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Fungal Diversity 2012年第1期52卷 1-12页

作者： paul Diederich james D.Lawrey Masoumeh Sikaroodi Pieter P.Gvan den Boom Damien Ertz Musée national d’histoire naturelle 25 rue Munster2160 LuxembourgLuxembourg Department of Environmental Science and Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA Arafura 16 5691 JA Sonthe Netherlands Jardin Botanique National de Belgique Domaine de Bouchout1860 MeiseBelgium

Morphological,anatomical,chemical and molecular data suggest that a relatively common lichenicolous coelomycete on Lecanora conizaeoides is conspecific with Phoma cytospora,previously known only from parmelioid lichens,and that further populations on Cladonia and Pertusaria belong to the same *** species is distinguished from Phoma by several taxonomically important characters and obviously represents a previously unrecognized genus,for which the name Briancoppinsia is *** analyses using nuLSU and mtSSU sequences of isolates obtained in pure culture suggest that the new genus belongs to the Arthoniaceae(Arthoniales).This is the first obligate lichenicolous,non-lichenized anamorph confirmed to belong to the Arthoniales based on molecular data.

关键词： Anamorphic fungi Arthonia Conidial fungi Mitosporic fungi

Occurrence and fate of endogenous steroid hormones,alkylphenol ethoxylates, bisphenol A and phthalates in municipal sewage treatment systems

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Journal of Environmental Sciences 2017年第11期29卷 49-58页

作者： Qian Wu james C.W.Lam Karen Y.Kwok Mirabelle M.P.Tsui paul K.S.Lam State Key Laboratory in Marine Pollution (SKLMP) Department of Biology and Chemistry Research Centre for the Oceans and Human Health Shenzhen Key Laboratory for Sustainable Use of Marine Biodiversity City University of Hong Kong Department of Science and Environmental Studies The Education University of Hong of Kong

Steroid hormones, alkylphenol ethoxylates（APEOs） and phthalic acid esters（PAEs） are emerging endocrine disrupting chemicals（EDCs） that can interfere with the endocrine function in organisms at low concentrations. The occurrence, distribution behavior, removal rate and the fate of 31 target EDCs in sewage treatment plants, which consist of various treatment facilities and receiving water in Hong Kong, were investigated. Estrone,nonylphenol-di-ethoxylate and diethyl phthalate were found to be dominant in each group of influent samples with concentrations ranging from 11–33, 747–3945 and 445–4635 ng/L,respectively. Conversely, progesterone, nonylphenol-mono-ethoxylate and bis（2-ethylhexyl）phthalate were the most abundant in dewatered sludge, with concentrations ranging from 0.9–237, 75–19,743 and 4310–37,016 ng/g（dry weight）. The removal rates of primary sedimentation and disinfection approaches were lower than 30% for most of the chemicals,while those of activated sludge and reverse osmosis were greater than 80% for more than two-thirds of the compounds, noticeably decreasing the estrogenic risk of sewage discharged into the environment. Steroid hormones were removed via biological degradation, while some APEOs and PAEs adsorbed to the sludge. Victoria Harbor poses a low to medium estrogenic risk mainly contributed by estrone and estradiol and deserves attention.

关键词： Endocrine disruptor Steroid hormone Alkylphenol ethoxylate Phthalic acid ester Risk assessment

Identification of pathologic features associated with “ulcerative colitis-like” Crohn's disease

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World Journal of Gastroenterology 2014年第36期20卷 13139-13145页

作者： Samuel D james paul E Wise Tania Zuluaga-Toro David A Schwartz M Kay Washington Chanjuan Shi Departments of Pathology Microbiology and Immunology Vanderbilt University Medical Center Nashville TN 37232 United States Section of Colon and Rectal Surgery Washington University in St. Louis Gainesville MO 63130 United States Department of Pathology University of Florida Gainesville FL 32611 United States Departments of Gastroenterology Hepatology and Nutrition Vanderbilt University Medical Center Nashville TN 37232 United States

AIM: To identify pathologic features associated with this “ulcerative colitis (UC)-like” subgroup of Crohn’s disease (CD).

