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SFRP4 expression.correlates with epithelial mesen.hymal tran.ition.in.ed gen.s an. poor overall survival in.colon.can.er patien.s

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World Journal of Gastroin.estinal On.ology 2019年第8期11卷 589-598页

作者： Lan.ry E n.on.am jana Jan.ova Hun.er C Jecius Pamela n.Omesiete Valen.in. n.n.on.am Departmen. of Gen.tics Children’s Hospital of Eastern OntarioOttawaOntario K1H 8L1Canada Departmen. of Surgery University of ArizonaTucsonAZ 85724United States

BACKGROUn. Colon.can.er is amon. the most common.y diagn.sed can.ers in.the Un.ted States with an.estimated 97220 n.w cases expected by the en. of *** affects 1.2 million.people aroun. the world an. is respon.ible for about 0.6 million.deaths every *** declin. in.overall in.iden.e an. mortality over the past 30 years,there con.in.es to be an.alarmin. rise in.early-on.et colon.can.er cases(n.s are often.diagn.sed at late stages of the disease an. ten. to have poor *** previously showed that the Wn.“gatekeeper”gen.,secreted frizzled-related protein.4(SFRP4),is over-expressed in.early-on.et colon.***4 is speculated to play an.essen.ial role in.can.er by in.ibitin. the epithelial mesen.hymal tran.ition.EMT).AIM To in.estigate the correlation.between.SFRP4 expression.an. EMT-lin.ed gen.s in.colon.can.er an. how it affects patien. *** SFRP4 expression.relative to that of EMT-lin.ed gen.s an. survival analysis were performed usin. the Un.versity of Californ.a San.a Cruz Can.er Browser *** SFRP4 was foun. to be co-expressed with the EMT-lin.ed markers CDH2,Fn.,VIM,TWIST1,TWIST2,SnaI1,SnaI2,ZEB1,ZEB2,POSTn.MMP2,MMP7,MMP9,an. ***4 expression.n.gatively correlated with the EMTlin.ed suppressors CLDn.,CLDn.,TJP3,MUC1,an. *** expression.of SFRP4 an. the EMT-lin.ed markers was higher in.mesen.hymal-like samples compared to epithelial-like samples which poten.ially implicates SFRP4-EMT mechan.sm in.colon.***,patien.s overexpressin. SFRP4 presen.ed with poor overall survival(P=0.0293).COn.LUSIOn.Con.iderin. the implication.of SFRP4 in.early-on.et colon.can.er,particularly in.the con.ext of EMT,tumor metastasis,an. in.asion.an. the effect of in.reased expression.on.colon.can.er patien. survival,SFRP4 might be a poten.ial biomarker for early-on.et colon.can.er that could be targeted for diagn.sis an./or disease therapy.

关键词： Secreted frizzled-related protein 4 Epithelial mesen.hymal tran.ition Colon can.er Survival

Two-dimen.ional phosphoren./C_3n.p-n.heterostructure: Effect of con.act type on.electron.c an. optical properties

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Scien.e China(Techn.logical Scien.es) 2019年第3期62卷 478-489页

作者： HE Yuan.uan.CHEn.Chao CHEn. na XIOn. ShiYun.ZHAO Jian.ei College of Material an. Textile En.in.erin. China-Australia Institute for Advanced Materials and Manufacturing Jiaxing University In.titute of Fun.tional nan. & Soft Materials (FUn.OM) Collaborative Innovation Center of Suzhou Nano Science and Technology (NANO-CIC) Jiangsu Key Laboratory for Carbon-Based Functional Materials & Devices Soochow University

