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Predicting an Athlete’s Physiological and Haematological Response to Live High-Train High Altitude Training Using a Hypoxic sensitivity Test

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Journal of science in sport and Exercise 2022年第4期4卷 371-385页

作者： Gareth Turner Kate L.spilsbury David J.Green Barry W.Fudge jamie s.m.pringle Alan J.Richardson Neil s.maxwell Environmental Extreme Laboratory University of BrightonEastbourneUK English Institute of sport Bisham AbbeyUK Queensland Academy of sport BrisbaneAustralia English Institute of sport LoughboroughUK Aspire Academy DohaQatar University of Birmingham BirminghamUK

Purpose Elite endurance runners frequently utilise live high-train high(LHTH)altitude training to improve endurance per-formance at sea level(sL).Individual variability in response to the hypoxic exposure have resulted in contradictory *** the present case study,changes in total haemoglobin mass(tHbmass)and physiological capacity,in response to 4-weeks of LHTH were *** tested if a hypoxic sensitivity test(HsT)could predict altitude-induced adaptations to *** Fifteen elite athletes were selected to complete 4-weeks of LHTH(~2400 m).Athletes visited the laboratory for preliminary testing(PRE),to determine lactate threshold(LT),lactate turn point(LTP),maximal oxygen uptake VO_(2max)and *** LHTH,athletes completed daily physiological measures[arterial oxygen saturation(spO2)and body mass]and subjective wellbeing *** was repeated,for those who completed the full camp,post-LHTH(POsT).Additionally,athletes completed the HsT prior to *** A difference(Ps found from PRE to POsT in average tHbmass(1.8%±3.4%),VO_(2max)(2.7%±3.4%),LT(6.1%±4.6%)and LTP(5.4%±3.8%),after 4-weeks *** revealed a decrease in oxygen saturation at rest(Δsp_(r))and higher hypoxic ventilatory response at rest(HVRr)predicted individual changes *** hypoxic cardiac response at rest(HCRr)and higher HVRr predicted individual changes VO_(2max).Conclusion Four weeks of LHTH at~2400 m increased tHbmass and enhanced physiological capacity in elite endurance *** was no observed relationship between these changes and baseline characteristics,pre-LHTH serum ferritin levels,or reported incidents of musculoskeletal injury or *** HsT did however,estimate changes in tHbmass and VO_(2max).HsT prior to LHTH could allow coaches and practitioners to better inform the acclimatisation strategies and train-ing load application of endurance runners at altitude.

关键词： Altitude training Runners Endurance Haemoglobin mass Performance Hypoxic sensitivity

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An emerging terpolymeric nanoparticle pore former as an internal recrystallization inhibitor of celecoxib in controlled release amorphous solid dispersion beads:Experimental studies and molecular dynamics analysis

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Acta Pharmaceutica sinica B 2024年第6期14卷 2669-2684页

作者： jamie Anne Lugtu-Pe Xuning Zhang sako mirzaie Hao Han R.Chang Nour AL-mousawi Kuan Chen Yongqiang Li Anil Kane Daniel Bar-shalom Xiao Yu Wu Advanced Pharmaceutics and Drug Delivery Laboratory Leslie Dan Faculty of PharmacyUniversity of TorontoToronto M5S 3M2Canada Candoo Pharmatech Company Inc. Mississauga L5N 5M1Canada Department of Pharmacy University of CopenhagenCopenhagen DK-2100Denmark Patheon by Thermo Fisher scientific Toronto Region Operations(TRO)Mississauga L5N 3X4Canada

