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Characterization of Fusobacterium nucleatum ATCC 23726 adhesins involved in strain-specific attachment to Porphyromonas gingivalis

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International Journal of Oral Science 2016年第3期8卷 138-144页

作者： jane park Bhumika Shokeen Susan K Haake Renate Lux School of Dentistry University of California at Los Angeles Los Angeles USA

Bacterial adherence is an essential virulence factor in pathogenesis and infection. Fusobacterium nucleatum has a central role in oral biofilm architecture by acting as a bridge between early Gram-positive and late Gram-negative colonizers that do not otherwise adhere to each other. In this study, we survey a key adherence interaction of F. nucleatum with Porphyromonas gingivalis, and present evidence that multiple fusobacterial adhesins have a role in the attachment of F. nucleatum ATCC 23726 to P. gingivalis in a highly strain-dependent manner. Interaction between these species displayed varying sensitivities to arginine, galactose and lactose. Arginine was found to hamper coaggregation by at least 62% and up to 89% with several P. gingivalis strains and galactose inhibition ranged from no inhibition up to 58% with the same P. gingivalis strains. Lactose consistently inhibited F. nucleatum interaction with these P. gingivalis strains ranging from 40% to 56% decrease in coaggregation. Among the adhesins involved are the previously described Fap2 and surprisingly, RadD, which was described in an earlier study for its function in attachment of F. nucleatum to Gram-positive species. We also provide evidence for the presence of at least one additional adhesin that is sensitive to arginine but unlike Fap2 and RadD, is not a member of the autotransporter family type of fusobacterial large outer membrane proteins. The strain-specific binding profile of multiple fusobacterial adhesins to P. gingivalis highlights the heterogeneity and complexity of interspecies interactions in the oral cavity.

关键词： adhesin bio?lm coaggregation Fusobacterium nucleatum Porphyromonas gingivalis

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Dynamic Interactions of Stock Market and Foreign Exchange Market for Six OECD Countries during the US Financial Crisis

Dynamic Interactions of Stock Market and Foreign Exchange Ma...

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2012 International Conference on Research Challenges in Social and Human Sciences(ICRCSHS 2012)

作者： jane park Sang-Ook Shin Hong-Ghi Min Department of Management Science

This paper shows the dynamic interactions of stock market and foreign exchange market for advanced countries from 2006 to *** analyzing DCC-EGARCH model and Granger causality,we identify DCCs of two markets and prove the dominance of foreign exchange market in the US *** examine DCCX model to find the determinants of DCCs between stock price returns and exchange *** results prove that the volatility index for stock market and foreign exchange market and TED spreads are highly significant for most countries.

关键词： Stock market Foreign exchange market DCC-EGARCH Granger Causality DCCX

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Contemporary management of locally advanced rectal cancer:Resolving issues, controversies and shifting paradigms

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Chinese Journal of Cancer Research 2018年第1期30卷 131-146页

作者： Aeris jane D.Nacion Youn Young park Nam Kyu Kim Department of Surgery Eastern Visayas Regional Medical Center Division of Colorectal Surgery Department of Surgery Yonsei University College of Medicine

Advancements in rectal cancer treatment have resulted in improvement only in locoregional control and have failed to address distant relapse, which is the predominant mode of treatment failure in rectal cancer. As the efficacy of conventional chemoradiotherapy（CRT） followed by total mesorectal excision（TME） reaches a plateau, the need for alternative strategies in locally advanced rectal cancer（LARC） has grown in relevance. Several novel strategies have been conceptualized to address this issue, including： 1） neoadjuvant induction and consolidation chemotherapy before CRT; 2） neoadjuvant chemotherapy alone to avoid the sequelae of radiation; and 3） nonoperative management for patients who achieved pathological or clinical complete response after CRT. This article explores the issues, recent advances and paradigm shifts in the management of LARC and emphasizes the need for a personalized treatment plan for each patient based on tumor stage, location, gene expression and quality of life.