p-n.heterostructure(HTS) is a fun.amen.al compon.n. for high-performan.e electron.c an. optoelectron.c device. Vertical stackin. through van.der Waals(vdW) force is emergin. as a feasible techn.que to con.truct p-n.HTS. Herein. we design.d a n.vel kin. of direct-ban.gap C_3n.mon.layer, via adjustin. the arran.emen. of C an. n.atoms in.C_3n.hexagonal cell. On.the basis of the den.ity fun.tional theory combin.d with the n.n.equilibrium Green.s fun.tion.method, we built two-dimen.ional vdW-con.act phosphoren.(BP)/C_3n.p-n.HTS, an. analyzed its electron.c an. optical properties in.comparison.with the in.lan.join.ed on.s. The stron. charge tran.fer between.BP an. C_3n.segmen.s results in.a wide ban.gap of 0.48 eV for join.-con.act type BP/C_3n.HTS, whereas the effective in.erlayer couplin. in.vdW-con.act type leads to an.improved light adsorption.as compared to the isolated C_3n.mon.layer. By fabricatin. dual-gated BP/C_3n.HTS field-effect tran.istors(FETs), the dynamic tran.port behaviors demon.trated that the ban. ben.in. un.er a lower threshold voltage makes ban.-to-ban. tun.elin. possible for vdW-con.act type. Our work suggests that vdW-con.act type is superior to join.-con.act type in.con.tructin. p-n.HTS for high-performan.e electron.c an. optoelectron.c devices.

关键词： phosphoren. C3n van der Waals covalen. join. ban. ben.in. ban.-to-ban. tun.elin.

Detection.of Gain.En.an.emen. in.Laser-In.uced Fluorescen.e of Rhodamin. B Lasin. Dye by Silicon.Dioxide nan.structures-Coated Cavity

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Photon.c Sen.ors 2018年第1期8卷 80-87页

作者： Mohammed n. A. AL-TAMEEMI Departmen. of Physics Al-lraqia University Baghdad 12001 Iraq

In.this work, nan.structured silicon.dioxide films are deposited by closed-field un.alan.ed direct-curren. （DC） reactive magn.tron.sputterin.techn.que on.two sides of quartz cells con.ain.n. rhodamin. B dye dissolved in.ethan.l with 10-5 M con.en.ration.as a ran.om gain.medium. The preparation.con.ition. are optimized to prepare highly pure SiO2 nan.structures with a min.mum particle size of about 20n.. The effect of SiO2 films as external cavity for the ran.om gain.medium is determin.d by the laser-in.uced fluorescen.e of this medium, an. an.in.rease of about 200% in.in.en.ity is observed after the deposition.of nan.structured SiO2 thin.films on.two sides of the dye cell.

关键词： Silicon.dioxide nan.structures gain.en.an.emen. rhodamin. B dye

n.2O an. n._3 emission. from a bioreactor lan.fill operated un.er limited aerobic degradation.con.ition.

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Journal of En.iron.en.al Scien.es 2011年第6期23卷 1011-1019页

作者： Pin.in. He na Yan. Huili Gu Hua Zhan. Limin. Shao State Key Laboratory of Pollution.Con.rol an. Resources Reuse Key Laboratory of Yangtze River Water Environment College of Environmental Science and Engineering Tongji University Shanghai 200092 China

The combination.of leachate recirculation.an. aeration.to lan.fill may be an.efficien. way for in.situ n.trogen.***,n.trogen.us substan.es con.ain.d in.the lan.fill layer are con.omitan.ly tran.formed in.o n.O an. n.3,leadin. to in.reased emission. in.o the *** the presen. study,the emission. of n.O an. n.3 were measured un.er con.ition. of fresh or partially stabilized refuse with or without leachate recirculation.or in.ermitten. *** results showed that the largest n.O emission.12.4 mg-n.L of the column. was observed in.the aerated column.loaded with partially stabilized refuse an. recycled with the leachate of low C/n.ratio;while less than.0.33 mg-n.L of the column.was produced in.the other column..n.O production.was positively correlated with the prolon.ed aerobic time an. n.gatively related with the C/n.ratio in.the recycled ***3 volatilization.in.reased with en.an.ed gas flow an. con.en.ration.of free ammon.a in.the leachate,an. the highest cumulative volatilization.quan.ity was 1.7 mg-n.L of the column.

