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Journal of Central South University 2016年第1期23卷 68-76页

作者： jan Zwolak Arkadiusz Palczak Department of Mechanics and Mechanical Engineering Faculty of Mathematics and Natural Sciences The University of Rzeszow Rejtana Ave. 16C Rzeszow 35-959 Poland

This work presented the characteristics of two gear teeth finishing methods, due to the properties of gear teeth surface layer obtained at the tooth working depth. These methods are: 1) the teeth carburization, hardening to a hardness of hRC 60-62 and then grinding, 2) the soft gear shaving as the final mechanical treatment and then carburizing and hardening to the hardness of hRC60-62. This work included the test results of the contact fatigue strength carried out on the circulating power system. The Wohler curves were plotted due to the obtained results, as the basis for the practical evaluation of the considered gear finishing methods. The parameters like volume distribution of the voids, content of the retained austenite, compressive residual stress value, but also the results of contact fatigue strength tests, are more favorable for the teeth shaving method than for the teeth grinding method.

关键词： gear teeth finishing treatment surface layer contact fatigue strength pitting

heavy rockbursts due to longwall mining near protective pillars:A case study

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International Journal of Mining Science and Technology 2018年第5期28卷 799-805页

作者： Petr Konicek jan Schreiber Department of Geomechanics and Mining Research Institute of Geonics Czech Academy of Science

Rockburst represents a very dangerous phenomenon in deep underground mining in unfavourable conditions such as great depth, high horizontal stress, proximity of important tectonic structures, and unmined pillars. The case study describes a recorded heavy rockburst in the Czech part of the Upper Silesian Coal Basin, which occurred during longwall mining near the protective pillar. The artificial dividing of geological blocks and creation of mining protective pillars(shaft pillars, crosscut pillars etc.) is a dangerous task in light of rockbursts occurring mainly due to overstressing of remaining pillars. A simple model of this situation is presented. Natural and mining conditions are analysed and presented in detail as well as registered seismicity during longwall mining in the area. Recorded rockbursts in the area of interest are described and their causes discussed. Many rockbursts near protective pillars were recorded in this mining region. Methodical instructions for rockburst prevention in proximity of protective pillars as well as for gates driving were devised based on the evaluation of rockburst causes. The paper presents these principles for prevention.

关键词： Rockburst Rockburst prevention hardcoal longwall mining Induced seismicity Protective pillar

Decision support for the development,simulation and optimization of dynamic process models

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Frontiers of Chemical Science and Engineering 2022年第2期16卷 210-220页

作者： Norbert Asprion Roger Böttcher jan Schwientek Johannes höller Patrick Schwartz Charlie Vanaret Michael Bortz BASF SE 67063 LudwigshafenGermany Fraunhofer ITWM 67663 KaiserslauternGermany

Simulation is besides experimentation the major method for designing,analyzing and optimizing chemical *** ability of simulations to reflect real process behavior strongly depends on model *** and adaption of process models are usually based on available plant *** such a model in various simulation and optimization studies can support the process designer in his *** steady state models there is also a growing demand for dynamic models either to adapt faster to changing conditions or to reflect batch *** this contribution challenges of extending an existing decision support framework for steady state models to dynamic models will be discussed and the resulting opportunities will be demonstrated for distillation and reactor examples.

关键词： decision support multicriteria optimization model validation dynamic model sensitivity analysis

Role of mucosal dendritic cells in inflammatory bowel disease

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World Journal of Gastroenterology 2008年第33期14卷 5138-5148页

作者： jan hendrik Niess Department of Internal Medicine I Ulm UniversityUlm 89031 Germany

The gastrointestinal innate and adaptive immune system continuously faces the challenge of potent stimuli from the commensal microflora and food constituents. These local immune responses require a tight control, the outcome of which is in most cases the induction of tolerance. Local T cell immunity is an important compartment of the specif ic intestinal immune system. T cell reactivity is programmed during the initial stage of its activation by professional presenting cells. Mucosal dendritic cells (DCs) are assumed to play key roles in regulating immune responses in the antigen-rich gastrointestinal environment. Mucosal DCs are a heterogeneous population that can either initiate (innate and adaptive) immune responses, or control intestinal inflammation and maintain tolerance. Defects in this regulation are supposed to lead to the two major forms of inflammatory bowel disease (IBD), Crohn's disease (CD) and ulcerative colitis (UC). This review will discuss the emerging role of mucosal DCs in regulating intestinal inflammation and immune responses.

