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Health risk of whole body vibration in mining trucks during various operational conditions

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journal of Central South University 2017年第8期24卷 1808-1816页

作者： Rahimdel m.j mirzaei m Sattarvand j Hoseinie S.H Department of mining Engineering Sahand University of TechnologyTabriz ***Iran Department of mechanical Engineering Sahand University of TechnologyTabriz ***Iran Department of mining Engineering Isfahan University of TechnologyIsfahan ***Iran

mining machineries are generally exposed to intensive vibrations in harsh mining environment. If vibrations are beyond the tolerable limit, the machine and its operator health will be under the risk. In this work, the vibration of a mining truck at different operational conditions are simulated and discussed. To achieve this aim, three haul roads with low, medium and poor qualities are considered based on the ISO standard. Accordingly, the vibration of a mining truck in different speeds, payload and distribution qualities of materials in the dump body are evaluated in each haul road quality using Trucksim software. The simulation results with statistical discussions indicate that the truck speed and the materials distribution quality have significant effects on the root mean square(RmS) of vertical vibrations. However, the effect of the payload is not considerable on the RmS. moreover, the accumulation of materials on the rear side of the truck dump body is efficient on the vibrational health risk.

关键词： mining trucks operational conditions health risk whole body vibration

Brain-penetrating neurotrophic factor mimetics: HER-096 as a disease-modifying therapy for Parkinson’s disease

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Neural Regeneration Research 2025年第4期20卷 1094-1095页

作者： Natalia Kulesskaya Kira m.Holmström Henri j.Huttunen Herantis Pharma Plc EspooFinland

Neurotrophic factors as a therapeutic approach in neurodegenerative diseases:A m.jor unmet need in the field of central nervous system diseases is disease-modifying *** for decades there have been various symptomatic treatments available to alleviate the symptoms of the disease,disease-modification,*** that stop,significantly delay,or reverse the progression of the disease,has been turned out to a difficult goal to achieve.

关键词： diseases treatment therapeutic

A revised generic classification of the jelly lichens, Collemataceae

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Fungal Diversity 2014年第1期64卷 275-293页

作者： mónica A.G.Otálora Per m.jørgensen mats Wedin Department of Botany Swedish Museum of Natural HistoryP.O.Box 50007SE-10405 StockholmSweden Department of Natural History Bergen University MuseumAllégt.41Box 78005020 BergenNorway

Phylogenetic studies have shown the need for a revised circumscription of generic boundaries in the jelly lichens(Collemataceae).Using a four-marker dataset from a recently published phylogeny of Collemataceae,we tested the monophyly of ten morphologically well-characterized *** achieve this,we performed Bayesian and maximum likelihood *** monophyly of the ten morphological groups was *** order to reconcile molecular and morphological data into a formal classification,we here propose new generic delimitations in *** and Leptogium are re-circumscribed and six old generic names are resurrected to accommodate the Collema Crispum-group(Blennothallia),the Collema Tenax-group(Enchylium),the Collema Cristatum-group(Lathagrium),the Collema Occultatum-group(Rostania),the former small Leptogium species(Scytinium),and Leptogium diffractum(Pseudoleptogium).In addition,two new genera are described to accommodate Collema multipartitum(Callome)and the Collema Italicum-group(Paracollema).The presence/absence of a eucortex,which was earlier used as the cardinal character to define genera in the family,is still useful,but only in combination with other traits such as thallus habit(size),lobe size,ascospore characteristics,thallus anatomical structure,and habitat preference.A key to the genera is *** are designated for Collema marginale Hoffm.,Synechoblastus nigrescens(Huds.)Trevis.,Eucollema(Cromb.)Horw.,Collema section Enchylium Ach.,Collema section Lathagrium Ach.,Collema *** Ach.,Collema section Scytinium Ach.,Collemodium *** Lamy,and Homodium *** Olivier.