关键词： Locally advanced rectal cancer neoadjuvant treatment chemoradiotherapy

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Seasonal movement of the American horseshoe crab Limulus polyphemus in a semi-enclosed bay on Cape Cod,Massachusetts (USA) as determined by acoustic telemetry

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Current Zoology 2010年第5期56卷 575-586页

作者： Mary-jane JAMES-PIRRI Graduate School of Oceanography University of Rhode Island

American horseshoe crabs Limulus polyphemus were tracked using acoustic telemetry and traditional tagging in a semi-enclosed bay on Cape Cod （Pleasant Bay）, Massachusetts, USA, to determine seasonal movement patterns. Fifty-five actively spawning females were fitted with transmitters in 2008 and 2009 and were tracked using acoustic telemetry from May 2008 through July 2010. Fil^een crabs with transmitters also had archive depth-temperature tags attached. In addition, over 2000 spawning crabs （males and females） were tagged with US Fish and Wildlife CIdSFWS） button tags over the same period. Ninety-one percent of the crabs with transmitters were detected during this study. In the spring, crabs were primarily located in the northern section of the bay near spawning beaches, whereas in the fall crabs moved towards the deeper portions of the bay, and some may have overwIntered in the bay. There was evidence that a majority （58%-71%） of the females with transmitters spawned in two sequential seasons. One archive tag was recovered resulting in a year-long continuous record of depth and tem- perature data that, when integrated with telemetry data, indicated that the crab overwintered in the bay. The live recapture rate of crabs with USFWS button tags was 11%, with all re-sighted crabs except one observed inside Pleasant Bay. Eighty-three percent of recaptures were found within 2.5kin of the tagging location, and 51% were observed at the same beach where they were tagged. This study provides further evidence that horseshoe crabs in Pleasant Bay may be philopatric to this embayment

关键词： Horseshoe crab New England Telemetry Seasonal movement

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Outcomes and patients' perspectives of transition from paediatric to adult care in inflammatory bowel disease

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World Journal of Gastroenterology 2016年第8期22卷 2611-2620页

作者： Alice L Bennett David Moore Peter A Bampton Robert V Bryant jane M Andrews Department of Gastroenterology Royal Adelaide Hospital North Terrace Adelaide SA 5000 Australia Department of Gastroenterology Flinders Medical Centre Flinders Drive Bedford Park SA 5042 Australia School of Medicine University of Adelaide Adelaide SA 5000 Australia Department of Gastroenterology Women's and Children's Hospital Adelaide SA 5006 Australia School of Medicine Flinders University Adelaide SA 5001 Australia

AIM: To describe the disease and psychosocial outcomes of an inflammatory bowel disease (IBD) transition cohort and their ***: Patients with IBD, aged > 18 years, who had moved from paediatric to adult care within 10 years were identified through IBD databases at three tertiary hospitals. Participants were surveyed regarding demographic and disease specific data and their perspectives on the transition process. Survey response data were compared to contemporaneously recorded information in paediatric service case notes. Data were compared to a similar age cohort who had never received paediatric IBD care and therefore who had not undergone a transition ***: There were 81 returned surveys from 46 transition and 35 non-transition patients. No statistically significant differences were found in disease burden, disease outcomes or adult roles and responsibilities between cohorts. Despite a high prevalence of mood disturbance (35%), there was a very low usage (5%) of psychological services in both cohorts. In the transition cohort, knowledge of their transition plan was reported by only 25/46 patients and the majority (54%) felt they were not strongly prepared. A high rate (78%) of discussion about work/study plans was recorded prior to transition, but a near complete absence of discussion regarding sex (8%), and other adult issues was recorded. Both cohorts agreed that their preferred method of future transition practices (of the options offered) was a shared clinic appointment with all key ***: Transition did not appear to adversely affect disease or psychosocial outcomes. Current transition care processes could be optimised, with better psychosocial preparation and agreed transition plans.

关键词： Transition care Crohn’ s disease Ulcerative colitis Chronic illness Inflammatory bowel disease Patient perspectives Disease outcomes

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Mansfield park

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作者： jane Austen edited by Claudia L. Johnson.