关键词： Dendritic cells Commensal Inflammatory bowel disease Mucosal immunity host defence

应变速率对纳米杆断裂分布与初始滑移分布相关性的影响

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化学研究与应用 2024年第5期36卷 1067-1077页

作者：宗文赵健伟马汉杰浙江理工大学信息科学与工程学院浙江杭州310000 嘉兴学院材料与纺织工程学院浙江嘉兴314001 浙江理工大学计算机科学与技术学院(人工智能学院) 浙江杭州310000

金属纳米材料具有独特的物理和化学性质,因此被广泛应用于各种领域的器件制造中。然而,纳米尺度下材料性能表现的外在响应具有很大的不确定性,应变速率是一个重要的影响因素。为了深入探究金属纳米材料机械力学性能对应变速率的响应以... 详细信息

金属纳米材料具有独特的物理和化学性质,因此被广泛应用于各种领域的器件制造中。然而,纳米尺度下材料性能表现的外在响应具有很大的不确定性,应变速率是一个重要的影响因素。为了深入探究金属纳米材料机械力学性能对应变速率的响应以及纳米杆断裂失效与初始微观结构之间的关系,本文构建了金属纳米杆模型,并通过分子动力学模拟研究了单晶Cu纳米杆在不同应变速率下拉伸的形变过程。利用基于密度的噪声应用空间聚类(DBSCAN)机器学习算法,获得了初始微观结构缺陷的位置。在对比了每个速率300个样本,共计2700个样本后,得出纳米杆断裂位置与初始滑移分布的相关性特征。结果表明,当应变速率高于0.08%ps^(-1)时,初始滑移主要分布在纳米杆两端,但断裂位置分布却集中在中间。随着应变速率的降低,初始滑移分布则愈发均匀,断裂位置分布则更趋向于两端。而纳米杆的断裂强度和塑性形变能力则随着应变速率的提高而提高。这一研究结果可以为金属纳米材料的设计和制造提供有价值的参考。

关键词：分子动力学应变速率 DBSCAN 初始滑移断裂位置

Experimental Study of Sand Bed Configurations in Front of a Vertical Wall Under Wave Action

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China Ocean Engineering 1998年第4期13卷 405-416页

作者： jan Chyan-Deng Professor Department of Hydraulics and Ocean Engineering National Cheng Kung University TainanTaiwan 70101 China.

When a 2-D progressive wave train normally or obliquely approaches a vertical wall and then is normally or obliquely reflected from it, the combination of the approaching and reflected waves may result in a standing wave or a short-crested wave in front of the wall. This paper presents the experimental observations of sand bed configurations under the action of these water waves in front of the wall. The geometry of sand ripples under these water waves in front of the vertical wall is presented as a function of flow parameters, such as the water particle semi-excursion and the mobility number.

关键词： sand bed wave action vertical sea wall bed form standing wave short-crested wave mobility number

Identification of serum proteins discriminating colorectal cancer patients and healthy controls using surface-enhanced laser desorption ionisation-time of flight mass spectrometry

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World Journal of Gastroenterology 2006年第10期12卷 1536-1544页

作者： Judith YMN Engwegen helgi h helgason Annemieke Cats Nathan harris Johannes MG Bonfrer jan hM Schellens Jos h Beijnen Department of Pharmacy and Pharmacology The Netherlands Cancer Institute/Slotervaart hospital AmsterdamThe Netherlands Department of Medical Oncology The Netherlands Cancer Institute/Antoni van Leeuwenhoek hospital AmsterdamThe Netherlands Department of Gastroenterology and hepatology The Netherlands Cancer Institute/Antoni van Leeuwenhoek hospital AmsterdamThe Netherlands Ciphergen Biosystems Inc. Freemont CaliforniaUnited States Department of Clinical Chemistry The Netherlands Cancer Institute/Antoni van Leeuwenhoek hospital AmsterdamThe Netherlands Utrecht University Faculty of Pharmaceutical Sciences Department of Biomedical analysisUtrechtThe Netherlands

