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Enhanced Free Radical Scavenging and Inhibition of DPP-4 and ACE Activities by Compounds from Salmon Tissues Digested in Vitro with Gastrointestinal Proteases

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Journal of Agricultural Science and Technology(B) 2014年第5期4卷 393-406页

作者： Susan Skanderup Falkenberg jan Stagsted henrik Hauch Nielsen National Food Institute Technical University of Denmark Kgs. Lyngby DK-2800 Denmark Department of Food Science Aarhus University Tjele DK-8830 Denmark

Research on marine bioactive peptides has mainly focused on characterization of peptides in hydrolysates prepared with commercial industrial enzymes and the usefulness of such hydrolysates in health and functional foods. However, a relevant question is whether digestion of fish proteins with gastrointestinal proteases per se generates peptides that also can have health promoting properties and can reduce, e.g., diabetes 2, inflammation and hypertension either in relation to gastrointestinal digestion or as alternative to industrial proteases. The aim of the study was to investigate hydrolysates obtained from in vitro sequential digestion of salmon muscle and skin with gastrointestinal proteases including pepsin, pancreatic and pancreatic ＋ mucosal proteases for their ability to scavenge ABTS^＋ radicals and inhibit activity of angiotensin I-converting enzyme （ACE） and dipeptidyl peptidase 4 （DPP-4）. Furthermore, it was the aim to study the inhibitory mechanism and stability towards ACE and DPP-4 activity. Analysis of〈 10 kDa hydrolysates showed that gastrointestinal proteases generated peptides with clear radical scavenging activity and DPP-4 and ACE inhibiting activity as well. Hydrolysates from pepsin digestion exhibited the lowest ECso values for radical scavenging activity and ACE inhibition, whereas ECso increased in hydrolysates after subsequent digestion with pancreatic and mucosal proteases. Interestingly, ECso values for the DPP-4 inhibition were hardly affected by sequential digestion. Inhibition modes for the muscle hydrolysates were both competitive and non-competitive, but prolonged incubation showed that the inhibitory properties were unstable and therefore they were probably digested as competitive substrates by gastrointestinal proteases.

关键词： Salmon bioactive components ACE DPP-4 radical scavenging in vitro digestion gastrointestinal proteases.

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“当然,如果你够有心”

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设计 2016年第12期29卷 54-59页

作者： msright henrik sorensen(图) 不详

1937年芬·居尔（FINNJUHL）结婚之后，于哥本哈根市外的奥德罗普格（ORDRUPGAARD）旁买了一块地，并在1942年建造完成他自己的家。在这个房里里，芬·居尔创造了一个整体。整个空间呈现不同区域之间的渐进，而不是几个不同空间的的简... 详细信息

1937年芬·居尔（FINNJUHL）结婚之后，于哥本哈根市外的奥德罗普格（ORDRUPGAARD）旁买了一块地，并在1942年建造完成他自己的家。在这个房里里，芬·居尔创造了一个整体。整个空间呈现不同区域之间的渐进，而不是几个不同空间的的简单集合。

关键词：哥本哈根空间整体简单集合

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Flex公司的物流运输

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现代制造 2018年第5期 30-30,32页

作者： henrik Vesterlund sorensen

奥地利（Karnten州）Althofen市的Flex公司能够为医疗技术、工业企业和汽车工业领域中的企业提供几乎全部的价值增值链外包服务从产品设计到生产制造和工程项目，直至物流。为了能够满足客户的要求，同时也能获益，Lean—Six—Sigma的... 详细信息

奥地利（Karnten州）Althofen市的Flex公司能够为医疗技术、工业企业和汽车工业领域中的企业提供几乎全部的价值增值链外包服务从产品设计到生产制造和工程项目，直至物流。为了能够满足客户的要求，同时也能获益，Lean—Six—Sigma的企业管理方法已经深深的扎根于Flex公司的企业管理理念中了。这一企业管理方法的好处之一就是：打造一个精益高效地价值增值链组织。

关键词： Flex 物流运输工业企业企业管理 Sigma 医疗技术工程项目生产制造

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Chronic intestinal ischemia and splanchnic blood-flow:Reference values and correlation with body-composition

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World Journal of Gastroenterology 2013年第6期19卷 882-888页

作者： Helle Damgaard Zacho Jens henrik henriksen jan Abrahamsen Department of Clinical Physiology Viborg Regional Hospital Department of Clinical Physiology Hvidovre HospitalUniversity of Copenhagen