solid oral controlled release formulations feature numerous clinical advantages for drug candidates with adequate solubility and dissolution ***,most new chemical entities exhibit poor water solubility,and hence are exempt from such *** combining drug amorphization with controlled release formulation is promising to elevate drug solubility,like other supersaturating systems,the problem of drug recrystallization has yet to be resolved,particularly within the dosage ***,we explored the potential of an emerging,non-leachable terpolymer nanoparticle(TPN)pore former as an internal recrystallization inhibitor within controlled release amorphous solid dispersion(CRAsD)beads comprising a poorly soluble drug(celecoxib)reservoir and insoluble polymer(ethylcellulose)*** to conventional pore former,polyvinylpyrrolidone(PVP),TPN-containing membranes exhibited superior structural integrity,less crystal formation at the CRAsD bead surface,and greater extent of celecoxib ***-atom molecular dynamics analyses revealed that in the presence of TPN,intra-molecular bonding,crystal formation tendency,diffusion coefficient,and molecular flexibility of celecoxib were reduced,while intermolecular H-bonding was increased as compared to *** work suggests that selection of a pore former that promotes prolonged molecular separation within a nanoporous controlled release membrane structure may serve as an effective strategy to enhance amorphicity preservation inside CRAsD.

关键词： Controlled release amorphous solid dispersion Poorly soluble drug Internal recrystallization membrane-reservoir coated beads molecular dynamics simulation Effect of pore formers Terpolymer nanogel Drug-polymer interactions

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The Evolving Role of Botanical Gardens and Natural Areas:A Floristic Case study from Royal Botanical Gardens,Canada

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植物分类与资源学报 2011年第1期33卷 123-131页

作者： David A.GALBRAITH Natalie E.IWANYCKI Brechann V.mcGOEY jamie mcGREGOR James s.pringle Carl J.ROTHFELs Tyler W.smITH Royal Botanical Gardens BurlingtonON University of Guelph GuelphON Duke University DurhamNC Eastern Kentucky University RichmondKY

As leaders calling for the conservation of the world's plants,botanical gardens protect plants within living *** also study,manage and restore plants in natural *** Botanical Gardens(Ontario,Canada) has integrated both horticultural and natural heritage in its mission for *** by municipal leaders in the 1920s as a combination of nature sanctuaries and civic gardens,RBG now includes forests,wetlands and other habitats,gardens and built *** RBG is Canada's largest botanical garden on the basis of *** the 1950s RBG began to inventory plant *** checklist of spontaneous vascular plants now exceeds 1 170 species,of which 752 are *** is 37% of Ontario's native vascular plants and 19% of the native vascular flora of *** RBG nature sanctuaries are among the richest locations in Canada for species-level *** examine the history of floristic exploration within RBG and compare plant species-area relationships among protected natural areas in *** comparison supports the contention that the nature sanctuaries,and in particular Cootes Paradise,could be considered an important area for plants in Canada,and relative to the nation's flora,a biodiversity *** fact that a candidate vascular plant hotspot for Canada lies within a major botanical garden presents opportunities for raising public awareness of the importance of plant diversity,as well as focusing attention on the scientific and conservation biology needs of communities and individual species in this area.

关键词： Botanical garden Ontario Natural areas Biodiversity species-area curve species richness

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mycophenolate mofetil for maintenance of remission in steroid-dependent autoimmune pancreatitis

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World Journal of Gastroenterology 2012年第18期18卷 2287-2290页

作者： jamie B sodikoff steven A Keilin sheila J Bharmal melinda m Lewis Gottumukkala s Raju Field F Willingham Division of Digestive Diseases Department of MedicineEmory University School of MedicineAtlantaGA 30322United States Department of Pathology Emory University School of MedicineAtlantaGA 30322United States Department of Gastroenterology the University of Texas MD Anderson Cancer CenterHoustonTX 77030United States