AIM： To detect the new serum biomarkers for colorectal cancer （CRC） by serum protein profiling with surfaceenhanced laser desorption ionisation - time of flight mass spectrometry （SELDI-TOF MS）. METhODS： Two independent serum sample sets were analysed separately with the ProteinChip technology （set A： 40 CRC ＋ 49 healthy controls; set B： 37 CRC ＋ 31 healthy controls）, using chips with a weak cation exchange moiety and buffer ph 5. Discriminative power of differentially expressed proteins was assessed with a classification tree algorithm. Sensitivities and specificities of the generated classification trees were obtained by blindly applying data from set A to the generated trees from set B and vice versa. CRC serum protein profiles were also compared with those from breast, ovarian, prostate, and non-small cell lung cancer. RESULTS： Mass-to-charge ratios （m/z） 3.1×10^3, 3.3× 10^3, 4.5×10^3, 6.6×10^3 and 28×10^3 were used as classitiers in the best-performing classification trees. Tree sensitivities and specificities were between 65% and 90%.host of these discriminative m/z values were also different in the other tumour types investigated. M/z 3.3× 10^3, main classifier in most trees, was a doubly charged form of the 6.6× 10^3-Da protein. The latter was identified as apolipoprotein C-I. M/z 3.1×10^3 was identified as an N-terminal fragment of albumin, and m/z 28× 10^3 as apolipoprotein A-I. CONCLUSION： SELDI-TOF MS followed by classification tree pattern analysis is a suitable technique for finding new serum markers for CRC. Biomarkers can be identified and reproducibly detected in independent sample sets with high sensitivities and specificities. Although not specific for CRC, these biomarkers have a potential role in disease and treatment monitoring.

关键词： Proteomics Colorectal cancer Biomarker Sensitivity Specificity

The Axial and Radial Solid Loadings up the CFB-Riser

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Chinese Journal of Chemical Engineering 2000年第2期8卷 171-175页

作者： Kathleen Smolders jan Baeyens Chemical Engineering Department Katholieke Universiteit Leuven de Croylaan 46B-3001 HeverleeBelgiumChemical Engineering DepartmentKatholieke Universiteit Leuven de Croylaan 46B-3001 HeverleeBelgium

1 INTRODUCTIONThe determination of the solids hold-up and local solidfluxes is of paramount importance in the study ofthe hydrodynamics of a two-phase *** tech-niques have been used during the past decades(Table1).The... 详细信息

关键词： circulating fluidized beds solids loading axial and radial profiles

Modern technology,liver surgery and transplantation

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hepatobiliary & Pancreatic Diseases International 2022年第4期21卷 307-309页

作者： jan Lerut Institut de Recherche Expérimentale et Clinique Universitécatholique de LouvainAvenue Hippocrate 551200BrusselsBelgium

Since the first right hepatectomy performed by Jean-Louis Lortat-Jacob on October 16,1951 and the first liver transplantation by Thomas Earl Starzl on March 1,1963,hepatobiliary surgery and liver transplantation had a spectacular development[1,2].After the hesitating beginning in the 1950’s and 1960’s,their evolution really took off in the 1980’,reaching high-speed velocity in the 21st century.

关键词： surgery liver really

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基于集成式张量域自适应的运动想象脑电分类

中国生物医学工程学报 2024年第4期43卷 399-407页

作者：高云园薛云峰张聪睿高坚杭州电子科技大学自动化(人工智能)学院杭州310018 杭州明州脑康康复医院神经康复中心杭州310018

实际应用中脑电信号一直面临采集成本高、用户间差异大等问题,制约着基于脑电信号的运动想象领域的发展。针对跨受试者运动想象脑电信号识别任务,本研究提出了一种基于集成式张量域自适应的迁移学习方法。首先采用改进的欧氏空间对齐方... 详细信息

实际应用中脑电信号一直面临采集成本高、用户间差异大等问题,制约着基于脑电信号的运动想象领域的发展。针对跨受试者运动想象脑电信号识别任务,本研究提出了一种基于集成式张量域自适应的迁移学习方法。首先采用改进的欧氏空间对齐方法对多维脑电数据进行协方差对齐,消除原始数据的边缘分布偏移;其次提出基于张量子空间的改进联合概率分布方法,求得不同类别的映射子空间并实现未知标签的目标域识别分类。分别在7人200个样本和9人144个样本的BCI数据集上进行了实验,平均准确率达到82.18%和76.45%,证明了该方法在跨域分类识别上具有很好的性能。同时对于该方法各环节的效果也进行了可视化验证,展示了该集成式方法在跨域问题上的效果。

关键词：运动想象脑电信号域自适应数据对齐张量子空间