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上海航天 1989年第3期6卷 55-57页

作者： N.K.jana K.Renganathan 黄浩英

术语a=内半径〔b〕=与应变和节点位移有关的矩阵b=外半径〔D(?)〕=弹性矩阵E_c=金属壳体的杨氏模量E_1,E_2=分别为纤维增强塑料壳体材料的轴向和环向杨氏模量G_1,G_(12)

关键词：推进剂药柱应力分析

Analysis of the damage mechanism of strainbursts by a global-local modeling approach

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Journal of Rock Mechanics and Geotechnical Engineering 2022年第6期14卷 1671-1696页

作者： Jun Wang Derek b.Apel Artur Dyczko Andrzej Walentek Stanislaw Prusek Huawei Xu Chong Wei School of Mining and Petroleum Engineering University of AlbertaEdmontonAlbertaT6G 2R3Canada Jastrze˛bska Spółka We˛glowa S.A.Group Aleja Jana Pawła II 4Jastrze˛bie-Zdrój44-330Poland Central Mining Institute Plac GwarkówKatowice140-166Poland

Strainburst is the most common type of *** research of strainburst damage mechanisms is helpful to improve and optimize the rock support design in the burst-prone *** this study,an improved global-local modeling approach was first adopted to study strainburst damage *** extracted stresses induced by multiple excavations from a three-dimensional(3D)global model established by fast Lagrangian analysis of continua in 3 dimensions(FLAC3D)are used as boundary conditions for a two-dimensional(2D)local model of a deep roadway built by universal distinct element code(UDEC)to simulate realistic stress loading paths and conduct a detailed analysis of rockburst damage from both micro and macro *** results suggest that the deformation and damage level of the roadway gradually increase with the growth of surrounding rock stress caused by the superposition of mining-or excavation-induced stresses of the panel and nearby *** significant increase of surrounding rock stresses will result in more accumulated strain energy in two sidewalls,providing a necessary condition for the strainburst occurrence in the dynamic *** strainburst damage mechanism for the study site combines three types of damage:rock ejection,rock bulking,and *** the strainburst,initiation,propagation,and development of tensile cracks play a crucial role in controlling macroscopic failure of surrounding rock masses,although the shear crack always accounts for the main proportion of damage *** deformation and damage level of the roadway during a strainburst positively correlate with the increasing peak particle velocities(PPVs).The yielding steel arch might not dissipate kinetic energy and mitigate strainburst damage effectively due to the limited energy absorption *** principles to control and mitigate strainburst damage are proposed in this *** study presents a systematic framework to investigate strainburst damage mechanisms

关键词： Strainburst Numerical modeling Damage mechanism Finite difference method(FDM) Discrete element method(DEM) Underground mining

Evaluation of Emmer Wheat Genetic Resources Aimed at Dietary Food Production

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Journal of Life Sciences 2011年第3期5卷 206-211页

作者： Zdenek Stehno Ivana Paulickova jana bradova Petr Konvalina Ivana Capouchova Eva Maskova Dana Gabrovska Marie Holasova Vlasta Fiedlerova Renata Winterova Jarmila Ouhrabkova Ladislav Dotlacil Department of Gene bank Crop Research Institute Praha 161 06 Czech Republic Department of Nutritive Substances Food Research Institute Praha 102 31 Czech Republic Faculty of Agriculture University of South Bohemia Ceskd Buddjovice 370 05 Czech Republic Faculty of Agrobiology Food and Natural Resources Czech University of Life Sciences Praha 165 21 Czech Republic

Emmer wheat cultivated by organic farmers is used as a component of some bio （organic） food products. Its positive influence on consumer health is caused by grain composition. With the aim of selecting varieties or landraces for their possible further use we tested selected emmer wheat accessions maintained in the Czech Gene bank. In the set of 8 emmer wheat accessions, the main grain components, bread making characteristics and contents of health supporting chemical substances such as total dietary fibre content and its components, content of total polyphenols plus catechin and ferulic acid contents, vitamins of the b group and E plus total content of carotenoids were evaluated by standard methods. Tests of bread making quality confirmed a very well known fact that emmer wheat grain is much more suitable for other purposes as whole grain mixtures, cereal pure, etc. than for bread preparation. The results indicate the possibilities to select emmer wheat genotypes differing in grain composition and containing compounds with positive effects on human health. Among the tested emmer wheat accessions the Rudico variety had a complex of positive characteristics such as content of total dietary fibre, total polyphenol content with prevailing catechin and the highest amount of b group vitamins such as b 1, b2, niacin, pantothenic acid and b6.