systemic corticosteroids represent the standard treatment for autoimmune pancreatitis with IgG4-associated *** steroid-dependent disease,azathioprine has been used for maintenance of *** mofetil has been used for transplant immunosuppression and more recently for autoimmune hepatitis;however,there are no case reports to date on the use of mycophenolate mofetil in adult patients with autoimmune pancreatitis.A patient with IgG4-mediated autoimmune pancreatitis and IgG4-associated cholangitis refractory to steroids and intolerant of azathioprine was treated with mycophenolate mofetil,which inhibits de novo guanosine synthesis and blockade of both B and T lymphocyte *** of mycophenolate mofetil and uptitration to 1000 mg by mouth twice daily over a treatment period of 4 mo was associated with improvement in the patient's energy level and blood glucose control and was not associated with any adverse *** patient was managed without a biliary ***,there was a return of symptoms,jaundice,increase in transaminases,and hyperbilirubinemia when the prednisone dose reached 11 mg per *** the first report of mycophenolate mofetil use in an adult patient with IgG4-associated autoimmune pancreatitis and IgG4-associated cholangitis,the introduction of mycophenolate mofetil was safe and well-tolerated without adverse events,but it did not enable discontinuation of the *** mofetil and other immunomodulatory therapies should continue to be studied for maintenance of remission in the large subset of patients with refractory or recurrent autoimmune pancreatitis.

关键词： Autoimmune diseases Pancreatitis mycophenolate mofetil Recurrence

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Physical separation from the mate diminishes male＇s attentiveness towards other females： a study in monogamous prairie voles microtus ochrogaster

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Current Zoology 2017年第5期63卷 537-544页

作者： Christine J. DELEVAN Natalia A. RODRIGUEZ Karine m. LEGZIm Fayeza ALIOU jamie T. PARKER maryam BAmsHAD Department of Biological sciences Lehman College--The City University of New York Bronx NY 10468 USA

We tested whether continuous cohabitation in monogamous voles affects the mated male＇s atten-tiveness to his breeding partner versus another female. Each male was housed in a 3-chamber ap-paratus with a Focal female （FF） and a Control female （CF） for 13 days then placed in a T-maze toassess his attentiveness to and memory of those females. The Distal male remained physically sep-arated from both females, but received their distal cues. The separate male cohabited with the FFfor 3 days then remained physically separated from both females. The Disrupt male＇s continuouscohabitation with the FF was disrupted by having him physically separated from her after 10 daysand placed with the CF for the last 3 days. The Continuous male cohabited continuously with the FFfor 13 days. With females in the T-maze, the separate and Disrupt males spent more time near theFF＇s box and the Disrupt males spent more time manipulating the FF＇s box than the CF＇s box. Theseparate males groomed themselves more when near the FF＇s box than the CF＇s box. The Distaland Continuous males＇ attentiveness to the two females did not differ. Results suggest that phys-ical distance from the partner may reduce male＇s attentiveness toward other potential *** voles might be similar to socially monogamous primates in using tactile cues as a signal formaintaining their social bonds.

关键词： attachment, monogamy, partner preference, partner separation, social cognition.

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Acoustics and Psychoacoustics 4

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2009年

作者： David m. Howard jamie A.s. Angus

ISBN: (纸本)9780240521756

The acoustics of a space can have a real impact on the sounds you create and capture. Acoustics and Psychoacoustics gives you an essential grounding and understanding to how real music sounds behave in different spaces whether during a performance or a recording and how they are perceived by performers and listeners. With their clear and simple style Howard and Angus walk you through the theory- the science of sound engineering and music production, the acoustics of musical instruments, how we hear musical sounds, and the practical- how to apply it to music spaces to create professional sound. Real-world examples and audio clips to work with are provided, providing practical materials to work with. The new edition uncovers the acoustic application for today's recording industry. The accompanying CD provides audio examples to help readers gain a clear understanding of the many concepts discussed in the book.