关键词： Classification Collemataceae Cyanolichens jelly lichens Test of monophyly

Sleep as a window to understand and regulate Alzheimer's disease:emerging roles of thalamic reticular nucleus

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Neural Regeneration Research 2025年第6期20卷 1711-1712页

作者： Haoqi Sun Shiqian Shen Robert j.Thomas m.Brandon Westover Can Zhang Department of Neurology Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Center for Translational Pain Research Department of AnesthesiaCritical Care and Pain MedicineMassachusetis General HospitalHarvard Medical SchoolBostonMAUSA Division of Pulmonary Critical Care and Sleep MedicineDepartment of MedicineBeth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA Genetics and Aging Research Unit McCance Center for Brain HealthMass General Institute for Neurodegenerative DiseaseDepartment of NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

Introduction:Alzheimer 's disease(AD) is a common neurodegenerative disorder and the primary cause of dementia. Considerable evidence supports the “amyloid hypothesis,” stating that the pathogenesis of AD is primarily caused by the deposition of amyloid-β(Aβ), which drives tau phosphorylation, neuroinflammation, and neurodegeneration in the brain. The amyloid hypothesis is strengthened by the significant and moderate benefit of lecanemab, a humanized antibody through an anti-amyloid mechanism,showing slowed clinical decline(van Dyck et al.,2023). The recent positive results of anti-amyloid trials have brought back focus on the amyloid hypothesis through biochemical, genetic, and pharmacological approaches(Zhang, 2023).

关键词： Alzheimer inflammation hypothesis

Effect of dietary fibre on the gastrointestinal microbiota during critical illness:A scoping review

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World journal of Critical Care medicine 2025年第1期14卷 49-59页

作者： Angajendra N Ghosh Calum.j Walsh matthew j maiden Tim P Stinear Adam m Deane Department of Intensive Care The Northern HospitalEpping 3076VictoriaAustralia Department of microbiology and Immunology The Peter Doherty Institute for Infection and ImmunityMelbourne 3052VictoriaAustralia Department of Intensive Care The Royal Melbourne HospitalThe University of MelbourneParkville 3050VictoriaAustralia Department of Intensive Care medicine The Royal Melbourne HospitalParkville 3050VictoriaAustralia

The systemic effects of gastrointestinal(GI)microbiota in health and during chronic diseases is increasingly *** strategies to modulate the GI microbiota during chronic diseases have demonstrated *** changes in dietary intake can rapidly change the GI microbiota,the impact of dietary changes during acute critical illness on the microbiota remain *** fibre is metabolised by carbohydrate-active enzymes and,in health,can alter GI *** aim of this scoping review was to describe the effects of dietary fibre supplementation in health and disease states,specifically during critical *** controlled trials and prospective cohort studies that include adults(>18 years age)and reported changes to GI microbiota as one of the study outcomes using non-culture methods,were *** show dietary fibres have an impact on faecal microbiota in health and *** fibre,inulin,has a marked and specific effect on increasing the abundance of faecal *** chain fatty acids produced by Bifidobacteria have been shown to be beneficial in other patient *** few trials have evaluated the effect of dietary fibre on the GI microbiota during critical *** research is necessary to establish optimal fibre type,doses,duration of intervention in critical illness.

关键词： Gastrointestinal microbiota Dietary fibre Health Critical illness Short chain fatty acids

Emerging role of A-kinase anchoring protein 5 signaling in reward circuit function

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Neural Regeneration Research 2025年第10期20卷 2913-2914页

作者： William.j.Flerlage mark L.Dell’Acqua Brian m.Cox Fereshteh S.Nugent Uniformed Services University of the Health Sciences Department of Pharmacology and Molecular TherapeuticsBethesdaMDUSA Department of Pharmacology University of Colorado School of MedicineAnschutz Medical CampusAuroraCOUSA

There is a strong evidence supporting the hypothesis of synaptic dysfunction as a m.jor contributor to neural circuit and network disruption underlying emotional and mood dysregulation in psychiatric disorders(Simmons et al.,2024).Diverse sets of distinct molecular signaling pathways converge on the synapse to regulate synaptogenesis,synaptic function,and synaptic plasticity in brain regions and circuits through complex interactions organized by numerous multivalent protein scaffolds,including the family of proteins known as A-kinase anchoring proteins(AKAPs).