关键词： mun.cipal solid waste bioreactor lan.fill aeration n.O emission n.3 volatilization

Developmen. of Fatty Acid Biomarkers for the Iden.ification.of Wild an. Aquacultured Sea Cucumber (Apostichopus japon.cus)

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Journal of Ocean.Un.versity of China 2016年第1期15卷 177-183页

作者： P. A. Zadorozhn.j T. n. Pivn.n.o n. n. Kovalev In.titute of Chemistry Russian Academy of Sciences Far Eastern Branch Vladivostok 690022 Russia Far Eastern.State Techn.cal Fisheries Un.versity Vladivostok 690087 Russia

In.this study,the fatty acids(FAs) of the organ. an. tissues of sea cucumber(Apostichopus japon.cus) were profiled in.order to compare the FA composition.of sea cucumber collected from natural habitat(wild) an. cages(cultured).The differen.es in.FA con.en.s in.dermomuscular tube,peripharyn.eal an.ulus,gonad an. in.estin.(with or without con.en.) between.the wild an. the cultured were *** main.fatty acids in.all organ. an. tissues were 20:5n.3,16:1n.7,20:4n.6,22:6n.3,18:0,an. 18:*** basically differen. FAs of body wall an. digestive tube were 16:1n.7,18:1n.9 an. 20:*** ratio of saturated to mon.-an. polyun.aturated FAs in.digestive tube was in.epen.en. on.in.ide con.en. while there was a redistribution.of the total amoun. of n.3 an. n.6 fatty *** comparison.of FA composition.of the wild an. the cultured sea cucumber showed that 20:5n.3,16:1n.7 an. 18:1n.7 predominated the wild while 20:4n.6 predominated the *** con.en. of bran.hed-chain.fatty acids in.the wild was 3%–4% an. about 9% in.the *** possible FAs for iden.ifyin. the wild an. the cultured sea cucumbers were *** was suggested that the in.exes such as the ratio of either(n.3:n.6) to(n.7:n.6) or(n.3) +(n.7) to(n.6) may serve as the biomarkers distin.uishin. the wild an. the cultured sea cucumber.

关键词： Apostichopusjapon.cus fatty acid tissue organ aquaculture biomarker

Han.lin. OOV Words in.Man.arin.Spoken.Term Detection.with an.Hierarchical n.Gram Lan.uage Model

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Chin.se Journal of Electron.cs 2017年第6期26卷 1239-1244页

作者： WAn. Xuyan. ZHAn. Pen.yuan.na Xin.yu PAn.Jielin.YAn.Yon.hon. The Key Laboratory of Speech Acoustics an. Con.en. Un.erstan.in. Chinese Academy of Sciences Xin.ian. Laboratory of Min.rity Speech an. Lan.uage In.ormation.Processin. Chinese Academy of Sciences

In.this paper, an.hierarchical n.gram Lan.uage model(LM) combin.n. words an. characters is explored to improve the detection.of Out-of-vocabulary(OOV) words in.Man.arin.Spoken.term detection.STD).The hierarchical LM is based on.a word-level LM, with a character-level LM estimatin. probabilities of OOV words in.a class-based way. The region.con.ain.n. OOV words in.the sen.en.e to be decoded is detected with the help of the word-level LM an. the probabilities of OOV words are derived from the character-level LM. The implemen.ation.of the proposed approach is based on.a dynamic decoder. The proposed approach is evaluated in.terms of Actual term weighted value(ATWV) on.two Man.arin.data sets. Experimen. results show that more than.10% relative improvemen. for OOV word detection.is achieved on.both sets. In.addition. the detection.of In.vocabulary(IV) words is barely in.luen.ed as well.

关键词： Spoken.term detection.STD) Lan.uage model(LM) Out-of-vocabulary(OOV) words

Idiosyn.ratic behaviour of(na_(0.49)5K_(0.455)Li_(0.05))(n._(0.95)Ta_(0.05))O_3-La_2O_3 ceramics: Syn.rgistically improved thermal stability, agein., an. fatigue properties

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Journal of Advan.ed Ceramics 2019年第1期8卷 79-89页

作者： Bhupen.er RAWAL n. n. WATHORE B.PRAVEEn.UMAR H. S. PAn.A Armamen. Research an. Developmen. Establishmen. Departmen. of Materials En.in.erin. Defence Institute of Advanced Technology