关键词： Ulcerative colitis-like Crohn’ s disease Ulcerative colitis Crohn’ s colitis Inflammatory bowel disease

Distraction ligamentotaxis for complex proximal interphalangeal joint fracture dislocations:a clinical study and themodified pins rubber band traction system revisited

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Burns & Trauma 2018年第3期6卷 234-241页

作者： Cheng Hean Lo Simone H.Nothdurft Hye-Sung Park Eldho paul james Leong Department of Plastic and Reconstructive Surgery Monash Health(Dandenong Hospital)135 David StDandenongVictoria 3175Australia Monash Health(Dandenong Hospital) 135 David StDandenongVictoria 3175Australia Department of Epidemiology and Preventive Medicine School of Public Health and Preventive MedicineMonash University553 St Kilda RoadMelbourneVictoria 3004Australia Department of Surgery Monash UniversityWellington RoadClaytonVictoria 3800Australia

Background:The purpose of this study is to present our experience with the modified pins and rubber band traction system, discuss problems encountered, and make recommendations to optimize outcomes. Methods:Data was collected prospectively from November 2013 to March 2017 at a tertiary referral hospital in Melbourne, Australia. Patients with closed complex proximal interphalangeal joint fracture dislocations that were considered unsuitable for other surgical options were included in the study. Patients underwent dynamic skeletal distraction using the modified (Deshmukh) pins rubber band traction system. Outcomes were measured using the Nominal Rating Scale for pain;Disabilities of the Arm, Shoulder, and Hand (DASH) score;active and passive range of motion;patient rating scale;and complications. Results:Twenty patients underwent the procedure, and 19 were included in analyses. At the final follow-up assessment, an average of 62° and 77° was achieved for proximal interphalangeal joint active and passive range of motion, respectively. Pain levels were low (median score of 0 at rest and 1 ranging, out of 10). Four patients suffered minor pin site infections. Conclusion:Distraction ligamentotaxis is a useful part of the armamentarium, especially in the absence of more suitable procedures. It is important to select appropriate patients, educate, and ensure adherence to postoperative therapy. Employing the Deshmukh frame modification streamlines the theatre processes, and removal of wires at approximately 4 weeks minimizes risk of pin site infection.

关键词： Intra-articular fracture dislocations Proximal interphalangeal Pins rubber band distraction Ligamentotaxis

Reliability and concurrent validity of postural asymmetry measurement in adolescent idiopathic scoliosis

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World Journal of Orthopedics 2017年第1期8卷 68-76页

作者： Ashleigh Prowse Berit Aslaksen Marie Kierkegaard james Furness paul Gerdhem Allan Abbott Faculty of Health Science and Medicine Bond University Department of Physio-therapy Karolinska University Hospital Department of Neurobiology Care Sciencesand Society (NVS)Division of PhysiotherapyKarolinska Institutet Department of Clinical Science Intervention and Technology (CLINTEC)Karolinska Institutet Department of Medical and Health Sciences Division of PhysiotherapyFaculty of Health SciencesLink?ping University

AIM To investigate the reliability and concurrent validity of the Baseline~? Body Level/Scoliosis meter for adolescent idiopathic scoliosis postural assessment in three anatomical *** This is an observational reliability and concurrent validity study of adolescent referrals to the Orthopaedic department for scoliosis screening at KarolinskaUniversity Hospital, Stockholm, Sweden between MarchMay 2012. A total of 31 adolescents with idiopathic scoliosis(13.6 ± 0.6 years old) of mild-moderate curvatures(25°± 12°) were consecutively recruited. Measurement of cervical, thoracic and lumbar curvatures, pelvic and shoulder tilt, and axial thoracic rotation(ATR) were performed by two trained physiotherapists in one day. The intraclass correlation coefficient(ICC) was used to determine the inter-examiner reliability(ICC2,1) and the intra-rater reliability(ICC3,3) of the Baseline~? Body Level/Scoliosis meter. Spearman's correlation analyses were used to estimate concurrent validity between the Baseline~? Body Level/Scoliosis meter and Gold Standard Cobb angles from radiographs and the Orthopaedic Systems Inc. *** There was excellent reliability between examiners for thoracic kyphosis(ICC2,1 = 0.94), ATR(ICC2,1 = 0.92) and lumbar lordosis(ICC2,1 = 0.79). There was adequate reliability between examiners for cervical lordosis(ICC2,1 = 0.51), however poor reliability for pelvic and shoulder tilt. Both devices were reproducible in the measurement of ATR when repeated by one examiner(ICC3,3 0.98-1.00). The device had a good correlation with the Scoliometer(rho = 0.78). When compared with Cobb angle from radiographs, there was a moderate correlation for ATR(rho = 0.627).CONCLUSION The Baseline~? Body Level/Scoliosis meter provides reliable transverse and sagittal cervical, thoracic and lumbar measurements and valid transverse plan measurements of mild-moderate scoliosis deformity.

关键词： Reliability Validity Scoliosis Posture Assessment

Skin bioprinting:the future of burn wound reconstruction?

