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Autoantibodies in chronic hepatitis C: A clinical perspective

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World Journal of Hepatology 2015年第8期7卷 1074-1085页

作者： janaína Luz Narciso-Schiavon Leonardo de Lucca Schiavon Department of Internal Medicine Gastroenterology Division Federal University of Santa Catarina

Non-organ-specific autoantibodies and thyroid autoantibodies have been frequently found in chronic carriers of hepatitis C virus(HCV). With respect to endomysial antibodies and tissue transglutaminase, it is controversial whether the prevalence of glutenrelated seromarkers is higher in patients with HCV. In such cases, in addition to acknowledging any currently existing autoimmune disease, recognizing the risk of the patient developing an autoimmune disease during interferon(IFN)-based treatment must be a principle concern. From a clinical point-of-view, the presence of autoantibodies arouses suspicion that an autoimmunedisease may be present or may be precipitated by IFNbased HCV treatment. In this paper, we review the prevalence of autoantibodies in individuals with hepatitis C, the clinical significance of these autoantibodies, and the approach recommended for such situations.

关键词： Hepatitis C Autoimmunity Antibodies Antinuclear Hepatitis Autoimmune Thyroid diseases Hashimoto disease Thyroglobulin Celiac disease Transglutaminases Diarrhea Interferon-alpha

Bioprinting of radiopaque constructs for tissue engineering and understanding degradation behavior by use of Micro-CT

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Bioactive Materials 2020年第3期5卷 569-576页

作者： Sudipto Datta Shuvodeep jana Ankita Das Arindam Chakraborty Amit Roy Chowdhury Pallab Datta Centre for Healthcare Science and Technology Indian Institute of Engineering Science and TechnologyShibpurHowrah711103WBIndia Department of Aerospace Engineering and Applied Mechanics Indian Institute of Engineering Science and TechnologyShibpurHowrah711103WBIndia Indian Institute of Technology KharagpurWest BengalIndia

Bioprinting has emerged as a potential technique to fabricate tissue engineering constructs and in vitro models directly using living cells as a raw material for fabrication,conforming to the heterogeneity and architectural complexity of the *** several of tissue engineering and in vitro disease modelling or surgical planning applications,it is desirable to have radiopaque constructs for monitoring and *** the present work,enhanced radiopaque constructs are generated by substituting Calcium ions with Barium ions for crosslinking of alginate *** constructs are characterized for their structural integrity and followed by cell culture studies to evaluate their *** was followed by the radiopacity *** radiological images obtained by micro-CT technique was further applied to investigate the degradation behavior of the *** conclusion,it is observed that barium crosslinking can provide a convenient means to obtain radiopaque constructs with potential for multi-faceted applications.

关键词： Bioprinting Radiopaque Barium Degradation Cell viability

A nonautonomous mat hematical model to assess the impact of algae on the abatement of atmospheric carbon dioxide

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International Journal of Biomathematics 2021年第7期14卷 227-264页

作者： Pankaj Kumar Tiwari Rajesh Kumar Singh Debaldev jana Yun Kang Arvind Kumar Misra Department of Basic Science and Humanities Indian Institute of Information Technology Bhagalpur 813210 India Government Shahid Kedamath P.G.College Mauganj Rewa 486331India Department of Mathematics&SRM Research Institute SRM Institute of Science and Technology Kattankulathur 603203 Tamil NaduIndia Science and Mathematics Faculty Arizona State University Mesa AZ 85212USA Department of Mathematics Institute of Science Banaras Hindu UniversityVaranasi 221005India

The world's oceans have played an important role in sequestering atmospheric carbon dioxide through solubility and the action of *** of atmospheric carbon dioxide by photoautotrophic algal cultures has the potential to diminish the release of carbon dioxide into the atmosphere,thereby helping to alleviate the trend toward global *** work investigates the role of algae in controlling the level of atmospheric carbon *** Rank Correlation Coefficients(PRCCs)technique is used to address how the concentration of atmospheric carbon dioxide is affected by changes in a specific parameter disregarding the uncertainty over the rest of the model *** related to algal growth are shown to significantly reduce the level of atmospheric CO_(2).Further,we explore the dynamics of nonautonomous system by incorporating the seasonal variations of sonic ecologically important model *** nonautonomous system exhibits globally attractive positive periodic solution,and also the appearance of double periodic solution is ***,by letting the seasonally forced parameters as almost periodic functions of time,we show almost periodic behavior of the *** findings suggest that the policy makers should focus on continuous addition of nutrients in the ocean to accelerate the algal growth thereby reducing the level of carbon dioxide in the atmosphere.

