析.最后,利用数值计算方法给出互... 详细信息

提出了一种基于工艺参数扰动的随机点匹配时延评估算法.该算法通过Cholesky分解将具有强相关性的工艺随机扰动转化为独立随机变量,并结合随机点匹配方法和多项式混沌理论对耦合随机互连线模型进行时延分析.最后,利用数值计算方法给出互连时延的有限维表达式.仿真实验结果表明,该算法与HSPICE仿真时延的相对误差不超过2%,且相比于HSPICE显著降低了电路模拟时间.

关键词：工艺参数扰动随机互连模型随机点匹配方法多项式混沌理论

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Influence of Glyphaea brevis twig extract on nucleus, tight junctions and expression of inhibin-β, stem cell factor, and androgen binding protein in TM4 Sertoli cells

引用

Asian pacific Journal of Reproduction 2019年第4期8卷 157-166页

作者： janet Olayemi Olugbodi Oladipupo David Oluwafemi Adeleke Ojo Afolabi Clement Akinmoladun Department of Biochemistry Bingham UniversityAbuja-Keffi RoadKaruNigeria Department of Medical Bioscience University of the Western CapeBellvilleCape TownSouth Africa Phytomedicine and Biochemical Toxicology Unit Department of BiochemistryAfe Babalola UniversityPMB 5454Ado-EkitiNigeria Phytomedicine Biochemical Pharmacology and Toxicology LaboratoriesDepartment of BiochemistrySchool of SciencesPMB 704The Federal University of TechnologyAkureNigeria

Objective: To examine the influence of Glyphaea (G.) brevis twig extract on the mitochondrial dehydrogenase activity, integrity of the tight junctions between adjacent cells, mitochondria, apoptosis, nucleus and expression of inhibin-β, stem cell factor, and androgen binding protein in TM4 Sertoli cells. Methods: TM4 cell line was used in this study as it exhibited properties similar to the Sertoli cells. TM4 Sertoli cells were exposed to G. brevis twig extract (0.1, 1.0, 10.0, 100.0, or 1000.0μg/mL) for 24, 48 and 72 h. Parameters studied included cell viability [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide assay], mitochondrial membrane potential (tetra methyl rhodamine ethyl ester dye), transepithelial electrical resistance, apoptosis (Annexin V Alexa Fluor?488/propidium iodide assay) and mRNA expression (quantitative reverse transcription polymerase chain reaction). Results: G. brevis twig extract had no cytotoxic impact on cell viability, thus, considerably increasing the activity of mitochondrial dehydrogenase enzyme after 24 and 72 h exposure. Transepithelial electrical resistance values revealed substantial (P<0.05) rise in treated groups, especially after 72 h of treatment. Moreover, there was a significant decrease in mitochondrial depolarization of TM4 Sertoli cells exposed to G. brevis twig extract when compared to controls. In addition, G. brevis twig extract significantly reduced necrosis and apoptosis of TM4 Sertoli cells when compared to control. Nevertheless, fluorescence microscopy revealed that the nuclei were egg-shaped and marked uniformly with consistent cell shape at the middle of the TM4 Sertoli cells. Significant stimulatory effects were observed on mRNA levels of inhibin-β, androgen binding protein and stem cell factor. Conclusions: G. brevis twig extract may increase the secretory roles of TM4 Sertoli cells, cells proliferation, as well as cell-cell tight junction integrity. Thus, G. brevis twig may enhance spermatogenesis

关键词： Glyphaea brevis twig TM4 Sertoli cell line Inhibin-β Androgen binding protein

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Evidence of neurodegeneration in autism spectrum disorder

引用

Translational Neurodegeneration 2013年第1期2卷 113-118页

作者： janet K Kern David A Geier Lisa K Sykes Mark R Geier Institute of Chronic Illnesses IncorporationSilver SpringMDUSA University of Texas Southwestern Medical Center at Dallas DallasTXUSA CoMeD IncorporationSilver SpringMDUSA

Autism spectrum disorder(ASD)is a neurological disorder in which a significant number of children experience a developmental regression characterized by a loss of previously-acquired skills and *** of neurological function in ASD,as observed in affected children who have regressed,can be explained as *** there is research evidence of neurodegeneration or progressive encephalopathy in ASD,the issue of neurodegeneration in ASD is still under *** of neurodegeneration in the brain in ASD includes:(1)neuronal cell loss,(2)activated microglia and astrocytes,(3)proinflammatory cytokines,(4)oxidative stress,and(5)elevated 8-oxo-guanosine *** evidence from this review suggests that neurodegeneration underlies the loss of neurological function in children with ASD who have experienced regression and loss of previously acquired skills and abilities,and that research into treatments to address the issue of neurodegeneration in ASD are warranted.

