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Oligodendroglial heterogeneity in health,disease,and recovery:deeper insights into myelin dynamics

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neural Regeneration Research 2025年第11期20卷 3179-3192页

作者： Pieter-jan Serneels Julie D.De Schutter Lies De Groef Lieve Moons Steven Bergmans KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionNeural Circuit Development&Regeneration Research GroupLeuvenBelgium KU Leuven Leuven Brain InstituteDepartment of BiologyAnimal Physiology and Neurobiology DivisionCellular Communication&Neurodegeneration Research GroupLeuvenBelgium

Decades of research asserted that the oligodendroglial lineage comprises two cell types:oligodendrocyte precursor cells and ***,recent studies employing single-cell RnA sequencing techniques have uncovered novel cell states,prompting a revision of the existing *** forward,the oligodendroglial lineage should be delineated into five distinct cell states:oligodendrocyte precursor cells,committed oligodendrocyte precursor cells,newly formed oligodendrocytes,myelin-forming oligodendrocytes,and mature *** new classification system enables a deeper understanding of the oligodendroglia in both physiological and pathological *** this uniform terminology will facilitate comparison and integration of data across ***,including the consolidation of findings from various demyelinating models,is essential to better understand the pathogenesis of demyelinating ***,comparing injury models across species with varying regenerative capacities can provide insights that may lead to new therapeutic strategies to overcome remyelination ***,by standardizing terminology and synthesizing data from diverse studies across different animal models,we can enhance our understanding of myelin pathology in central nervous system disorders such as multiple sclerosis,Alzheimer's disease,and amyotrophic lateral sclerosis,all of which involve oligodendroglial and myelin dysfunction.

关键词： animal models demyelination fish mammals multiple sclerosis myelin neurodegeneration oligodendrocytes oligodendroglial lineage remyelination

Characterization of image spaces of Riemann-Liouville fractional integral operators on Sobolev spaces W^(m,p)(Ω)

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Science China Mathematics 2021年第12期64卷 2611-2636页

作者： Lijing Zhao Weihua deng jan S.Hesthaven School of Mathematics and Statistics Northwestern Polytechnical UniversityXi'an 710129China School of Mathematics and Statistics Gansu Key Laboratory of Applied Mathematics and Complex SystemsLanzhou UniversityLanzhou 730000China EPFL-SB-MATHICSE-MCSS Ecole Polytechnique Federale de LausanneLausanne CH-1015Switzerland

Fractional operators are widely used in mathematical models describing abnormal and nonlocal *** there are extensive numerical methods for solving the corresponding model problems,theoretical analysis such as the regularity result,or the relationship between the left-side and right-side fractional operators is seldom *** of considering the fractional derivative spaces,this paper starts from discussing the image spaces of Riemann-Liouville fractional integrals of L_(p)(Ω) functions,since the fractional derivative operators that are often used are all *** the high regularity situation-the image spaces of Riemann-Liouville fractional integral operators on the W^(m,p)(Ω) space is *** characterizations of the defined spaces,as well as those of the intersection of the left-side and right-side spaces are *** behavior of the functions in the defined spaces at both the nearby boundary point/points and the points in the domain is demonstrated in a clear ***,tempered fractional operators are shown to be reciprocal to the corresponding Riemann-Liouville fractional operators,which is expected to contribute some theoretical support for relevant numerical ***,we also provide some instructions on how to take advantage of the introduced spaces when numerically solving fractional equations.

关键词： image space Riemann-Liouville integral regularity property approximation

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Effects of particle fractions on the Bingham yield stress and viscosity of fine-coarse particle suspensions

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Journal of Mountain Science 2021年第11期18卷 2960-2970页

作者： DEY Litan jan chy.n-deng WAnG Ji-Shang Department of Hydraulic and Ocean Engineering National Cheng Kung UniversityTainan 701Chinese Taipei Ecological Soil and Water Conservation Research Center National Cheng Kung UniversityTainan 701Chinese Taipei

The rheological behaviors of highly concentrated fine particle suspensions(clay-silt-water mixtures)and coarse particle suspensions(coarse particles within a fine particle suspension)were investigated in this *** results demonstrated that the Bingham Fluid Model with two rheological parameters,Bingham yield stressand viscosity,wellcharacterized the rheological behavior of fine particle suspensions at shear rates between 4 and 20 s^(-1).The inclusion of coarse particles within a fine particle suspension induced an enhancement to the rheological *** rheological parameters of a coarse particle suspension not only depend on its total particle fraction but also on its relative fine/coarse particle *** equations of these two parameters were proposed,quantitatively related to both fine and coarse particle *** indicated that the Bingham yield stress and viscosity are much more(an order larger)sensitive to changes in fine particle fraction than to changes in coarse particle fraction.

