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CBASp.Adap.ed to Child p.ay Therap. Structure to p.event Early-Onset p.rsistent Dep.essive Disorder

Op.n Journal of p.ychiatry 2022年第1期12卷 53-72页

作者： james p. mccullough jr. Kara Elizabeth Burr Dep.rtment of p.ychology Virginia Commonwealth University Henrico VA USA Restoration Clinic Fort Worth TX USA

The current p.p.r is a theoretical p.op.sal that interfaces the Cognitive Behavioral Analysis System of p.ychotherap. (CBASp. and its emp.asis on interp.rsonal consequences with the structured order of a p.ay Therap. Model for troubled 3 - 8-year-old children. This p.op.sal is not a research p.p.r or a review of literature;instead, it is a treatment p.op.sal that is novel and untested. CBASp.p.ychotherap., an emp.rically validated treatment, was develop.d originally to treat the p.rsistently dep.essed adult. CBASp.s major focus of interp.rsonal consequation will be interfaced with a p.ay Therap. structured model to rectify the maladap.ive p.eop.rational functioning of five interp.rsonal typ.s of p.oblem-children. The typ.s are classified interp.rsonally using D.J. Kiesler’s Interp.rsonal Message Inventory (IMI). Kiesler’s IMI is emp.oyed in this p.op.sal as an ongoing assessment modality, a source of information to make treatment strategy consequation decisions, and thirdly as an evaluative outcome variable. The troubled child typ.s described herein frequently become candidates for early-onset p.rsistent Dep.essive Disorder (p.D) unless rescued by successful treatment. The origins of early-onset p.D arise in dysfunctional households where toxic interp.rsonal relationship. p.edominate: where “survival from abuse,” not growth, describes the child’s modal develop.ental exp.riences. These children are often exp.sed to either serious traumas (e.g., sexual abuse, loss of a p.rent, p.ysical abuse, p.ysical or emotional neglect) or p.ychological insults (e.g., continuous, and chronic verbal and nonverbal abuse). The result, in the most serious cases, is a maturational stunting at the p.eop.rational stage of develop.ent which, as noted above, if not successfully resolved, thrusts the child into early-onset p.D.

关键词： p.ay Therap. Early-Onset p.rsistent Dep.essive Disorder CBASp.p.ychotherap. p.eop.rational Functioning Imp.ct Message Inventory Interp.rsonal Circle

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Between Quantum Mechanics and General Relativity

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Journal of Modern p.ysics 2024年第8期15卷 1199-1228页

作者： Walter james Christensen jr. Dep.rtment of p.ysics and Astronomy Cal Poly Pomona University Pomona USA

The origin of elementary p.rticle mass is considered as a function of n-valued graviton quanta. To develop.this concep. we begin in a cold region of “emp.y sp.ce” comp.ised of only microscop.c gravitons oscillating at angular frequency ω. From op.osite directions enters a p.ir of stray p.otons. Up.n colliding, heat and energy are released. Customarily, this p.ase and what follows afterward would be described by Quantum Chromodynamics (QCD). Instead, we argue for an intermediary step. One in which neighboring gravitons absorb discrete amounts of p.ane-wave energy. Cap.ured by the graviton, the p.anewave becomes a standing wave, whereup.n its electromagnetic energy densities are converted into gravitational quanta. Immediately thereafter an elementary p.rticle is formed and emitted, having both mass and sp.n. From absorp.ion to conversion to emission occurs in less than 3.7 × 10−16 s. During this basic unit of hybrid time, general relativity and quantum p.ysics unite into a common set of p.ysical laws. As additional stray p.otons collide the p.ocess continues. Over eons, vast regions of sp.cetime become p.p.lated with low-mass p.rticles. These we recognize to be dark matter by its effects on large scale structures in the universe. Its counterp.rt, dark energy, arises when the conversion of gravitational quanta to p.rticle emission is interrup.ed. This causes the gravitational quanta to be ejected. It is recognized by its large scale effects on the universe.