关键词： function supporting

Clinical,laboratory,and therapeutic differences between immunoglobulin E-mediated and non-immunoglobulin E-mediated cow’s milk protein allergy in children

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World journal of Clinical Pediatrics 2025年第1期14卷 78-92页

作者： Hasan m Isa marwa j Abdulnabi Nawra S Naser Fatema N Lahmda Noor m AlAnsari Zahra H Isa Afaf m mohamed Department of Pediatrics Salmaniya Medical ComplexManama 26671Bahrain Department of Pediatrics Arabian Gulf UniversityManama 26671Bahrain Faculty of medicine Mansoura UniversityMansoura 35516Egypt Public Health Directorate Ministry of HealthManama 26671Bahrain

BACKGROUND Although breast milk is ideal for newborns,in some cases,it is replaced with cow’s milk,which contains proteins that increase the risk of cow’s milk protein allergy(CmPA).AIm To evaluate CmPA prevalence in Bahrain and compare clinical characteristics of children with immunoglobulin E(IgE)-and non-IgE-mediated *** This retrospective cohort study examined children with CmPA diagnosed at the pediatric gastroenterology outpatient clinic of the Salmaniya medical Complex,Bahrain,between 2014 and 2022,and assessed CmPA *** presentations,laboratory findings,dietary modifications,and outcomes were compared between children with IgE-mediated and non-IgE-mediated *** variables were compared using Fisher’s exact test or Pearson’sχ2 test,whereas continuous variables were compared using Student’s t-test or the mann-Whitney U *** Of 8332 patients,6022(72.3%)adhered to their *** them,618(10.3%)were suggested of having CmPA and 595(96.3%)were included;CmPA prevalence was 2%.most patients were Bahraini(93.8%)and males(55.3%).Non-IgE-mediated type accounted for 77.3%cases and IgE-mediated type,22.7%.IgE-mediated CmPA presented more in boys(P=0.030),and later in life(5.1 months±4.5 months vs 4.2 months±4.2 months,P=0.016,95%CI:0.08-1.73),had more associated diseases(Pmore cutaneous(P=0.024)and respiratory(P=0.003)manifestations,severe symptoms[rash/dry skin(P=0.031),facial swelling/angioedema(P=0.003),failure to thrive(P=0.013),apparent life-threatening event(Pmediated *** patients were exclusively fed cow milk formula(50.3%).The amino acid-based formula(AAF)was most prescribed(60.5%)with no difference between the two types(P=0.173).Although breastfeeding was recommended to 49.6%,only 8.2%were exclusively ***-mediated CmPA was associated with a longer follow-up duration than non-IgE-mediated CmPA(17.3 months±14.0 mo

关键词： Children milk allergy Immunoglobulin E Breastfeeding Infant formula Bahrain

mICROBRIDGE TESTING OF YOUNG'S mODULUS AND RESIDUAL STRESS OF NICKEL FILm ELECTROPLATED ON SILICON WAFER

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Acta metallurgica Sinica(English Letters) 2004年第3期17卷 247-254页

作者： Y.Zhou C.S.Yang j.A. Chen G.F. Ding L. Wang m.j Wang Y.m Zhang T.H Zhang Key Laboratory for Thin Film and microfabrication of ministry of Education Research Institute of Micro/Nanometer Science and Technology Shanghai Jiaotong University Shanghai 200030 China State Key Laboratory of Nonlinear mechanics (LNm) Institute of Mechanics The Chinese Academy of Sciences Beijing 100080 China.

microbridge testing is used to measure the Young's modulus and residual stresses of metallic *** film microbridges with widths of several hundred microns are fabricated by microelectromechanical *** order to measure the mechanical properties of nickel film microbridges,special shaft structure is designed to solve the problem of getting the load--deflection curves of metal film microbridge by Nanoin--denter XP system with normal Berkovich *** analysis of the micro--bridge load--deflection curve is proposed to evaluate the Young's modulus and residual stress of the films *** calculated results based on the experimental measurements show that the average Young's modulus and residual stress are around 190GPa and 175mPa respectively,while the Young's modulus measured by Nano-hardness method on nickel film with silicon substrate is 186.8±7.34GPa.

关键词： nickel film microbridge mEmS mechanical property loadeflection measurement

Study skills in English Frist

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