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呼吸道合胞病毒和副流感病毒疫苗研制现状WHO疫苗开发规划会议报告

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国外医学（预防．诊断．治疗用生物制品分册） 1996年第1期19卷 25-27页

作者： jamese 刘建

副粘病毒科中的呼吸道合胞病毒(RSV)和3型副流感病毒(PIV_3)可引起婴幼儿细支气管炎和肺炎,PIV_3还引起哮吼,由这两种病毒导致住院治疗的婴幼儿占所有因呼吸道疾病住院儿童的30%.迄今尚无获准使用的预防这两种病毒感染的疫苗.1994年3月2... 详细信息

副粘病毒科中的呼吸道合胞病毒(RSV)和3型副流感病毒(PIV_3)可引起婴幼儿细支气管炎和肺炎,PIV_3还引起哮吼,由这两种病毒导致住院治疗的婴幼儿占所有因呼吸道疾病住院儿童的30%.迄今尚无获准使用的预防这两种病毒感染的疫苗.1994年3月27日,全球疫苗规划处(GPV)在瑞士尼翁组织了一次专题讨论会,回顾了这两种疫苗的研究状况,并探索能用于预防RSV和PIV_3所致疾病的新免疫接种方法.WHO希望评价用RSV和PIV_3的cDNA克隆拯救感染性病毒的方法学建立方面的进展.该技术一旦建立,对研制新一代候选疫苗和阐明现有疫苗减毒作用的遗传学基础均具有重要价值.

关键词：呼吸道合胞病毒副流感病毒疫苗

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65.肺栓塞

江西医药 1986年第6期 568-574页

作者： jamese.WilsonⅢ

【定义】肺栓塞即脱落的血栓或其它颗粒性物质嵌顿在肺血管床中。肺梗死则为血液供应障碍所致肺实质的坏死。因肺拥有双重血液供应,故肺栓塞大多不致发生梗死。【病因】肺栓塞的诱因,可按Virchow在1856年最初提出的方式分为以下几类:血... 详细信息

【定义】肺栓塞即脱落的血栓或其它颗粒性物质嵌顿在肺血管床中。肺梗死则为血液供应障碍所致肺实质的坏死。因肺拥有双重血液供应,故肺栓塞大多不致发生梗死。【病因】肺栓塞的诱因,可按Virchow在1856年最初提出的方式分为以下几类:血流郁滞、静脉损伤、血凝机能亢进。固定、肥胖、静脉曲张、充血性心力衰竭和妊娠等,皆可使血流郁滞。静脉损伤见于外科手术、外伤和灼烧等情况。血凝机能亢进的确切定义尚有争议;从广义来说,它是指导致血栓形成的凝血系统的功能改变,见于以下情况:癌瘤、真性红细胞增多、溶血性贫血、脾切

关键词：肺栓塞复发性深静脉血栓形成抗凝治疗肺血管床肺血管造影肺灌注扫描

Suppression of bile acid synthesis by thyroid hormone in primary human hepatocytes

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World Journal of Gastroenterology 2006年第29期12卷 4640-4645页

作者： Ewa Cristine Siljevik ellis Department of Medicine Division of Gastroenterology and Hepatology and the Department of Laboratory MedicineDivision of Clinical ChemistryKarolinska University Hospital at HuddingeKarolinska InstituteStockholmSweden

AIM： It is known that thyroid hormones alter the bile acid metabolism in humans, however the effect on individual enzymes has been difficult to elucidate. This is mainly due to the lack of human liver cell lines producing bile acids. We used cultures of primary human hepatocytes to study the effects of triiodothyronine （T3） on bile acid synthesis.METHODS： Primary hepatocytes were isolated from liver tissue obtained from three different patients undergoing liver resection due to underlying malignancy. The hepatocytes were cultured under serum-free conditions and treated from d 1 to d 5 with culture containing 0.1 - 1000 nmol/L of T3. Bile acid formation and mRNA levels of key enzymes were analysed. RESULTS： The lowest concentration of T3 decreased cholic acid （CA） formation to 43%-53% of controls and chenodeoxycholic acid （CDCA） to 52%-75% of controls on d 5. The highest dose further decreased CA formation to 16%-48% of controls while CDCA formation remained at 50%-117% of controls. Expression of mRNA levels of cholesterol 7α-hydroxylase （CYP7A1） and sterol 12α-hydroxylase （CYPSB1） dose-dependently decreased. Sterol 27-hydroxylase （CYP27A1） levels also decreased, but not to the same extent. CONCLUSION： T3 dose-dependently decreased total bile acid formation in parallel with decreased expression of CYP7A1 and CYP8B1. CA formation is inhibited to a higher degree than CDCA, resulting in a marked decrease in the CA/CDCA ratio.

关键词： Hepatocytes Human Bile acids CYP7A1 CYPSB1 CYP27A1

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欢迎来到司美格鲁肽之都

商业周刊（中文版） 2024年第16期 46-53页

作者：许诺(译) 不详

几年前,当玛丽·埃利斯(Marie ellis)第一次听说司美格鲁肽(Ozempic)的时候,她并不觉得这种药适合自己。当时她40多岁,体重265磅(约120公斤),有肝病家族史,虽然她需要减肥,但她觉得打减肥针是电影明星或电视真人秀里各种奇葩人物的专利。

关键词：电视真人秀埃利斯减肥格鲁电影明星肽家族史

Characterization of Pyrolytic Lignin Extracted from Bio-oil

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Chinese Journal of Chemical Engineering 2010年第6期18卷 1018-1022页

作者： JIANG Xiaoxiang Naoko ellis ZHONG Zhaoping Thermoenergy Engineering Research Institute Southeast University Nanjing 210096 China Department of Chemical and Biological Engineering University of British Columbia Vancouver Canada

Bio-oil is a new liquid fuel produced by fast pyrolysis,which is a promising technology to convert bio-mass into liquid. Pyrolytic lignin extracted from bio-oil,a fine powder,contributes to the instability of bio-oil. The paper presents the structural features of three kinds of pyrolytic lignin extracted from bio-oil with different methods(WIF,HMM,and LMM) . The pyrolytic lignin samples are characterized by Fourier transform infrared spectrometer(FTIR) and X-ray photoelectron spectroscopy(XPS) . FTIR data indicate that the three pyrolytic lignin samples have similar functional groups,while the absorption intensity is different,and show characteristic vibra-tions of typical lignocellulosic material groups O H(3340-3380 cm-1) ,C H(2912-2929 cm-1) and C O(1652-1725 cm-1) . Comparison in the region(3340-3380 cm-1) indicates that WIF has more O H stretch groups than HMM and LMM. The carbon spectra are fitted to four peaks:C1,C C or C H,BE 283.5 eV;C2,C OR or C OH,BE 284.5-285.8 eV;C3,C O or HO C OR,BE 286.10-287.10 eV;C4,O C O,BE 287.5-287.7 eV. The absence of C1,C C or C H indicates the dominant polymerization structure of aro-matic carbon in pyrolytic lignin samples. For HMM and WIF,C2a and C2b can not be separated,so there is no free hydroxyl group in the samples. The oxygen peaks are also fitted to four peaks:O1,OH,BE = 530.3 eV;O2,RC O,BE 531.45-531.72 eV;O3,O C O,BE = 532.73-533.74 eV;O4,H2O,BE 535 eV. The absence of O1 and O4 indicates that little hydroxyl groups and adsorbed water are present in the samples.

关键词： bio-oil pyrolytic lignin Fourier transform infrared spectrometer X-ray photoelectron spectroscopy

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