关键词： Emmer wheat Triticum diccocon grain quality HMW glutenin subunits polyphenols vitamins wheat genetic resources

Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani Joachim Altschmied Katharina bottermann jana brendler Judith Haendeler Susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudolf Schönheimer Institute of biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

A novel fluorescent labeling compound for GluN2A containing N-methyl-D-aspartate receptors identified by autodisplay-based screening

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Journal of Pharmaceutical Analysis 2024年第7期14卷 1091-1094页

作者： Alexander Dombovski Ruben Steigerwald Nadine Ritter Paul Disse Gunnar Goerges jana Osthues Isabel Aymanns Carina Dilkaute Julian Schreiber Martina Düfer Guiscard Seebohm bernhard Wünsch Joachim Jose University of Münster Institute of Pharmaceutical and Medicinal ChemistryPharmacampus48149MünsterGermany University of Münster GRK 2515Chemical Biology of Ion Channels(Chembion)48149MünsterGermany University of Münster Institute for Genetics of Heart Diseases(IfGH)Department of Cardiovascular MedicineUniversity Hospital Münster48149MünsterGermany

Autodisplay of N-methyl-D-aspartate(NMDA)receptor[1]ligand binding domains(LbDs)was done by inserting the coding sequence for each LbD[2]into a plasmid for maximized autotransporter-mediated expression(pMATE)between the coding sequences of signal peptide and translocator domain[3](Figs.1A and S1).Surface display and functionality of LbDs was confirmed by protease accessibility and radioligand binding(Figs.S2 and S3).This is discussed in more detail in the Sections S1.1S1.5 in the Supplementary *** with surface displayed LbDs were applied for a flow cytometry-based binding assay to evaluate fluorescent TCN-201 derivatives[4](Figs.1b,S4,and S5).More detailed information about the structural prerequisites of TCN-201 derivatives for interacting with the modulatory binding site and synthesis of fluorescent derivatives is given in the Sections S1.6 and S1.7 in the Supplementary data.

关键词： compound synthesis sequences

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创伤患者的输血管理

麻醉与镇痛 2012年第2期8卷 20-28页

作者： bethH．Shaz beth H. Shaz Christopher J. Dente Robert S. Harris jana b. MacLeod Christopher D. Hillyer 孙世伟（译）陈卫民（校） Departments of Pathology and Laboratory Medicine Atlanta Georgia Departments of Surgery Emory University School of Medicine Atlanta Georgia Departments of anesthesia Emory University School of Medicine Atlanta Georgia

随着对创伤性凝血功能障碍的机制和晶体输液局限性的进一步了解，以及大量输血方案（massivetransfusionproto。col，MTP）的建立，对需要大量输血的创伤患者的管理有了一定的改善。MTP包括输血管理及为减轻致死性三联征（低温、酸中毒... 详细信息

随着对创伤性凝血功能障碍的机制和晶体输液局限性的进一步了解，以及大量输血方案（massivetransfusionproto。col，MTP）的建立，对需要大量输血的创伤患者的管理有了一定的改善。MTP包括输血管理及为减轻致死性三联征（低温、酸中毒、凝血功能障碍）的措施。近来的数据显示早期积极地利用近似于全血的血制品来进行输血急救能够明显降低死亡率，因此目前在美国和世界范围内MTP有了新的改变。本文中MTP是急救措施中的关键因素，它被定义为对已有致死性三联征的严重创伤患者的一种系统性的治疗方法。MTP需要用足量的血浆及凝血因子来改善患者的预后。目前，在MTP中对于输入的血浆、血小板、冷沉淀以及其他凝血因子的剂量与输入红细胞的剂量间的精确比例并不清楚。目前，在尚未得到前瞻性的随机临床试验的结果时，较倾向于血浆：红细胞：血小板的比例为1：1：1。未来仍需进一步的前瞻性临床试验完善MTP，以提高创伤患者的整体治疗水平。

关键词：创伤患者输血管理凝血功能障碍随机临床试验大量输血凝血因子 MTP 数据显示

Multiplexed biosensing Diagnostic Platforms Detecting Autoantibodies to Tumor-Associated Antigens from Exosomes Released by CRC Cells and Tissue Samples Showed High Diagnostic Ability for Colorectal Cancer

