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Cyclooxygenase-2 polymorphisms and the risk of esophageal adeno-or squamous cell carcinoma

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World Journal of Gastroenterology 2009年第28期15卷 3493-3497页

作者： Jón O Kristinsson Paul van Westerveld Rene HM te Morsche Hennie MJ Roelofs T Wobbes Ben JM Witteman adriaan CITL Tan Martijn GH van Oijen jan BMJ jansen Wilbert HM Peters Department of Gastroenterolog Radboud University Nijmegen Medical Center PO Box 9106500 HB Nijmegen The Netherlands Department of Surgery Radboud UniversityNijmegen Medical Center PO Box 9101 6500 HB NijmegenThe Netherlands Department of Gastroenterology Hospital Gelderse Vallei PO Box 9025 6710 HN Ede The Netherlands Department of Gastroenterology Canisius Wilhelmina Hospital Weg door Jonkerbos 100 6532 SZ Nijmegen The Netherlands

AIM： TO determine whether -1195 A→G and/or -765 G→C polymorphisms in Cyclooxygenase-2 CCOX-2） may have a risk modifying effect on the development of esophageal carcinoma in a Dutch Caucasian population. METHODS： Two study groups were recruited, 252 patients with esophageal carcinoma and 240 healthy controls, matched for race, age, gender and recruiting area. DNA was isolated from whole blood and used for genotyping. PCR products were digested with restriction enzymes and products were analyzed by agarose gel electrophoresis. Odds ratios （OR） and 95% confidence intervals （CI） were estimated. RESULTS： The distribution of the -1195A→G polymorphism was significantly different in esophageal cancer patients compared to controls. The -1195 GG genotype resulted in a higher risk of developing esophageal adenocarcinoma （OR = 3.85, 95% CI： 1.45-10.3） compared with the -1195AA genotype as a reference. The -765 G→C genotype distribution was not different between the two groups. The GG/ GG haplotype was present more often in esophageal adenocarcinoma patients than in controls （OR = 3.45, 95% CI： 1.24-9.58; with AG/AG as a reference）. The same trends were observed in patients with squamous cell carcinomas, however, the results did not reach statistical significance. CONCLUSION： Presence of the COX-2 -1195 GG genotype and of the GG/GG haplotype may result in a higher risk of developing esophageal carcinoma.

关键词： Adenocarcinoma Cyclooxygenase-2 Esophagus Genetic polymorphism Squamous cellcarcinoma

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适度设计的交通枢纽——鹿特丹中心车站

设计家 2014年第2期 88-93页

作者： Team CS jan Benthem Marcel Blom adriaan Geuze Jeroen van Schooten jannesL inders

设计背景鹿特丹中心站是荷兰最重要的交通枢纽之一，它于2014年3月13日，由荷兰国王威廉-亚历山大亲自揭幕投入运营。该站每日发送旅客达110000人次，拥有与阿姆斯特丹史基浦（Schiphol）机场相当的客流量。除了是欧洲高铁网络的一部分... 详细信息

设计背景鹿特丹中心站是荷兰最重要的交通枢纽之一，它于2014年3月13日，由荷兰国王威廉-亚历山大亲自揭幕投入运营。该站每日发送旅客达110000人次，拥有与阿姆斯特丹史基浦（Schiphol）机场相当的客流量。除了是欧洲高铁网络的一部分，鹿特丹中心站还连接着轻轨系统．随着高铁和轻轨的到来，到2025年，鹿特丹中心站每日发送旅客人数预计会增加至大约323000人。

关键词：交通枢纽设计背景鹿特丹中心车站轻轨系统阿姆斯特丹中心站亚历山大

Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well:results from the MR CLEAN Registry

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Stroke & Vascular Neurology 2021年第4期6卷 572-580,I0037-I0048页

作者： Luuk Dekker Esmee Venema F Anne V Pirson Charles B L M Majoie Bart J Emmer Ivo G H jansen Maxim J H L Mulder Robin Lemmens Robert-jan B Goldhoorn Marieke J H Wermer Jelis Boiten Geert J LycklamaàNijeholt Yvo B W E M Roos adriaan C G M van Es Hester F Lingsma Diederik W J Dippel Wim H van Zwam Robert J van Oostenbrugge Ido R van den Wijngaard on behalf of the MR CLEAN Registry investigators Neurology Leiden University Medical CentreLeidenThe Netherlands Neurology Erasmus MCRotterdamThe Netherlands Public Health Erasmus MCRotterdamThe Netherlands Neurology Maastricht University Medical Centre+MaastrichtThe Netherlands Radiology and Nuclear Medicine Amsterdam University Medical CentreLocation AMCAmsterdamThe Netherlands Neurology University Hospitals LeuvenLeuvenBelgium Neurosciences Experimental Neurology and Leuven Brain InstituteUniversity of LeuvenLeuvenBelgium VIB Center for Brain&Disease ResearchLaboratory of NeurobiologyLeuvenBelgium Neurology Haaglanden Medical CentreDen HaagThe Netherlands Radiology Haaglanden Medical CentreDen HaagThe Netherlands Neurology Amsterdam University Medical CentreLocation AMCAmsterdamThe Netherlands Radiology Leiden University Medical CentreLeidenThe Netherlands Radiology Maastricht University Medical Centre+MaastrichtThe Netherlands