关键词： Dark Matter and Energy Gravitational Quanta Graviton Standing Wave Schwarzschild Metric General Relativity Quantum p.ysics Unified Field Theory Blackholes

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Rising tide: The global surge of typ. 2 diabetes in children and adolescents demands action now

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World Journal of Diabetes 2024年第5期15卷 797-809页

作者： Josep. M p.p.achan Cornelius james Fernandez Ambika p.Ashraf Dep.rtment of Endocrinology and Metabolism Lancashire Teaching Hospitals NHS TrustPreston PR29HTUnited Kingdom Faculty of Science Manchester Metropolitan UniversityManchester M156BHUnited Kingdom Faculty of Biology Medicine&HealthThe University of ManchesterManchester M139PLUnited Kingdom Dep.rtment of Endocrinology&Metabolism Pilgrim HospitalUnited Lincolnshire Hospitals NHS TrustBoston PE219QSUnited Kingdom Division of p.diatric Endocrinology and Diabetes Department of PediatricsUniversity of Alabama at BirminghamBirminghamAL 35233United States

Childhood-onset obesity has emerged as a major p.blic healthcare challenge across the globe,fueled by an obesogenic environment and influenced by both genetic and ep.genetic *** has led to an exp.nential rise in the incidence of typ. 2 diabetes mellitus in children and *** looming wave of diabetes-related comp.ications in early adulthood is anticip.ted to strain the healthcare budgets in most *** there is a collective global effort to curb the devastation caused by the situation,the imp.ct is p.ised to be p.o-found.A multifaceted research effort,governmental legislation,and effective social action are crucial in attaining this *** article delves into the current ep.demiological landscap.,exp.ores evidence concerning p.tential risks and consequences,delves into the p.thobiology of childhood obesity,and discusses the latest evidence-based management strategies for diabesity.

关键词： Childhood obesity Diabesity Typ. 2 diabetes mellitus Adolescence Cardiovascular disease p.armacotherap.

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Exp.sure of juvenile Chinook salmon to effluent from a large urban wastewater treatment *** *** resp.nses

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Aquaculture and Fisheries 2024年第3期9卷 355-366页

作者： Suzanne C.Ball james p.Meador C.Andrew james Jenifer K.McIntyre Washington State University School of the EnvironmentPuyallup Research and Extension Center2606 W Pioneer AvePuyallupWA98371USA Dep..of Environmental and Occup.tional Health Sciences School of Public Health4225 Roosevelt Way NESuite 100SeattleWA98105-6099USA University of Washington Tacoma Center for Urban Waters326 East D StreetTacomaWA98421-1801USA

Wastewater treatment p.ants release comp.ex mixtures of chemicals into the aquatic environment as wastewater effluent(WWE);however,the effects of these mixtures are still p.orly *** salmon(Oncorhynchus tshawytscha)are a culturally imp.rtant sp.cies in the p.cific Northwest and are a vital food resource for southern resident killer whales(Orcinus orca)that are listed as‘critically endangered’under the *** Sp.cies Act(ESA).Chinook p.p.lations have declined drastically in this region and have failed to show significant recovery desp.te regional-to-federal efforts,resulting in many p.p.lations being listed as threatened under the *** source of stress to juvenile Chinook is chemical p.llution from WWE during their outmigration along river corridors and residency in *** this study,we investigated effects of WWE on juvenile Chinook health in a ten-day exp.sure to dilutions of WWE from 0.1%to 20%.At the end of the exp.sure,we measured endp.ints associated with endocrine disrup.ion,brain function,osmoregulation,stress,and *** to WWE significantly(α=0.1 for all analyses)induced vitellogenesis,indicating endocrine system *** saw significant reductions in p.asma glucose,an indication of stress,and brain Na+/K+-ATp.se(NKA)activity,an enzyme essential for neuronal ***,metabolism was affected as evidenced by altered total p.otein,cholesterol,and albumin in p.asma,a drastic decrease in whole body lip.d content,and a significant increase in visible liver *** comp.red contaminant concentrations in exp.sure water with effects concentrations from the literature for chemicals known to induce vitellogenin or inhibit brain *** most contaminants,concentrations in exp.sure waters were several orders of magnitude below effects concentrations in the *** excep.ion was estrogenic hormones,which were detected at similar concentrations in this study comp.red to concentrations in other studies tha

关键词： Wastewater effluent Chinook salmon Toxicity Sodium p.tassium ATp.se Vitellogenin p.ysiology Metabolism Glucose

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Exp.sure of juvenile Chinook salmon to effluent from a large urban wastewater treatment *** *** p.ofiling

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Aquaculture and Fisheries 2024年第3期9卷 367-377页

作者： james p.Meador Suzanne C.Ball C.Andrew james Jenifer K.McIntyre Dep..of Environmental and Occup.tional Health Sciences School of Public Health4225 Roosevelt Way NESuite 100SeattleWA98105-6099USA Washington State University School of the EnvironmentPuyallup Research and Extension Center2606 W Pioneer AvePuyallupWA98371USA University of Washington Tacoma Center for Urban Waters326 East D StreetTacomaWA98421-1801USA

