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Green tea polyphenols ameliorate non-alcoholic fatty liver disease through upregulating AMPK activation in high fat fed Zucker fatty rats

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World Journal of Gastroenterology 2017年第21期23卷 3805-3814页

作者： Yi Tan jane Kim Jing Cheng Madeleine Ong Wei-Guo lao Xing-liang Jin Yi-Guang lin linda Xiao Xue-Qiong Zhu Xian-Qin Qu School of Medical and Molecular Biosciences University of Technology Sydney The Second Affiliated Hospital of Wenzhou Medical University

AIM To investigate protective effects and molecular mechanisms of green tea polyphenols(GTP) on nonalcoholic fatty liver disease(NAFlD) in Zucker fatty(ZF) *** Male ZF rats were fed a high-fat diet(HFD) for 2 wk then treated with GTP(200 mg/kg) or saline(5 m l/kg) for 8 wk, with Zucker lean rat as their control. At the end of experiment, serum and liver tissue were collected for measurement of metabolic parameters, alanine aminotransferase(AlT) and aspartate aminotransferase(AST), inflammatory cytokines and hepatic triglyceride and liver histology. Immunoblotting was used to detect phosphorylation of AMP-activated protein kinase(AMPK) acetyl-Co A carboxylase(ACC), and sterol regulatory element-binding protein 1c(SREBP1c). RESUlTS Genetically obese ZF rats on a HFD presented with metabolic features of hepatic pathological changes comparable to human with NAFlD. GTP intervention decreased weight gain(10.1%, P = 0.052) and significantly lowered visceral fat(31.0%, P ls, GTP treatment significantly reduced fasting serum insulin, glucose and lipids levels. Reduction in serum AlT and AST levels(both P lso attenuated the elevated TNFα and Il-6 in the circulation. The increased hepatic TG accumulation and cytoplasmic lipid droplet were attenuated by GTP treatment, associated with significantly increased expression of AMPK-Thr172(P lated ACC and SREBP1c(both P lipogenesis and triglycerides out flux from liver in GTP treated rats. CONClUSION The protective effects of GTP against HFD-induced NAFlD in genetically obese ZF rats are positively correlated to reduction in hepatic lipogenesis through upregulating the AMPK pathway.

关键词： Non-alcoholic fatty liver disease Green tea polyphenols Hepatic lipogenesis Inflammatory cytokines AMP-activated protein kinase

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Associations between partial foot amputation level,gait parameters,and minimum impairment criteria in para-sport:A research study protocol

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Sports Medicine and Health Science 2022年第1期4卷 70-73页

作者： Fabio C.lucas de Oliveira Samuel Williamson Clare l.Ardern Neil Heron Dina Christa Janse van Rensburg Marleen G.T.Jansen Sean O'Connor linda Schoonmade jane Thornton Babette M.Pluim Center for Interdisciplinary Research in Rehabilitation and Social Integration CIUSSS-CNUniversite LavalQuebec CityQuebecCanada Research Unit in Sport and Physical Activity(CIDAF) Faculty of Sport Sciences and Physical EducationUniversity of CoimbraCoimbraPortugal English Institute of Sport LondonUK Division of Physiotherapy Karolinska InstituteStockholmSweden Center for Public Health Queen's University BelfastBelfastUK Department of General Practice Keele UniversityStaffordshireUK Section Sports Medicine Faculty of Health SciencesUniversity of PretoriaPretoriaSouth Africa Royal Dutch lawn Tennis Association(KNlTB) Amstelveenthe Netherlands Centre for Human Movement Sciences University Medical Centre GroningenUniversity of GroningenGroningenthe Netherlands School of Medicine Dentistry and Biomedical Sciences Centre for Public HealthQueen's University BelfastBelfastUK Medical library Vrije Universiteit AmsterdamAmsterdamthe Netherlands Department of Family Medicine Schulich School of Medicine&DentistryUniversity of Western OntarioLondonOntarioCanada Department of Epidemiology&Biostatistics Schulich School of Medicine&DentistryUniversity of Western OntarioLondonOntarioCanada AMC/VUmc IOC Research Center of Excellence Amsterdam Collaboration on Health&Safety in Sports(ACHSS)AmsterdamNetherlands