关键词： Autism spectrum disorder(ASD) Autism Neurodegeneration Regression Neuronal cell loss Microglia Oxidative stress Cytokines

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

混合/流体润滑状态下原位离子液体添加剂的摩擦学性能研究

引用

摩擦学学报 2018年第3期38卷 342-348页

作者：杨淑燕 Wong janet 蔡美荣周峰中国科学院兰州化学物理研究所固体润滑国家重点实验室甘肃兰州730000 青岛理工大学机械工程学院山东青岛266520 英国帝国理工学院机械工程系

本工作重点研究了混合/流体润滑状态下原位离子液体添加剂的摩擦学性能,选用聚乙二醇(PEG-400)作基础油,将双(三氟甲基磺酰)亚胺锂盐(Li TFSI)溶解在PEG中原位合成离子液体.利用微型牵引力试验机测量在室温、60和80℃以及不同滑滚比下... 详细信息

本工作重点研究了混合/流体润滑状态下原位离子液体添加剂的摩擦学性能,选用聚乙二醇(PEG-400)作基础油,将双(三氟甲基磺酰)亚胺锂盐(Li TFSI)溶解在PEG中原位合成离子液体.利用微型牵引力试验机测量在室温、60和80℃以及不同滑滚比下摩擦系数随卷吸速度的变化,研究离子液体添加剂的有效性以及离子液体添加剂对PEG流变行为的影响.本研究中将为深入研究离子液体的润滑机理提供一种新的研究手段,对于指导设计新型离子液体润滑材料具有较为重要的意义.

关键词：离子液体添加剂混合/流体润滑 Stribeck曲线流变特性

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

IGF-1 Signaling is Essential for Differentiation of Mesenchymal Stem Cells for Peak Bone Mass

引用

Bone Research 2013年第2期1卷 186-194页

作者： janet L. Crane Luo Zhao Joseph S. Frye Lingling Xian Tao Qiu Xu Cao Department of Pediatrics Johns Hopkins University School of Medicine Department of Orthopaedic Surgery Johns Hopkins University School of Medicine Department of Orthopedics Peking Union Medical College HospitalPeking Union Medical College and Chinese Academy of Medical Sciences University of Missouri School of Medicine

Survival of children with chronic medical illnesses is leading to an increase in secondary osteoporosis due to impaired peak bone mass （PBM）. Insulin-like growth factor type Ⅰ （IGF-1） levels correlate with the pattern of bone mass accrual and many chronic illnesses are associated with low IGF-1 levels. Reduced serum levels of IGF-1 minimally affect the integrity of the skeleton, whereas recent studies suggest that skeletal IGF-I regulates PBM. To determine the role of IGF-1 in postnatal bone mass accrual regardless of source, we established an inducible type 1 Igf receptor Cre/lox knockout mouse model, in which the type 1 Igf receptor was deleted inducibely in the mesenchymal stem cells （MSCs） from 3-7 weeks of age. The size of the mouse was not affected as knockout and wild type mice had similar body weights and nasoanal and femoral lengths. However, bone volume and trabecular bone thickness were decreased in the secondary spongiosa of female knockout mice relative to wild type controls, indicating that IGF-1 is critical for bone mass. IGF-1 signaling in MSCs in vitro has been implicated to be involved in both migration to the bone surface and differentiation into bone forming osteoblasts. To clarify the exact role of IGF-1 in bone, we found by immunohistochemical analysis that a similar number of Osterix-positive osteoprogenitors were on the bone perimeter, indicating migration of MSCs was not affected. Most importantly, 56% fewer osteocalcin-positive mature osteoblasts were present on the bone perimeter in the secondary spongiosa in knockout mice versus wild type littermates. These in vivo data demonstrate that the primary role of skeletal IGF-1 is for the terminal differentiation of osteoprogenitors, but refute the role of IGF-1 in MSC migration in vivo. Additionally, these findings confirm that impaired IGF-1 signaling in bone MSCs is sufficient to impair bone mass acquisition.

关键词： osteoblasts knockout mice cell migration IGF receptor nestin

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The social life of the Japanese language

The social life of the Japanese language

引用

作者： Shigeko Okamoto and janet S. Shibamoto-Smith

来源：南通市图书馆图书评论

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：