关键词： Psychoacoustics. music sound

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The relationship of high-intensity cross-training with arterial stiffness

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Journal of sport and Health science 2019年第4期8卷 370-375页

作者： jamie F.Burr Jenny L.Beck John J.Durocher Department of Human Health and Nutritional sciences University of GuelphGuelphON NIG 2W1Canada Applied Human sciences University of Prince Edward IslandCharlottetownPE CIA 4P3Canada Department of Biological sciences Michigan Technological UniversityHoughtonMI 49931USA

Background'.Central arterial stiffness is a cardiovascular risk factor that can be readily affected through engagement in physical exercise training,with resistance and aerobic exercise having disparate *** the growing popularity of high-intensity cross-training(HICT),little is currently known about the effects of this mixed modality exercise stimulus on arterial ***,the purpose of this study was to characterize the arterial stiffness of habitual HICT participants *** active and sedentary controls using a cross-sectional ***'.A total of 30 participants were recruited:10 middle-aged long-term participants of HICT(CrossFit)and 20 age,sex,and height matched controls(10 recreationally active,10 sedentary).Central and peripheral pulse wave velocities were measured for the carotid-femoral and femoral-dorsalis pedis arterial *** fitness(maximal oxygen uptake,VChmax)was measured and typical exercise participation rates were self-reported for each ***'.HICT participants manifested central pulse wave velocity(PWV)(5.3±1.0 m/s,mean±sD)and VChmax(43±6 mL/kg/min)values nearly identical to active *** active groups had significantly better values than sedentary controls(7.1±1.0 m/s,p≤0.001;and 32±7 mL/kg/min,p=0.01).No differences were observed in peripheral PWV between ***'.Habitual participation in HICT exercise was not associated with increased central nor peripheral arterial ***-term HICT participants presented with similar fitness and arterial stiffness as compared with participants who practiced traditional aerobic *** to sedentary living,HICT may offer musculoskeletal and cardiovascular health benefits without negatively impacting arterial stiffness.

关键词： Circuit training CrossFit Pulse wave velocity Resistance exercise Vascular Weight training

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High-Pressure single-Crystal Neutron scattering study of magnetic and Fe Vacancy Orders in （T1,Rb）：Fe4se5 superconductor

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Chinese Physics Letters 2014年第12期31卷 111-114页

作者：叶峰鲍威池松雪 Antonio m. dos santos jamie J. molaison 方明虎王杭栋毛乾辉汪晋辰刘娟娟盛洁明 Quantum Condensed matter Division Oak Ridge National Laboratory Oak Ridge 37831 USA Department of Physics and Astronomy University of Kentucky Lexington 40506 USA Department of Physics Renmin University of China Beijing 100872 Department of Physics Zhejiang University Hangzhou 310027

The recently discovered metal-intercalated iron selenide superconductors A2Fe4se5 （A=K, Cs, T1- K, Rb, T1-Rb）（245） compounds, with Tc ～30K, have attracted much interest A high transition- temperature （TN ≈ 470-560K） and large magnetic moment （3.3μB/Fe） block antiferromagnetic （AFm） order exists in the superconducting samples. mag- netic order-parameter experiences an anomaly when Tc is approached. The superconductors crystal- lize with a highly ordered √5 × √5 superstructure, in which the Fel site of the I4/m structure is only a few percents occupied and the Fe2 site is fully occupied. The non-superconducting samples at low-T also crystallize in the I4/m structure, while both Fe sites are fractionally occupied, since the numbers of the Fe vacancies in the samples and the vacant sites in the √5 × √5 pattern are mismatched. The partially ordered √5× √5 vacancy order becomes one of three competing phases for temperature below room temperature up to ～ 500K, namely, these sam- ples are phase-separated and in the miscibility gap 1lacier the n,mhi^nt condition.