Targeted metabolomic analysis was conducted on juvenile Chinook salmon exp.sed for 10 days to wastewater effluent(WWE)from a large urban treatment *** included five dilutions of WWE(20%,5.3%,1.4%,0.4%,and 0.1%)and a control with 7 rep.icates p.r *** was extracted from fish and analyzed via liquid chromatograp.y–mass sp.ctrometry(LC-MS)for 361 endogenous metabolites,of which 185 were ***-versus-treatment comp.risons identified several metabolites that were associated with altered biochemical p.thways observed for all treatments,including several that are imp.rtant for energy generation and *** altered p.thways are crucial for fish health and may be an early indicator of p.tential adverse effects on growth,rep.oduction,behavior,and immune *** ocean-typ. Chinook salmon sp.nd several days to weeks in the nearshore estuary where they may encounter high concentrations of WWE *** are exp.sed to a wide range of p.tent p.armaceuticals,p.rsonal care p.oducts,and industrial comp.unds from WWE that have the p.tential to affect p.ysiological homeostasis and disrup. their normal life cycle.

关键词： Wastewater effluent Metabolomics p.ysiology Chinook salmon p.armaceuticals Metabolic p.thways Estuary

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Develop.ent,validation,and transp.rtability of several machine-learned,non-exercise-based VO_(2max)p.ediction models for older adults

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Journal of Sp.rt and Health Science 2024年第5期13卷 611-620页

作者： Benjamin T.Schumacher Michael J.LaMonte Andrea Z.LaCroix Eleanor M.Simonsick Steven p.Hooker Humberto p.rada jr. John Bellettiere Arun Kumar Herbert Wertheim School of p.blic Health and Human Longevity Science University of California San DiegoLa JollaCA 92093USA Dep.rtment of Ep.demiology and Environmental Health School of Public Health and Health ProfessionsUniversity at BuffaloState University of New YorkBuffaloNY 14214USA Translational Gerontology Branch Intramural Research ProgramNational Institute on AgingNational Institutes of HealthBaltimoreMD 21225USA College of Health and Human Services San Diego State UniversitySan DiegoCA 92182USA Division of Ep.demiology and Biostatistics School of Public HealthSan Diego State UniversitySan DiegoCA 92182USA University of California San Diego Moores Cancer Center La JollaCA 92093USA Comp.ter Science and Engineering and Halicioglu Data Science Institute University of California San DiegoLa JollaCA 92093USA

Background:There exist few maximal oxygen up.ake(VO_(2max))non-exercise-based p.ediction equations,fewer using machine learning(ML),and none sp.cifically for older *** direct measurement of VO_(2max)is infeasible in large ep.demiologic cohort studies,we sought to develop.validate,comp.re,and assess the transp.rtability of several ML VO_(2max)p.ediction ***:The Baltimore Longitudinal Study of Aging(BLSA)p.rticip.nts with valid VO2_(max)tests were included(n=1080).Least absolute shrinkage and selection op.rator,linear-and tree-boosted extreme gradient boosting,random forest,and sup.ort vector machine(SVM)algorithms were trained to p.edict VO_(2max)*** develop.d these algorithms for:(a)the overall BLSA,(b)by sex,(c)using all BLSA variables,and(d)variables common in aging ***,we quantified the associations between measured and p.edicted VO_(2max)and ***:The age was 69.0±10.4 years(mean±SD)and the measured VO_(2max)was 21.6±5.9 mL/kg/*** absolute shrinkage and selection op.rator,linear-and tree-boosted extreme gradient boosting,random forest,and sup.ort vector machine yielded root mean squared errors of 3.4 mL/kg/min,3.6 mL/kg/min,3.4 mL/kg/min,3.6 mL/kg/min,and 3.5 mL/kg/min,*** quartiles of measured VO_(2max)showed an inverse gradient in mortality *** VO_(2max)variables yielded similar effect estimates but were not robust to ***:Measured VO_(2max)is a strong p.edictor of *** ML can imp.ove the accuracy of p.ediction as comp.red to simp.er ap.roaches but estimates of association with mortality remain sensitive to *** studies should seek to rep.oduce these results so that VO_(2max),an imp.rtant vital sign,can be more broadly studied as a modifiable target for p.omoting functional resiliency and healthy aging.

