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Non-invasive diagnosis of liver fibrosis in chronic hepatitis C

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World Journal of Gastroenterology 2014年第11期20卷 2854-2866页

作者： Leonardo de Lucca schiavon janaína luz narciso-schiavon Roberto José de Carvalho-Filho Gastroenterology Division Department of Internal MedicineFederal University of Santa CatarinaFlorianópolisSC 88040-900Brazil Gastroenterology Division Department of MedicineFederal University of Sao PauloSao PauloSP 04023-900Brazil

Assessment of liver fibrosis in chronic hepatitis C virus(HCV)infection is considered a relevant part of patient care and key for decision *** liver biopsy has been considered the gold standard for staging liver fibrosis,it is an invasive technique and subject to sampling errors and significant intra-and inter-observer *** the last decade,several noninvasive markers were proposed for liver fibrosis diagnosis in chronic HCV infection,with variable *** the clear advantage of being noninvasive,a more objective interpretation of test results may overcome the mentioned intra-and inter-observer variability of liver *** addition,these tests can theoretically offer a more accurate view of fibrogenic events occurring in the entire liver with the advantage of providing frequent fibrosis evaluation without additional ***,in general,these tests show low accuracy in discriminating between intermediate stages of fibrosis and may be influenced by several hepatic and extrahepatic *** methods are either serum markers(usually combined in a mathematical model)or imaging modalities that can be used separately or combined in algorithms to improve *** this review we will discuss the different noninvasive methods that are currently available for the evaluation of liver fibrosis in chronic hepatitis C,their advantages,limitations and application in clinical practice.

关键词： Liver fibrosis Liver cirrhosis Hepatitis C Diagnosis Elasticity imaging techniques

Central nervous system vasculitis and polyneuropathy as first manifestations of hepatitis C

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World Journal of Gastroenterology 2012年第2期18卷 188-191页

作者： Roberto J Carvalho-Filho janaína luz narciso-schiavon Luciano HL Tolentino Leonardo L schiavon Maria Lucia G Ferraz Antonio Eduardo B Silva Division of Gastroenterology Hepatitis SectionFederal University of Sao Paulo04037-003 Sao PauloBrazil

Sensory or motor peripheral neuropathy may be observed in a significant proportion of hepatitis C virus (HCV)-infected ***,central nervous system (CNS) involvement is uncommon,especially in cryoglobulin-negative *** describe a case of peripheral neuropathy combined with an ischemic CNS event as primary manifestations of chronic HCV infection without *** improvement was observed after antiviral *** discuss the spectrum of neurological manifestations of HCV infection and review the literature.

关键词： Hepatitis C Central nervous system Poly-neuropathy Interferon-α

Autoantibodies in chronic hepatitis C: A clinical perspective

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World Journal of Hepatology 2015年第8期7卷 1074-1085页

作者： janaína luz narciso-schiavon Leonardo de Lucca schiavon Department of Internal Medicine Gastroenterology Division Federal University of Santa Catarina

Non-organ-specific autoantibodies and thyroid autoantibodies have been frequently found in chronic carriers of hepatitis C virus(HCV). With respect to endomysial antibodies and tissue transglutaminase, it is controversial whether the prevalence of glutenrelated seromarkers is higher in patients with HCV. In such cases, in addition to acknowledging any currently existing autoimmune disease, recognizing the risk of the patient developing an autoimmune disease during interferon(IFN)-based treatment must be a principle concern. From a clinical point-of-view, the presence of autoantibodies arouses suspicion that an autoimmunedisease may be present or may be precipitated by IFNbased HCV treatment. In this paper, we review the prevalence of autoantibodies in individuals with hepatitis C, the clinical significance of these autoantibodies, and the approach recommended for such situations.

关键词： Hepatitis C Autoimmunity Antibodies Antinuclear Hepatitis Autoimmune Thyroid diseases Hashimoto disease Thyroglobulin Celiac disease Transglutaminases Diarrhea Interferon-alpha

Circulating insulin-like growth factor-binding protein 3 as prognostic biomarker in liver cirrhosis

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World Journal of Hepatology 2016年第17期8卷 739-748页

作者： Carina Gabriela Correa Bruno da Silveira Colombo Marcelo Fernando Ronsoni Pedro Eduardo Soares e Silva Leonardo Fayad Telma Erotides Silva Letícia Muraro Wildner Maria Luiza Bazzo Esther Buzaglo Dantas-Correa janaína luz narciso-schiavon Leonardo de Lucca schiavon Division of Gastroenterology Federal University of Santa Catarina Department of Clinical Analysis Federal University of Santa Catarina