关键词： Mathematical model algae atmospheric CO2 sensitivity analysis:seasonality periodic solution

Biotechnological preparation of chicken skin gelatine using factorial design of experiments

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Food Bioscience 2022年第3期47卷 898-907页

作者： Petr Mrázek Robert Gál Pavel Mokrejš jana Orsavová Dagmar Janáčová Tomas Bata University in Zlín Department of Polymer EngineeringVavrečkova 275760 01ZlínCzech Republic Tomas Bata University in Zlín Department of Food TechnologyMostní 5139760 01ZlínCzech Republic Tomas Bata University in Zlín Language CentreŠtefánikova 5670760 01ZlínCzech Republic Tomas Bata University in Zlín Department of Automation and Control EngineeringNad Stráněmi 4511760 01ZlínCzech Republic

Poultry meat production steadily increases and its by-products including legs or skins may be further utilized to prepare gelatine,generally by using alkali or acid *** they are toxic,different methods are desirable,*** proteolytic *** enzymes is beneficial as they shorten processing time and reduce the required water *** conditions(the enzyme amount during the pre-treatment,first and second extraction temperature and time)of the process may influence gelatine quality and its *** this study,gelatines were prepared from chicken skin at different conditions in the series of combined factorial design of *** significance of the influence of the conditions on the quality(gel strength,viscosity,melting and gelling point)and yield of chicken skin gelatine(CSG)was *** highest yield(31.5%)was obtained at the conditions of the enzyme amount of 0.8%,first extraction temperature 80℃ and time 30 min,second extraction temperature 90℃ and time 60 ***,the highest CSG quality of gel strength(190 Bloom),viscosity(4.06 mPas),melting point(38.3℃)and gelling point(20.5℃)was obtained at the conditions of 0.2%/50℃/30 min in the first extraction.

关键词： Collagen Chicken skin Enzyme pre-treatment Gelatine Gelling properties

Long-term follow-up of children and adolescents with primary sclerosing cholangitis and autoimmune sclerosing cholangitis

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Hepatobiliary & Pancreatic Diseases International 2016年第4期15卷 412-418页

作者： Vratislav Smolka Eva Karaskova Oksana Tkachyk Kvetoslava Aiglova Jiri Ehrmann Kamila Michalkova Michal Konecny jana Volejnikova Department of Pediatrics Faculty of Medicine and DentistryPalacky University and University Hospital OlomoucI.P.Pavlova 6Olomouc 77900Czech Republic Department of Internal Medicine Faculty of Medicine and DentistryPalacky University and University Hospital OlomoucI.P.Pavlova 6Olomouc 77900Czech Republic Department of Clinical and Molecular Pathology Faculty of Medicine and DentistryPalacky University and University Hospital OlomoucI.P.Pavlova 6Olomouc 77900Czech Republic Department of Radiology Faculty of Medicine and DentistryPalacky University and University Hospital OlomoucI.P.Pavlova 6Olomouc 77900Czech Republic

BACKGROUND： Sclerosing cholangitis（SC） is a chronic cholestatic hepatobiliary disease with uncertain long-term prognosis in pediatric patients. This study aimed to evaluate longterm results in children with SC according to the types of ***： We retrospectively followed up 25 children with SC over a period of 4-17 years（median 12）. The diagnosis of SC was based on biochemical, histological and cholangiographic findings. Patients fulfilling diagnostic criteria for probable or definite autoimmune hepatitis at the time of diagnosis were defined as having autoimmune sclerosing cholangitis（ASC）; other patients were included in a group of primary sclerosing cholangitis（PSC）. The incidence of the following complications was studied： obstructive cholangitis, portal hypertension, advanced liver disease and death associated with the primary ***： Fourteen（56%） patients had PSC and 11（44%） had ASC. Patients with ASC were significantly younger at the time of diagnosis（12.3 vs 15.4 years, P=0.032） and had higher Ig G levels（22.7 vs 17.2 g/L, P=0.003）. The mentioned complications occurred in 4（16%） patients with SC, exclusively in the PSC group： one patient died from colorectal cancer, one patient underwent liver transplantation and two patients, in whom severe bile duct stenosis was present at diagnosis, were endoscopically treated for acute cholangitis. Furthermore, twoother children with ASC and 2 children with PSC had elevated aminotransferase levels. The 10-year overall survival was 95.8% in all patients, 100% in patients without complicated liver disease, and 75.0% in patients with ***： In children, ASC is a frequent type of SC, whose prognosis may be better than that in patients with PSC.