关键词： Coarse particle suspension Bingham Fluid Model Particle fractions Rheologicalparameters

A new design approach for the established flow region of vertical,dilute-phase pneumatic conveyors

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Particuology 2022年第7期20卷 10-20页

作者： John M.Wheeldon jan Baeyens Shuo Li Yimin deng European Powder and Process Technology Longfellow DriveKetteringUnited Kingdom KU Leuven Department of Chemical EngineeringProcess and Environmental Technology LabJ.De Nayerlaan 52860 Sint-Katelijne-WaverBelgium Beijing University of Chemical Technology Beijing Advanced Centre of Smart Matter Science and EngineeringBeijingChina

An analysis has been completed for a comprehensive set of vertical,dilute-phase pneumatic conveying pressure drop data from an investigation by *** data were collected in the established flow region for eight different materials conveyed in 0.05-,0.10-,0.20-m internal diameter,20-m tall steel *** velocities derived from the pressure drop data were used to develop an equation of motion that includes terms for pipe diameter,terminal velocity,coefficient of restitution,and particle *** best data fit was achieved using the actual gas density and the actual gas velocity adjusted for *** the terminal velocity for voidage,an approach recommended by many investigators,did not improve the fit for reasons identified by the present *** the equation of motion,particle velocities were predicted and used to calculate total pressure drops that are within±15%of the measured *** calculated values also produce the characteristic trough-shaped total pressure drop curves allowing the minimum pressure drop gas velocity to be determined without recourse to a separate correlation.A comparison with other studies using shorter risers indicates that data from these studies likely include acceleration effects.A separate study will investigate this observation further.

关键词： Dilute-phase Vertical Pneumatic conveying Design equations Pressure drops

Fiber Bundle Topology Optimization for Surface Flows

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Chinese Journal of Mechanical Engineering 2024年第3期37卷 236-264页

作者： Yongbo deng Weihong Zhang Jihong Zhu Yingjie Xu jan G Korvink State Key Laboratory of Applied Optics Changchun Institute of OpticsFine Mechanics and PhysicsChinese Academy of SciencesChangchun 130033China State IJR Center of Aerospace Design and Additive Manufacturing Northwestern Polytechnical UniversityXi’an 710072China Institute of Microstructure Technology(IMT) Karlsruhe Institute of Technology(KIT)Hermann-von-Helmholtzplatz 176344 Eggenstein-LeopoldshafenGermany

This paper presents a topology optimization approach for the surface flows on variable design *** this approach,the matching between the pattern of a surface flow and the 2-manifold used to define the pattern can be optimized,where the 2-manifold is implicitly defined on another fixed 2-manifold named as the base *** fiber bundle topology optimization approach is developed based on the description of the topological structure of the surface flow by using the differential geometry concept of the fiber *** material distribution method is used to achieve the evolution of the pattern of the surface *** evolution of the implicit 2-manifold is realized via a homeomorphous *** design variable of the pattern of the surface flow and that of the implicit 2-manifold are regularized by two sequentially implemented surface-PDE *** two surface-PDE filters are coupled,because they are defined on the implicit 2-manifold and base manifold,*** surface navier-Stokes equations,defined on the implicit 2-manifold,are used to describe the surface *** fiber bundle topology optimization problem is analyzed using the continuous adjoint method implemented on the first-order Sobolev *** numerical examples have been provided to demonstrate this approach,where the combination of the viscous dissipation and pressure drop is used as the design objective.

关键词： Fiber bundle Topology optimization 2-manifold Surface flow Material distribution method Porous medium model

numerical Simulation on a Tremendous Debris Flow Caused by Typhoon Morakot in the Jiaopu Stream,Taiwan

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Journal of Mountain Science 2014年第1期11卷 1-18页

作者： HSU Yu-chao YEn Haw TSEnG Wen-hsiao jan chy.n-deng Department of Hydraulic and Ocean Engineering National Cheng Kung University Blackland Research and Extension Center Texas A&M AgriLife Research Sun-Rise Engineering Consultant Company

In August 2009,Typhoon Morakot brought a large amount of rainfall with both high intensity and long duration to a vast area of ***,this resulted in a catastrophic landslide in Hsiaolin Village,***,large amounts of landslides were formed in the Jiaopu Stream watershed near the southeast part of the Hsiaolin *** Hsiaolin Village access road(Provincial Highway no.21 and Bridge no.8) was completely destroyed by the landslide and consequent debris *** major scope of this study is to apply a debris flow model to simulate the disaster caused by the debris flow that occurred in the Jiaopu Stream during Typhoon *** to the interviews with local residents,this study applied the destruction time of Bridge no.8 and Chen's house to verify the numerical debris flow *** the spatial rainfall distributions information,the numerical simulations of the debris flow are conducted in two *** the first stage(before the landslide-dam failure),the elevation of the debris flow and the corresponding potential damages toward residential properties were *** the second stage(after the landslidedam failure),comparisons of simulation results between the longitudinal and cross profiles of the Jiaopu Stream were performed using topographic maps and satellite *** summary,applications of the adopted numerical debris flow model have shown positive impact on supporting better understanding of the occurrence and movement of debris flow processes.