AIM:To determine the splanchnic blood flow and oxygen uptake in healthy-subjects and patients and to relate the findings to ***:The total splanchnic blood flow (SBF) and oxygen uptake (SO2U) were measured in 20 healthy volunteers (10 women) and 29 patients with suspected chronic intestinal ischemia (15 women),age 40-85 years,prior to and after a standard *** method is based on the Fick principle using the continuous infusion of an indicator (99mTechnetium-labelled mebrofenin) and catheterization of an artery and the hepatic *** angiography of the intestinal arteries was performed during the same investigation.A whole-body dual-energy x-ray absorptiometry scan was performedin healthy volunteers to determine body ***:Angiography revealed no atherosclerotic lesions in the intestinal *** mean baseline SBF was 1087mL/min (731-1390),and this value increased significantly to 1787 mL/min after the meal in healthy volunteers (P<0.001).The baseline SBF in patients was 1080 mL/min,which increased to 1718 mL/min postprandially (P<0.001).The baseline SBF was independent of age,sex,lean body mass and percentage of body *** mean meal-induced increase in SBF was equal to 282mL/min + 5.4mL/min × bodyweight,(P=0.025).The SO2U in healthy volunteers and patients was 50.7mL/min and 48.0mL/min,respectively,and these values increased to 77.5 mL/min and 75mL/min postprandially,*** baseline and postprandial SO2U were directly related to lean body *** and sex exerted no impact on ***:A direct correlation between body weight and the postprandial increase in SBF was *** effect of body weight should be considered in the diagnosis of chronic intestinal ischemia.

关键词： Splanchnic circulation Postprandial period Body composition Mesenteric vascular occlusion Middle aged

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Impact of Biomechanical Forces on Antibiotics Release Kinetics from Hydroxyapatite Coated Surgical Fixation Pins

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Journal of Biomaterials and Nanobiotechnology 2013年第4期4卷 343-350页

作者： Mirjam Lilja jan H.sorensen Torben C.sorensen Maria Astrand Philip Procter Hartwig Steckel Maria Stromme Division for Nanotechnology and Functional Materials Department of Engineering SciencesThe Angstrom LaboratoryUppsala UniversityUppsalaSweden Sandvik Coromant AB StockholmSweden Department of Pharmaceutics and Biopharmaceutics Christian Albrecht University KielKielGermany Stryker Trauma GmbH SchonkirchenGermany Stryker Trauma AG SelzachSwitzerland School of Engineering and Design Brunel UniversityUxbridgeUK

This work investigates the impact of biomechanical wear and abrasion on the antibiotic release profiles of hydroxyapatite (HA) coated fixation pins during their insertion into synthetic bone. Stainless steel fixation pins are coated with crystalline TiO2 by cathodic arc evaporation forming the bioactive layer for biomimetic deposition of Tobramycin containing HA. Tobramycin is either introduced by co-precipitation during HA formation or by adsorption-loading after HA deposition. The samples containing antibiotics are inserted into bone mimicking polyethylene foam after which the drug release is monitored using high performance liquid chromatography. This analysis shows that HA coating wear and delamination significantly decrease the amount of drug released during initial burst, but only marginally influence the sustained release period. Spalled coating fragments are found to remain within the synthetic bone material structure. The presence of HA within this structure supports the assumption that the local release of Tobramycin is not only expected to eliminate bacteria growth directly at the pin interface but as well at some distance from the implant. Furthermore, no negative effect of gamma sterilization could be observed on the drug release profile. Overall, the observed results demonstrate the feasibility of a multifunctional implant coating that is simultaneously able to locally deliver clinically relevant doses of antibiotics and an HA coating capable of promoting osteoconduction. This is a potentially promising step toward orthopaedic devices that combine good fixation with the ability to treat and prevent post-surgical infections.

关键词： Hydroxyapatite Fixation Pin Tobramycin Coating Wear Drug Release Gamma Sterilization

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AGV移动机器人提高物料搬运效率

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现代制造 2018年第6期 22-23页

作者： henrik Verterlund sorensen

许多生产企业都非常相信精益技术：对细节的敏锐观察力使企业能够发现价值增值链中的任何浪费，最终实现精益生产。

关键词：移动机器人物料搬运 AGV 生产企业精益生产观察力

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Peginterferon Lambda-1a, a New Therapeutic for Hepatitis C Infection, from Bench to Clinic

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Journal of Clinical and Translational Hepatology 2013年第2期1卷 116-124页