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Lower esophageal sphincter relaxation is impaired in older patients with dysphagia

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World Journal of Gastroenterology 2011年第10期17卷 1326-1331页

作者： Laura K Besanko Carly M Burgstad Reme Mountifi eld jane M Andrews Richard Heddle Helen Checklin Robert JL Fraser Investigation and Procedures Unit Repatriation General Hospital Department of Gastroenterology and Hepatology Royal Adelaide Hospital Discipline of Medicine University of Adelaide Adelaide 5000 South Australia Australia Department of Medicine Flinders University of South Australia Bedford Park 5042 South Australia Australia

AIM: To characterize the effects of age on the mechanisms underlying the common condition of esophageal dysphagia in older patients, using detailed manometric analysis. METHODS: A retrospective case-control audit was performed on 19 patients aged ≥ 80 years (mean age 85 ± 0.7 year) who underwent a manometric study for dysphagia (2004-2009). Data were compared with 19 younger dysphagic patients (32 ± 1.7 years). Detailed manometric analysis performed prospectively included basal lower esophageal sphincter pressure (BLESP), pre-swallow and nadir LESP, esophageal body pressures and peristaltic duration, during water swallows (5 mL) in right lateral (RL) and upright (UR) postures and with solids. Data are mean ± SE; a P-value < 0.05 was considered significant. RESULTS: Elderly dysphagic patients had higher BLESP than younger patients (23.4 ± 3.8 vs 14.9 ± 1.2 mmHg; P < 0.05). Pre-swallow LESP was elevated in the elderly in both postures (RL: 1 and 4 s P = 0.019 and P = 0.05; UR: P < 0.05 and P = 0.05) and solids (P < 0.01). In older patients, LES nadir pressure was higher with liquids (RL: 2.3 ± 0.6 mmHg vs 0.7 ± 0.6 mmHg, P < 0.05; UR: 3.5 ± 0.9 mmHg vs 1.6 ± 0.5 mmHg, P = 0.01) with shorter relaxation after solids (7.9 ± 1.5 s vs 9.7 ± 0.4 s, P = 0.05). No age-related differences were seen in esophageal body pressures or peristalsis duration. CONCLUSION: Basal LES pressure is elevated and swallow-induced relaxation impaired in elderly dysphagic patients. Its contribution to dysphagia and the effects of healthy ageing require further investigation.

关键词： Dysphagia Elderly Esophageal Motility Lower Esophageal Sphincter Aging

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Synthesis, characterization and biological activities of Schiff bases derived from 2-hydroxy-3-nitrobenzaldehyde

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Journal of Chinese Pharmaceutical Sciences 2017年第12期26卷 858-871页

作者： Monisola Itohan Ikhile Marthe Carine Djuidje Fotsing Charmaine Ardeme jane Catherine Ngila Derek Tantoh Ndinteh Department of Applied Chemistry University of JohannesburgDoornfontein CampusPO 17011Johannesburg 2028South Africa Department of Chemistry University of JohannesburgP O Box 524Auckland ParkJohannesburg 2006South Africa

Four novel Schiff bases were synthesized by the condensation reaction of 2-hydroxyl-3-nitrobenzaldehyde with either benzothiazoles or benzimidazolamines. The compounds 1–4 were characterized by spectroscopic and analytical methods. The crystal structures of 6-methoxy-1,3-benzothiazol-2-amine and compound 2 are reported only. The 6-methoxy-1,3-benzothiazol-2-amine was found to crystallize in the orthorhombic crystal system in the space group Pbca, having eight molecules in the unit cell, while compound 2 was found to crystallize in the monoclinic crystal system in the space group P2_1/c. The biological activities of these compounds were investigated by evaluating their antibacterial, antifungal, antimalarial, anti-HIV and anti-trypanosomiasis activities. These compounds displayed very interesting antibacterial, antifungal, antimalarial, anti-trypanosomiasis, anti-HIV and low cytotoxicity activity against HeLa cells.