Background Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment(EVT)for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen ***,outcomes after EVT in these late window patients without perfusion imaging are largely *** assessed their characteristics and outcomes in routine clinical *** The Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry,a prospective,multicentre study in the Netherlands,included patients with an anterior circulation occlusion who underwent EVT between 2014 and *** perfusion was no standard imaging *** used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age,prestroke modified Rankin Scale(mRS),National Institutes of Health Stroke Scale,Alberta Stroke Programme Early CT Score(ASPECTS),collateral status,location of occlusion and treatment with intravenous *** included 3-month mRS score,functional independence(defined as mRS 0-2),and *** Of 3264 patients who underwent EVT,106(3.2%)were treated beyond 6.5 hours(median 8.5,IQR 6.9-10.6),of whom 93(87.7%)had unknown time of stroke *** perfusion was not performed in 87/106(80.2%)late window *** window patients were younger(mean 67 vs 70 years,p<0.04)and had slightly lower ASPECTS(median 8 vs 9,p<0.01),but better collateral status(collateral score 2-3:68.3%vs 57.7%,p=0.03).No differences were observed in proportions of functional independence(43.3%vs 40.5%,p=0.57)or death(24.0%vs 28.9%,p=0.28).After matching,outcomes remained similar(adjusted common OR for 1 point improvement in mRS 1.04,95%CI 0.56 to 1.93).Conclusions Without the use of CT perfusion selection criteria,EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/C

关键词： treatment beyond Registry

The Role of <sup>18</sup>F-FDG-PET/CT in the Management of Patients with High-Risk Breast Cancer: Case Series and Guideline Comparison

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Advances in Molecular Imaging 2014年第3期4卷 35-41页

作者： Ben F. Bulten Marie J. de Haas Haiko J. Bloemendal adriaan J. van Overbeeke jan Paul Esser Henk J. Baarslag Lioe-Fee de Geus-Oei C. J. Rodenburg John M. H. de Klerk Department of Oncology Meander Medical Centre Amersfoort The Netherlands Department of Radiology and Nuclear Medicine Meander Medical Centre Amersfoort The Netherlands Department of Radiology and Nuclear Medicine Radboud University Medical Centre Nijmegen The Netherlands Department of Radiology Meander Medical Centre Amersfoort The Netherlands Department of Surgery Meander Medical Centre Amersfoort The Netherlands

Objectives: In grade III-IV breast cancer, dissemination of disease needs to be assessed. Until now this was done by conventional imaging (liver ultrasonography, chest X-ray and bone scintigraphy), but evidence favoring the use of FDG-PET/CT is accumulating. Methods: Patients with high-risk breast cancer, who had received conventional imaging and FDG-PET/CT, were included. Patients were staged and assigned a treatment after 1) conventional imaging and 2) FDG-PET/CT, both by a multidisciplinary oncology team. Equivocal FDG-PET/CT findings were histologically confirmed. Results: 16 patients were included (mean age 59 years). TNM-stage changed in 5 patients (31%) after FDG-PET/CT. In 3 patients (19%) unknown distant metastases were detected by FDG-PET/CT. An adjustment of treatment took place in 4 patients (25%). Conclusions: Our case series emphasizes the role of FDG-PET/CT in the staging of high-risk breast carcinoma, especially in the assessment of distant metastases. We suggest replacing conventional imaging with FDG-PET/CT.

关键词： Breast Cancer FDG-PET/CT Staging Dissemination Guidelines

二甲双胍长期治疗2型糖尿病患者以及维生素B12缺乏的危险性：随机安慰剂对照研究（摘要）

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英国医学杂志中文版 2010年第5期13卷 304-305页

作者： Jolien de Jager adriaan Kooy Philippe Lehert Michiel G Wulffele jan van der Kolk Daniel Bets Joop Verburg Ab J M Donker Coen D A Stehouwer 许翎岭(译) Department of Ophthalmology Academic Medical Center Amsterdam Netherlands Bethesda Diabetes Research Centre Bethesda General Hospital Hoogeveen Netherlands Department of Internal Medicine Bethesda General Hospital HoogeveenNetherlands Department of Statistics Faculty of Economics Facultes Universitaires Catholiques de Mons Louvain Academy Mons Belgium Clinical Laboratory Bethesda General Hospital Hoogeveen Netherlands Clinical Research and Meek AmeterdamNetherlands Department of Internal Medicine Free University Medical Center Amsterdam Netherlands Department of Internal Medicine Masstricht University Medical Center Maastricht Netherlands 北京协和医院内分泌科

目的研究接受胰岛素治疗的2型糖尿病患者中，二甲双胍所致维生素B12缺乏（〈150pmol／L）、低浓度维生素B12（150—220pmol／L）的发生率，以及叶酸和同型半胱氨酸的浓度。

关键词：维生素B12缺乏 2型糖尿病二甲双胍安慰剂对照长期治疗患者危险性摘要