关键词： Typhoon Morakot Debris flow numerical simulation Jiaopu Stream Hsiaolin Village

Learning-based joint UAV trajectory and power allocation optimization for secure IoT networks

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Digital Communications and networks 2022年第4期8卷 415-421页

作者： Dan deng Xingwang Li Varun Menon Md Jalil Piran Hui Chen Mian Ahmad jan School of Information Engineering Guangzhou Panyu PolytechnicGuangzhou410630China School of Physics and Electronic Information Engineering Henan Polytechnic UniversityJiaozuo454150China Department of Computer Science and Engineering SCMS School of Engineering and TechnologyIndia Department of Computer Science and Engineering Sejong UniversitySouth Korea Department of Computer Science Abdul Wali Khan University MardanPakistan

non-Orthogonal Multiplex Access(nOMA)can be deployed in Unmanned Aerial Vehicle(UAV)networks to improve spectrum *** to the broadcasting feature of nOMA-UAV networks,it is essential to focus on the security of the wireless *** paper focuses on maximizing the secrecy sum rate under the constraint of the achievable rate of the legitimate *** tackle the non-convexity optimization problem,a reinforcement learning-based alternative optimization algorithm is ***,with the help of successive convex approximations,the optimal power allocation scheme with a given UAV trajectory is obtained by using convex optimization ***,through plenty of explorations of the wireless environment,the Q-learning networks approach the optimal location transition strategy of the UAV,even without the wireless channel state information.

关键词： Unmanned aerial vehicle(UAV) nOMA Reinforcement learning Secure communications Deep Q-learning

Intermittent slipping of landslide regulated by dilatancy evolution and velocity-weakening friction law: an efficient numerical scheme

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Journal of Mountain Science 2016年第8期13卷 1333-1344页

作者： jan chy.n-deng YAnG Ray-yeng HWUnG Hwung-hweng CHEn Wen-yau Department of Hydraulic & Ocean Engineering National Cheng Kung University International Wave Dynamics Research Center National Cheng Kung University

When a block of dense sandy soil moves downhill, the shear-induced soil dilatancy along the basal shear boundary produces a negative value of excess pore pressure that increases the basal frictional resistance. Dilatancy angle,Ψ, the degree to which the basal soil dilates due to the shear, normally evolves during slope failure. A study by other researchers shows that if Ψ is constant, the block of dense soil will remain stable(or unstable) sliding when the velocity-weakening rate of the basal friction coefficient of the block is small(or large) enough. Moreover, during unstable sliding processes, the block of dense soil exhibits "periodic" patterns of intermittent slipping. Here, we used a more efficient and accurate numerical scheme to revisit that study. We expanded their model by assuming Ψ evolves during slope failure. Consequently, we acquired completely different results. For instance, even though the velocity-weakening rate of the friction coefficient is fixed at the same smaller(or larger) value that those researchers use, the stable(or unstable) steady states of landslide they predict will inversely change to unstable(or stable) when Ψ decreases(or increases) with the increase of slide displacement to a value small(or large) enough. Particularly, in unstable processes, the soil block exhibits "aperiodic" styles of intermittent slipping, instead of "periodic". We found out that the stick states appearing later last longer(or shorter) in the case of decreasing(or increasing) Ψ. Moreover, because the basic states of landslides with impacts of dilatancy evolution are not steady nor periodic, traditional stability-analysis methods cannot be "directly" used to analyze the stability of such landslides. Here, we broke through this technical problem to a degree. We showed that combining a concept called "quasi-steady-state approximation" with a traditional stability-analysis technique can qualitatively predict the instability onset of the landslides. Through this st

关键词： Landslide Stability analysis Intermittent slipping Dilatancy angle

Etching Mechanism of Ti_(3)C_(2)Cl_(2) MXene Phases by CuCl_(2)-Lewis Molten Salt Method

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Journal of Wuhan University of Technology(Materials Science) 2024年第4期39卷 863-868页

作者：严明 ZHU Yu HUAnG Jiangtao CHEn Haoyu deng Yuxiao CHEn Yanlin 王娟 jan-Michael Albina Hubei Provincial Key Laboratory of Green Materials for Light Industry Hubei University of TechnologyWuhan 430068China new Materials and Green Manufacturing Talent Introduction and Innovation Demonstration Base Hubei University of TechnologyWuhan 430068China Hubei Longzhong Laboratory Xiangyang 441000China

We described a method for obtaining fluorine-free Ti_(3)C_(2)Cl_(2)MXene phases by melting copper in CuCl_(2)instead of aluminum in Ti_(3)AlC_(2).XRD results show that when molten salt CuCl_(2)etches Ti_(3)AlC_(2),it forms an intermediate product Ti_(3)CuC_(2),and then reacts with Ti_(3)CuC_(2)to obtain Ti_(3)C_(2)Cl_(2).The reaction of Ti_(3)AlC_(2)and CuCl_(2)at a temperature of 800℃for 2 h to obtain Ti_(3)C_(2)Cl_(2)with an optimal lamellar structure is shown in SEM *** pseudopotential plane-wave(PP-PW)method is used to calculate on the electronic *** etching mechanism is investigated by the total energies of each *** chemical reaction of Ti_(3)AlC_(2)and CuCl_(2)will first become Ti_(3)CuC_(2)and Cu,and then become Ti_(3)C_(2)Cl_(2)during the Lewis acid etching process,which are consistent with the experimental results.

关键词： molten salt method CuCl_(2) MXene first-principles calculations etching mechanism