关键词： High-Pressure single-Crystal Neutron scattering study Vacancy Orders

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Primary Lymphoma of Bone: Imaging Findings to Improve Diagnosis of a Rarely Considered Disease Prior to Biopsy

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Open Journal of Clinical Diagnostics 2015年第3期5卷 97-106页

作者： jamie T. Caracciolo Trevor Rose marilyn m. Bui Department of Diagnostic Imaging Moffitt Cancer Center Tampa USA Department of sarcoma Moffitt Cancer Center Tampa USA Department of Anatomic Pathology Moffitt Cancer Center Tampa USA

Objective: Primary lymphoma of bone (PLB) is a rare malignant bone tumor often presenting in the fifth-sixth decades involving appendicular long bones. Published radiological findings indicate that PLB typically presents as a moth-eaten osteolytic lesion with periosteal reaction, while mRI commonly demonstrates marrow infiltration with extraosseous extension. Given rarity and variable appearances, PLB may not be primarily considered prior to biopsy. Our objective was to evaluate preoperative imaging findings in effort to increase awareness and improve a perceived deficiency in preoperative diagnosis. materials and methods: Following IRB approval, retrospective review identified 60 patients with newly diagnosed bone lesions proven to represent PLB in accordance with WHO definition. Preoperative radiographs (n = 46), mRI (n = 33) and PET (n = 37) were independently reviewed by two radiologists. At radiography, lesions were classified: purely lytic, mixed, purely sclerotic, or occult;lytic lesions were graded utilizing Lodwick’s classification. At mRI, lesions were defined as focal or infiltrative and the presence or absence of extraosseous disease was recorded. Extraosseous masses were defined as small (1 cm) and subjectively correlated with degree of cortical destruction. At PET, lesions were recorded as FDG-avid or not. Primary radiograph reports when available (n = 33) were reviewed and exact wording of differential considerations was recorded. Results: Radiographs demonstrated mixed (n = 22), lytic (n = 15), and sclerotic (n = 8) appearances;one radiographically occult lesion was seen by mRI. Lytic lesions were graded: IB (n = 3), IC (n = 5), II (n = 4), and III (n = 3);none were IA. At mRI, 30 lesions were infiltrative and 3 were focal;11 were not associated with extraosseous extension, while 22 showed bony disease with small (n = 7) or large (n = 15) soft tissue mass. Of large masses, 13 demonstrated minimal cortical destruction. At PET, 36 demonstrated FDG upta

关键词： Primary Lymphoma of Bone Preoperative Diagnosis Radiological Findings

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monitoring the autoproteolysis of hiv-1 protease by site-directed spin-labeling and electron paramagnetic resonance spectroscopy

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Journal of Biophysical Chemistry 2011年第2期2卷 137-146页

作者： jamie L. Kear Luis Galiano Angelo m. Veloro Laura s. Busenlehner Gail E. Fanucci Department of Chemistry University of Florida Gainesville Florida USA

site-directed spin-labeling with continuous wave electron paramagnetic resonance spectroscopy was used to monitor autoproteolysis of HIV-1 protease, an enzyme essential for viral maturation. Two protein constructs were examined, namely subtype F and the circulating recombinant form CRF01_A/E. As the protease undergoes self-cleavage, protein unfolds and small peptide fragments containing the spin label are generated, which collectively give rise to a sharp spectral component that is easily discernable in the high-field resonance line in the EPR spectrum. By monitoring the intensity of this spectral component over time, the autoproteolytic stability of each construct was characterized under various conditions. Data were collected for samples stored at 4 °C, 25 °C, and 37 °C, and on a subtype F HIV-1 protease sample stored at 25 °C and containing the FDA-approved protease inhibitor Tipranavir. As expected, the rate of autoproteolysis decreased as the storage temperature was lowered. minimal autoproteolysis was seen for the sample that contained Tipranavir, providing direction for future spectroscopic studies of active protease samples. When compared to standard methods of monitoring protein degradation such as gel electrophoresis or chromatographic analyses, spin-labeling with CW EPR offers a facile, real-time, non-consuming way to monitor autoproteolysis or protein degradation. Additionally, mass spectrometry studies revealed that the N-termini of both constructs are sensitive to degradation and that the sites of specific autoproteolysis vary.

关键词： HIV-1 Protease Autoproteolysis self-Proteolytic Activity site-Directed spin-Labeling Electron Paramagnetic Resonance (EPR) spectroscopy

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