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首届东方药理论坛暨2018年全国心脑血管药理学术会议、上海市药理学会第十九届学术年会

作者： YunLiu Brian Tomlinson Jiyuan Guo Mahnaz Asghamejad Lars Bauer Erwin Surmann Xiaojuan Guo jan-peer elshoff Shanghai Xuhui Central Hospital Prince of Wales Hospital UCB Pharma

Purpose:The pharmacokinetics(PK) of rotigotine transdermal patch are well characterized in Caucasian patients with Parkinson's disease(PD) but not in Chinese *** report the PK,safety,and tolerability of rotigotine transdermal patch(2 mg/24 hours and 4 mg/24 hours cold-chain PR2.1.1 formulation) in healthy Chinese subjects(SP0913;NCT01675024).A second separate study(PD0011;NCT02070796)evaluated the relative bioavailability of the cold-chain(PR2.1.1) and room temperature stable(PR2.2.1) formulations of rotigotine in healthy Chinese ***:In Treatment Period 1 of study SP0913,subjects received a single application of rotigotine 2 mg/24 hours on day 1 followed by a washout period(days2-6);Treatment Period 2(days 6-14) involved multiple doses of rotigotine 2 mg/24 hours(days 7-9) followed by multiple doses of rotigotine 4 mg/24 hours(days 10-12),with patches applied for 24 hours *** study PD0011,subjects received a single dose(2 mg/24 hours) of each rotigotine formulation(PR2.2.1 and PR2.1.1) for 24 hours each in a crossover *** samples were collected at scheduled time points to determine plasma concentrations of *** and tolerability were evaluated by adverse events ***:Twenty-four healthy(12 male,12 female) Chinese subjects were enrolled and completed *** mean plasma concentrations of unconjugated and total rotigotine increased to a plateau beginning at～8 hours(multiple dose) to 16 hours(single dose) post-dose;no characteristic Tmax was observed for unconjugated and total *** respective geometric mean Cmax,Cmax,ss,AUC0-tz,AUC0-24,ss values for unconjugated and total rotigotine were similar when rotigotine2 mg/24 hours was applied as a single dose and as a multiple-dose *** the multiple-dose period,geometric mean Cmax,ss and AUC0-24,ss of both unconjugated and total rotigotine were-2-fold higher for rotigotine 4 mg/24 hours than for rotigotine 2 mg/24 ***-seven of 50 male C

关键词： bioequivalence Chinese dopamine agonist pharmacokinetics rotigotine tolerabiity transdermal delivery

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Research on retention forestry in Northern Europe

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Ecological Processes 2020年第1期9卷 33-45页

作者： Lena Gustafsson Mats Hannerz Matti Koivula Ekaterina Shorohova Ilkka Vanha-Majamaa jan Weslien Department of Ecology Swedish University of Agricultural SciencesP.O Box 7044SE-75007 UppsalaSweden Silvinformation AB Bergauddsvägen 22BSE-39359 KalmarSweden School of Forest Sciences University of Eastern FinlandP.O.Box 111FI-80101 JoensuuFinland Forest Research Institute of the Karelian Research Centre Russian Academy of SciencesPushkinskaya str.11Petrozavodsk 185910Russia Natural Resources Institute Finland(Luke) Latokartanonkaari 9FI-00790 HelsinkiFinland Saint-Petersburg State Forest Technical University Institutsky str.5Saint Petersburg 194021Russia The Forestry Research Institute of Sweden(Skogforsk) SE-75183 UppsalaSweden.

Retention approaches in forest management are today common in several North European countries,integrated into the clearcutting practice as a way to promote biodiversity and maintain ecosystem *** green trees and retention patches(tree groups)are retained at final harvest,and deadwood is left at site or ***,we review research on retention in Sweden,Finland,Norway,the Baltic States,and NW Russia,with special focus on *** the first publication in 1994,about 180 peer-reviewed articles have been *** present results from a systematic search of the retention literature,separated into the following topics:buffer zones,retention patches,high stumps,other types of deadwood,European aspen Populus tremula,and *** literature is synthesized separately since studies from this region have so far almost exclusively been published in the Russian ***,we describe six ongoing large-scale,replicated experiments with varying retention levels,five in Finland and one in Sweden,and summarize their main *** main conclusions for practice from the literature and experiments are that retention patches as large as 0.5 ha and 10-mwide buffers to watercourses are not enough to maintain pre-harvest species composition but survival of forest species is still larger than on conventional *** on clearcuts may present important habitats to saproxylic species,including rare and red-listed ones and a prioritization of tree species per stand is *** identify several important future research directions including switch of focus towards the landscape as well as the species population *** in parts of European Russia where retention has been unintentionally implemented already for a century would indicate possible future trajectories of biodiversity and their drivers in other regions of Northern Europe.A stronger link to ecological theory would help in study designs and in th