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Engineering 2021年第10期7卷 1393-1412页

作者： Ana Montero-Calle Itziar Aranguren-Abeigon María Garranzo-Asensio Carmen Poves María Jesús Fernández-Aceñero Javier Martínez-Useros Rodrigo Sanz jana Dziaková Javier Rodriguez-Cobos Guillermo Solís-Fernández Eloy Povedano Maria Gamella Rebeca Magnolia Torrente-Rodríguez Miren Alonso-Navarro Vivian de los Ríos J.Ignacio Casal Gemma Domínguez Ana Guzman-Aranguez Alberto Peláez-García JoséManuel Pingarrón Susana Campuzano Rodrigo barderas Chronic Disease Program(UFIEC) Carlos III Health InstituteMadrid E-28220Spain Department of biochemistry and Molecular biology Faculty of Optics and OptometryComplutense University of MadridMadrid E-28040Spain Gastroenterology Unit San Carlos Clinical HospitalMadrid E-28040Spain Surgical Pathology Department San Carlos Clinical HospitalMadrid E-28040Spain Translational Oncology Division OncoHealth InstituteJimenez Diaz Foundation University HospitalMadrid E-28040Spain Department of biochemistry Faculty of MedicineAlberto Sols Institute of Biomedical ResearchCSIC-UAMMadrid E-28029Spain Department of Analytical Chemistry Faculty of Chemical SciencesComplutense University of MadridMadrid E-28040Spain Center for biological Research Spanish National Research Council(CSIC)MadridE-28040Spain Molecular Pathology and Therapeutic Targets Group La Paz University Hospital(IdiPAZ)Madrid E-28046Spain

Colorectal cancer(CRC)is the second leading cause of cancer-related death *** five-year survival rate of CRC patients depends on the stage at diagnosis,being higher than 80%when CRC is diagnosed in the early stages but lower than 10%when CRC is diagnosed in advanced *** against specific CRC autoantigens(tumor-associated antigens(TAAs))in the sera of patients have been widely demonstrated to aid in early ***,we herein aim to identify autoantigens target of autoantibodies specific to CRC that possess a significant ability to discriminate between CRC patients and healthy individuals by means of liquid *** that end,we examined the protein content of the exosomes released by five CRC cell lines and tissue samples from CRC patients by means of immunoprecipitation coupled with mass spectrometry analysis.A total of 103 proteins were identified as potential autoantigens specific to *** bioinformatics and meta-analysis,we selected 15 proteins that are more likely to be actual CRC autoantigens in order to evaluate their role in CRC prognosis by Western blot(Wb)and immunohistochemistry(IHC).We found dysregulation at the protein level for 11 of these proteins in both tissue and plasma exosome samples from patients,along with an association of nine of these proteins with CRC *** validation,all but one showed a statistically significant high diagnostic ability to distinguish CRC patients and individuals with premalignant lesions from healthy individuals,either by luminescence Halotag-based beads,or by a multiplexed biosensing platform involving the use of magnetic microcarriers as solid support modified with covalently immobilized Halotag fusion proteins constructed for CRC *** together,our results highlight the usefulness of the approach defined here to identify the TAAs specific to chronic diseases;they also demonstrate that the measurement of autoantibody levels in plasma against the TAAs identified here

关键词： Autoantibodies Diagnosis Colorectal cancer Exosomes Tumor microenviroment Humoral immune response Point of care biosensors

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冻存卵巢组织移植成功--首次报道

中华生殖与避孕杂志 2018年第9期38卷 724-729页

作者：阮祥燕杜娟李扬璐金凤羽孔为民卢丹吴玉梅代荫梅周琦赵群阴赪宏严松彪 Matthias Korell jana Liebenthron Markus Montag 王虎生程姣姣李雪谷牧青 Alfred O.Mueck 首都医科大学附属北京妇产医院内分泌科 100026 首都医科大学附属北京妇产医院妇科肿瘤科 100026 首都医科大学附属北京妇产医院妇科 100026 德国诺伊斯约翰娜艾蒂安医院 41462 德国多塞尔多夫大学妇产医院生殖力保护中心 40225 德国海德堡大学妇科内分泌与生殖中心 69120 德国图宾根大学妇产医院内分泌与绝经中心 72076