AIM: To investigate the prognostic significance of insulin-like growth factor-binding protein 3(IGFBP-3) in patients with ***: Prospective study that included two cohorts: outpatients with stable cirrhosis(n = 138) and patients hospitalized for acute decompensation(n = 189). Development of complications, mortality or liver transplantation was assessed by periodical phone calls and during outpatient visits. The cohort of stable cirrhosis also underwent clinical and laboratory evaluation yearly(2013 and 2014) in predefined study visits. In patients with stable cirrhosis, IGFBP-3 levels were measured at baseline(2012) and at second re-evaluation(2014). In hospitalized subjects, IGFBP-3 levels were measured in serum samples collected in the first and in the third day after admission and stored at-80 ℃. IGFBP-3 levels were measured by ***: IGFBP-3 levels were lower in hospitalized patients as compared to outpatients(0.94 mcg/mL vs 1.69 mcg/m L, P nalysis showed that death or transplant was associated with lower IGFBP-3 levels(1.44 mcg/mL vs 1.74 mcg/m L, P = 0.027). The Kaplan-Meier transplant-free survival probability was 88.6% in patients with IGFBP-3 ≥ 1.67 mcg/mL and 72.1% for those with IGFBP3 < 1.67 mcg/mL(P = 0.015). In the hospitalized cohort, 30-d mortality was 24.3% and was independently associated with creatinine, INR, SpO_2/FiO_2 ratio and IGFBP-3 levels in the logistic regression. The 90-d transplant-free survival probability was 80.4% in patients with IGFBP-3 ≥ 0.86 mcg/mL and 56.1% for those with IGFBP3 < 0.86 mcg/mL(P < 0.001). CONCLUSION: Lower IGFBP-3 levels were associated with worse outcomes in patients with cirrhosis, and might represent a promising prognostic tool that can be incorporated in clinical practice.

关键词： Liver cirrhosis Acute decompensation Insulin-like growth factor binding protein 3 Acute-onchronic liver failure Prognosis

Celiac disease screening in patients with cryptogenic cirrhosis

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World Journal of Gastroenterology 2023年第2期29卷 410-412页

作者： janaina luz narciso-schiavon Leonardo Lucca schiavon Gastroenterology Division Internal Medicine DepartmentFederal University of Santa CatarinaFlorianopolis 88040-900SCBrazil

We write a letter to the editor commenting the article“Who to screen and how to screen for celiac disease”.We discuss the present literature on cirrhosis and celiac disease(CD)and recommend screening and treating CD... 详细信息

关键词： Celiac disease Liver cirrhosis Liver failure Aspartate aminotransferase Alanine aminotransferase

Fatty liver and celiac disease:Why worry?

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World Journal of Hepatology 2023年第5期15卷 666-674页

作者： janaina luz narciso-schiavon Leonardo Lucca schiavon Department of Internal Medicine Gastroenterology DivisionFederal University of Santa CatarinaFlorianópolis 88040-900Santa CatarinaBrazil

Celiac disease(CD)is a chronic inflammatory intestinal disorder mediated by the ingestion of gluten in genetically susceptible *** involvement in CD has been widely described,and active screening for CD is recommended in patients with liver diseases,particularly in those with autoimmune disorders,fatty liver in the absence of metabolic syndrome,noncirrhotic intrahepatic portal hypertension,cryptogenic cirrhosis,and in the context of liver ***-alcoholic fatty liver disease is estimated to affect approximately 25%of the world’s adult population and is the world’s leading cause of chronic liver *** view of both diseases’global significance,and to their correlation,this study reviews the available literature on fatty liver and CD and verifies particularities of the clinical setting.

关键词： liver involvement diseases

Initial host-pathogen interactions explained by the Organism Prearranged Recognition Theory: fundamental role of saccharides

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Life Research 2024年第3期7卷 9-23页

作者： luz P.Blanco Systemic Autoimmunity Branch National Institute of Arthritis and Musculoskeletal and Skin DiseasesNational Institute of HealthBethesdaUSA