关键词： autoimmune sclerosing cholangitis childhood inflammatory bowel disease primary sclerosing cholangitis prognosis

Dynamic Multi-Layer Perceptron for Fetal Health Classification Using Cardiotocography Data

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Computers, Materials & Continua 2024年第8期80卷 2301-2330页

作者： Uddagiri Sirisha Parvathaneni Naga Srinivasu Panguluri Padmavathi Seongki Kim Aruna Pavate jana Shafi Muhammad Fazal Ijaz Department of Computer Science and Engineering Prasad V Potluri Siddhartha Institute of TechnologyVijayawada520007India Amrita School of Computing Amrita Vishwa VidyapeethamAmaravatiAndhra Pradesh522503India Department of Tele informatics Engineering Federal University of CearáFortaleza60455-970Brazil Department of Computer Science and Engineering Koneru Lakshmaiah Education FoundationVaddeswaramGunturAndhra Pradesh522302India Department of Computer Engineering Chosun UniversityGwangju61452Republic of Korea School of CSIT Symbiosis Skills and Professional UniversityPune412101India Department of Computer Engineering and Information College of Engineering inWadi AlddawasirPrince Sattam bin Abdulaziz UniversityWadi Alddawasir11991Saudi Arabia School of IT and Engineering Melbourne Institute of TechnologyMelbourne3000Australia

Fetal health care is vital in ensuring the health of pregnant women and the *** check-ups need to be taken by the mother to determine the status of the fetus’growth and identify any potential *** know the status of the fetus,doctors monitor blood reports,Ultrasounds,cardiotocography(CTG)data,***,in this research,we have considered CTG data,which provides information on heart rate and uterine contractions during *** researchers have proposed various methods for classifying the status of fetus *** processing of CTG data is time-consuming and ***,automated tools should be used to classify fetal *** study proposes a novel neural network-based architecture,the Dynamic Multi-Layer Perceptron model,evaluated from a single layer to several layers to classify fetal *** strategies were applied,including pre-processing data using techniques like Balancing,Scaling,Normalization hyperparameter tuning,batch normalization,early stopping,etc.,to enhance the model’s performance.A comparative analysis of the proposed method is done against the traditional machine learning models to showcase its accuracy(97%).An ablation study without any pre-processing techniques is also *** study easily provides valuable interpretations for healthcare professionals in the decision-making process.

关键词： Fetal health cardiotocography data deep learning dynamic multi-layer perceptron feature engineering

The Paleoarchean Northern Mundo Novo Greenstone Belt,São Francisco Craton:Geochemistry,U-Pb-Hf-O in zircon and pyriteδ^(34)S-Δ^(33)S-Δ^(36)S signatures

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Geoscience Frontiers 2022年第5期13卷 190-206页

作者： Guilherme S.Teles Farid Chemale Jr. janaína N.Ávila Trevor R.Ireland Unidade Acadêmica de Mineração e Geologia Universidade Federal de Campina GrandeCampina GrandeBrazil Programa de Pós-Graduação em Geologia Universidade de BrasíliaBrasíliaBrazil Programa de Pós-Graduação em Geologia Universidade do Vale do Rio dos SinosSão LeopoldoBrazil Research School of Earth Sciences The Australian National UniversityCanberraACT 2601Australia Griffith Centre for Social and Cultural Research Griffith UniversityNathanQueensland 4111Australia