关键词： Biodiversity Buffer strips Conservation Deadwood Experiments Forestry High stumps Retention patches Variable retention

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A 3D-printable device allowing fast and reproducible longitudinal preparation of mouse intestines

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Animal Models and Experimental Medicine 2022年第2期5卷 189-196页

作者： Beckey DeLucia Sergey Samorezov Megan T.Zangara Rachel L.Markley Lucas J.Osborn Karlee B.Schultz Christine McDonald jan Claesen Department of Cardiovascular and Metabolic Sciences Lerner Research InstituteCleveland ClinicClevelandOhioUSA Center for Microbiome and Human Health Lerner Research InstituteCleveland ClinicClevelandOhioUSA Department of Biomedical Engineering Lerner Research InstituteCleveland ClinicClevelandOhioUSA Department of Molecular Medicine Cleveland Clinic Lerner College of Medicine of Case Western Reserve UniversityClevelandOhioUSA Department of Inflammation and Immunity Lerner Research InstituteCleveland ClinicClevelandOhioUSA College of Arts and Sciences John Carroll UniversityUniversity HeightsOhioUSA

Accurate and reproducible analysis of murine small and large intestinal tissue is key for preclinical models involving intestinal ***,there is no easily ac-cessible,standardized method that allows researchers of different skill levels to con-sistently dissect intestines in a time-efficient ***,we describe the design and use of the 3D-printed“Mouse Intestinal Slicing Tool”(MIST),which can be used to longitudinally dissect murine intestines for further *** benchmarked the MIST against a commonly used procedure involving scissors to make a longitudinal cut along the *** of the MIST halved the time per mouse to prepare the intestines and outperformed alternative methods in smoothness of the cutting edge and overall *** sharing the plans for printing the MIST,we hope to contribute a uniformly applicable method for saving time and increasing consistency in studies of the mouse gastrointestinal tract.

关键词： adenoma dissection i ntestines mice printing three-dimensional reproducibility of results

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Henry’s Equilibrium Partitioning between Ground Water and Soil Air: Predictions versus Observations

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Journal of Environmental Protection 2011年第7期2卷 873-881页

作者： Jeroen Provoost Robbe Ottoy Lucas Reijnders jan Bronders Ilse Van Keer Frank Swartjes Daniel Wilczek David Poelmans 不详

Humans spend 64% - 94% of their time indoors;therefore, indoor air quality is very important for potential exposure to volatile organic compounds (VOC). The source of VOC in the subsurface may come from accidental or intentional releases, leaking landfills or leaking underground and above-ground storage tanks. Once these contaminants are present near or beneath buildings, they may move as a vapour through soil gas and enter the building. A large number of vapour intrusion (VI) algorithms have been published in peer-reviewed publications that link indoor VOC concentrations to the contamination of soils. These models typically include phase partitioning calculations of VOC based on Henry’s law to estimate the concentration of a particular contaminant in soil gas. This paper presents the results from a series of laboratory experiments concerning the use of the Henry’s Law constant for the calculation of toluene concentrations in equilibrium between ground water and soil air. A series of column experiments were conducted with various toluene concentrations in artificial (ground) water to contrast the predicted and observed (soil) air concentrations. The experiments which exclude soil material show a toluene fugacity behaviour roughly in line with Henry’s law whereas the experiments which include soil material result in equilibrium soil concentrations which were around one order-of-magnitude lower than was expected from a Henry Law-based estimation. It is concluded that for toluene inclusion of Henry’s Law in VI algorithms does not provide an adequate description of volatilisation in soils and may lead to an overestimation of health risk. Instead, a model based on a simple description of the relevant intermolecular interactions could be explored.

关键词： Henry Law Coefficient Equilibrium Partitioning Ground Water Soil Air Toluene Algorithm

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中小学群体构成效应研究：基于比利时荷语区的经验

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外国中小学教育 2018年第9期 15-21页

作者： (比利时)扬·范达姆张培菡(编译) 比利时荷语鲁汶大学上海师范大学国际与比较教育研究院上海200234

学校和班级是儿童成长与发展的重要场所。在这一场所中,同伴群体构成了影响儿童发展的重要情境。长期以来,群体构成对儿童发展的影响就是教育学、心理学、经济学、社会学等领域重点关注的话题。研究发现,群体构成具有多个指标,社会经济... 详细信息