作者： henrik Andersen Jeff Meyer Jeremy Freeman Sean E.Doyle Kevin Klucher Dennis M.Miller Diana Hausman jan L.Hillson ZymoGenetics/Bristol-Myers Squibb Seattle WA 98102 USA EMD Serono Billerica MA USA Oncothyreon Inc. Seattle WA USA CPTxBio Woodinville WA USA

Chronic infection with hepatitis C virus (HCV) is estimated to affect approximately 3% of the world's population and cause 350,000 deaths each *** number of years,the standard of care has been combination therapy with recombinant alfa interferons—originally as native proteins but more recently as polyethyleneglycol-modified derivatives—and ribavirin,with the recent addition of an NS3 protease inhibitor for HCV genotype ***,therapeutic alfa interferons are associated with a significant burden of treatment-limiting adverse events,including musculoskeletal and influenza-like symptoms,hematologic cytopenias,autoimmune disease,fatigue,and other neurologic *** 2003,a team at ZymoGenetics (now a fully owned subsidiary of Bristol-Myers Squibb) and a second,independent group simultaneously identified a new class of interferons—the type Ⅲ lambda interferons—with near-identical activity to the type Ⅰ alfa interferons in hepatocytes but with an unrelated and less ubiquitous *** evaluation of the type Ⅲ interferon system demonstrated antiviral activity against HCV in vitro with limited activity in peripheral blood mononuclear cells and other nonhepatocyte cell types,supporting its development as a potentially better-tolerated therapy for viral *** lambda-1a (Lambda) is an investigational type Ⅲ therapeutic agent originally developed at ZymoGenetics that is currently in Phase 3 studies for the treatment of *** this review,we describe the selection of the Lambda molecule and its preclinical and early clinical development,and how the resulting data have helped to establish the differentiated safety profile for Lambda—with fewer influenza-like and musculoskeletal symptoms and less hematologic toxicity than the alfa interferons—that was seen in later studies.

关键词： Discovery HCV Interferonλ

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一步浸渍合成具有多重孔隙的铸型炭体(英文)

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新型炭材料 2003年第4期18卷 265-270页

作者：陆安慧 jan-henrik Smtt Mika Lindn Ferdi Schüth Max-Planck-Institut für Kohlenforschung Kaiser-Wilhelm-Platz 1D-45470 Mülheim an der Ruhr Max-Planck-Institut für Kohlenforschung Kaiser-Wilhelm-Platz 1 D-45470 Mülheim an der Ruhr

　以多孔块状硅体为模板,通过一步浸渍、炭化、酸处理工艺,制备出结构可控、孔隙联通且具有多重孔隙的铸型炭体。分别采用氮吸附技术、高分辨透射电镜和扫描电镜对模板硅、硅碳复合物及相应炭体进行了结构表征。从微米尺度分析,该炭体... 详细信息

　以多孔块状硅体为模板,通过一步浸渍、炭化、酸处理工艺,制备出结构可控、孔隙联通且具有多重孔隙的铸型炭体。分别采用氮吸附技术、高分辨透射电镜和扫描电镜对模板硅、硅碳复合物及相应炭体进行了结构表征。从微米尺度分析,该炭体是由高度联接的枝状结构单元为骨架构筑而成。与模板硅相比较,此炭体是硅体的正复本。从纳米尺度分析,这种炭体枝状骨架是由分布均匀且相互连接的中孔构成,此中孔及其孔壁对应于模板硅的孔壁及中孔,是多孔硅的负复本。此外构成中孔的炭骨架本体又含有大量炭化过程产生的微孔。因此该法合成的铸型炭具有孔隙高度发达和结构层层嵌套的特点。

关键词：铸型炭体一步浸渍法合成多重孔隙结构表征

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用于柔性化轻型机器人的无侧隙传动装置

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现代制造 2014年第38期 72-73页

作者： henrik Vesterlund sorensen Dominik Kaiser

为了优化生产流程，注塑行业内的一家生产企业使用了柔性化轻型机器人。这种机器人安装了谐波传动装置，该传动装置的扭矩容量达到了保障作业的水平，同时可使人与机器人直接合作。

关键词：传动装置机器人柔性化轻型侧隙生产流程生产企业扭矩容量

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The IEC Academy:standardization and the human factor

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China Standardization 2018年第5期83卷 62-64,F0003页

作者： jan-henrik tiedemann iec academy

jan-henrik Tiedemann started working at the IEC as Communtiy Manager in 2011.A seasoned standardzation professinal with experience at the Internatioanl Organization for Standardizatioin （ISO）and the German Institute... 详细信息

关键词： IEC 人的因素研究所

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