Altered biomechanics due to amputation can contribute to substantial limitations,influencing sporting *** with lower extremity amputations or congenital lower limb deficiency are encouraged to participate in ***,to compete in Paralympic sports,the candidate must have an impairment that results in lower extremity loss of function and meets or exceeds the sport's minimum impairment criteria(MIC).This review will focus on the MIC for competitive wheelchair *** deficiency is known as one of the MIC used to regulate participation in competitive para-sports since it impacts gait,kinematics,and biomechanics of both the upper and lower ***,it is questionable whether the MIC concerning limb deficiency is set at the correct level for determining eligibility for participating in Paralympic *** study aims to provide an overview of the evidence examining the impact of different partial foot amputation(PFA)levels on gait as a proxy for sporting *** scoping review will be based on a 6-step methodological framework and Preferred Reporting Items for Systematic Reviews and Meta-Analysis,extension for scoping reviews(PRISMA-ScR).Studies will be selected from PubMed,Embase,CINAHl,and *** authors will screen the titles/abstracts *** studies will be scrutinised,and the same authors will extract *** will be relevant to informing the evidence-based development of MIC for lower limb impairment after PFA and may be extrapolated to specific Paralympic sports,including wheelchair *** will be disseminated through scientific publications and conferences to audiences interested in Paralympic sports.

关键词： Amputees Congenital deficiency Gait analysis Paralympic sport Partial foot amputation Wheelchair tennis

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Students’ perception of effective clinical teaching and teacher behaviour

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Open Journal of Nursing 2013年第1期3卷 63-70页

作者： Ijeoma l. Okoronkwo jane-lovena Onyia-pat Mary-Ann E. Agbo Pat U. Okpala Afam C. Ndu Department of Nursing Sciences University of Nigeria Enugu Campus Enugu Nigeria

learning in the clinical environment is an integral part of nursing education programme. In tertiarybased nursing courses, students spend time learning in the clinical setting as they do in their classroombased studies. The purpose of this study was to explore teaching skills considered by undergraduate student nurses as effective in the clinical setting as well as qualities that make a clinical teacher effective. A descriptive design was employed using questionnaires to collect data. Respondents comprised year four undergraduate student nurses admitted through direct entry (DE) and university matriculation examination (UME) results. Using validated structured questionnaire, data were collected from 101 students who had completed their six months consolidated clinical experience on their perception of teaching skills and teacher qualities considered effective in the clinical setting. Data were analyzed using both descriptive and inferential statistics. Specifically, frequencies, percentage and standard deviation were used for descriptive analysis of scores while chi square and Mann-Whitney tests were used to test the mean differences in the teaching skills and to test whether there was a significant difference in their perception of teacher behaviours respectively at 0.05 level of significance. The result showed that having both clinical (professional) and teaching knowledge were the most important teaching skills for effective clinical teaching. Five qualities ranked by students as teacher behaviours important for effective teaching include being honest with students, motivation to teach, willingness to listen and using good communication skills, supervising students effectively and being positive role model. These factors could be considered when recruiting future clinical teachers and when planning inservice education programmes for clinical teachers to promote student learning.

关键词： Clinical Teaching in Nursing Direct Entry and University Matriculation Examination Students Student Nurses’ Perceptions Teachers’ Behaviours

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Suitability of Drinking Water Sources from Nyaruzinga Wetland for Domestic Use in Bushenyi Municipality, Uganda

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Journal of Water Resource and Protection 2017年第13期9卷 1587-1611页

作者： lauben Muhangane John Bosco Nkurunungi jane Yatuha Morgan Andama Department of Biology Faculty of Science Mbarara University of Science and Technology Mbarara Uganda