目的通过卵巢组织冻存技术及自体移植手术保护癌症患者生育力与内分泌功能。方法对1例40岁宫颈鳞癌IIb期患者在放化疗前进行卵巢组织取材、冻存,待其癌症痊愈后进行冻存卵巢组织自体移植手术,随访监测患者的激素水平、卵泡发育情况、月... 详细信息

目的通过卵巢组织冻存技术及自体移植手术保护癌症患者生育力与内分泌功能。方法对1例40岁宫颈鳞癌IIb期患者在放化疗前进行卵巢组织取材、冻存,待其癌症痊愈后进行冻存卵巢组织自体移植手术,随访监测患者的激素水平、卵泡发育情况、月经恢复情况以及绝经相关症状。结果卵巢组织移植4个月后,改良Kupperman评分由20分降低至b超监测到有卵泡发育且月经恢复。结论卵巢组织冻存移植4个月后卵巢功能恢复正常,证明卵巢组织在临床上移植成功。

关键词：卵巢组织冻存移植宫颈癌卵巢储备功能

Fungal diversity notes 1036-1150:taxonomic and phylogenetic contributions on genera and species of fungal taxa

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Fungal Diversity 2019年第3期96卷 1-242页

作者： Kevin D.Hyde Danushka S.Tennakoon Rajesh Jeewon DJayarama bhat Sajeewa S.N.Maharachchikumbura Walter Rossi Marco Leonardi Hyang burm Lee Hye Yeon Mun Jos Houbraken Thuong T.T.Nguyen Sun Jeong Jeon Jens Christian Frisvad Dhanushka N.Wanasinghe Robert Lucking Andre Aptroot Marcela E.S.Caceres Samantha C.Karunarathna Sinang Hongsanan Rungtiwa Phookamsak Nimali Ide Silva Kasun M.Thambugala Ruvishika S.Jayawardena Indunil C.Senanayake Saranyaphat boonmee Jie Chen Zong-Long Luo Chayanard Phukhamsakda Olinto L.Pereira Vanessa P.Abreu Andre Wilson Campos Rosado buyck bart Emile Randrianjohany Vale rie Hofstetter Tatiana b.Gibertoni Adriene Mayrada Silva Soares Helio Longoni Plautz Jr Helen Maria Pontes Sotao William Kalhy Silva Xavier Jadson Diogo Pereira bezerra Thays Gabrielle Linsde Oliveira Cristina Mariade Souza-Motta Oliane Maria Correia Magalhaes Digvijayini bundhun Dulanjalee Harishchandra Ishara S.Manawasinghe Wei Dong Sheng-Nan Zhang Dan-Feng bao Milan C.Samarakoon Dhandevi Pem Anuruddha Karunarathna Chuan-Gen Lin Jing Yang Rekhani H.Perera Vinit Kumar Shi-Ke Huang Monika C.Dayarathne Anusha H.Ekanayaka Subashini C.Jayasiri Yuanpin Xiao Sirinapa Konta Tuula Niskanen Kare Liimatainen Yu-Cheng Dai Xiao-Hong Ji Xue-Mei Tian Armin Mesic Sanjay K.Singh Kunthida Phutthacharoen Lei Cai Touny Sorvongxay Vinodhini Thiyagaraja Chada Norphanphoun Napalai Chaiwan Yong-Zhong Lu Hong-bo Jiang Jin-Feng Zhang Pranami D.Abeywickrama Janith V.S.Aluthmuhandiram Rashika S.brahmanage Ming Zeng Thilini Chethana Deping Wei Martina Reblova Jacques Fournier jana Nekvindova Renan do Nascimento barbosa Jose Ewerton Felintodos Santos Neiva Tintide Oliveira Guo-Jie Li Damien Ertz Qiu-Ju Shang Alan J.L.Phillips Chang-Hsin Kuo Erio Camporesi Timur S.bulgakov Saisamorn Lumyong E.b.Gareth Jones Putarak Chomnunti Eleni Gentekaki Frank bungartz Xiang-Yu Zeng Sally Fryar Zdenko Tkalcec Junmin Liang Guangshuo Li Ting-Chi Wen Paras Nath Singh Yusufjon Gafforov Itthayakorn Promputtha Erandi Yasanthika Ishani D.Goonasekara Rui-Lin Zhao Qi Zhao Paul M Key Laboratory for Plant Diversity and biogeography of East Asia Kunming Institute of BotanyChinese Academy of ScienceKunming 650201YunnanPeople’s Republic of China School of Science Mae Fah Luang UniversityChiang Rai 57100Thailand Center of Excellence in Fungal Research Mae Fah Luang UniversityChiang Rai 57100Thailand East and Central Asia Regional Office World Agroforestry Centre(ICRAF)Kunming 650201YunnanPeople’s Republic of China Department of biology Faculty of ScienceChiang Mai UniversityChiang Mai 50200Thailand Mushroom Research Foundation 128 M.3 Ban Pa Deng T.Pa PaeA.Mae TaengChiang Mai 50150Thailand Department of Plant Medicine National Chiayi University300 Syuefu RoadChiayi City 60004TaiwanPeople’s Republic of China Department of Health Sciences Faculty of ScienceUniversity of MauritiusReduitMauritius Formerly Department of botany Goa UniversityGoaIndia No.128/1-J Azad Housing SocietyCurcaGoa Velha 403108India Department of Crop Sciences College of Agricultural and Marine SciencesSultan Qaboos UniversityPO Box 8123 Al KhoudOman Sect.Environmental Sciences Dept.MeSVAUniversity of L’Aquila67100 CoppitoAQItaly Division of Food Technology Biotechnology&AgrochemistryCollege of Agriculture&Life SciencesChonnam National UniversityGwangju 61186Korea Fungal Resources Research Division NNIBRSangju-si 37242Korea Westerdijk Fungal biodiversity Institute Uppsalalaan 83584 CT UtrechtThe Netherlands Department of biotechnology and biomedicine DTUBioengineeringTechnical University of Denmark2800 Kongens LyngbyDenmark botanischer Garten und botanisches Museum berlin Freie Universitat BerlinKonigin-Luise-StraßBe 6-814195 BerlinGermany Laboratorio de botanica/Liquenologia Instituto de BiocienciasUniversidade Federal de Mato Grosso do SulAvenida Costa e Silva s/nBairro UniversitarioCampo GrandeMatto Grosso do Sul CEP 79070-900Brazil Departamento de biociencias Universidade Federal de SergipeItabaianaSergipe CEP:49500-000Brazil Shenzhen Key Laboratory of Microbial