Herein based on literature available a hypothesis is provided about molecular basis for initial events in establishment *** hypothesis asserts that:"recognition and interaction that occur between organisms is *** are membrane receptors with or without soluble components derived from the respective organisms that bridge specific interactions".Organisms'prearranged recognition theory(OPRT)can be specifically applied to host-microbe interactions where most microbes are coated(opsonised)by soluble components(opsonins)from the host,but there are also some microbes that can bypass host opsonization expressing receptors for the host cells or secreting host’s opsonin-like *** receptors involved in organism's interactions,their specificity and repertoire depend on saccharides from glycoproteins,glycolipids,and polysaccharides(glycans)which are abundant extracellular *** in OPRT is possible to explain species-specific interactions and several other phenomena,such as hyper-infectivity,tissue tropism,differential sensitivity to disease depending on type O-blood,and tumoral cell *** lipid raft domain in cellular membrane is proposed as the main location where interactions will trigger cellular *** scientific and biotechnology applications and alternative routes to modify organism's interactions and consequences are *** is a novel hypothesis regarding the degree to which an organism's interactions are prearranged and the role of saccharides epitopes.

关键词： Species-specificity saccharides extracellular-matrix host-pathogen antibodies

Simulated rainfall in Brazil:An alternative for assesment of soil surface processes and an opportunity for technological development

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International Soil and Water Conservation Research 2024年第1期12卷 29-42页

作者： Camila Calazans da Silva luz Wilk Sampaio de Almeida Adilson Pacheco de Souza Nivaldo Schultz Jamil Alexandre Ayach Anache Daniel Fonseca de Carvalho Postgraduate Program in Agronomy-Soil Sciences Federal Rural University of Rio de JaneiroSeropédicaRJBrazil Agronomy Department Federal Institute of EducationScience and Technology of RondôniaAriquemesROBrazil Federal University of Mato Grosso SinopMTBrazil Federal Rural University of Rio de Janeiro SeropédicaRJBrazil Federal University of Mato Grosso do Sul Campo GrandeMSBrazil

Rainfall simulators(RS)have been used,above all,to evaluate hydrological processes related to soil water infiltration,surface runoff and soil *** allow repeatability of rain application with different precipitation intensities in field and/or laboratory conditions and should produce events with physical characteristics similar to natural *** this manuscript,we carried out a bibliometric and scientometric analysis of studies with simulated rainfall in Brazil to assess the temporal evolution of publications,the main topics addressed and the degree of technological development of the *** searched for the terms“rainfall simulator”OR“simulated rainfall”AND“Brazil”in the Scopus,Web of Science,SciELO and Google Scholar *** found 143 articles published in the last 37 years(1985-2022).Our findings indicate that the main research areas covered in papers are soil erosion(57.34%),soil water infiltration(24.47%),nutrient losses(9.8%)and RS development and calibration/assessment(8.39%).In recent years,the number of published papers in international high-impact factor journals has *** of the papers(49.65%)refer to studies carried out by institutions located in the south and southeast regions of ***,there is a large gap of studies on simulated rainfall in other regions of Brazil,where important biomes such as the Cerrado,Amazon,Caatinga,and their transitions are *** study informs research priorities on soil erosion under simulated rainfall and provides a bibliographic database that can assist in more detailed future analyses.

关键词： Rainfall simulator Soil and water losses Soil water infiltration Bibliometrics Scientific review

Optimization of a photovoltaic-battery system using deep reinforcement learning and load forecasting

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Energy and AI 2024年第2期16卷 168-183页

作者： António Corte Real G.Pontes luz J.M.C.Sousa M.C.Brito S.M.Vieira IDMEC Instituto Superior TécnicoUniversidade de LisboaLisboa1049-001Portugal Instituto Dom Luiz Faculdade de CiênciasUniversidade de LisboaCampo Grande1749-016LisboaPortugal

Home Energy Management Systems(HEMS)are increasingly relevant for demand-side management at the residential level by collecting data(energy,weather,electricity prices)and controlling home appliances or storage *** control can be performed with classical models that find optimal solutions,with high real-time computational cost,or data-driven approaches,like Reinforcement Learning,that find good and flexible solutions,but depend on the availability of load and generation data and demand high computational resources for *** this work,a novel HEMS is proposed for the optimization of an electric battery operation in a real,online and data-driven environment that integrates state-of-the-art load forecasting combining CNN and LSTM neural networks to increase the robustness of *** Reinforcement Learning agents are trained with different algorithms(Double DQN,Dueling DQN,Rainbow and Proximal Policy Optimization)in order to minimize the cost of electricity purchase and to maximize photovoltaic self-consumption for a PV-Battery residential *** show that the best Reinforcement Learning agent achieves a 35%reduction in total cost when compared with an optimization-based agent.

关键词： Energy management system Deep reinforcement learning Demand-side management Load forecasting Deep learning Energy storage systems