This study determined the physico-chemical and bacterial quality of raw (bore-hole, springs, wells) and tap water sources from Nyaruzinga wetland for domestic use in Bushenyi Municipality. Forty samples of raw water were randomly collected from Kacuncu, Kyeitembe and Kikuba tributaries of the wetland and 40 samples of tap water generated from the same wetland were randomly drawn from Ishaka, Nyakabirizi and Central divisions of the Municipality. The samples were analyzed for apparent colour (AC), turbidity, electrical conductivity (EC), total hardness, pH, total iron, residual alum, free residual chlorine and faecal coliforms using standard methods and their values compared with standard local UNBS (2008) and international WHO (2011) drinking water quality guidelines. The results showed that the mean pH of the protected spring below Kikuba Hill (5.21);the AC (Pt/Co) of the borehole below Bweranyangi Junior School (17.28) and the surface well below Nyandozo Primary School (157.58) both situated in Kacuncu as well as the free residual chlorine (mg/l) in tap water at Kanyamabona Trading Centre, Ishaka division (0.192) were below the standard values of WHO (pH, 6.0 - 8.0;free residual chlorine, 0.2 - 0.5) and UNBS (AC, lectrical conductivity, EC (μS/cm) and total hardness (mg/l) of all the selected water sources were within the WHO standards (EC, l hardness, l alum (mg/l) in all the tap water sources was also within the WHO guideline (l iron content (0.32 mg/l) of the surface well below Nyandozo Primary School were above WHO guidelines of ly. Furthermore, the mean faecal coliform counts (CFU/100 ml) in the surface well below Nyandozo Primary School (6.90) and the borehole below Bweranyangi Junior School (16.83) including the surface well below Kyeitembe Trading Centre (9.25) were above

关键词： Bacterial load Bushenyi Municipality Drinking Water Sources Physico-Chemical Parameters

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Impact of Expressing p-Coumaryl Transferase in Medicago sativa l. on Cell Wall Chemistry and Digestibility

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American Journal of Plant Sciences 2016年第17期7卷 2553-2569页

作者： jane M. Marita Dave Rancour Ronald Hatfield Paul Weimer CWBURU of U.S. Dairy Forage Research Center Madison WI USA

The addition of p-coumaric acid (pCA) to lignin molecules is frequently found in members of the grass family. The role of this addition is not clearly understood, but is thought to potentially aid in the formation of syringyl-type lignin. This is because the incorporation is as a conjugate of pCA ester linked to sinapyl alcohol, a major component of lignin. The forage legume alfalfa (Medicago sativa l.) does not contain appreciable levels of pCA in its more heavily lignified stem tissues. The maize p-coumaryltransferase (pCAT) gene was used to transform alfalfa to determine its impact upon lignin composition and its potential to alter cell wall digestibility. A constitutive expression vector using the cassava vein mosaic virus (CsVMV) promoter was used to drive expression of maize pCAT in alfalfa. Expression of the pCAT transgene was detected in both leaves and stems. Though there was a range of pCAconcentration in transformed alfalfa stems (0.2 - 1.79 micrograms (μg)), this was a clear increase over bound pCA in control stems (0.15 - 0.2 mean = 0.17 micrograms (μg)). This did not lead to consistent responses concerning total lignin in the stem tissues. leaf tissue, on the other hand, already has a relatively high level of pCA (0.85 - 1.2, mean = 0.99 micrograms (μg)) and those expressing pCAT gene showed on average a small increase, but there is a wide range of values among the transformants (0.38 - 1.55, mean = 1.06 micrograms (μg)). lignin in leaves did not appear to be significantly impacted. However, incorporation of pCA into the wall appears to cause a shift in lignin composition. Testing the pCAT expressing stem cell walls for digestibility using a rumen in vitro system showed there was no change in the digestibility of the stem compared to empty vectors and control alfalfa stems. Although expression of pCAT gene in alfalfa changes the amount of wall bound pCA, it does not appear to change lignin levels or impact digestibility.

关键词： Alfalfa p-Coumarate Cell Wall lignin Digestibility

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EXTRACTION　AND　SEPARATION　OF　RADISH　RED　PIGMENT　FROM　A　WASTE　WATER　OF　SAlTING　RADISH　BY　D61　RESIN

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Chinese Journal of Reactive Polymers 1996年第1期5卷 32-38页

作者： Zhou Xiaohua Kang jane Shan Xueming(Resorses’ Comprehensive Utilization Engineering Centre of Chongqing University, Chongqing)

ＥＸＴＲＡＣＴＩＯＮＡＮＤＳＥＰＡＲＡＴＩＯＮＯＦＲＡＤＩＳＨＲＥＤＰＩＧＭＥＮＴＦＲＯＭＡＷＡＳＴＥＷＡＴＥＲＯＦＳＡＬＴＩＮＧＲＡＤＩＳＨＢＹＤ６１ＲＥＳＩＮＺｈｏｕＸｉａｏｈｕａ；ＫａｎｇＪａｎｅ；ＳｈａｎＸｕ... 详细信息