Greenstone belts contain several clues about the evolutionary history of primitive ***,we describe the volcano-sedimentary rock association exposed along the eastern margin of the Gavião Block,named the Northern Mundo Novo Greenstone Belt(N-MNGB),and present data collected with different techniques,including U–Pb–Hf–O isotopes of zircon and multiple sulfur isotopes(^(32)S,^(33)S,^(34)S,and ^(36)S)of pyrite from this supracrustal sequence.A pillowed metabasalt situated in the upper section of the N-MNGB is 3337±25 Ma old and has zircon with ε_(Hf)(t)=2.47 to1.40,Hf model ages between 3.75 Ga and 3.82 Ga,and δ^(18)O=+3.6‰to+7.3‰.These isotopic data,together with compiled whole-rock trace element data,suggest that the mafic metavolcanic rocks formed in a subduction-related setting,likely a back-arc basin juxtaposed to a continental *** this context,the magma interacted with older Eoarchean crustal components from the Gavião *** zircons from the overlying quartzites of the Jacobina Group are sourced from Paleoarchean rocks,in accordance with previous studies,yielding a maximum depositional age of 3353±22 *** detrital zircons have ε_(Hf)(t)=5.40 to0.84,Hf model ages between 3.66 Ga and 4.30 Ga,and δ^(18)O=+4.8‰to+6.4‰.The pyrite multiple sulfur isotope investigation of the 3.3 Ga supracrustal rocks from the N-MNGB enabled a further understanding of Paleoarchean sulfur *** samples have diverse isotopic compositions that indicate sulfur sourced from distinct ***,they preserve the signal of the anoxic Archean atmosphere,expressed by MIF-S signatures(Δ^(33)S between1.3‰to+1.4‰)and a Δ^(36)S/Δ^(33)S slope of0.81 that is indistinguishable from the so-called Archean array.A BIF sample has a magmatic origin of sulfur,as indicated by the limited Δ^(34)S range(0 to+2‰),Δ^(33)S~0‰,and Δ^(36)S~0‰.A carbonaceous schist shows positive Δ^(34)S(2.1‰–3.5‰)and elevated Δ^(33)S(1.2‰–1.4‰)values,with corresponding negative Δ^(36)S

关键词： Northern Mundo Novo Greenstone Belt Multiple sulfur isotopes Geochronology Paleoarchean Gavião Block São Francisco Craton

Enhancement of the ‘tractor-beam’ pulling force on an optically bound structure

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Light(Science & Applications) 2017年第1期6卷 136-141页

作者： jana Damková Lukáš Chvátal Jan Ježek Jindřich Oulehla Oto Brzobohatý Pavel Zemánek Institute of Scientific Instruments of the CAS v.v.i.Královopolská147Brno 61264Czech Republic

Recently,increasing attention has been devoted to mastering a new technique of optical delivery of micro-objects tractorbeam’1–*** beams have uniform intensity profiles along their propagation direction and can exert a negative force that,in contrast to the familiar pushing force associated with radiation pressure,pulls the scatterer toward the light *** was experimentally observed that under certain circumstances,the pulling force can be significantly enhanced6 if a non-spherical scatterer,for example,a linear chain of optically bound objects10–12,is optically *** we demonstrate that motion of two optically bound objects in a tractor beam strongly depends on theirs mutual distance and spatial *** configuration-dependent optical forces add extra flexibility to our ability to control matter with *** these interactions opens the door to new applications involving the formation,sorting or delivery of colloidal self-organized structures.

关键词： beam scatter mutual

COHERENT HEMODYNAMICS SPECTROSCOPY BASED ON A PACED BREATHING PARADIGM-REVISITED

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Journal of Innovative Optical Health Sciences 2014年第1期7卷 91-99页

作者： jana M.KAINERSTORFER ANGELO SASSAROLI MICHELE L.PIERRO BERTAN HALLACOGLU SER.GIO FANTINI Department of Biomedical Engineering Tufts University 4 ColbyStreetMedfordMA 02155USA

A novel hemodynamic model has been recently introduced,which provides analytical relation-ships between the changes in cerebral blood volume(CBV),cerebral blood flow(CBF),andcerebral metabolic rate of oxy gen(CMRO2),and associat ed changes in the tissue concentrationsof oxy-and deoxy-hemoglobin(AO and AD)measured with near-infrared,spectroscopy(NIRS)[***,Neuroimage 85,202-221(2014)].This novel model can be applied tomeasurements of the amplit ude and phase of induced hemodynamic oscillations as a function ofthe frequency of oscillation,realizing the novel technique of coherent hemodynamics spectroscopy(CHS)[***,Neuroimage 85,202-221(2014);*** et al.,Neuroimage 85,222-233(2014)]:In a previous work,,we have demonstrated an in vivo application of CiHS on hunanSubjects during paced breat hing[*** et al,Neuroimage 85,222-233(2014)].In thiswork,we present a new analysis of the collected data duringpaced breat hing based on a slightlyrevised formulation of the hemodynamic model and ann efficient fitting *** we haveinitially treated all 12 model parameindeependent,we have found that,in this new in-plementation of CHS,the number of independent is *** this article,we identifythe eight independent model parameters and,we show that our previous results are consistentwith the new formulation,once the individual parameters of the earlier analysis are combinedinto the new set of independent parameters.

关键词： Hemodynamic model near-infrared spectroscopy cerebral autoregulation cerebralblood flow metabolic rate of oxygen.