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Burns & Trauma 2019年第1期7卷 25-36页

作者： Mathew Varkey Dafydd O.Visscher paul P.Mvan Zuijlen Anthony Atala james J.Yoo Wake Forest Institute for Regenerative Medicine Wake Forest School of MedicineMedical Center BoulevardWinston-SalemNC 27101USA Department of Plastic Reconstructive and Hand SurgeryAmsterdam University Medical Center1081HVAmsterdamThe Netherlands Amsterdam Movement Sciences AmsterdamThe Netherlands Burn Center Red Cross Hospital1942LEBeverwijkThe Netherlands Association of Dutch Burn Centres 1942LEBeverwijkThe Netherlands

Burns are a significant cause of trauma,and over the years,the focus of patient care has shifted from just survival to facilitation of improved functional ***,burn treatment,especially in the case of extensive burn injuries,involves surgical excision of injured skin and reconstruction of the burn injury with the aid of skin *** skin substitutes do not contain all skin cell types and do not facilitate recapitulation of native skin ***-dimensional(3D)bioprinting for reconstruction of burn injuries involves layer-by-layer deposition of cells along with scaffolding materials over the injured *** bioprinting can be done either in situ or in *** these approaches are similar except for the site of printing and tissue *** are technological and regulatory challenges that need to be overcome for clinical translation of bioprinted skin for burn ***,the use of bioprinting for skin reconstruction following burns is promising;bioprinting will enable accurate placement of cell types and precise and reproducible fabrication of constructs to replace the injured or damaged ***,3D bioprinting is a very transformative technology,and its use for wound reconstruction will lead to a paradigm shift in patient *** this review,we aim to introduce bioprinting,the different stages involved,in vitro and in vivo skin bioprinting,and the various clinical and regulatory challenges in adoption of this technology.

关键词： Bioprinting Skin Burns Reconstruction

Age predicts the absence of caloric-induced vertigo

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Journal of Otology 2018年第1期13卷 5-9页

作者： Gary P.Jacobson Erin G.Piker Sarah L.grantham Lauren N.English Department of Hearing and Speech Sciences Divisions of Audiology and Vestibular Sciences Vanderbilt University Medical Center Nashville TN USA Department of Communication Sciences and Disorders James Madison University Harrisonburg VA USA

Introduction: The absence of vertigo during the caloric test, despite a robust response, has been suggested to represent a central vestibular system phenomenon. The purpose of this investigation was to determine the prevalence of absent caloric-induced vertigo perception in an unselected group of patients and to assess possible predicting ***: Prospective investigation of 92 unselected patients who underwent caloric testing. Inclusion criteria were that each patient generate a maximum slow phase velocity(maxSPV) > 15 deg/sec and a caloric asymmetry of≤10%. Following the caloric, patients were asked, "Did you have any sensation of motion?"Results: Results showed 75% of patients reported motion with a mean age of 56.51 years compared to a mean age of 66.55 in the 25% of patients reporting an absence of motion. A logistic regression was performed and the overall model was statistically significant accounting for 29% of the variance in caloric perception. The significant predictor variables were patient age and maxSPV of the caloric response. The effect size for both variables was small with an odds ratio of.9 for maxSPV and 1.06 for ***: The current investigation showed that both age and maxSPV of the caloric response were significant predictors of vertigo perception during the caloric exam. However, the association between age and caloric perception is not conclusive. Although there is evidence to suggest that these findings represent age-related changes in the central processing of vestibular system stimulation, there are additional unmeasured factors that influence the perception of caloric-induced vertigo.

关键词： Vestibular Vertigo Central processing Caloric test Aging

The role of latanoprost in an inflammatory bowel disease flare

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Gastroenterology Report 2014年第3期2卷 232-234页

作者： Sonali paul Martin Wand Geoffrey T.Emerick james M.Richter Department of Gastroenterology and Hepatology Tufts Medical CenterBostonMAUSA Department of Ophthalmology University of Connecticut School of Medicine and Consulting OphthalmologistsFarmingtonCTUSA Department of Gastroenterology Massachusetts General HospitalBostonMAUSA

Ulcerative colitis and Crohn’s disease(CD)are characterized by inflammation of the intestinal mucosa and symptoms of abdominal pain and *** studies have shown an association between elevated levels of prostaglandins and mucosal damage in inflammatory bowel *** report a 50-year-old woman with a history of CD and open-angle *** glaucoma was treated with latanoprost,a prostaglandin analog,which was associated with an exacerbation of her *** discontinuation of latanoprost,her CD symptoms disappeared *** case suggests that in a patient with CD,topical administration of latanoprost may result in sufficient systemic absorption and circulation to promote a relapse of *** finding has important implications,not only for patients with inflammatory bowel disease and glaucoma,but also for both ophthalmologists and gastroenterologists.