This article is the tenth series of the Fungal Diversity Notes,where 114 taxa distributed in three phyla,ten classes,30 orders and 53 families are described and *** described in the present study include one new family(*** in Dothideomycetes),five new genera(Caatingomyces,Cryptoschizotrema,Neoacladium,Paramassaria and Trochilispora)and 71 new species,(*** thailandica,Amniculicola aquatica,***,Angustimassarina sylvatica,blackwellomyces lateris,boubovia gelatinosa,buellia viridula,Caatingomyces brasiliensis,Calophoma humuli,Camarosporidiella mori,Canalisporium dehongense,Cantharellus brunneopallidus,***,Castanediella meliponae,Coprinopsis psammophila,Cordyceps succavus,Cortinarius minusculus,***,Diaporthe italiana,***,Diatrypella delonicis,Dictyocheirospora aquadulcis,***,Digitodesmium chiangmaiense,Distoseptispora dehongensis,***,Dothiorella styphnolobii,Ellisembia aurea,Falciformispora aquatic,Fomitiporia carpinea,***,Grammothele aurantiaca,***,Hermatomyces bauhiniae,Jahnula queenslandica,Kamalomyces mangrovei,Lecidella yunnanensis,Micarea squamulosa,Muriphaeosphaeria angustifoliae,Neoacladium indicum,Neodidymelliopsis sambuci,Neosetophoma miscanthi,***,Nodulosphaeria aquilegiae,***,Paramassaria samaneae,Penicillium circulare,***,***-pumilae,***,***,Phaeoisaria siamensis,Phaeopoacea asparagicola,Phaeosphaeria penniseti,Plectocarpon galapagoense,Porina sorediata,Pseudoberkleasmium chiangmaiense,Pyrenochaetopsis sinensis,Rhizophydium koreanum,Russula prasina,Sporoschisma chiangraiense,Stigmatomyces chamaemyiae,***,***,***,***,Thysanorea uniseptata,Torula breviconidiophora,***,Trochilispora schefflerae and Vaginatispora palmae).Further,twelve new combinations(*** cryptotrema,Prolixandromyces australi,***,***,***,P.

关键词： 71 new taxa Ascomycota basidiomycota Dothideomycetes Eurotiomycetes Lecanoromycetes Leotiomycetes Pezizomycetes Phylogeny Taxonomy