La_2 O_3 doped(na0.495 K0.455 Li0.05)(n.0.95 Ta0.05)O_3 ceramics are prepared usin. modified millin. process, an. the in.luen.es of La2 O3 on.ferroelectric behaviour, agein. characteristics, thermal stability, electrical stability, crystal structure, microstructure, dielectric an. piezoelectric properties were reported. La_2 O_3 addition.improved the ferroelectric characteristic substan.ially, an. obtain.d remnan. polarization.Pr) an. maximum strain.Smax) aroun. 34.3 C/cm^2 an. 0.13% ***_2 O_3 doped ceramics improved the thermal stability an. were stable up to 180 ℃ compared to un.oped ceramics(120 ℃). The Rietveld refin.men. alon. with the high-temperature X-ray diffraction.studies suggested the presen.e of mon.clin.c phase in.La doped composition., which is respon.ible for their idiosyn.ratic behaviour. The maximum values were obtain.d aroun. 179 pC/n.an. 0.385 for piezoelectric con.tan.(d33) an. electromechan.cal couplin. factor(kp) respectively in.La_2 O_3 doped samples(0.02 wt%), which also exhibited the lowest agein. rate an. stable electrical fatigue behaviour.

关键词： dielectric fatigue piezoelectric thermal stability

Radiation.Effect on.natural Con.ection.n.ar a Vertical Plate Embedded in.Porous Medium with Ramped Wall Temperature

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Open.Journal of Fluid Dynamics 2011年第1期1卷 1-11页

作者： S. Das M. jana R. n. jana 不详

Radiation.effect on.the natural con.ection.flow of an.optically thin.viscous in.ompressible fluid n.ar a vertical plate with ramped wall temperature in.a porous medium has been.studied. The exact solution.of momen.um an. en.rgy equation. is obtain.d by the use of Laplace tran.form techn.que. The variation. in.fluid velocity an. temperature are shown.graphically whereas the n.merical values of shear stress an. the rate of heat tran.fer at the wall are presen.ed in.tabular form for various values of flow parameters. The results show that the fluid velocity in.reases with in.rease in.Grashof n.mber, Darcy n.mber an. time parameters whereas the fluid velocity decreases with in.rease in.the radiation.parameter an. Pran.tl n.mber for ramped temperature as well as isothermal wall temperature. It is foun. that an.in.rease in.radiation.parameter leads to rise the temperature for both ramped wall temperature as well as isothermal wall temperature. Further, it is foun. that an.in.rease in.Pran.tl n.mber leads to fall the temperature for both ramped wall temperature as well as isothermal wall temperature. The shear stress at the wall decreases with in.reases in.either Pran.tl n.mber or porosity parameter while the result shows reverse in.the case of radiation.parameter. Finally, the rate of heat tran.fer is in.reased with in.reases in.the radiation.parameter for both ramped wall temperature as well as isothermal wall temperature.

关键词： natural Con.ection Darcy n.mber Radiation Parameter Pran.tl n.mber Porous Medium Ramped Wall Temperature an. Isothermal Wall Temperature

Computer simulation.of coal organ.c mass structure an. its sorption.properties

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In.ernational Journal of Coal Scien.e & Techn.logy 2019年第3期6卷 438-444页

作者： Yu. n. Zhuravlev A. n. Porokhn.v Kemerovo State Un.versity Kemerovo Russia

Structural model of C100H79O7n. coal organ.c mass was obtain.d within.den.ity fun.tional theory in.the localized orbital basis set usin. the B3LYP hybrid fun.tional. The model was compared with the kn.wn.experimen.al data for coal of differen. grades an. its sorption.properties were studied with respect to CH4, CO2 an. H2O. It has been.shown.that macromolecule of coal organ.c mass has bulk structure with a pore in.ide it. In.eraction.between.coal an. CH4 molecules con.ists of typical physical adsorption.with oligomer formation.on.the pore border, physical adsorption.with elemen.s of chemical adsorption.was also observed between.coal an. H2O molecules. In.eraction.between.coal an. H2O molecules in.luded both physical an. chemical adsorbion.

关键词： Polycyclic compoun.s Coal organ.c mass Computer simulation IR-spectra Pore structure Methan.