关键词： Schiff bases Biological activity Synthesis X-ray diffraction Characterization

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Evaluation of obstetrics procedure competency of family medicine residents

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Family Medicine and Community Health 2015年第2期3卷 69-78页

作者： Haijun Wang Eric Warwick Maria CMejia de Grubb Nanfu Deng jane Corboy Department of Family and Community Medicine Baylor College of MedicineHoustonTXUSA Medical School Baylor College of MedicineHoustonTXUSA Department of Family Medicine Oregon Health&Science University3181 SW Sam Jackson Park RdPortlandOR 97239-3098USA

Objective:To establish a procedure evaluation system to monitor residents’improvement in obstetrics(OB)procedures performance and skills during the training ***:A web-based procedure logging and evaluation system was developed using *** technology with a SQL server as a backend ***’logged OB proce-dures were captured by the *** OB procedures logged within 7 days were evaluated by supervising faculty using three observable outcomes(procedure competency,procedure-related medical knowledge level,and patient care).Results:Between 1 July 2005 and 30 June 2008,a total of 8543 procedures were reported,of which 1263 OB procedures were evaluated by supervising *** were significant varia-tions in the number of logged procedures by gender,residency track,and US versus non-US medi-cal *** 84%of the procedures were performed(independently or with assis-tance)by ***’procedure skills,procedure-related medical knowledge,and patient care skills improved over time,with significant variations by gender among the three ***:The benefits of specific evaluation of procedural competence in postgraduate medical education are well *** and reliable tools to assess and monitor resi-dents’procedural skills are warranted.

关键词： Resident procedure family medicine evaluation

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Does exercise have a protective effect on cognitive function under hypoxia? A systematic review with meta-analysis

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Journal of Sport and Health Science 2020年第6期9卷 562-577页

作者： Myungjin Jung Liye Zou jane Jie Yu Seungho Ryu Zhaowei Kong Lin Yang Minsoo Kang Jingyuan Lin Hong Li Lee Smith Paul D.Loprinzi Health and Sport Analytics Laboratory Department of HealthExercise Science and Recreation ManagementUniversity of MississippiUniversity ParkMS 38677USA Exercise and Mental Health Laboratory School of PsychologyShenzhen UniversityShenzhen 518060China Department of Sports Science and Physical Education The Chinese University of Hong KongShatinNew TerritoriesHong Kong 999077China Faculty of Education University of MacaoTaipaMacao 999078China Department of Cancer Epidemiology and Prevention Research CancerControl AlbertaAlberta Health ServicesCalgaryAB T2S 3C3Canada Departments of Oncology and Community Health Sciences Cumming School of MedicineUniversity of CalgaryCalgaryAB T2N 4Z6Canada The Cambridge Centre for Sport and Exercise Sciences Anglia Ruskin UniversityCambridgeCB11PTUK Exercise and Memory Laboratory Department of HealthExercise Science and Recreation ManagementUniversity of MississippiOxfordMS 38677USA

Objective:This study aimed to examine(1)the independent effects of hypoxia on cognitive function and(2)the effects of exercise on cognition while under ***:Design:Systematic review with *** sources:PubMed,Scopus,Web of Science,PsychInfo,and SPORTDiscus were *** criteria for selecting studies:randomized controlled trials and nonrandomized controlled studies that investigated the effects of chronic or acute exercise on cognition under hypoxia were considered(Aim 2),as were studies investigating the effects of hypoxia on cognition(Aim 1).Results:In total,18 studies met our inclusionary criteria for the systematic review,and 12 studies were *** to hypoxia impaired attentional ability(standardized mean difference(SMD)=-0.4),executive function(SMD=-0.18),and memory function(SMD=-0.26),but not information processing(SMD=0.27).Aggregated results indicated that performing exercise under a hypoxia setting had a significant effect on cognitive improvement(SMD=0.3,95%confidence interval:0.14-0.45,I^2=54%,p<0.001).Various characteristics(e.g.,age,cognitive task type,exercise type,exercise intensity,training type,and hypoxia level)moderated the effects of hypoxia and exercise on cognitive ***:Exercise during exposure to hypoxia improves cognitive *** association appears to be moderated by individual and exercise/hypoxia-related characteristics.

关键词： Cognition Executive function Exercise Hypoxia Memory

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