ＥＸＴＲＡＣＴＩＯＮＡＮＤＳＥＰＡＲＡＴＩＯＮＯＦＲＡＤＩＳＨＲＥＤＰＩＧＭＥＮＴＦＲＯＭＡＷＡＳＴＥＷＡＴＥＲＯＦＳＡＬＴＩＮＧＲＡＤＩＳＨＢＹＤ６１ＲＥＳＩＮＺｈｏｕＸｉａｏｈｕａ；ＫａｎｇＪａｎｅ；ＳｈａｎＸｕｅｍｉｎｇ（Ｒｅｓｏｒｓｅｓ＇Ｃｏ...

关键词：萝卜色素提取 D61树脂红色素废水盐淹萝卜

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Control of Bone Mass by Novel Runx2 Regulatory Pathways

Control of Bone Mass by Novel Runx2 Regulatory Pathways

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第十届国际骨矿研究学术会议暨第十二届国际骨质疏松研讨会

作者： jane B.lian Gary S.Stein Andre J.van Wijnen janet l.Stein Department of Cell Biology University of Massachusetts Medical School

＜正＞Osteoporosis is a multifactorial disease with many contributing factors leading to bone loss caused by an age-related decrease in the number and activity of osteoblasts and further exacerbated by hormonal changes leading to increased osteoclast bone *** discovery of the master transcription factor,Runx2 that is essential for commitment and differentiation of mesenchymal stem cells（MSCs）to osteoblasts and bone

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通过文学理解成人世界:以《绿山墙的安妮》、《阿文利的安妮》和《复杂的善意》为例(英文)

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外国文学研究 2007年第6期29卷 19-28页

作者：简.麦迪森瑞典克里斯提安斯塔德大学

本文以三部加拿大小说——《绿山墙的安妮》、《阿文利的安妮》和《复杂的善意》——为例,探讨了在不同文化或宗教社区中、不同历史时期内,青少年文学如何帮助青少年读者理解成人社会和其中的规则。这三部作品(前两部作者为l.M.蒙哥玛丽... 详细信息

本文以三部加拿大小说——《绿山墙的安妮》、《阿文利的安妮》和《复杂的善意》——为例,探讨了在不同文化或宗教社区中、不同历史时期内,青少年文学如何帮助青少年读者理解成人社会和其中的规则。这三部作品(前两部作者为l.M.蒙哥玛丽,后一部为玛丽安.陶厄斯)多年来均受到了评论家的重视和青少年读者的喜爱。这些作品超越时间、国籍和信仰,通过小说主人公面临的问题探讨了大多数青少年可能要面对的问题。

关键词：青少年净化认同身份

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国际艾滋病会议对抗病毒药物和疫苗的研究评价

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药学实践与服务 1988年第1期 13-16页

作者： jane l.Miller 杨树桐宋雁

第三届国际艾滋病(AIDS)会议于1987年6月1～5日在华盛顿特区召开,会议就有关抗病毒治疗的新发现和疫苗开发的进展这两个题目进行了广泛深入的讨论。虽然会议对于获得性免疫缺陷综合征(AIDS)的治疗没有宣布什么主要的进展,但是会议的整... 详细信息

第三届国际艾滋病(AIDS)会议于1987年6月1～5日在华盛顿特区召开,会议就有关抗病毒治疗的新发现和疫苗开发的进展这两个题目进行了广泛深入的讨论。虽然会议对于获得性免疫缺陷综合征(AIDS)的治疗没有宣布什么主要的进展,但是会议的整个基调是乐观的。一、抗病毒药物的发展目前研究的重点是抗病毒药物通过抑制逆转录酶以终断DNA系列。此类药如叠氮胸甙(AZT)及双脱氧胞嘧啶(DDC)必

关键词：艾滋病获得性免疫缺陷综合征性病抗病毒药物抗病毒药逆转录病毒 AZT AIDS 疫苗菌苗会议

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爱玛 .下

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1982年

作者： (英)奥斯汀(Austen jane)原

来源：汇雅图书（南通市图书馆... 评论

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