关键词： lantanoprost Crohn’s disease prostaglandin glaucoma

Phylogenetic placement of lichenicolous Phoma species in the Phaeosphaeriaceae(Pleosporales,Dothideomycetes)

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Fungal Diversity 2012年第4期55卷 195-213页

作者： james D.Lawrey paul Diederich Matthew P.Nelsen Colin Freebury Dries Van den Broeck Masoumeh Sikaroodi Damien Ertz Department of Environmental Science and Policy George Mason University4400 University DriveFairfaxVA 22030-4444USA Musée national d’histoire naturelle 25 rue MunsterL-2160 LuxembourgLuxembourg Committee on Evolutionary Biology University of Chicago1025 E.57th StreetChicagoIL 60637USA Department of Botany The Field Museum1400 S.Lake Shore DriveChicagoIL 60605USA Canadian Museum of Nature P.O.Box 3443Station DOttawaON K1P 6P4Canada Jardin Botanique National de Belgique Domaine de BouchoutB–1860 MeiseBelgium

More than twenty species of lichenicolous fungi have been described in Phoma,a large anamorphic genus of primarily plant-associated pathogens with broad geographic *** obtained nuclear and mitochondrial rDNA sequences from 19 fungal cultures isolated from specimens representing four described and two undescribed lichenicolous species in the *** multilocus phylogeny indicates that lichenicolous Phoma species represent at least two phylogenetically distinct clades in the Phaeosphaeriaceae,one including a new species,Phoma puncteliae,isolated from a specimen of Punctelia rudecta collected inMaryland,USA,and another group of primarily lichenicolous *** latter group includes four described lichenicolous Phoma species,an unidentified melanized rock fungus,and a new lichenicolous Phoma species isolated from Xanthomendoza species collected in Canada that we are naming *** specimens in this clade collected from different lichen genera and species were found to be very similar genetically,which calls into question the recent practice of recognizing lichenicolous Phoma species mainly by differences in host preference.

关键词： Anamorphic fungi Coelomycetes Conidial fungi Parasitic fungi

Phylogenetic insights resolve Dacampiaceae(Pleosporales)as polyphyletic:Didymocyrtis(Pleosporales,Phaeosphaeriaceae)with Phoma-like anamorphs resurrected and segregated from Polycoccum(Trypetheliales,Polycoccaceae ***.)

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Fungal Diversity 2015年第5期74卷 53-89页

作者： Damien Ertz paul Diederich james D.Lawrey Franz Berger Colin E.Freebury Brian Coppins Alain Gardiennet Josef Hafellner Department Bryophytes-Thallophytes(BT) Botanic Garden MeiseNieuwelaan 38B-1860 MeiseBelgium Musée national d’histoire naturelle 25 rue MunsterL-2160 LuxembourgLuxembourg Department of Biology George Mason University4400 University DriveFairfaxVA 22030USA Raiffeisenweg 130 A-4794 KopfingAustria Canadian Museum of Nature PO Box 3443Stn.BDOttawaOntarion K1P 6P4Canada Royal Botanic Garden Edinburgh 20A Inverleith RowEdinburgh EH35LRUK 14 rue Roulette F-21260 VéronnesFrance Institute for Plant Sciences NAWI GrazKarl-Franzens-University GrazHolteigasse 6A-8010 GrazAustria

A phylogenetic analysis of nuLSU and ITS sequences representing genera previously included in Dacampiaceae indicates that the family is strongly polyphyletic and that the type species of Dacampia is placed in *** genus Munkovalsaria *** placed in Didymosphaeriaceae(Pleosporales).Polycoccum *** two species of Clypeococcum are shown to form a new lineage sister to the Trypetheliaceae in Trypetheliales and described here as *** members of Polycoccum *** included in the Pleosporales and are closely related to lichenicolous Phoma-like species of the family *** genus Didymocyrtis is resurrected for these species and for lichenicolous species previously assigned to Diederichia,Diederichomyces,Leptosphaeria and *** genera Diederichia and Diederichomyces are synonymized with *** new combinations Didymocyrtis bryonthae,***,***,***,***,***,***,***,*** and *** are made,and the new name *** is introduced for Phoma *** anamorph-teleomorph relationships are resolved,such as Didymocyrtis ramalinae–Phoma ficuzzae and Didymocyrtis consimilis–Phoma caloplacae,the phylogenetic results being supported by single ascospore cultures that lead to the asexual stage producing pycnidia and conidia in *** by host switching is assumed to be important in the genus *** identification key to Didymocyrtis species is provided.

关键词： Dothideomycetes Leptosphaeria Diederichia Diederichomyces Lichenicolous fungi Phylogeny