学校和班级是儿童成长与发展的重要场所。在这一场所中,同伴群体构成了影响儿童发展的重要情境。长期以来,群体构成对儿童发展的影响就是教育学、心理学、经济学、社会学等领域重点关注的话题。研究发现,群体构成具有多个指标,社会经济文化构成、学习能力构成、学习氛围等都会对儿童的成长产生不同的影响。本文中,扬·范达姆教授及其团队对比利时荷语区50余所学校数千名中学生的数学成绩及语言成绩进行了测量,并运用多层次线性模型分析了学校与班级的群体构成对学生学业成就的影响。研究结果表明群体构成对学生的学业成绩有重要影响,班级的学习氛围是影响学生学业成绩的重要因素;群体层面(学校与班级同伴)的相关态度会引发学生学业成绩的性别差异。

关键词：群体构成效应中小学比利时

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女性性工作者艾滋病相关干预服务利用及影响因素研究

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中国社会医学杂志 2016年第3期33卷 265-268页

作者：谭京广蔡蕊陈琳 jan Hendrik Richardus Sake J.de Vlas 深圳市疾病预防控制中心广东深圳518055 伊拉斯姆斯大学公共卫生学院

目的探索女性性工作者艾滋病相关干预措施利用及影响因素。方法采用方便抽样,调查深圳市1 656名女性性工作者艾滋病相关干预服务利用情况。对不进行艾滋病检测、不使用安全套以及不参与同伴教育的影响因素进行分析。同时评价未参加艾滋... 详细信息

目的探索女性性工作者艾滋病相关干预措施利用及影响因素。方法采用方便抽样,调查深圳市1 656名女性性工作者艾滋病相关干预服务利用情况。对不进行艾滋病检测、不使用安全套以及不参与同伴教育的影响因素进行分析。同时评价未参加艾滋病检测、安全套使用与艾滋病相关知识水平之间的关系。结果女性性工作者的艾滋病检测率、安全套使用率和接受同伴教育率分别为21.5%、47.8%和28.0%。低年龄组和工作年限短与不利用3项干预服务有关。持续使用安全套和较高的艾滋病相关知识水平可提高艾滋病相关干预服务的利用率。结论深圳市女性性工作者艾滋病相关干预服务的利用率较低。鉴于安全套使用与艾滋病相关知识水平与干预措施的利用相关,应针对年轻和刚从事性服务工作者,提高其安全套使用率和艾滋病相关知识水平。

关键词：女性性工作者艾滋病相关干预影响因素横断面研究

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女性性工作者艾滋病相关干预服务低利用率影响因素分析

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医学与社会 2016年第7期29卷 27-30,34页

作者：谭京广蔡蕊陈琳林凌云 jan Hendrik Richardus Sake J.de Vlas 深圳市疾病预防控制中心深圳518055 伊拉斯姆斯大学公共卫生学院深圳市司法局第一强制隔离戒毒所

目的:本研究旨在探索影响女性性工作者对艾滋病干预服务利用率低的原因和干预措施利用率的相关影响因素。方法:采用分层随机抽样方法,对深圳市1656名女性性工作者的社会人口学特征、行为以及艾滋病相关干预服务利用情况进行调查。对不... 详细信息

目的:本研究旨在探索影响女性性工作者对艾滋病干预服务利用率低的原因和干预措施利用率的相关影响因素。方法:采用分层随机抽样方法,对深圳市1656名女性性工作者的社会人口学特征、行为以及艾滋病相关干预服务利用情况进行调查。对不进行艾滋病检测、安全套使用以及参与同伴教育的影响因素进行Logistic回归分析。分析未参加艾滋病检测、安全套使用与艾滋病相关知识水平之间的关系。结果:女性性工作者的艾滋病检测率、安全套使用率和接受同伴教育率分别为21.5%、47.8%和28.0%。低年龄组和工作年限短与不利用干预服务有关。结论:深圳市女性性工作者艾滋病相关干预服务的利用率较低。应提高年轻和刚从事性工作者安全套使用和艾滋病相关知识水平。

关键词：艾滋病干预女性性工作者

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P2P文件共享框架中激励机制的研究

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重庆邮电学院学报（自然科学版） 2006年第1期18卷 123-125页

作者：宿建宗李秉智重庆邮电学院重庆400065

传统的peer-to-peer(P2P)网络都假设每个用户能积极共享自己的资源,这导致了大量免费搭车者(Freerider)的出现。提出了一种基于节点贡献大小的接纳控制和资源分配结合使用的激励策略。为网络做出较多贡献的节点能得到相应的回报,因此可... 详细信息

传统的peer-to-peer(P2P)网络都假设每个用户能积极共享自己的资源,这导致了大量免费搭车者(Freerider)的出现。提出了一种基于节点贡献大小的接纳控制和资源分配结合使用的激励策略。为网络做出较多贡献的节点能得到相应的回报,因此可以预期整个网络的性能将得到极大提高。

关键词：对等接纳控制资源分配

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