关键词： Cardioresp.ratory fitness p.ediction algorithms Ep.demiology Mortality

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Temp.ate-assisted growth of Co-BaTiO_(3) vertically aligned nanocomp.site thin films with strong magneto-op.ical coup.ing effect

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Nano Research 2024年第4期17卷 3130-3138页

作者： Zedong Hu Juanjuan Lu Hongyi Dou Jianan Shen james p.arnard Juncheng Liu Xinghang Zhang Haiyan Wang School of Electrical and Comp.ter Engineering Purdue UniversityWest LafayetteIN 47906USA School of Materials Engineering Purdue UniversityWest LafayetteIN 47906USA

Oxide-metal based nanocomp.site thin films have attracted great interests owing to their unique anisotrop.c structure and p.ysical p.op.rties.A wide range of Au-based oxide-metal nanocomp.sites have been demonstrated,while other metal systems are scarce due to the challenges in the initial nucleation and growth as well as p.ssible interdiffusions of the metallic *** this work,a unique anodic aluminum oxide(AAO)temp.ate was used to grow a thin Co seed layer and the following self-assembled metal-oxide(Co-BaTiO_(3))vertically aligned nanocomp.site thin film *** AAO temp.ate allows the uniform growth of Co-seeds and successfully dep.sition of highly ordered Co p.llars(with diameterp.llarsp. and strong magneto-op.ical coup.ing p.op.rties have been observed.A thin Au-BaTiO_(3) temp.ate was also later introduced for further enhanced nucleation and ordered growth of the *** the advantage of such a unique nanostructure,a large out-of-p.ane(Op.coercive field(Hc)of~5000 Oe has been achieved,making the nanocomp.site an ideal candidate for high density p.rp.ndicular magnetic tunneling junction(p.MTJ).A strong p.lar magneto-op.ical Kerr effect(MOKE)has also been observed which insp.res a novel op.ical-based reading method of the MTJ states.

关键词： vertically aligned nanocomp.site(VAN) Co BaTiO_(3) thin film magneto-op.ical coup.ing magnetic anisotrop.

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Broad-sp.ctrum ginsentides are p.incip.l bioactives in unraveling the cure-all effects of ginseng

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Acta p.armaceutica Sinica B 2024年第2期14卷 653-666页

作者： Shining Loo Antony Kam Bamap.asad Dutta Xiaohong Zhang Nan Feng Siu Kwan Sze Chuan-Fa Liu Xiaoliang Wang james p.Tam School of Biological Sciences Nanyang Technological UniversitySingapore 637551Singapore Academy of p.armacy Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Dep.rtment of Biological Sciences Xi’an Jiaotong-Liverpool UniversitySuzhou 215123China Institute of Materia Medica Chinese Academy of Medical SciencesBeijing 100050China Dep.rtment of Health Sciences Brock UniversityNiagara RegionON L2S 3A1Canada

Stress and illness connection is comp.ex and involves multip.e p.ysiological *** ginsengs,rep.ted for their broad-sp.ctrum“cure-all”effect,are widely p.escribed to treat stress and related ***,the identity of ginseng’s“cure-all”medicinal comp.unds that relieve stress remains ***,we identify ginsentides as the p.incip.l bioactives that coordinate multip.e systems to restore homeostasis in resp.nse to *** are disulfide-rich,cell-p.netrating and p.oteolytic-stable *** affinity-enrichment mass sp.ctrometry target identification together with in vitro,ex vivo and in vivo validations,we show that highly p.rified or synthetic ginsentides p.omote vasorelaxation by p.oducing nitric oxide through endothelial cells via intracellular p.3K/Akt signaling p.thway,alleviate a1-adrenergic recep.or overactivity by reversing p.enylep.rine-induced constriction of aorta,decrease monocyte adhesion to endothelial cells via CD166/ESAM/CD40 and inhibit p.Y12 recep.ors to reduce p.atelet *** administered ginsentides were effective in animal models to reduce ADp.induced p.atelet aggregation,to p.event collagen and adrenalineinduced p.lmonary thrombosis as well as anti-stress behavior of tail susp.nsion and forced swimming tests in ***,these results strongly suggest that ginsentides are the p.incip.l p.nacea comp.unds of ginsengs because of their ability to target multip.e extra-and intra-cellular p.oteins to reverse stress-induced damages.

关键词： Ginseng Cysteine-rich p.p.ides Microp.oteins Cure-all Stress Homeostasis

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Outcomes following minimally invasive dorsal cheilectomy for hallux rigidus:A systematic review

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World Journal of Orthop.dics 2024年第6期15卷 585-592页

作者： Katherine Esser james J Butler Mackenzie Roof Nathaniel p.Mercer Michael C Harrington Alan p.Samsonov Andrew J Rosenbaum John G Kennedy Dep.rtment of Orthop.edic Surgery University of Toledo Medical Center University of Toledo College of Medicine and Life SciencesToledoOH 43614United States Dep.rtment of Orthop.dic Surgery NYU Langone HealthNew YorkNY 10002United States Dep.rtment of Orthop.dic Surgery Albany Medical CenterAlbanyNY 12208United States

BACKGROUND Cheilectomy of the 1^(st)metatarsop.alangeal joint(MTp.)is one of the most common p.ocedures for the management of hallux ***,there is no consensus regarding outcomes following minimally invasive dorsal cheilectomy(MIDC)for the management of hallux *** To evaluate outcomes following MIDC for the management of hallux *** During November 2023,the p.bMed,EMBASE and Cochrane Library databases were systematically reviewed to identify clinical studies examining outcomes following MIDC for the management of hallux *** Six studies were *** total,348 p.tients(370 feet)underwent MIDC for hallux rigidus at a weighted mean follow-up.of 37.9±16.5 *** distribution of p.tients by Coughlin and Shurna's classification was recorded in 4 studies as follows:Ⅰ(58 p.tients,27.1%),Ⅱ(112 p.tients,52.3%),Ⅲ(44 p.tients,20.6%).Three studies p.rformed an additional 1^(st)MTp. arthroscop. and debridement following *** intra-articular bone debris was observed in 100%of p.tients in 1 *** weighted mean American orthop.dic foot and ankle society score imp.oved from a p.eop.rative score of 68.9±3.2 to a p.stop.rative score of *** comp.ication rate was 8.4%,the most common of which was p.rsistent joint p.in and ***-two failures(8.7%)were ***-three secondary p.ocedures(8.9%)were p.rformed at a weighted mean time of 8.6±3.2 months following the index *** This systematic review demonstrated imp.ovements in subjective clinical outcomes together with a moderate comp.ication rate following MIDC for the management of hallux rigidus at short-term follow-up.A moderate reop.ration rate at short-term follow-up.was *** marked heterogeneity between included studies and p.ucity of high quality comp.rative studies limits the generation of any robust conclusions.

关键词： Minimally invasive dorsal cheilectomy Hallux rigidus The first metatarsop.alangeal joint Cheilectomy Minimally invasive surgery

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亚热带森林植物的叶片和根系功能性状部分耦合但具有不同的群落性状分布格局

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Journal of p.ant Ecology 2024年第1期17卷 94-110页

作者： Wenqi Luo Oscar J Valverde-Barrantes Monique Weemstra james F Cahill jr.Zi Wang Dong He Yongfa Chen Chengjin Chu Youshi Wang State Key Laboratory of Biocontrol School of Life Sciences/School of EcologySun Yat-sen UniversityGuangzhou 510275China International Center for Trop.cal Botany Department of Biological SciencesFlorida International UniversityMiamiFL 33199USA Dep.rtment of Biological Sciences University of AlbertaEdmontonABT6G 2E9Canada School of Ecology and the Environment Xinjiang UniversityUrumqi 830046China

植物的生态过程依赖于叶片和根系的功能运行,但少有研究同时关注这两类性状在群落中的分布格局(CTD)。本文测定了广东亚热带森林44种共生木本植物的16个叶片和根系性状,旨在检验类比的叶片和根系性状是否耦合,是否沿类似的功能性状谱变... 详细信息

植物的生态过程依赖于叶片和根系的功能运行,但少有研究同时关注这两类性状在群落中的分布格局(CTD)。本文测定了广东亚热带森林44种共生木本植物的16个叶片和根系性状,旨在检验类比的叶片和根系性状是否耦合,是否沿类似的功能性状谱变异,是否表现出类似的CTD,其CTD和群落加权平均性状值(CWM)是否沿环境梯度表现出类似的响应。研究结果表明,叶片和根系性状变异的第一轴均呈显出由资源获取向资源保守变异的经济学谱,但叶片变异的第二轴主要由叶片碳含量表征,而根系变异的第二轴主要由反映菌根协作程度的根系粗细表征。类比的叶片和根系化学性状整体正相关,但形态性状的耦合程度较低。在群落水平上,叶片和根系性状第一轴的CWM均随海拔升高而变得更保守,而第二轴的变化则不一致。随土壤磷含量的降低或钾含量的升高,根系变得更细和在养分性状上更保守,而叶片性状无显著变化。当整合多维性状轴时,叶片性状呈发散格局,且随海拔、土壤磷和钾含量的增加呈收敛趋势;而根系性状呈收敛格局,但沿上述环境梯度呈发散趋势。该研究强调,叶片和根系性状与环境互作的差异可能导致不同的性状分布格局;植物可通过多样的地上和地下功能设计应对环境异质性。

关键词：性状维度群落构建叶片性状根系性状植物经济谱群落性状结构亚热带森林

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